JP2011503065A5 - - Google Patents

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Publication number
JP2011503065A5
JP2011503065A5 JP2010533100A JP2010533100A JP2011503065A5 JP 2011503065 A5 JP2011503065 A5 JP 2011503065A5 JP 2010533100 A JP2010533100 A JP 2010533100A JP 2010533100 A JP2010533100 A JP 2010533100A JP 2011503065 A5 JP2011503065 A5 JP 2011503065A5
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JP
Japan
Prior art keywords
beta
alpha
integrin inhibitor
proteinuria
αvβ3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010533100A
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English (en)
Japanese (ja)
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JP5637855B2 (ja
JP2011503065A (ja
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Publication date
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Priority claimed from PCT/US2008/012541 external-priority patent/WO2009061448A2/en
Publication of JP2011503065A publication Critical patent/JP2011503065A/ja
Publication of JP2011503065A5 publication Critical patent/JP2011503065A5/ja
Application granted granted Critical
Publication of JP5637855B2 publication Critical patent/JP5637855B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010533100A 2007-11-08 2008-11-07 蛋白尿症の治療のための方法及び組成物 Expired - Fee Related JP5637855B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US244507P 2007-11-08 2007-11-08
US61/002,445 2007-11-08
PCT/US2008/012541 WO2009061448A2 (en) 2007-11-08 2008-11-07 Methods and compositions for the treatment of proteinuric diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014120429A Division JP2014205690A (ja) 2007-11-08 2014-06-11 蛋白尿症の治療のための医薬組成物

Publications (3)

Publication Number Publication Date
JP2011503065A JP2011503065A (ja) 2011-01-27
JP2011503065A5 true JP2011503065A5 (https=) 2011-12-22
JP5637855B2 JP5637855B2 (ja) 2014-12-10

Family

ID=40626390

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010533100A Expired - Fee Related JP5637855B2 (ja) 2007-11-08 2008-11-07 蛋白尿症の治療のための方法及び組成物
JP2014120429A Pending JP2014205690A (ja) 2007-11-08 2014-06-11 蛋白尿症の治療のための医薬組成物
JP2015247171A Pending JP2016104767A (ja) 2007-11-08 2015-12-18 蛋白尿症の治療のための方法及び組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014120429A Pending JP2014205690A (ja) 2007-11-08 2014-06-11 蛋白尿症の治療のための医薬組成物
JP2015247171A Pending JP2016104767A (ja) 2007-11-08 2015-12-18 蛋白尿症の治療のための方法及び組成物

Country Status (5)

Country Link
US (3) US9345739B2 (https=)
EP (2) EP2730282A1 (https=)
JP (3) JP5637855B2 (https=)
ES (1) ES2457822T3 (https=)
WO (1) WO2009061448A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2730282A1 (en) 2007-11-08 2014-05-14 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
CA2779958A1 (en) * 2008-11-06 2010-05-14 University Of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
DE102009000854A1 (de) * 2009-02-13 2010-08-19 Ernst-Moritz-Arndt-Universität Greifswald Osteopontin-Rezeptor-Liganden zur Behandlung des chronischen Nierenversagens
EP2608804A4 (en) * 2010-08-27 2015-03-11 Univ Miami TREATMENT OF KIDNEY DISEASES
ES2765006T3 (es) 2011-05-09 2020-06-05 The Univ Of Miami Reducción del receptor soluble de urocinasa en la circulación
CA2882757A1 (en) 2012-08-31 2014-03-06 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)
WO2017053976A1 (en) * 2015-09-25 2017-03-30 The General Hospital Corporation DIAGNOSTIC ASSAYS FOR SUPAR-β3 INTEGRIN DRIVEN KIDNEY DISEASES
SG11201805387RA (en) 2015-12-30 2018-07-30 Univ Saint Louis Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
GB201916071D0 (en) * 2019-11-05 2019-12-18 Univ Bristol Treatment for nephrotic syndrome
IL296239A (en) * 2020-03-06 2022-11-01 Allegro Pharmaceuticals Llc Treatments to improve or reduce damage to mitochondrial function
GB202003618D0 (en) 2020-03-12 2020-04-29 Univ Bristol Gene Therapy
GB202010009D0 (en) * 2020-06-30 2020-08-12 Syncona Investment Man Ltd Vector
WO2022125776A2 (en) 2020-12-09 2022-06-16 Siwa Corporation Methods and compositions for treating kidney diseases
JP7699774B2 (ja) * 2021-09-07 2025-06-30 公立大学法人名古屋市立大学 間質性膀胱炎・膀胱痛症候群の予防又は治療用医薬組成物

