JP2011506324A5 - - Google Patents
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- Publication number
- JP2011506324A5 JP2011506324A5 JP2010536950A JP2010536950A JP2011506324A5 JP 2011506324 A5 JP2011506324 A5 JP 2011506324A5 JP 2010536950 A JP2010536950 A JP 2010536950A JP 2010536950 A JP2010536950 A JP 2010536950A JP 2011506324 A5 JP2011506324 A5 JP 2011506324A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- compound
- independently
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 46
- 150000001875 compounds Chemical class 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 42
- 239000001257 hydrogen Substances 0.000 claims description 39
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 150000002825 nitriles Chemical class 0.000 claims description 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 3
- 125000002837 carbocyclic group Chemical group 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 239000000543 intermediate Substances 0.000 description 5
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 2
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1240907P | 2007-12-07 | 2007-12-07 | |
| US1240807P | 2007-12-07 | 2007-12-07 | |
| US1241107P | 2007-12-07 | 2007-12-07 | |
| US61/012,411 | 2007-12-07 | ||
| US61/012,409 | 2007-12-07 | ||
| US61/012,408 | 2007-12-07 | ||
| US8004808P | 2008-07-11 | 2008-07-11 | |
| US61/080,048 | 2008-07-11 | ||
| PCT/US2008/013512 WO2009075823A1 (en) | 2007-12-07 | 2008-12-08 | Intermediates in the synthesis of zearalenone macrolide analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506324A JP2011506324A (ja) | 2011-03-03 |
| JP2011506324A5 true JP2011506324A5 (https=) | 2012-02-02 |
| JP5492786B2 JP5492786B2 (ja) | 2014-05-14 |
Family
ID=40445478
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536950A Active JP5492786B2 (ja) | 2007-12-07 | 2008-12-08 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
| JP2010536949A Active JP5496908B2 (ja) | 2007-12-07 | 2008-12-08 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
| JP2014042331A Withdrawn JP2014141498A (ja) | 2007-12-07 | 2014-03-05 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536949A Active JP5496908B2 (ja) | 2007-12-07 | 2008-12-08 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
| JP2014042331A Withdrawn JP2014141498A (ja) | 2007-12-07 | 2014-03-05 | ゼラレノンマクロライドアナログを作製するための中間体および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8507696B2 (https=) |
| EP (2) | EP2231634B1 (https=) |
| JP (3) | JP5492786B2 (https=) |
| CN (2) | CN101889006B (https=) |
| BR (2) | BRPI0820958B1 (https=) |
| CA (2) | CA2708141C (https=) |
| IL (2) | IL205954A (https=) |
| MX (2) | MX2010006091A (https=) |
| RU (2) | RU2478630C2 (https=) |
| WO (2) | WO2009075823A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003224672B2 (en) * | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| US8609640B2 (en) | 2007-07-25 | 2013-12-17 | Eisai, Inc. | Multikinase inhibitors for use in the treatment of cancer |
| BRPI0820958B1 (pt) * | 2007-12-07 | 2022-04-05 | Eisai R&D Management Co., Ltd | Compostos macrolídeos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561147B2 (en) * | 1982-09-13 | 1987-04-30 | Eli Lilly And Company | 20-amino macrolide antibiotics |
| GB9225396D0 (en) | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5795910A (en) | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| SK286592B6 (sk) * | 1997-07-08 | 2009-01-07 | Bristol-Myers Squibb Company | Derivát epotilónu, farmaceutický prostriedok s jeho obsahom a jeho použitie |
| JP2004292315A (ja) | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | Ｔａｋ１阻害剤 |
| JP2004292314A (ja) | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
| US7915306B2 (en) | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| AU2003224672B2 (en) | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| CN103539769B (zh) | 2006-08-11 | 2016-03-16 | 斯特拉斯堡大学 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
| US8513440B2 (en) * | 2007-06-05 | 2013-08-20 | Universite De Strasbourg | Compositions and methods comprising analogues of radicicol A |
| US8609640B2 (en) | 2007-07-25 | 2013-12-17 | Eisai, Inc. | Multikinase inhibitors for use in the treatment of cancer |
| TW200924749A (en) * | 2007-07-25 | 2009-06-16 | Eisai R & Amp D Man Co Ltd | Zearalenone macrolide derivatives and uses of the same |
| BRPI0820958B1 (pt) * | 2007-12-07 | 2022-04-05 | Eisai R&D Management Co., Ltd | Compostos macrolídeos |
-
2008
- 2008-12-08 BR BRPI0820958-8A patent/BRPI0820958B1/pt active IP Right Grant
- 2008-12-08 US US12/746,675 patent/US8507696B2/en active Active
- 2008-12-08 MX MX2010006091A patent/MX2010006091A/es active IP Right Grant
- 2008-12-08 JP JP2010536950A patent/JP5492786B2/ja active Active
- 2008-12-08 WO PCT/US2008/013512 patent/WO2009075823A1/en not_active Ceased
- 2008-12-08 CN CN2008801195442A patent/CN101889006B/zh active Active
- 2008-12-08 BR BRPI0820953-7A patent/BRPI0820953B1/pt active IP Right Grant
- 2008-12-08 MX MX2010005999A patent/MX2010005999A/es active IP Right Grant
- 2008-12-08 EP EP08860344.4A patent/EP2231634B1/en active Active
- 2008-12-08 WO PCT/US2008/013498 patent/WO2009075818A1/en not_active Ceased
- 2008-12-08 RU RU2010128103/04A patent/RU2478630C2/ru active
- 2008-12-08 US US12/746,672 patent/US8350059B2/en active Active
- 2008-12-08 CN CN200880119543.8A patent/CN101889005B/zh active Active
- 2008-12-08 CA CA2708141A patent/CA2708141C/en active Active
- 2008-12-08 JP JP2010536949A patent/JP5496908B2/ja active Active
- 2008-12-08 RU RU2010128096/04A patent/RU2497803C2/ru active
- 2008-12-08 CA CA2708143A patent/CA2708143C/en active Active
- 2008-12-08 EP EP08860534.0A patent/EP2231635B1/en active Active
-
2010
- 2010-05-25 IL IL205954A patent/IL205954A/en active IP Right Grant
- 2010-05-26 IL IL205983A patent/IL205983A/en active IP Right Grant
-
2013
- 2013-01-03 US US13/733,562 patent/US20130211103A1/en not_active Abandoned
-
2014
- 2014-03-05 JP JP2014042331A patent/JP2014141498A/ja not_active Withdrawn
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