JP2011507860A5 - - Google Patents

Info

Publication number

JP2011507860A5

JP2011507860A5 JP2010539517A JP2010539517A JP2011507860A5 JP 2011507860 A5 JP2011507860 A5 JP 2011507860A5 JP 2010539517 A JP2010539517 A JP 2010539517A JP 2010539517 A JP2010539517 A JP 2010539517A JP 2011507860 A5 JP2011507860 A5 JP 2011507860A5

Authority

JP

Japan

Prior art keywords

connexin

composition

polynucleotide

medicament

scar

Prior art date

2008-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 77
• 108091033319 polynucleotide Proteins 0.000 claims description 58
• 239000002157 polynucleotide Substances 0.000 claims description 58
• 102000040430 polynucleotide Human genes 0.000 claims description 58
• 238000000034 method Methods 0.000 claims description 57
• 231100000241 scar Toxicity 0.000 claims description 45
• 230000000692 anti-sense effect Effects 0.000 claims description 38
• 239000008194 pharmaceutical composition Substances 0.000 claims description 36
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
• 239000003814 drug Substances 0.000 claims description 34
• 239000003795 chemical substances by application Substances 0.000 claims description 25
• 230000002159 abnormal effect Effects 0.000 claims description 24
• 241000124008 Mammalia Species 0.000 claims description 20
• 239000000816 peptidomimetic Substances 0.000 claims description 20
• 208000032544 Cicatrix Diseases 0.000 claims description 17
• 230000037387 scars Effects 0.000 claims description 17
• 241001465754 Metazoa Species 0.000 claims description 16
• 102000001045 Connexin 43 Human genes 0.000 claims description 12
• 108010069241 Connexin 43 Proteins 0.000 claims description 12
• 108020004999 messenger RNA Proteins 0.000 claims description 12
• 239000002773 nucleotide Substances 0.000 claims description 12
• 125000003729 nucleotide group Chemical group 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
• 102000010970 Connexin Human genes 0.000 claims description 6
• 108050001175 Connexin Proteins 0.000 claims description 6
• 108091030071 RNAI Proteins 0.000 claims description 6
• 108020004459 Small interfering RNA Proteins 0.000 claims description 6
• 230000000295 complement effect Effects 0.000 claims description 6
• 238000002844 melting Methods 0.000 claims description 6
• 230000008018 melting Effects 0.000 claims description 6
• 230000004962 physiological condition Effects 0.000 claims description 6
• 230000036573 scar formation Effects 0.000 claims description 5
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
• 210000003976 gap junction Anatomy 0.000 claims description 4
• 244000144972 livestock Species 0.000 claims description 4
• 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 4
• 238000011200 topical administration Methods 0.000 claims description 4
• 206010023330 Keloid scar Diseases 0.000 claims description 3
• 230000015572 biosynthetic process Effects 0.000 claims description 3
• 230000001969 hypertrophic effect Effects 0.000 claims description 3
• 238000001802 infusion Methods 0.000 claims description 2
• 238000002347 injection Methods 0.000 claims description 2
• 239000007924 injection Substances 0.000 claims description 2
• 239000005022 packaging material Substances 0.000 claims description 2
• 229920001983 poloxamer Polymers 0.000 claims description 2
• 238000001356 surgical procedure Methods 0.000 claims description 2
• 230000037390 scarring Effects 0.000 claims 5
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 239000003607 modifier Substances 0.000 description 2
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1