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1996026190A1 (en) 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
IL123164A (en) 1995-08-30 2001-03-19 Searle & Co Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
CZ203898A3 (cs) 1995-12-29 1999-03-17 Smithkline Beecham Corporation Antagonista vitronektinového receptoru, farmaceutický přípravek s jeho obsahem, způsob a použití
WO1997024122A1 (en) 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
UA60311C2 (uk) 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
US5942492A (en) 1996-11-12 1999-08-24 Angstrom Pharmaceuticals, Inc. Cyclic peptides that bind to urokinase-type plasminogen activator receptor
US6794358B1 (en) 1997-03-28 2004-09-21 Brigham And Women's Hospital Peptide ligands of the urokinase receptor
EP1000031A4 (en) 1997-07-25 2001-08-16 Smithkline Beecham Corp VITRONECTIN RECEPTOR ANTAGONISTS
AU8689798A (en) 1997-08-04 1999-02-22 Smithkline Beecham Corporation Integrin receptor antagonists
BR9907218A (pt) 1998-01-23 2000-10-24 Merck Patent Gmbh Anticorpo monoclonal anti alfav-integrina e seu uso para inibir a fixação de alfav-beta6-integrina à fibronectina
US6852318B1 (en) 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
US6492325B1 (en) 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
IT1299575B1 (it) 1998-07-23 2000-03-16 Demetrio Biancucci Suola per calzatura provvista di rampini o mezzi chiodati in grado di passare da una posizione a contatto con il suolo ad una posizione
EP0982036A1 (en) 1998-08-28 2000-03-01 Wilex Biotechnology GmbH Modulation of Beta2 -integrin-mediated cell adhesion
US6451972B1 (en) 1998-11-16 2002-09-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
PL350057A1 (en) 1999-02-20 2002-11-04 Merck Patent Gmbh β-ALANINE DERIVATIVES
ES2274781T3 (es) 1999-04-13 2007-06-01 Wilex Ag Empleo diagnostico y terapeutico de anticuerpos contra el receptor de la urocinasa.
CN1589145A (zh) 1999-06-02 2005-03-02 麦克公司 αv整联蛋白受体拮抗剂
WO2001017544A1 (en) 1999-09-03 2001-03-15 The Brigham And Women's Hospital, Inc. Peptides that bind to urokinase receptor
SI1214091T1 (sl) 1999-09-14 2006-10-31 Biogen Idec Inc Terapija za kronicno ledvicno odpoved z uporabo enega ali vec integrinskih antagonistov
US6955808B2 (en) 1999-09-24 2005-10-18 Uab Research Foundation Capsid-modified recombinant adenovirus and methods of use
DE10028575A1 (de) 2000-06-14 2002-03-14 Basf Ag Integrinliganden
GB9928882D0 (en) 1999-12-08 2000-02-02 Zeneca Ltd Assay method
US6825167B1 (en) 2000-04-03 2004-11-30 Regents Of The University Of Minnesota Genetic modification of endostatin
GB0011817D0 (en) 2000-05-16 2000-07-05 Pharmacia & Upjohn Spa Antagonists of integrin receptors
AU2001269821A1 (en) 2000-06-15 2001-12-24 Barbara Chen Cycloalkyl alkanoic acids as integrin receptor antagonists
WO2001096310A1 (en) 2000-06-15 2001-12-20 Pharmacia Corporation Dihydrostilbene alkanoic acid derivatives useful as vitronectin antagonists
US6649597B1 (en) 2000-06-22 2003-11-18 The University Of Iowa Research Foundation Targeting vector to the urokinase plasminogen activator receptor
GB0016791D0 (en) 2000-07-07 2000-08-30 Novartis Ag Organic compounds
US7163681B2 (en) * 2000-08-07 2007-01-16 Centocor, Inc. Anti-integrin antibodies, compositions, methods and uses
JP2004521079A (ja) 2000-08-29 2004-07-15 ファルマシア・コーポレーション アルファーvベータ3アンタゴニストとして有用な二環式環系を含有する化合物
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6720327B2 (en) 2000-09-27 2004-04-13 Pharmacia Corporation Lactone integrin antagonists
US20020072500A1 (en) 2000-09-27 2002-06-13 Thomas Rogers Hydroxy acid integrin antagonists
