CN101932693B - 微型反应器 - Google Patents

微型反应器 Download PDF

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Publication number
CN101932693B
CN101932693B CN2008801192016A CN200880119201A CN101932693B CN 101932693 B CN101932693 B CN 101932693B CN 2008801192016 A CN2008801192016 A CN 2008801192016A CN 200880119201 A CN200880119201 A CN 200880119201A CN 101932693 B CN101932693 B CN 101932693B
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CN
China
Prior art keywords
microreactor
lid
arbitrary
cavity
section
Prior art date
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Active
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CN2008801192016A
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English (en)
Chinese (zh)
Other versions
CN101932693A (zh
Inventor
F·肯西
C·米勒
J·布克斯
M·芬克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
M2p Labs GmbH
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M2p Labs GmbH
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Publication date
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Publication of CN101932693A publication Critical patent/CN101932693A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN2008801192016A 2007-10-08 2008-10-08 微型反应器 Active CN101932693B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102007048201.0 2007-10-08
DE102007048201 2007-10-08
DE102008008256.2 2008-02-08
DE102008008256A DE102008008256A1 (de) 2007-10-08 2008-02-08 Mikroreaktor
PCT/DE2008/001623 WO2009046697A2 (de) 2007-10-08 2008-10-08 Mikroreaktor

Publications (2)

Publication Number Publication Date
CN101932693A CN101932693A (zh) 2010-12-29
CN101932693B true CN101932693B (zh) 2013-03-27

Family

ID=40418270

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801192016A Active CN101932693B (zh) 2007-10-08 2008-10-08 微型反应器

Country Status (7)

Country Link
US (1) US8828337B2 (cg-RX-API-DMAC7.html)
EP (1) EP2205716B1 (cg-RX-API-DMAC7.html)
JP (1) JP2011501689A (cg-RX-API-DMAC7.html)
CN (1) CN101932693B (cg-RX-API-DMAC7.html)
DE (2) DE102008008256A1 (cg-RX-API-DMAC7.html)
DK (1) DK2205716T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009046697A2 (cg-RX-API-DMAC7.html)

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WO2011026559A1 (en) * 2009-09-05 2011-03-10 Lonza Biologics Plc Deepwell plate system with lid
DE102009057223B4 (de) * 2009-12-05 2016-03-24 Chemagen Biopolymer-Technologie Aktiengesellschaft Probengefäßmatrix und deren Herstellungsverfahren
GB201103665D0 (en) * 2011-03-04 2011-04-13 Univ Cardiff Correlative microscopy
US9333471B2 (en) * 2012-04-11 2016-05-10 STAT—Diagnostica & Innovation, S.L. Fluidically integrated magnetic bead beater
US9872448B2 (en) * 2012-08-06 2018-01-23 Council Of Scientific & Industrial Research Bioreactor vessel for large scale growing of plants under aseptic condition
US9550972B2 (en) 2014-09-29 2017-01-24 General Electric Company Devices, systems and methods for automated cell culturing
DE102016116377A1 (de) 2016-09-01 2018-03-01 Rheinisch-Westfälisch Technische Hochschule (RWTH) Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern in Flüssigkulturen
WO2018136752A2 (en) * 2017-01-19 2018-07-26 Essen Bioscience, Inc. Methods and apparatus for perfusion and environment control of microplate labware
US11975330B2 (en) * 2017-01-31 2024-05-07 Myriad Women's Health, Inc. Devices for handling laboratory plates and methods of using the same
GB201709140D0 (en) * 2017-06-08 2017-07-26 Vitrolife As Lid for culture dish
WO2019014541A2 (en) * 2017-07-13 2019-01-17 Greiner Bio-One North America, Inc. CULTURE PLATES FOR IMAGING
DE102018112895B4 (de) 2018-05-30 2024-05-08 Presens Precision Sensing Gmbh System, Vorrichtung und Verfahren zur Erfassung mindestens einer Veränderlichen während eines biologisch / chemischen Prozesses
WO2021106015A1 (en) 2019-11-28 2021-06-03 Council Of Scientific And Industrial Research A continuous flow reactor
CN110907420B (zh) * 2019-12-04 2021-07-02 中国科学院过程工程研究所 一种不互溶液-液相间传质平衡时间的测量装置及利用其的测量方法
EP3910051A1 (en) 2020-05-13 2021-11-17 Evonik Operations GmbH Bioreactors for orbitally shaking cell cultures, in particular suspension cultures
JP2022067072A (ja) * 2020-10-19 2022-05-02 Ａｇｃテクノグラス株式会社 培養容器
EP3995211A1 (en) * 2020-11-10 2022-05-11 National Health Research Institutes High-efficiency single-cell collection method
WO2022236141A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Container assembly for microbioreactor
WO2022235597A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Control of ph in parallel culture wells
WO2022236146A1 (en) 2021-05-07 2022-11-10 Beckman Coulter, Inc. Container assembly for microbioreactor
WO2024188448A1 (de) * 2023-03-13 2024-09-19 Hombrechtikon Systems Engineering Ag Behälter, mischungsvorrichtung und verfahren zur verwendung einer mischungsvorrichtung
WO2025136489A1 (en) 2023-12-19 2025-06-26 Beckman Coulter, Inc. Automated system for clone selection based on antibody production and measurement of cell health parameters

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DE10117275B4 (de) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Vorrichtung zur Archivierung und Analyse von Materialien
EP1395366B1 (en) * 2001-06-14 2006-05-03 Millipore Corporation Multiwell test apparatus
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Also Published As

Publication number Publication date
DE102008008256A1 (de) 2009-04-09
EP2205716B1 (de) 2017-09-27
JP2011501689A (ja) 2011-01-13
EP2205716A2 (de) 2010-07-14
WO2009046697A9 (de) 2009-07-23
CN101932693A (zh) 2010-12-29
DE112008002590A5 (de) 2010-06-24
DE112008002590B4 (de) 2022-02-24
US20100248995A1 (en) 2010-09-30
WO2009046697A3 (de) 2009-09-11
US8828337B2 (en) 2014-09-09
DK2205716T3 (en) 2017-12-04
WO2009046697A2 (de) 2009-04-16

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