JP2011500696A5 - - Google Patents
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- Publication number
- JP2011500696A5 JP2011500696A5 JP2010530052A JP2010530052A JP2011500696A5 JP 2011500696 A5 JP2011500696 A5 JP 2011500696A5 JP 2010530052 A JP2010530052 A JP 2010530052A JP 2010530052 A JP2010530052 A JP 2010530052A JP 2011500696 A5 JP2011500696 A5 JP 2011500696A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- methyl
- pyridinyl
- disease
- benzofuranyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 methanesulfonylmethyl Chemical group 0.000 claims 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- UEXCJVNBTNXOEH-UHFFFAOYSA-N Ethynylbenzene Chemical compound C#CC1=CC=CC=C1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 125000005433 dihydrobenzodioxinyl group Chemical group O1C(COC2=C1C=CC=C2)* 0.000 claims 2
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 2
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000005476 oxopyrrolidinyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006225 propoxyethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- BAYMNWJMIJZNLH-UHFFFAOYSA-N 2-[2-(2-methoxyethyl)hydrazinyl]ethanol Chemical compound COCCNNCCO BAYMNWJMIJZNLH-UHFFFAOYSA-N 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- DWTGRRBWZVSRSG-UHFFFAOYSA-N CNC(C(NC=O)N(C)C)(NCCO)OC Chemical compound CNC(C(NC=O)N(C)C)(NCCO)OC DWTGRRBWZVSRSG-UHFFFAOYSA-N 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010024264 Lethargy Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001804 chlorine Chemical class 0.000 claims 1
- 125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060107P | 2007-10-17 | 2007-10-17 | |
| US60/980,601 | 2007-10-17 | ||
| PCT/US2008/079760 WO2009052065A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500696A JP2011500696A (ja) | 2011-01-06 |
| JP2011500696A5 true JP2011500696A5 (https=) | 2011-07-28 |
| JP5255644B2 JP5255644B2 (ja) | 2013-08-07 |
Family
ID=40243633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530052A Expired - Fee Related JP5255644B2 (ja) | 2007-10-17 | 2008-10-14 | 置換されたｎ−フェニル−ビピロリジンカルボキサミド及びその治療上の使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8618159B2 (https=) |
| EP (1) | EP2212282B1 (https=) |
| JP (1) | JP5255644B2 (https=) |
| KR (1) | KR20100092441A (https=) |
| CN (1) | CN101903339B (https=) |
| AT (1) | ATE525350T1 (https=) |
| AU (1) | AU2008312638B2 (https=) |
| BR (1) | BRPI0818626A2 (https=) |
| CA (1) | CA2702482C (https=) |
| CO (1) | CO6190616A2 (https=) |
| CY (1) | CY1112683T1 (https=) |
| DK (1) | DK2212282T3 (https=) |
| ES (1) | ES2374116T3 (https=) |
| HR (1) | HRP20110953T1 (https=) |
| IL (1) | IL205003A0 (https=) |
| MA (1) | MA31855B1 (https=) |
| MX (1) | MX2010004094A (https=) |
| MY (1) | MY149650A (https=) |
| NZ (1) | NZ584688A (https=) |
| PL (1) | PL2212282T3 (https=) |
| PT (1) | PT2212282E (https=) |
| RU (1) | RU2477719C2 (https=) |
| SI (1) | SI2212282T1 (https=) |
| WO (1) | WO2009052065A1 (https=) |
| ZA (1) | ZA201001946B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009052068A1 (en) | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
| CN101903342B (zh) * | 2007-10-17 | 2012-11-21 | 赛诺菲-安万特 | 取代的n-苯基-吡咯烷基甲基吡咯烷酰胺及其作为组胺h3受体调节剂的治疗用途 |
| CN101903340B (zh) * | 2007-10-17 | 2013-03-27 | 赛诺菲-安万特 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| WO2011143162A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| WO2011143155A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| TW201206889A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| TW201206898A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| EP2569297A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| WO2012162291A1 (en) | 2011-05-24 | 2012-11-29 | The Wistar Institute | Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1 |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2006227815B2 (en) | 2005-03-17 | 2011-09-22 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| EP1904442B1 (en) * | 2005-07-01 | 2011-09-07 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| CA2627234A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| CN101903340B (zh) * | 2007-10-17 | 2013-03-27 | 赛诺菲-安万特 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
| WO2009052068A1 (en) * | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
| CN101903342B (zh) * | 2007-10-17 | 2012-11-21 | 赛诺菲-安万特 | 取代的n-苯基-吡咯烷基甲基吡咯烷酰胺及其作为组胺h3受体调节剂的治疗用途 |
-
2008
- 2008-10-14 EP EP08839473A patent/EP2212282B1/en active Active
- 2008-10-14 ES ES08839473T patent/ES2374116T3/es active Active
- 2008-10-14 WO PCT/US2008/079760 patent/WO2009052065A1/en not_active Ceased
- 2008-10-14 SI SI200830482T patent/SI2212282T1/sl unknown
- 2008-10-14 HR HR20110953T patent/HRP20110953T1/hr unknown
- 2008-10-14 DK DK08839473.9T patent/DK2212282T3/da active
- 2008-10-14 NZ NZ584688A patent/NZ584688A/en not_active IP Right Cessation
- 2008-10-14 CN CN2008801211996A patent/CN101903339B/zh not_active Expired - Fee Related
- 2008-10-14 KR KR1020107010545A patent/KR20100092441A/ko not_active Ceased
- 2008-10-14 AU AU2008312638A patent/AU2008312638B2/en not_active Ceased
- 2008-10-14 PL PL08839473T patent/PL2212282T3/pl unknown
- 2008-10-14 CA CA2702482A patent/CA2702482C/en not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818626A patent/BRPI0818626A2/pt not_active IP Right Cessation
- 2008-10-14 MY MYPI2010001276A patent/MY149650A/en unknown
- 2008-10-14 PT PT08839473T patent/PT2212282E/pt unknown
- 2008-10-14 RU RU2010119560/04A patent/RU2477719C2/ru not_active IP Right Cessation
- 2008-10-14 JP JP2010530052A patent/JP5255644B2/ja not_active Expired - Fee Related
- 2008-10-14 AT AT08839473T patent/ATE525350T1/de active
- 2008-10-14 MX MX2010004094A patent/MX2010004094A/es active IP Right Grant
-
2010
- 2010-03-15 US US12/724,035 patent/US8618159B2/en not_active Expired - Fee Related
- 2010-03-18 ZA ZA201001946A patent/ZA201001946B/xx unknown
- 2010-04-11 IL IL205003A patent/IL205003A0/en unknown
- 2010-04-16 CO CO10044768A patent/CO6190616A2/es not_active Application Discontinuation
- 2010-05-17 MA MA32846A patent/MA31855B1/fr unknown
-
2011
- 2011-12-21 CY CY20111101272T patent/CY1112683T1/el unknown
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