JP2014532706A5 - - Google Patents

Download PDF

Info

Publication number
JP2014532706A5
JP2014532706A5 JP2014540059A JP2014540059A JP2014532706A5 JP 2014532706 A5 JP2014532706 A5 JP 2014532706A5 JP 2014540059 A JP2014540059 A JP 2014540059A JP 2014540059 A JP2014540059 A JP 2014540059A JP 2014532706 A5 JP2014532706 A5 JP 2014532706A5
Authority
JP
Japan
Prior art keywords
antibody
antigen
binding fragment
chain variable
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014540059A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014532706A (ja
JP6117225B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/062929 external-priority patent/WO2013067098A1/en
Publication of JP2014532706A publication Critical patent/JP2014532706A/ja
Publication of JP2014532706A5 publication Critical patent/JP2014532706A5/ja
Application granted granted Critical
Publication of JP6117225B2 publication Critical patent/JP6117225B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014540059A 2011-11-02 2012-11-01 抗kdr抗体およびその使用方法 Active JP6117225B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161554758P 2011-11-02 2011-11-02
US61/554,758 2011-11-02
US201261609581P 2012-03-12 2012-03-12
US61/609,581 2012-03-12
PCT/US2012/062929 WO2013067098A1 (en) 2011-11-02 2012-11-01 Anti-kdr antibodies and methods of use

Publications (3)

Publication Number Publication Date
JP2014532706A JP2014532706A (ja) 2014-12-08
JP2014532706A5 true JP2014532706A5 (cg-RX-API-DMAC7.html) 2015-11-19
JP6117225B2 JP6117225B2 (ja) 2017-04-19

Family

ID=48192738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014540059A Active JP6117225B2 (ja) 2011-11-02 2012-11-01 抗kdr抗体およびその使用方法

Country Status (12)

Country Link
US (1) US9441042B2 (cg-RX-API-DMAC7.html)
EP (1) EP2785742B1 (cg-RX-API-DMAC7.html)
JP (1) JP6117225B2 (cg-RX-API-DMAC7.html)
KR (1) KR102027603B1 (cg-RX-API-DMAC7.html)
AU (1) AU2012318246B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014010774A2 (cg-RX-API-DMAC7.html)
CA (1) CA2854153A1 (cg-RX-API-DMAC7.html)
IL (1) IL232383B (cg-RX-API-DMAC7.html)
MX (1) MX356412B (cg-RX-API-DMAC7.html)
RU (1) RU2014122184A (cg-RX-API-DMAC7.html)
TW (1) TWI571473B (cg-RX-API-DMAC7.html)
WO (1) WO2013067098A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2014122184A (ru) 2011-11-02 2015-12-10 Апексиджен, Инк. Антитела к kdr и способы их применения
WO2016057726A2 (en) 2014-10-07 2016-04-14 Kadmon Corporation, Llc Human anti-vegfr-2/kdr antibodies
KR101896882B1 (ko) 2015-11-30 2018-09-11 앱클론(주) Vegfr2에 특이적으로 결합하는 항체
CN109952315A (zh) * 2016-11-16 2019-06-28 伊莱利利公司 用于转移性结直肠癌的治疗
WO2018237287A1 (en) * 2017-06-22 2018-12-27 Apexigen, Inc. Anti-vista antibodies and methods of use
CN114174335B (zh) * 2019-07-19 2023-12-15 神州细胞工程有限公司 一种人源化vegfr2抗体及其应用
CA3215430A1 (en) * 2021-04-14 2022-10-20 Suzhou Transcenta Therapeutics Co., Ltd. Novel anti-hvegfr2 antibodies
KR20230039943A (ko) * 2021-09-15 2023-03-22 주식회사 파멥신 항-vegfr2(kdr) 개량 항체 및 이의 용도

