JP2011501689A - マイクロリアクタ - Google Patents

マイクロリアクタ Download PDF

Info

Publication number
JP2011501689A
JP2011501689A JP2010527321A JP2010527321A JP2011501689A JP 2011501689 A JP2011501689 A JP 2011501689A JP 2010527321 A JP2010527321 A JP 2010527321A JP 2010527321 A JP2010527321 A JP 2010527321A JP 2011501689 A JP2011501689 A JP 2011501689A
Authority
JP
Japan
Prior art keywords
microreactor
cover
microreactor according
cross
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010527321A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011501689A5 (cg-RX-API-DMAC7.html
Inventor
ケンシー，フランク
ミューラー，カルステン
ブックス，ヨヘン
フンケ，マッティアス
Original Assignee
エム２ピー−ラブス ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エム２ピー−ラブス ゲーエムベーハー filed Critical エム２ピー−ラブス ゲーエムベーハー
Publication of JP2011501689A publication Critical patent/JP2011501689A/ja
Publication of JP2011501689A5 publication Critical patent/JP2011501689A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2010527321A 2007-10-08 2008-10-08 マイクロリアクタ Pending JP2011501689A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007048201 2007-10-08
DE102008008256A DE102008008256A1 (de) 2007-10-08 2008-02-08 Mikroreaktor
PCT/DE2008/001623 WO2009046697A2 (de) 2007-10-08 2008-10-08 Mikroreaktor

Publications (2)

Publication Number Publication Date
JP2011501689A true JP2011501689A (ja) 2011-01-13
JP2011501689A5 JP2011501689A5 (cg-RX-API-DMAC7.html) 2011-11-10

Family

ID=40418270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010527321A Pending JP2011501689A (ja) 2007-10-08 2008-10-08 マイクロリアクタ

Country Status (7)

Country Link
US (1) US8828337B2 (cg-RX-API-DMAC7.html)
EP (1) EP2205716B1 (cg-RX-API-DMAC7.html)
JP (1) JP2011501689A (cg-RX-API-DMAC7.html)
CN (1) CN101932693B (cg-RX-API-DMAC7.html)
DE (2) DE102008008256A1 (cg-RX-API-DMAC7.html)
DK (1) DK2205716T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009046697A2 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020523008A (ja) * 2017-06-08 2020-08-06 ヴィトロライフ アー／エス 培養皿のための蓋
JP2020526215A (ja) * 2017-07-13 2020-08-31 グライナー バイオ‐ワン ノース アメリカ，インコーポレイテッド 撮像用の培養プレート
JP2022067072A (ja) * 2020-10-19 2022-05-02 Ａｇｃテクノグラス株式会社 培養容器

