JP2011502521A - Hiv−1外被糖タンパク質オリゴマー及び使用方法 - Google Patents

Hiv−1外被糖タンパク質オリゴマー及び使用方法 Download PDF

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JP2011502521A
JP2011502521A JP2010533337A JP2010533337A JP2011502521A JP 2011502521 A JP2011502521 A JP 2011502521A JP 2010533337 A JP2010533337 A JP 2010533337A JP 2010533337 A JP2010533337 A JP 2010533337A JP 2011502521 A JP2011502521 A JP 2011502521A
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polypeptide
r2gp140
fusion polypeptide
fusion
trimer
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Japanese (ja)
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JP2011502521A5 (enExample
Inventor
ジェラルド クイナン,
クリストファー ブロダー,
Original Assignee
ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド
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Publication of JP2011502521A publication Critical patent/JP2011502521A/ja
Publication of JP2011502521A5 publication Critical patent/JP2011502521A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036Retroviridae, e.g. leukemia viruses
    • C07K16/1045Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2010533337A 2007-11-12 2008-11-12 Hiv−1外被糖タンパク質オリゴマー及び使用方法 Pending JP2011502521A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98728707P 2007-11-12 2007-11-12
PCT/US2008/083190 WO2009102357A2 (en) 2007-11-12 2008-11-12 Hiv-1 envelope glycoprotein oligomer and methods of use

Publications (2)

Publication Number Publication Date
JP2011502521A true JP2011502521A (ja) 2011-01-27
JP2011502521A5 JP2011502521A5 (enExample) 2011-11-17

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JP2010533337A Pending JP2011502521A (ja) 2007-11-12 2008-11-12 Hiv−1外被糖タンパク質オリゴマー及び使用方法

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US (1) US8597658B2 (enExample)
EP (1) EP2235065A4 (enExample)
JP (1) JP2011502521A (enExample)
AU (1) AU2008350273B2 (enExample)
CA (1) CA2705373A1 (enExample)
WO (1) WO2009102357A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018138581A (ja) * 2012-07-26 2018-09-06 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド 多量体融合タンパク質ワクチン及び免疫療法
JP2019522626A (ja) * 2016-05-02 2019-08-15 ザ スクリプス リサーチ インスティテュート Hiv−1免疫原に関連した組成物および方法
JP2020503839A (ja) * 2017-11-17 2020-02-06 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 哺乳類で発現した新規なヒト免疫不全ウイルスエンベロープタンパク質抗原

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002522039A (ja) * 1998-08-04 2002-07-23 ザ ヘンリー エム. ジャクソン ファウンデイション 広い反応性の中和抗体応答を伴うhiv−1エンベロープタンパク質の発現およびキャクタライゼーション
WO2006026508A2 (en) * 2004-08-27 2006-03-09 The Henry M. Jackson Foundation Modified hiv-1 envelope proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292646A (en) * 1991-02-06 1994-03-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US6039957A (en) * 1993-12-10 2000-03-21 United States Of America, As Represented By The Department Of Health And Human Services Oligomeric HIV-1 envelope glycoproteins
CA2384271A1 (en) * 1999-09-17 2001-03-22 Joseph G. Sodroski Stabilized soluble glycoprotein trimers
WO2003077838A2 (en) * 2002-03-05 2003-09-25 National Institutes Of Health Office Of Technology Transfer Hiv-1 envelope glycoproteins stabilized by flexible linkers as potent entry inhibitors and immunogens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002522039A (ja) * 1998-08-04 2002-07-23 ザ ヘンリー エム. ジャクソン ファウンデイション 広い反応性の中和抗体応答を伴うhiv−1エンベロープタンパク質の発現およびキャクタライゼーション
WO2006026508A2 (en) * 2004-08-27 2006-03-09 The Henry M. Jackson Foundation Modified hiv-1 envelope proteins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6013041724; J. Virol., 2003, vol.77, no.5, p.3119-3130 *
JPN6013041725; J. Virol., 2002, vol.76, no.9, p.4634-4642 *
JPN6013041726; J. Virol., 2000, vol.74, no.10, p.4746-4754 *
JPN6013041727; J. Virol., 2000, vol.74, no.12, p.5716-5725 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018138581A (ja) * 2012-07-26 2018-09-06 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド 多量体融合タンパク質ワクチン及び免疫療法
JP2019522626A (ja) * 2016-05-02 2019-08-15 ザ スクリプス リサーチ インスティテュート Hiv−1免疫原に関連した組成物および方法
JP7046832B2 (ja) 2016-05-02 2022-04-04 ザ スクリプス リサーチ インスティテュート Hiv-1免疫原に関連した組成物および方法
JP2020503839A (ja) * 2017-11-17 2020-02-06 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 哺乳類で発現した新規なヒト免疫不全ウイルスエンベロープタンパク質抗原
JP2022022308A (ja) * 2017-11-17 2022-02-03 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 哺乳類で発現した新規なヒト免疫不全ウイルスエンベロープタンパク質抗原
JP2023057154A (ja) * 2017-11-17 2023-04-20 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 哺乳類で発現した新規なヒト免疫不全ウイルスエンベロープタンパク質抗原
JP7615190B2 (ja) 2017-11-17 2025-01-16 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 哺乳類で発現した新規なヒト免疫不全ウイルスエンベロープタンパク質抗原

Also Published As

Publication number Publication date
WO2009102357A2 (en) 2009-08-20
WO2009102357A3 (en) 2009-10-22
EP2235065A2 (en) 2010-10-06
US20100316661A1 (en) 2010-12-16
AU2008350273A1 (en) 2009-08-20
EP2235065A4 (en) 2011-09-28
CA2705373A1 (en) 2009-08-20
US8597658B2 (en) 2013-12-03
AU2008350273B2 (en) 2014-04-10

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