EP1197553A1 (en) 2000-10-12 2002-04-17 A3D GmbH, Antisense Design & Drug Development Antisense nucleic acid against alphaV integrin
DE10112771A1 (de) 2001-03-16 2002-09-26 Merck Patent Gmbh Inhibitoren des Integrins alpha¶v¶beta¶6¶
US6794385B2 (en) 2001-08-08 2004-09-21 Pharmacia & Upjohn, S.P.A. Benzoxazine derivatives useful as integrin receptor antagonists
DE10204789A1 (de) * 2002-02-06 2003-08-14 Merck Patent Gmbh Inhibitoren des Integrins alpha¶v¶beta6
US7138230B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
ITRM20020402A1 (it) 2002-07-29 2004-01-29 Sigma Tau Ind Farmaceuti Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
AU2003259891A1 (en) * 2002-08-16 2004-03-19 Janssen Pharmaceutica N.V. Piperidinyl compounds that selectively bind integrins
EP1592421A1 (en) 2002-12-20 2005-11-09 Pharmacia Corporation Heteroarylalkanoic acids as integrin receptor antagonists
JP2006514050A (ja) 2002-12-20 2006-04-27 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のR異性体
DE502004007051D1 (de) 2003-02-06 2008-06-19 Merck Patent Gmbh Peptidische sulfonamide
WO2004090108A2 (en) 2003-04-03 2004-10-21 Alnylam Pharmaceuticals Irna conjugates
KR100568755B1 (ko) 2003-04-03 2006-04-07 주식회사 리젠 바이오텍 Yh 모티프를 포함하는 펩타이드를 유효성분으로함유하는 혈관신생 억제제
US7560244B2 (en) * 2003-06-04 2009-07-14 Joslin Diabetes Center, Inc. Method of evaluating a subject for risk or predisposition of reduced renal function over time
US7365154B2 (en) 2003-06-23 2008-04-29 Centocor, Inc. Peptides antagonistic to an anti-angiogenic antibody and uses therefor
ITMI20031476A1 (it) 2003-07-18 2005-01-19 Univ Degli Studi Milano Composti peptido-mimetici a struttura azabicicloalcanica comprendenti la sequenza rgd
US8187595B2 (en) 2004-05-07 2012-05-29 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I
EP1755660B1 (en) * 2004-05-07 2010-03-24 The University of North Carolina at Chapel Hill Method for enhancing or inhibiting insulin-like growth factor-i
PT1765397E (pt) 2004-05-25 2013-02-04 Tactic Pharma Llc Anticorpos inibidores que se ligam ao complexo ativador plasminogénico do tipo uroquinasa (upa) e seu receptor (upar)
JP2008516947A (ja) 2004-10-14 2008-05-22 ファルマシア コーポレーション ビフェニルインテグリンアンタゴニスト
WO2007056435A2 (en) 2005-11-08 2007-05-18 The General Hospital Corporation Dynamin mediated diseases and associated methods and products
US20070244046A1 (en) 2006-03-29 2007-10-18 Margarita Gutova Identification and characterization of cancer stem cells and methods of use
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
US20080020979A1 (en) * 2006-06-09 2008-01-24 Rapraeger Alan C Peptides of Syndecan-1 For Inhibiting Angiogenesis
US8815519B2 (en) 2006-12-22 2014-08-26 Hvidovre Hospital Method for predicting cancer and other diseases
US20100158858A1 (en) * 2007-04-13 2010-06-24 Liangxian Cao Administration of carboline derivatives useful in the treatment of cancer and other diseases
JP2011503531A (ja) 2007-10-26 2011-01-27 ジェネンテック, インコーポレイテッド ウロキナーゼ型プラスミノーゲン活性化因子(uPA)活性の阻害
EP2730282A1 (en) * 2007-11-08 2014-05-14 The General Hospital Corporation Methods and compositions for the treatment of proteinuric diseases
NZ610239A (en) 2008-04-30 2014-11-28 Immunogen Inc Cross-linkers and their uses
CA2779958A1 (en) 2008-11-06 2010-05-14 University Of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
EP2608804A4 (en) 2010-08-27 2015-03-11 Univ Miami TREATMENT OF KIDNEY DISEASES
CA2882757A1 (en) * 2012-08-31 2014-03-06 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)

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