JP2011500870A - 安定化されたカリスバメートの小児用懸濁液 - Google Patents
安定化されたカリスバメートの小児用懸濁液 Download PDFInfo
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- JP2011500870A JP2011500870A JP2010531607A JP2010531607A JP2011500870A JP 2011500870 A JP2011500870 A JP 2011500870A JP 2010531607 A JP2010531607 A JP 2010531607A JP 2010531607 A JP2010531607 A JP 2010531607A JP 2011500870 A JP2011500870 A JP 2011500870A
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- charisbamate
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Classifications
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
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Abstract
Description
本出願は、2007年10月31日に出願された米国特許仮出願第60/984,144号の優先権の利益を主張する。前記の関連する米国特許出願の全開示は、これによりすべての目的のために参照として編入する。
本発明は、小児および成人が使用するためのカリスバメートの安定化された製薬学的懸濁液を提供する。より詳細にはこの懸濁液は、懸濁した粒子の結晶成長を防止し、そして多形状態が変化する薬物製品の再結晶を防止するために安定化される。さらに、この製剤は味が遮蔽されて、錠剤またはカプセルを飲み込むことが困難な患者、例えば小児患者に容易に投与することができる製剤を提供する。
本発明は、懸濁液を安定化するための湿潤剤として作用するために、しかも結晶の成長および再形成を制御し、そして結晶構造を安定化するために、ヒプロメロースを約1.8〜約2.0mg/mlで添加したカリスバメート粒子の水中懸濁液を含んでなる製薬学的製剤を対象とする。
Bossingerらへの米国特許第3,265,728号明細書に記載された様々な置換フェニルアルキルカルバメート化合物は、哺乳動物で鎮痙性を有し、すなわちヒトにおいて癲癇のような疾患の処置に有用性を有する。
スバメートの水性懸濁液を提供する。
0mg/ml、好ましくは0.3%〜3.0mg/ml、そして最も好ましくは1.5〜2.5mg/mlの範囲でよい。
う行動障害、精神遅滞および自閉における行動障害、双極躁病、鬱および不安に罹患しているヒトの処置法に関し、該方法は治療に有効な量のこれまでに記載した水性懸濁液の投与を含んでなる。治療に有効な量のカリスバメートは、50〜1200mgの毎日の総用量を、1から4回の等用量で投与される。
Claims (7)
- a)約10〜約30mgのカリスバメート;および
b)約5.0〜約15.0mgのヒプロメロース;および
c)約1mlの水
を含んでなる水性懸濁液状態の製薬学的組成物。 - 組成物がさらに懸濁剤および湿潤剤、そして場合により1もしくは複数の保存剤、バッファー、甘味料および風味料を含んでなる請求項1に記載の組成物。
- 製薬学的組成物の形成法であって:
a)安息香酸ナトリウムを、室温22℃で水の総容量の約30%で溶解することにより一つの溶液を調製し;
b)クエン酸、スクラロースおよび風味料を混合しながら加え;
c)ヒプロメロース(HPMC)およびカリスバメートを、22℃で水の総容量の約70%で混合しながら分散することにより第2溶液を調製し;
d)第一溶液を第二溶液に混合しながら加えて、安定化された懸濁液を形成し;
e)クエン酸一水和物を加えて最終製剤のpHをpH3.5から4.5の間に調整する、ことを含んでなる上記形成法。 - 請求項1の方法により作成される請求項3に記載の製薬学的組成物。
- 保存剤がベンジルアルコールであり、そして等張剤がマンニトールまたはリン酸バッファーである、請求項4に記載の組成物。
- 哺乳動物に治療に有効な量の請求項1に記載の製薬学的組成物を投与することを含んでなる、処置が必要な哺乳動物の癲癇の処置法。
- 処置が必要な哺乳動物の癲癇、神経障害性疼痛、振せん、癲癇誘発、神経保護、統合失調症、非分裂的精神病、認知症、精神遅滞および自閉における行動障害、双極躁病、鬱および不安からなる群から選択される障害の処置法であって、哺乳動物に治療に有効な量の本発明の任意の製薬学的組成物を投与することを含んでなる上記処置法。
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PCT/IB2008/003331 WO2009056980A1 (en) | 2007-10-31 | 2008-10-31 | Stabilized pediatric suspension of carisbamate |
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JP2016136713A Active JP6273589B2 (ja) | 2007-10-31 | 2016-07-11 | 安定化されたカリスバメートの小児用懸濁液 |
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