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2459739B1 (en) * 2009-07-30 2016-09-28 Helmholtz-Zentrum für Infektionsforschung GmbH Methods and tests for screening bacterial biofilms
WO2011026559A1 (en) * 2009-09-05 2011-03-10 Lonza Biologics Plc Deepwell plate system with lid
DE102009057223B4 (de) * 2009-12-05 2016-03-24 Chemagen Biopolymer-Technologie Aktiengesellschaft Probengefäßmatrix und deren Herstellungsverfahren
GB201103665D0 (en) * 2011-03-04 2011-04-13 Univ Cardiff Correlative microscopy
US9333471B2 (en) * 2012-04-11 2016-05-10 STAT—Diagnostica & Innovation, S.L. Fluidically integrated magnetic bead beater
US9872448B2 (en) * 2012-08-06 2018-01-23 Council Of Scientific & Industrial Research Bioreactor vessel for large scale growing of plants under aseptic condition
US9550972B2 (en) 2014-09-29 2017-01-24 General Electric Company Devices, systems and methods for automated cell culturing
DE102016116377A1 (de) 2016-09-01 2018-03-01 Rheinisch-Westfälisch Technische Hochschule (RWTH) Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern in Flüssigkulturen
WO2018136752A2 (en) * 2017-01-19 2018-07-26 Essen Bioscience, Inc. Methods and apparatus for perfusion and environment control of microplate labware
US11975330B2 (en) * 2017-01-31 2024-05-07 Myriad Women's Health, Inc. Devices for handling laboratory plates and methods of using the same
DE102018112895B4 (de) 2018-05-30 2024-05-08 Presens Precision Sensing Gmbh System, Vorrichtung und Verfahren zur Erfassung mindestens einer Veränderlichen während eines biologisch / chemischen Prozesses
WO2021106015A1 (en) 2019-11-28 2021-06-03 Council Of Scientific And Industrial Research A continuous flow reactor
CN110907420B (zh) * 2019-12-04 2021-07-02 中国科学院过程工程研究所 一种不互溶液-液相间传质平衡时间的测量装置及利用其的测量方法
EP3910051A1 (en) 2020-05-13 2021-11-17 Evonik Operations GmbH Bioreactors for orbitally shaking cell cultures, in particular suspension cultures
EP3995211A1 (en) * 2020-11-10 2022-05-11 National Health Research Institutes High-efficiency single-cell collection method
WO2022236141A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Container assembly for microbioreactor
WO2022235597A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Control of ph in parallel culture wells
WO2022236146A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Container assembly for microbioreactor
WO2024188448A1 (de) * 2023-03-13 2024-09-19 Hombrechtikon Systems Engineering Ag Behälter, mischungsvorrichtung und verfahren zur verwendung einer mischungsvorrichtung
WO2025136489A1 (en) 2023-12-19 2025-06-26 Beckman Coulter, Inc. Automated system for clone selection based on antibody production and measurement of cell health parameters

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20121739U1 (de) * 2001-10-08 2003-08-28 Mecadi GmbH-Chemicals/Processing, 66424 Homburg Platte für parallelisierte Analysen und Synthesen
JP2003344433A (ja) * 2002-05-22 2003-12-03 Okutekku:Kk マイクロアレイ、マイクロアレイシステム及び被検物質の測定方法
JP2006345862A (ja) * 2005-06-16 2006-12-28 Millipore Corp ずれたウエル及びｕ字形底を有する受け板を備えた多ウエルろ過装置
EP1944080A1 (de) * 2007-01-11 2008-07-16 F.Hoffmann-La Roche Ag Vorrichtung und Verfahren zum Bewegen einer Flüssigkeit in einer Kavität
WO2009013869A1 (ja) * 2007-07-25 2009-01-29 Panasonic Corporation バイオセンサ

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225164A (en) * 1991-09-30 1993-07-06 Astle Thomas W Microplate laboratory tray with rectilinear wells
CA2286195C (en) * 1997-04-09 2006-02-14 Minnesota Mining And Manufacturing Company Method and devices for partitioning biological sample liquids into microvolumes
USD403077S (en) * 1997-05-12 1998-12-22 Neogen Corporation Microorganism culture tray
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
US6896848B1 (en) 2000-12-19 2005-05-24 Tekcel, Inc. Microplate cover assembly
DE10117275B4 (de) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Vorrichtung zur Archivierung und Analyse von Materialien
EP1395366B1 (en) * 2001-06-14 2006-05-03 Millipore Corporation Multiwell test apparatus
AT500167B1 (de) * 2001-06-18 2007-10-15 Greiner Bio One Gmbh Reaktionsgefäss
US6890488B2 (en) * 2001-06-22 2005-05-10 Matrix Technologies, Inc. Apparatus for sealing test tubes and the like
DE10159091A1 (de) * 2001-12-01 2003-06-12 Evotec Ag Trägersysteme und Verfahren zu ihrer Herstellung
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US7211224B2 (en) * 2002-05-23 2007-05-01 Millipore Corporation One piece filtration plate
EP1508373A3 (de) * 2003-08-19 2005-08-03 Herbener, Heinz-Gerd Probenträger mit Flüssigkeitskanal
DE102004017039A1 (de) 2004-04-02 2005-11-03 Rwth Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern von Reaktionsflüssigkeiten in mehreren geschüttelten Mikroreaktoren
JP3978500B2 (ja) * 2005-02-18 2007-09-19 国立大学法人埼玉大学 多種微量試料の注入、移行方法
DE202006004642U1 (de) * 2005-03-29 2006-06-08 Sartorius Ag Mikroarray-Vorrichtung zum Präparieren eines Probenträgers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20121739U1 (de) * 2001-10-08 2003-08-28 Mecadi GmbH-Chemicals/Processing, 66424 Homburg Platte für parallelisierte Analysen und Synthesen
JP2003344433A (ja) * 2002-05-22 2003-12-03 Okutekku:Kk マイクロアレイ、マイクロアレイシステム及び被検物質の測定方法
JP2006345862A (ja) * 2005-06-16 2006-12-28 Millipore Corp ずれたウエル及びｕ字形底を有する受け板を備えた多ウエルろ過装置
EP1944080A1 (de) * 2007-01-11 2008-07-16 F.Hoffmann-La Roche Ag Vorrichtung und Verfahren zum Bewegen einer Flüssigkeit in einer Kavität
WO2009013869A1 (ja) * 2007-07-25 2009-01-29 Panasonic Corporation バイオセンサ

