JP2011509311A5 - - Google Patents
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- JP2011509311A5 JP2011509311A5 JP2010542394A JP2010542394A JP2011509311A5 JP 2011509311 A5 JP2011509311 A5 JP 2011509311A5 JP 2010542394 A JP2010542394 A JP 2010542394A JP 2010542394 A JP2010542394 A JP 2010542394A JP 2011509311 A5 JP2011509311 A5 JP 2011509311A5
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- JP
- Japan
- Prior art keywords
- composition
- hydrophobic
- solution
- chain
- main chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 81
- 230000002209 hydrophobic effect Effects 0.000 claims description 60
- 229920000642 polymer Polymers 0.000 claims description 46
- 230000001681 protective effect Effects 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 14
- 150000004676 glycans Chemical class 0.000 claims description 14
- 229920001282 polysaccharide Polymers 0.000 claims description 14
- 239000005017 polysaccharide Substances 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- 239000003125 aqueous solvent Substances 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 12
- 125000003277 amino group Chemical group 0.000 claims description 10
- 238000011068 loading method Methods 0.000 claims description 10
- 229920001542 oligosaccharide Polymers 0.000 claims description 10
- 150000002482 oligosaccharides Chemical class 0.000 claims description 10
- -1 polythreonine Proteins 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 108010039918 Polylysine Proteins 0.000 claims description 6
- 150000001718 carbodiimides Chemical class 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229920000656 polylysine Polymers 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims description 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 4
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims description 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 claims description 4
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims description 4
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims description 4
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims description 4
- 102000016267 Leptin Human genes 0.000 claims description 4
- 108010092277 Leptin Proteins 0.000 claims description 4
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 claims description 4
- 102400000015 Vasoactive intestinal peptide Human genes 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims description 4
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 claims description 4
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 4
- 229940039781 leptin Drugs 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000004856 Lectins Human genes 0.000 claims description 2
- 108090001090 Lectins Proteins 0.000 claims description 2
- 229920000805 Polyaspartic acid Polymers 0.000 claims description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 2
- 229920002125 Sokalan® Chemical class 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims description 2
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 230000027455 binding Effects 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 230000015861 cell surface binding Effects 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 125000001165 hydrophobic group Chemical group 0.000 claims description 2
- 239000002523 lectin Substances 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 229920000962 poly(amidoamine) Chemical class 0.000 claims description 2
- 239000004584 polyacrylic acid Chemical class 0.000 claims description 2
- 108010064470 polyaspartate Proteins 0.000 claims description 2
- 108010077051 polycysteine Proteins 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- 108010000222 polyserine Proteins 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000000935 solvent evaporation Methods 0.000 claims description 2
- 150000005846 sugar alcohols Chemical class 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/971,482 US20090176892A1 (en) | 2008-01-09 | 2008-01-09 | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| PCT/US2009/030678 WO2009089506A1 (en) | 2008-01-09 | 2009-01-09 | Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259956A Division JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509311A JP2011509311A (ja) | 2011-03-24 |
| JP2011509311A5 true JP2011509311A5 (https=) | 2013-01-31 |
Family
ID=40845092
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542394A Withdrawn JP2011509311A (ja) | 2008-01-09 | 2009-01-09 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2013259956A Active JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2014110975A Withdrawn JP2014156486A (ja) | 2008-01-09 | 2014-05-29 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2016104890A Active JP6244400B2 (ja) | 2008-01-09 | 2016-05-26 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2017149174A Active JP6342556B2 (ja) | 2008-01-09 | 2017-08-01 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259956A Active JP5878912B2 (ja) | 2008-01-09 | 2013-12-17 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2014110975A Withdrawn JP2014156486A (ja) | 2008-01-09 | 2014-05-29 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2016104890A Active JP6244400B2 (ja) | 2008-01-09 | 2016-05-26 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
| JP2017149174A Active JP6342556B2 (ja) | 2008-01-09 | 2017-08-01 | 治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20090176892A1 (https=) |
| EP (1) | EP2240165B1 (https=) |
| JP (5) | JP2011509311A (https=) |
| WO (1) | WO2009089506A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| JP5281358B2 (ja) * | 2008-10-27 | 2013-09-04 | 学校法人常翔学園 | 高分子、経上皮吸収促進剤、及び医薬用製剤 |
| JP5820378B2 (ja) | 2009-09-09 | 2015-11-24 | ファーマイン コーポレーションＰｈａｒｍａｉｎ Ｃｏｒｐｏｒａｔｉｏｎ | 治療剤の送達のための陰イオンコア組成物およびその製造ならびに使用方法 |
| US20120093762A1 (en) * | 2010-10-14 | 2012-04-19 | Nitto Denko Corporation | Nucleic acid delivery compounds |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| CA2966333C (en) * | 2014-11-03 | 2023-02-14 | Pharmain Corporation | Method of production of graft co-polymer excipient with a superior peptide and protein binding property |
| WO2018017954A1 (en) * | 2016-07-21 | 2018-01-25 | Rutgers, The State University Of New Jersey | Antimicrobial cationic systems and methods of use |
| FR3083086A1 (fr) * | 2018-06-29 | 2020-01-03 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| BR112020011479A2 (pt) | 2017-12-07 | 2020-11-17 | Adocia | composições na forma de uma solução aquosa injetável caracterizada pelo fato de que compreende amilina, um agonista do receptor de amilina ou um análogo de amilina e um co-poliaminoácido |
| US20190275108A1 (en) * | 2017-12-07 | 2019-09-12 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analogue and a co-polyamino acid |
| WO2019110797A1 (fr) | 2017-12-07 | 2019-06-13 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide |
| MX2020005916A (es) | 2017-12-07 | 2020-10-19 | Adocia | Composiciones en forma de una solución acuosa inyectable que comprende amilina, un receptor agonista de amilina o un análogo de amilina y un copoliaminoácido. |
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-
2008
- 2008-01-09 US US11/971,482 patent/US20090176892A1/en not_active Abandoned
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2009
- 2009-01-09 EP EP09700547.4A patent/EP2240165B1/en active Active
- 2009-01-09 JP JP2010542394A patent/JP2011509311A/ja not_active Withdrawn
- 2009-01-09 WO PCT/US2009/030678 patent/WO2009089506A1/en not_active Ceased
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2010
- 2010-02-24 US US12/711,564 patent/US8999930B2/en active Active
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2013
- 2013-12-17 JP JP2013259956A patent/JP5878912B2/ja active Active
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2014
- 2014-05-29 JP JP2014110975A patent/JP2014156486A/ja not_active Withdrawn
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2015
- 2015-02-20 US US14/628,118 patent/US9562111B2/en active Active
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2016
- 2016-05-26 JP JP2016104890A patent/JP6244400B2/ja active Active
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2017
- 2017-08-01 JP JP2017149174A patent/JP6342556B2/ja active Active
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