JP2011503191A - イオンチャネルのモジュレーターとしての複素環誘導体 - Google Patents
イオンチャネルのモジュレーターとしての複素環誘導体 Download PDFInfo
- Publication number
- JP2011503191A JP2011503191A JP2010534132A JP2010534132A JP2011503191A JP 2011503191 A JP2011503191 A JP 2011503191A JP 2010534132 A JP2010534132 A JP 2010534132A JP 2010534132 A JP2010534132 A JP 2010534132A JP 2011503191 A JP2011503191 A JP 2011503191A
- Authority
- JP
- Japan
- Prior art keywords
- pain
- aliphatic
- mmol
- compound
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *C(CCN1C2=CC=CCC2)C1=O Chemical compound *C(CCN1C2=CC=CCC2)C1=O 0.000 description 8
- VZWOXDYRBDIHMA-UHFFFAOYSA-N Cc1ncc[s]1 Chemical compound Cc1ncc[s]1 VZWOXDYRBDIHMA-UHFFFAOYSA-N 0.000 description 5
- NVZPVFQTOYYQEK-LJQANCHMSA-O CC(C)(C)C[SH+](c1ccccc1)(c1ccccc1)O[C@H](CCO1)C1=O Chemical compound CC(C)(C)C[SH+](c1ccccc1)(c1ccccc1)O[C@H](CCO1)C1=O NVZPVFQTOYYQEK-LJQANCHMSA-O 0.000 description 1
- CEAXTTTVRDUBMT-UHFFFAOYSA-N CC1=CCCC=NS1 Chemical compound CC1=CCCC=NS1 CEAXTTTVRDUBMT-UHFFFAOYSA-N 0.000 description 1
- XBBYDBIBHIVKCQ-UHFFFAOYSA-N CC1=NCCC=CS1 Chemical compound CC1=NCCC=CS1 XBBYDBIBHIVKCQ-UHFFFAOYSA-N 0.000 description 1
- OYLKAJRZGTZKKB-ZZXKWVIFSA-N CN(C)/C=N/C(N)=S Chemical compound CN(C)/C=N/C(N)=S OYLKAJRZGTZKKB-ZZXKWVIFSA-N 0.000 description 1
- QMHIMXFNBOYPND-UHFFFAOYSA-N Cc1c[s]cn1 Chemical compound Cc1c[s]cn1 QMHIMXFNBOYPND-UHFFFAOYSA-N 0.000 description 1
- RLYUNPNLXMSXAX-UHFFFAOYSA-N Cc1cnc[s]1 Chemical compound Cc1cnc[s]1 RLYUNPNLXMSXAX-UHFFFAOYSA-N 0.000 description 1
- QLXOJLUHWBDVKZ-UHFFFAOYSA-N Cc1ncn[s]1 Chemical compound Cc1ncn[s]1 QLXOJLUHWBDVKZ-UHFFFAOYSA-N 0.000 description 1
- SUXBGTJPBXVYBY-UHFFFAOYSA-N OC(CCN1C(CC2)=CC=C2S(NC2CCCCCCCCC2)(=O)=O)C1=O Chemical compound OC(CCN1C(CC2)=CC=C2S(NC2CCCCCCCCC2)(=O)=O)C1=O SUXBGTJPBXVYBY-UHFFFAOYSA-N 0.000 description 1
- KTBNCHHCXNDBOX-HSZRJFAPSA-N O[C@H](CCN1c(cc2)ccc2S(N(C2CCCCCCC2)S(c(cc2)ccc2F)(=O)=O)(=O)=O)C1=O Chemical compound O[C@H](CCN1c(cc2)ccc2S(N(C2CCCCCCC2)S(c(cc2)ccc2F)(=O)=O)(=O)=O)C1=O KTBNCHHCXNDBOX-HSZRJFAPSA-N 0.000 description 1
- FWIBCWKHNZBDLS-GSVOUGTGSA-N O[C@H](CCO1)C1=O Chemical compound O[C@H](CCO1)C1=O FWIBCWKHNZBDLS-GSVOUGTGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98749007P | 2007-11-13 | 2007-11-13 | |
| PCT/US2008/083173 WO2009064752A2 (en) | 2007-11-13 | 2008-11-12 | Heterocyclic derivatives as modulators of ion channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011503191A true JP2011503191A (ja) | 2011-01-27 |
| JP2011503191A5 JP2011503191A5 (OSRAM) | 2012-12-20 |
Family
ID=40298764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534132A Withdrawn JP2011503191A (ja) | 2007-11-13 | 2008-11-12 | イオンチャネルのモジュレーターとしての複素環誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8097636B2 (OSRAM) |
| EP (1) | EP2220080B1 (OSRAM) |
| JP (1) | JP2011503191A (OSRAM) |
| KR (1) | KR20100101601A (OSRAM) |
| CN (1) | CN101910166A (OSRAM) |
| AT (1) | ATE540036T1 (OSRAM) |
| AU (1) | AU2008321142A1 (OSRAM) |
| CA (1) | CA2705547A1 (OSRAM) |
| ES (1) | ES2377172T3 (OSRAM) |
| IL (1) | IL205696A0 (OSRAM) |
| MX (1) | MX2010005307A (OSRAM) |
| NZ (1) | NZ585729A (OSRAM) |
| RU (1) | RU2010123876A (OSRAM) |
| WO (1) | WO2009064752A2 (OSRAM) |
| ZA (1) | ZA201003352B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| CN101218226A (zh) * | 2005-05-16 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
