JP2011507807A5 - - Google Patents
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- JP2011507807A5 JP2011507807A5 JP2010537225A JP2010537225A JP2011507807A5 JP 2011507807 A5 JP2011507807 A5 JP 2011507807A5 JP 2010537225 A JP2010537225 A JP 2010537225A JP 2010537225 A JP2010537225 A JP 2010537225A JP 2011507807 A5 JP2011507807 A5 JP 2011507807A5
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- JP
- Japan
- Prior art keywords
- peptide
- lipid
- nanoscaffold
- lipid nanoscaffold
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 24
- 150000001413 amino acids Chemical group 0.000 claims description 16
- 239000003446 ligand Substances 0.000 claims description 15
- -1 sterol ester Chemical class 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 239000002105 nanoparticle Substances 0.000 claims description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002062 molecular scaffold Substances 0.000 claims 56
- 201000010099 disease Diseases 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
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- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 claims 4
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
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- BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical group CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
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- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical compound C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 claims 1
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| WO2010057203A2 (en) | 2008-11-17 | 2010-05-20 | The Board Of Regents Of The University Of Texas System | Hdl particles for delivery of nucleic acids |
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| WO2011035279A2 (en) * | 2009-09-21 | 2011-03-24 | Board Of Regents, The University Of Texas System | Nanocarriers for imaging and therapy applications |
| US10498796B2 (en) * | 2009-10-16 | 2019-12-03 | Real Innovations International Llc | System and method for providing real-time data |
| US20130034599A1 (en) | 2010-01-19 | 2013-02-07 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| KR101405403B1 (ko) * | 2010-01-20 | 2014-06-11 | 주식회사 진코스 | 클로린 유도체와 불포화 지방산의 접합체, 이를 함유하는 광감작제, 및 이를 포함하는 광역학 치료에 사용하기 위한 암 치료용 조성물 |
| US9592268B2 (en) | 2011-05-23 | 2017-03-14 | Cornell University | Endothelium protective materials and methods of use |
| CA2883080A1 (en) * | 2011-08-26 | 2013-03-07 | Vecoy Nanomedicines Ltd. | Pathogen and substance traps |
| US9901616B2 (en) | 2011-08-31 | 2018-02-27 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| CA2865279C (en) * | 2012-02-22 | 2023-04-25 | Northwestern University | Nanostructures for treating cancers and other conditions |
| JP2014129317A (ja) * | 2012-02-23 | 2014-07-10 | Canon Inc | 光音響造影剤用色素含有ナノ粒子 |
| CN102766215B (zh) | 2012-06-07 | 2014-08-13 | 华中科技大学 | 一种具有协同靶向诊疗鼻咽癌功能的多肽和携带此多肽的纳米颗粒及其应用 |
| EP2882459A1 (en) | 2012-08-10 | 2015-06-17 | University of North Texas Health Science Center | Drug delivery vehicle comprising conjugates between targeting polyamino acids and fatty acids |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| JP6692748B2 (ja) | 2013-09-26 | 2020-05-13 | ナショナル ユニヴァーシティー オブ シンガポール | リゾホスファチジルコリンの足場を利用する組成物及び方法 |
| MX389323B (es) | 2013-12-03 | 2025-03-20 | Univ Northwestern | Particulas liposomales, metodos para elaborarlas y sus usos. |
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| EP3183007B1 (en) | 2014-08-19 | 2020-06-17 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| JP6741673B2 (ja) | 2014-10-06 | 2020-08-19 | イグジキュア, インコーポレーテッドExicure, Inc. | 抗ｔｎｆ化合物 |