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020523008A (ja) * 2017-06-08 2020-08-06 ヴィトロライフ アー／エス 培養皿のための蓋
JP2020526215A (ja) * 2017-07-13 2020-08-31 グライナー バイオ‐ワン ノース アメリカ，インコーポレイテッド 撮像用の培養プレート
JP7212028B2 (ja) 2017-07-13 2023-01-24 グライナー バイオ‐ワン ノース アメリカ，インコーポレイテッド 撮像用の培養プレート
US12049612B2 (en) 2017-07-13 2024-07-30 Greiner Bio-One North America, Inc. Culture plates for imaging
JP2022067072A (ja) * 2020-10-19 2022-05-02 Ａｇｃテクノグラス株式会社 培養容器

Also Published As

Publication number Publication date
CN101932693B (zh) 2013-03-27
DE102008008256A1 (de) 2009-04-09
EP2205716B1 (de) 2017-09-27
EP2205716A2 (de) 2010-07-14
WO2009046697A9 (de) 2009-07-23
CN101932693A (zh) 2010-12-29
DE112008002590A5 (de) 2010-06-24
DE112008002590B4 (de) 2022-02-24
US20100248995A1 (en) 2010-09-30
WO2009046697A3 (de) 2009-09-11
US8828337B2 (en) 2014-09-09
DK2205716T3 (en) 2017-12-04
WO2009046697A2 (de) 2009-04-16

Similar Documents

Publication Publication Date Title
JP2011501689A (ja) マイクロリアクタ
JP5490803B2 (ja) 懸滴プレートおよび同懸滴プレートを使用する方法
Gruenberger et al. Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation
JP6869185B2 (ja) マルチウェルプレート用の嵌合蓋
US20090148941A1 (en) Disposable mini-bioreactor device and method
EP2085463A1 (en) Culture plate comprising a lid for lateral ventilation
WO2006130670A1 (en) Cell culture flasks, systems, and methods for automated processing
EP1851304A1 (en) Culture device
US9701934B2 (en) Culture vessel and method of growing cells in culture vessel
JPH11509420A (ja) 透析式マルチプルウエル組織培養プレート
WO2019055448A1 (en) SUSPENDED CULTURE DEVICES AND ASSOCIATED SYSTEMS AND METHODS
Demming et al. Disposable parallel poly (dimethylsiloxane) microbioreactor with integrated readout grid for germination screening of Aspergillus ochraceus
WO2022136170A1 (en) Microfluidic device and method for isolating objects
US20250027021A1 (en) Cell culture sampling from fixed bed bioreactor methods and apparatus
US12496586B2 (en) Microplate for containing a plurality of samples
US11959101B2 (en) Cell activation reactor and cell activation method
WO2020067891A1 (en) Device for controlled stirring, method for controlled stirring using the device

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110919

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110919

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121204

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130424

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130514

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130813

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130828

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130913

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131011

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140701

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141001

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141022

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141031

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141121

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141201

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141225

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150310