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4137230A (en) 1977-11-14 1979-01-30 Takeda Chemical Industries, Ltd. Method for the production of maytansinoids
US4265814A (en) 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
JPS5562090A (en) 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS5566585A (en) 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS55164685A (en) 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4309428A (en) 1979-07-30 1982-01-05 Takeda Chemical Industries, Ltd. Maytansinoids
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
CA2026147C (en) 1989-10-25 2006-02-07 Ravi J. Chari Cytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5264586A (en) 1991-07-17 1993-11-23 The Scripps Research Institute Analogs of calicheamicin gamma1I, method of making and using the same
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US6765087B1 (en) 1992-08-21 2004-07-20 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
ATE204325T1 (de) 1993-04-29 2001-09-15 Unilever Nv Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5675063A (en) 1995-02-28 1997-10-07 Loyola University Of Chicago Immortalized rabbit hybridoma fusion partner
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US20020064528A1 (en) 2000-01-28 2002-05-30 Zhenping Zhu Antibodies specific to KDR and uses thereof
EP2110138A1 (en) * 1999-08-27 2009-10-21 Genentech, Inc. Dosages for treatment of anti-erbB2 antibodies
KR20020087453A (ko) 2000-03-31 2002-11-22 임클론 시스템즈 인코포레이티드 혈관 내피 성장 인자 수용체 길항제를 사용한, 포유동물의비충실성 종양의 치료 방법
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
US8093357B2 (en) 2002-03-01 2012-01-10 Xencor, Inc. Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7657380B2 (en) 2003-12-04 2010-02-02 Xencor, Inc. Methods of generating variant antibodies with increased host string content
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
DE60333554D1 (de) 2002-03-04 2010-09-09 Imclone Llc Kdr-spezifische humane antikörper und deren anwendung
ES2897506T3 (es) 2003-01-09 2022-03-01 Macrogenics Inc Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
AU2005274905B2 (en) 2004-08-04 2010-12-23 Mentrik Biotech, Llc Variant Fc regions
US7462697B2 (en) 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
AU2005335714B2 (en) 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
JP2008528010A (ja) 2005-01-31 2008-07-31 アブリンクス ナームローゼ フェンノートシャップ 重鎖抗体の可変ドメイン配列を作出する方法
EP1871808A2 (en) 2005-03-31 2008-01-02 Xencor, Inc. Fc VARIANTS WITH OPTIMIZED PROPERTIES
US7429487B2 (en) 2005-07-05 2008-09-30 Epitomics, Inc. Fusion partner for production of monoclonal rabbit antibodies
EA016609B1 (ru) 2005-11-28 2012-06-29 Генмаб А/С Рекомбинантные моновалентные антитела и способы их получения
KR100883430B1 (ko) 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
JP2010534469A (ja) 2007-07-25 2010-11-11 アストラゼネカ アクチボラグ Kdr指向性標的化結合物質およびその使用
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
US8293483B2 (en) * 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
RU2014122184A (ru) 2011-11-02 2015-12-10 Апексиджен, Инк. Антитела к kdr и способы их применения
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Similar Documents

Publication Publication Date Title
JP2014532706A5 (cg-RX-API-DMAC7.html)
CN106659779B (zh) 双特异性四价抗体及其制造和使用方法
JP2017535257A5 (cg-RX-API-DMAC7.html)
JP2014518615A5 (cg-RX-API-DMAC7.html)
JP2013527761A5 (cg-RX-API-DMAC7.html)
JP2018503380A5 (cg-RX-API-DMAC7.html)
RU2014122184A (ru) Антитела к kdr и способы их применения
JP2014503189A5 (cg-RX-API-DMAC7.html)
JP2013506428A5 (cg-RX-API-DMAC7.html)
FI3515487T3 (fi) Bispesifisiä anti-MUC16-CD3-vasta-aineita ja anti-MUC16-lääkekonjugaatteja
IL273424B2 (en) Novel bispecific cd3/cd19 polypeptide complexes
RU2016136527A (ru) Улучшенные способы лечения васкуляризированных злокачественных опухолей
JP2019535670A5 (cg-RX-API-DMAC7.html)
JP2017537620A5 (cg-RX-API-DMAC7.html)
JP2014509510A5 (cg-RX-API-DMAC7.html)
ME02148B (me) Notch-vezivni agensi i antagonisti i postupci za njihovo korišćenje
JP2018504105A5 (cg-RX-API-DMAC7.html)
JP2014158469A5 (cg-RX-API-DMAC7.html)
JP2017529838A5 (cg-RX-API-DMAC7.html)
NZ602892A (en) Antibodies that bind human cd27 and uses thereof
JP2017506067A5 (cg-RX-API-DMAC7.html)
JP2013527762A5 (cg-RX-API-DMAC7.html)
CA2798390A1 (en) Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
JP2018507188A5 (cg-RX-API-DMAC7.html)
JP2014522850A5 (cg-RX-API-DMAC7.html)