| MX2008003337A (es) | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| CA2626190A1 (en) * | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| WO2008147797A2 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| WO2009064747A2 (en) * | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| WO2010002956A2 (en) * | 2008-07-01 | 2010-01-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| US9403839B2 (en) * | 2012-01-16 | 2016-08-02 | Vertex Pharmaceuticals Incorporated | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| CN106045908B (zh) * | 2016-06-14 | 2018-09-28 | 郑州轻工业学院 | 一种新型化合物6,7-二溴-1,2,3,4-四氢异喹啉及其制备方法 |
| US11299467B2 (en) | 2017-07-21 | 2022-04-12 | Antabio Sas | Chemical compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH666623A5 (de) * | 1985-05-17 | 1988-08-15 | Idc Chemie Ag | Vorrichtung zur behandlung von brandwunden oder verbruehungen. |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| AU2004263179B8 (en) * | 2003-08-08 | 2011-07-14 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| AU2006244206A1 (en) * | 2005-05-10 | 2006-11-16 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| CN101218226A (zh) * | 2005-05-16 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| ATE551333T1 (de) * | 2005-10-12 | 2012-04-15 | Vertex Pharma | Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen |
| CA2626190A1 (en) * | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| CN101365686A (zh) * | 2005-12-21 | 2009-02-11 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的杂环衍生物 |
| WO2008147797A2 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| WO2009064747A2 (en) * | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| WO2010002956A2 (en) * | 2008-07-01 | 2010-01-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
-
2008
- 2008-11-12 RU RU2010123876/04A patent/RU2010123876A/ru not_active Application Discontinuation
- 2008-11-12 MX MX2010005307A patent/MX2010005307A/es active IP Right Grant
- 2008-11-12 AT AT08848685T patent/ATE540036T1/de active
- 2008-11-12 ES ES08848685T patent/ES2377172T3/es active Active
- 2008-11-12 AU AU2008321142A patent/AU2008321142A1/en not_active Abandoned
- 2008-11-12 NZ NZ585729A patent/NZ585729A/en not_active IP Right Cessation
- 2008-11-12 JP JP2010534132A patent/JP2011503191A/ja not_active Withdrawn
- 2008-11-12 WO PCT/US2008/083173 patent/WO2009064752A2/en not_active Ceased
- 2008-11-12 KR KR1020107012966A patent/KR20100101601A/ko not_active Withdrawn
- 2008-11-12 CA CA2705547A patent/CA2705547A1/en not_active Abandoned
- 2008-11-12 US US12/269,109 patent/US8097636B2/en active Active
- 2008-11-12 CN CN2008801223353A patent/CN101910166A/zh active Pending
- 2008-11-12 EP EP08848685A patent/EP2220080B1/en not_active Not-in-force
-
2010
- 2010-05-11 IL IL205696A patent/IL205696A0/en unknown
- 2010-05-12 ZA ZA2010/03352A patent/ZA201003352B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8097636B2 (en) | 2012-01-17 |
| AU2008321142A8 (en) | 2010-06-24 |
| EP2220080A2 (en) | 2010-08-25 |
| IL205696A0 (en) | 2010-11-30 |
| KR20100101601A (ko) | 2010-09-17 |
| CN101910166A (zh) | 2010-12-08 |
| WO2009064752A3 (en) | 2009-08-27 |
| NZ585729A (en) | 2012-04-27 |
| US20090124655A1 (en) | 2009-05-14 |
| ATE540036T1 (de) | 2012-01-15 |
| CA2705547A1 (en) | 2009-05-22 |
| ES2377172T3 (es) | 2012-03-23 |
| ZA201003352B (en) | 2011-08-31 |
| EP2220080B1 (en) | 2012-01-04 |
| WO2009064752A2 (en) | 2009-05-22 |
| RU2010123876A (ru) | 2011-12-20 |
| AU2008321142A1 (en) | 2009-05-22 |
| MX2010005307A (es) | 2010-07-28 |
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