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| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
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| CN106831997B (zh) * | 2015-12-03 | 2020-04-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 多肽、脂蛋白样纳米粒子及其应用 |
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| CA3021645A1 (en) | 2016-04-29 | 2017-11-02 | Icahn School Of Medicine At Mount Sinai | Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis |
| KR102617833B1 (ko) | 2016-05-06 | 2023-12-27 | 엑시큐어 오퍼레이팅 컴퍼니 | 인터류킨 17 수용체 mRNA의 특이적 녹다운을 위한 안티센스 올리고뉴클레오티드 (ASO)를 제시하는 리포좀성 구형 핵산 (SNA) 구축물 |
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| KR102757675B1 (ko) | 2017-08-03 | 2025-01-20 | 앨러스틴 스킨케어, 인크. | 피부 이완 및 신체 윤곽의 개선을 위한 조성물 및 방법 |
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| WO2019133914A1 (en) * | 2017-12-29 | 2019-07-04 | Wayne State University | Method of treatment for solid tumors containing hypoxia and/or stroma features |
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| CN110123761B (zh) * | 2019-05-07 | 2022-09-06 | 沈阳药科大学 | 一种仿生型高密度脂蛋白纳米粒及其制备和应用 |
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| CN111012555A (zh) * | 2019-12-03 | 2020-04-17 | 刘训伟 | 载放射性核素微纳米涂层支架及其制备方法 |
| CN111150834A (zh) * | 2020-01-06 | 2020-05-15 | 吉林大学 | 一种载脂蛋白e与盐霉素复合纳米粒及制备方法和应用 |
| CN111494641B (zh) * | 2020-04-22 | 2021-08-03 | 南开大学 | 肿瘤微环境响应性的表面电荷可反转纳米药物递送载体 |
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| CN117355298A (zh) | 2021-03-19 | 2024-01-05 | 生物治疗探索股份有限公司 | 用于调节训练免疫的化合物及其使用方法 |
| WO2022231724A1 (en) * | 2021-04-28 | 2022-11-03 | The Regents Of The University Of California | Adipocyte-derived anti-cancer lipid droplets |
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| US5166214A (en) * | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
| JPH07501540A (ja) | 1991-11-25 | 1995-02-16 | リチャードソン、ビックス、インコーポレーテッド | 皮膚シワ及び／又は皮膚萎縮を調節するための組成物 |
| DE69725714T2 (de) | 1996-04-23 | 2004-07-29 | The Procter & Gamble Company, Cincinnati | Verfahren und regelung des hautaussehens mit vitamin - b3 - verbindungen |
| US6664230B1 (en) * | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US20040234588A1 (en) * | 2000-09-21 | 2004-11-25 | University Of Georgia Research Foundation, Inc. | Artificial lipoprotein carrier system for bioactive materials |
| KR101186210B1 (ko) * | 2002-12-03 | 2012-10-08 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 혈뇌장벽을 통과하는 물질 수송용 인공 저밀도 지단백질 운반체 |
| US8097283B2 (en) * | 2004-01-15 | 2012-01-17 | Mount Sinai School Of Medicine | Methods and compositions for imaging |
| EP1778298A4 (en) * | 2004-04-01 | 2010-03-31 | Univ Pennsylvania | LIPOPROTEIN-NANO PLATFORMS |
| BRPI0513402A (pt) * | 2004-07-16 | 2008-05-06 | Tufts College | miméticos de apolipoproteìna a1 e usos dos mesmos |
| US8101741B2 (en) * | 2005-11-02 | 2012-01-24 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| WO2007145659A1 (en) * | 2005-11-10 | 2007-12-21 | The Regents Of The University Of California | Synthetic ldl as targeted drug delivery vehicle |
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- 2008-12-12 WO PCT/CA2008/002203 patent/WO2009073984A1/en not_active Ceased
- 2008-12-12 JP JP2010537225A patent/JP5658568B2/ja not_active Expired - Fee Related
- 2008-12-12 CA CA2708719A patent/CA2708719A1/en not_active Abandoned
- 2008-12-12 CN CN200880126584XA patent/CN102027019A/zh active Pending
- 2008-12-12 EP EP08859772.9A patent/EP2229411B1/en active Active
- 2008-12-12 CN CN201610245387.6A patent/CN105903029A/zh active Pending
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