JP2011509311A5 - - Google Patents
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- JP2011509311A5 JP2011509311A5 JP2010542394A JP2010542394A JP2011509311A5 JP 2011509311 A5 JP2011509311 A5 JP 2011509311A5 JP 2010542394 A JP2010542394 A JP 2010542394A JP 2010542394 A JP2010542394 A JP 2010542394A JP 2011509311 A5 JP2011509311 A5 JP 2011509311A5
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- JP
- Japan
- Prior art keywords
- composition
- hydrophobic
- solution
- chain
- main chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 81
- 230000002209 hydrophobic effect Effects 0.000 claims description 60
- 229920000642 polymer Polymers 0.000 claims description 46
- 230000001681 protective effect Effects 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 14
- 150000004676 glycans Chemical class 0.000 claims description 14
- 229920001282 polysaccharide Polymers 0.000 claims description 14
- 239000005017 polysaccharide Substances 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- 239000003125 aqueous solvent Substances 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 12
- 125000003277 amino group Chemical group 0.000 claims description 10
- 238000011068 loading method Methods 0.000 claims description 10
- 229920001542 oligosaccharide Polymers 0.000 claims description 10
- 150000002482 oligosaccharides Chemical class 0.000 claims description 10
- -1 polythreonine Proteins 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 108010039918 Polylysine Proteins 0.000 claims description 6
- 150000001718 carbodiimides Chemical class 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229920000656 polylysine Polymers 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims description 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 4
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims description 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 claims description 4
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims description 4
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims description 4
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims description 4
- 102000016267 Leptin Human genes 0.000 claims description 4
- 108010092277 Leptin Proteins 0.000 claims description 4
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 claims description 4
- 102400000015 Vasoactive intestinal peptide Human genes 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims description 4
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 claims description 4
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 4
- 229940039781 leptin Drugs 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000004856 Lectins Human genes 0.000 claims description 2
- 108090001090 Lectins Proteins 0.000 claims description 2
- 229920000805 Polyaspartic acid Polymers 0.000 claims description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 2
- 229920002125 Sokalan® Chemical class 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims description 2
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 230000027455 binding Effects 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 230000015861 cell surface binding Effects 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 125000001165 hydrophobic group Chemical group 0.000 claims description 2
- 239000002523 lectin Substances 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 229920000962 poly(amidoamine) Chemical class 0.000 claims description 2
- 239000004584 polyacrylic acid Chemical class 0.000 claims description 2
- 108010064470 polyaspartate Proteins 0.000 claims description 2
- 108010077051 polycysteine Proteins 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- 108010000222 polyserine Proteins 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000000935 solvent evaporation Methods 0.000 claims description 2
- 150000005846 sugar alcohols Chemical class 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/971,482 US20090176892A1 (en) | 2008-01-09 | 2008-01-09 | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| PCT/US2009/030678 WO2009089506A1 (en) | 2008-01-09 | 2009-01-09 | Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259956A Division JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509311A JP2011509311A (ja) | 2011-03-24 |
| JP2011509311A5 true JP2011509311A5 (https=) | 2013-01-31 |
Family
ID=40845092
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542394A Withdrawn JP2011509311A (ja) | 2008-01-09 | 2009-01-09 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2013259956A Active JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2014110975A Withdrawn JP2014156486A (ja) | 2008-01-09 | 2014-05-29 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2016104890A Active JP6244400B2 (ja) | 2008-01-09 | 2016-05-26 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2017149174A Active JP6342556B2 (ja) | 2008-01-09 | 2017-08-01 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259956A Active JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2014110975A Withdrawn JP2014156486A (ja) | 2008-01-09 | 2014-05-29 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2016104890A Active JP6244400B2 (ja) | 2008-01-09 | 2016-05-26 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2017149174A Active JP6342556B2 (ja) | 2008-01-09 | 2017-08-01 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20090176892A1 (https=) |
| EP (1) | EP2240165B1 (https=) |
| JP (5) | JP2011509311A (https=) |
| WO (1) | WO2009089506A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| JP5281358B2 (ja) * | 2008-10-27 | 2013-09-04 | 学校法人常翔学園 | 高分子、経上皮吸収促進剤、及び医薬用製剤 |
| CA2773737C (en) * | 2009-09-09 | 2021-11-16 | Pharmain Corporation | Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same |
| WO2012051457A1 (en) * | 2010-10-14 | 2012-04-19 | Nitto Denko Corporation | Nucleic acid delivery compounds |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US10035885B2 (en) * | 2014-11-03 | 2018-07-31 | Pharmain Corporation | Method of production of graft co-polymer excipient with a superior peptide and protein binding property |
| WO2018017954A1 (en) * | 2016-07-21 | 2018-01-25 | Rutgers, The State University Of New Jersey | Antimicrobial cationic systems and methods of use |
| WO2019110788A1 (fr) | 2017-12-07 | 2019-06-13 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| US20190275108A1 (en) * | 2017-12-07 | 2019-09-12 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analogue and a co-polyamino acid |
| FR3083086A1 (fr) * | 2018-06-29 | 2020-01-03 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| SG11202005319PA (en) | 2017-12-07 | 2020-07-29 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog and a copolyamino acid |
| WO2019110797A1 (fr) | 2017-12-07 | 2019-06-13 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
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-
2008
- 2008-01-09 US US11/971,482 patent/US20090176892A1/en not_active Abandoned
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2009
- 2009-01-09 WO PCT/US2009/030678 patent/WO2009089506A1/en not_active Ceased
- 2009-01-09 JP JP2010542394A patent/JP2011509311A/ja not_active Withdrawn
- 2009-01-09 EP EP09700547.4A patent/EP2240165B1/en active Active
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2010
- 2010-02-24 US US12/711,564 patent/US8999930B2/en active Active
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2013
- 2013-12-17 JP JP2013259956A patent/JP5878912B2/ja active Active
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2014
- 2014-05-29 JP JP2014110975A patent/JP2014156486A/ja not_active Withdrawn
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2015
- 2015-02-20 US US14/628,118 patent/US9562111B2/en active Active
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2016
- 2016-05-26 JP JP2016104890A patent/JP6244400B2/ja active Active
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2017
- 2017-08-01 JP JP2017149174A patent/JP6342556B2/ja active Active
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