|
US3896111A
(en)
|
1973-02-20 |
1975-07-22 |
Research Corp |
Ansa macrolides
|
|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4169888A
(en)
|
1977-10-17 |
1979-10-02 |
The Upjohn Company |
Composition of matter and process
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4761111A
(en)
|
1981-09-18 |
1988-08-02 |
Brown Andrew M |
Automobile lifting and towing equipment
|
|
US4418064A
(en)
|
1982-09-29 |
1983-11-29 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
AU616161B2
(en)
|
1986-10-09 |
1991-10-24 |
Neorx Corporation |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
|
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
CA2078118C
(en)
|
1990-04-25 |
1999-11-16 |
Paul A. Aristoff |
Cc-1065 analogs
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5998656A
(en)
|
1991-09-23 |
1999-12-07 |
Florida State University |
C10 tricyclic taxanes
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US6080777A
(en)
|
1992-01-31 |
2000-06-27 |
The Trustees Of Columbia University In The City Of New York |
Taxol as a radiation sensitizer
|
|
US5200534A
(en)
|
1992-03-13 |
1993-04-06 |
University Of Florida |
Process for the preparation of taxol and 10-deacetyltaxol
|
|
EP0563475B1
(en)
|
1992-03-25 |
2000-05-31 |
Immunogen Inc |
Cell binding agent conjugates of derivatives of CC-1065
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5703247A
(en)
|
1993-03-11 |
1997-12-30 |
Virginia Tech Intellectual Properties, Inc. |
2-Debenzoyl-2-acyl taxol derivatives and methods for making same
|
|
US5475011A
(en)
|
1993-03-26 |
1995-12-12 |
The Research Foundation Of State University Of New York |
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
US6740734B1
(en)
|
1994-01-14 |
2004-05-25 |
Biovitrum Ab |
Bacterial receptor structures
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US5763477A
(en)
|
1994-07-22 |
1998-06-09 |
Dr. Reddy's Research Foundation |
Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
|
|
AU5305796A
(en)
|
1995-03-10 |
1996-10-02 |
Hauser Chemical Research, Inc. |
Cephalomannine epoxide, its analogues and a method for preparing the same
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US6692742B1
(en)
*
|
1996-06-27 |
2004-02-17 |
Chugai Seiyaku Kabushiki Kaisha |
Remedies for myeloma to be used together with nitrogen mustard antitumor agents
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6962702B2
(en)
|
1998-06-22 |
2005-11-08 |
Immunomedics Inc. |
Production and use of novel peptide-based agents for use with bi-specific antibodies
|
|
US6087362A
(en)
|
1999-03-16 |
2000-07-11 |
Pentech Pharmaceuticals, Inc. |
Apomorphine and sildenafil composition
|
|
CA2388063C
(en)
|
1999-11-24 |
2010-06-08 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
|
US20030203451A1
(en)
|
2000-08-24 |
2003-10-30 |
Genentech, Inc. |
IL-17 homologous polypeptides and therapeutic uses thereof
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
AU8678501A
(en)
|
2000-08-24 |
2002-03-04 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
|
ATE412009T1
(de)
|
2000-08-24 |
2008-11-15 |
Genentech Inc |
Methode zur inhibierung von il-22 induziertem pap1
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
NZ571596A
(en)
*
|
2001-08-03 |
2010-11-26 |
Glycart Biotechnology Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
US6534660B1
(en)
|
2002-04-05 |
2003-03-18 |
Immunogen, Inc. |
CC-1065 analog synthesis
|
|
SG187991A1
(en)
|
2002-05-02 |
2013-03-28 |
Wyeth Corp |
Calicheamicin derivative-carrier conjugates
|
|
US6596757B1
(en)
|
2002-05-14 |
2003-07-22 |
Immunogen Inc. |
Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
|
|
US7390898B2
(en)
|
2002-08-02 |
2008-06-24 |
Immunogen Inc. |
Cytotoxic agents containing novel potent taxanes and their therapeutic use
|
|
US20040126379A1
(en)
|
2002-08-21 |
2004-07-01 |
Boehringer Ingelheim International Gmbh |
Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
EP2248892B1
(en)
|
2003-01-22 |
2015-04-22 |
Roche Glycart AG |
Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function
|
|
EP1627081A4
(en)
*
|
2003-05-02 |
2006-08-16 |
Health Research Inc |
USE OF JAG2 EXPRESSION IN THE DIAGNOSIS OF PLASMA CELL FAULT
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
UA101945C2
(uk)
|
2003-05-30 |
2013-05-27 |
Дженентек, Инк. |
Лікування злоякісного новоутворення за допомогою бевацизумабу
|
|
ATE496944T1
(de)
|
2003-07-21 |
2011-02-15 |
Immunogen Inc |
Ca6-antigenspezifisches zytotoxisches konjugat und verfahren zu dessen anwendung
|
|
US7271245B2
(en)
|
2004-02-13 |
2007-09-18 |
The Scripps Research Institute |
Methods and compositions for inhibition of metastasis
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
KR101151957B1
(ko)
|
2004-07-22 |
2012-06-01 |
로저 킹돈 크레이그 |
결합 분자
|
|
CA2486285C
(en)
|
2004-08-30 |
2017-03-07 |
Viktor S. Goldmakher |
Immunoconjugates targeting syndecan-1 expressing cells and use thereof
|
|
JP5225069B2
(ja)
*
|
2005-03-23 |
2013-07-03 |
ゲンマブ エー／エス |
多発性骨髄腫の治療のためのｃｄ３８に対する抗体
|
|
JP2008535491A
(ja)
|
2005-04-07 |
2008-09-04 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド |
癌に関連した遺伝子（ＰＴＰε）
|
|
KR20070120156A
(ko)
|
2005-04-15 |
2007-12-21 |
이뮤노젠 아이엔씨 |
종양에서 이종 또는 혼성 세포 집단의 제거 방법
|
|
AU2006323415A1
(en)
*
|
2005-12-06 |
2007-06-14 |
Domantis Limited |
Bispecific ligands with binding specificity to cell surface targets and methods of use therefor
|
|
AU2007245164A1
(en)
*
|
2006-03-28 |
2007-11-08 |
Biogen Idec Ma Inc. |
Anti-IGF-IR antibodies and uses thereof
|
|
CN104761637B
(zh)
|
2006-03-31 |
2021-10-15 |
中外制药株式会社 |
调控抗体血液动力学的方法
|
|
EP2015772A2
(de)
*
|
2006-05-03 |
2009-01-21 |
Elke Pogge Von Strandmann |
Mittel zur behandlung von malignen erkrankungen
|
|
WO2009043851A2
(en)
|
2007-10-04 |
2009-04-09 |
Nestec S.A. |
Integrated heater for a beverage preparation device
|
|
WO2009080832A1
(en)
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Methods and agents for improving targeting of cd138 expressing tumor cells
|
|
US9221914B2
(en)
|
2007-12-26 |
2015-12-29 |
Biotest Ag |
Agents targeting CD138 and uses thereof
|
|
CN101965366B
(zh)
|
2007-12-26 |
2016-04-27 |
生物测试股份公司 |
靶向cd138的免疫缀合物及其应用
|
|
WO2009080831A1
(en)
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
|
CA2761120A1
(en)
|
2009-05-06 |
2010-11-11 |
Biotest Ag |
Uses of immunoconjugates targeting cd138
|