JP2011173866A5 - - Google Patents
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- Publication number
- JP2011173866A5 JP2011173866A5 JP2011000720A JP2011000720A JP2011173866A5 JP 2011173866 A5 JP2011173866 A5 JP 2011173866A5 JP 2011000720 A JP2011000720 A JP 2011000720A JP 2011000720 A JP2011000720 A JP 2011000720A JP 2011173866 A5 JP2011173866 A5 JP 2011173866A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- carboxyphenoxy
- bis
- formulation
- butylidenephthalide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 15
- 238000009472 formulation Methods 0.000 claims 11
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims 10
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims 6
- WMBOCUXXNSOQHM-FLIBITNWSA-N (Z)-3-butylidenephthalide Chemical compound C1=CC=C2C(=C/CCC)/OC(=O)C2=C1 WMBOCUXXNSOQHM-FLIBITNWSA-N 0.000 claims 5
- WMBOCUXXNSOQHM-DHZHZOJOSA-N 3-Butylidenephthalide Natural products C1=CC=C2C(=C/CCC)\OC(=O)C2=C1 WMBOCUXXNSOQHM-DHZHZOJOSA-N 0.000 claims 5
- LFPLRGMCQXEYDO-UHFFFAOYSA-N 4-[1-(4-carboxyphenoxy)propoxy]benzoic acid Chemical group C=1C=C(C(O)=O)C=CC=1OC(CC)OC1=CC=C(C(O)=O)C=C1 LFPLRGMCQXEYDO-UHFFFAOYSA-N 0.000 claims 5
- WMBOCUXXNSOQHM-UHFFFAOYSA-N n-butylidenephthalide Natural products C1=CC=C2C(=CCCC)OC(=O)C2=C1 WMBOCUXXNSOQHM-UHFFFAOYSA-N 0.000 claims 5
- 229920002732 Polyanhydride Polymers 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- QFGCFKJIPBRJGM-UHFFFAOYSA-N 12-[(2-methylpropan-2-yl)oxy]-12-oxododecanoic acid Chemical compound CC(C)(C)OC(=O)CCCCCCCCCCC(O)=O QFGCFKJIPBRJGM-UHFFFAOYSA-N 0.000 claims 2
- DFOCUWFSRVQSNI-UHFFFAOYSA-N 3-[4-(2-carboxyethyl)phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=C(CCC(O)=O)C=C1 DFOCUWFSRVQSNI-UHFFFAOYSA-N 0.000 claims 2
- FQJXYULOQZUKBZ-UHFFFAOYSA-N 4-[6-(4-carboxyphenoxy)hexoxy]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1OCCCCCCOC1=CC=C(C(O)=O)C=C1 FQJXYULOQZUKBZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 claims 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- YPPKNIZFJLHYFX-UHFFFAOYSA-N 4-[1-(4-carboxyphenoxy)octoxy]benzoic acid Chemical compound C=1C=C(C(O)=O)C=CC=1OC(CCCCCCC)OC1=CC=C(C(O)=O)C=C1 YPPKNIZFJLHYFX-UHFFFAOYSA-N 0.000 claims 1
- LWXZVICIANJHIR-UHFFFAOYSA-N 4-[3-(4-carboxyphenoxy)butan-2-yloxy]benzoic acid Chemical compound C(=O)(O)C1=CC=C(OC(C)C(C)OC2=CC=C(C=C2)C(=O)O)C=C1 LWXZVICIANJHIR-UHFFFAOYSA-N 0.000 claims 1
- HQTSLPQTKQJJAH-UHFFFAOYSA-N 4-[3-(4-carboxyphenoxy)pentan-3-yloxy]benzoic acid Chemical compound C(=O)(O)C1=CC=C(OC(CC)(CC)OC2=CC=C(C=C2)C(=O)O)C=C1 HQTSLPQTKQJJAH-UHFFFAOYSA-N 0.000 claims 1
- IMMQBCHAIJTDKS-UHFFFAOYSA-N 4-[4-(4-carboxyphenoxy)heptan-4-yloxy]benzoic acid Chemical compound C(=O)(O)C1=CC=C(OC(CCC)(CCC)OC2=CC=C(C=C2)C(=O)O)C=C1 IMMQBCHAIJTDKS-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 239000002077 nanosphere Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29231110P | 2010-01-05 | 2010-01-05 | |
| US61/292,311 | 2010-01-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011173866A JP2011173866A (ja) | 2011-09-08 |
| JP2011173866A5 true JP2011173866A5 (https=) | 2013-12-19 |
| JP5727236B2 JP5727236B2 (ja) | 2015-06-03 |
Family
ID=43801814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011000720A Active JP5727236B2 (ja) | 2010-01-05 | 2011-01-05 | 抗がん製剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110165201A1 (https=) |
| EP (1) | EP2343051B1 (https=) |
| JP (1) | JP5727236B2 (https=) |
| DK (1) | DK2343051T3 (https=) |
| ES (1) | ES2522167T3 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI386203B (zh) | 2011-01-07 | 2013-02-21 | Univ China Medical | 治療腦癌或用以降低腦癌細胞對替莫唑胺之抗藥性之醫藥組合物及其應用 |
| TWI472519B (zh) * | 2011-12-20 | 2015-02-11 | Nat Univ Dong Hwa | 含正－亞丁基苯酞之醫藥組成物用於治療肝損傷及改善肝功能 |
| US8927601B2 (en) * | 2011-12-20 | 2015-01-06 | National Dong Hwa University | Uses of N-butylidenephthalide in treating a liver injury and improving liver function |
| TWI522099B (zh) * | 2014-06-04 | 2016-02-21 | 中國醫藥大學 | 治療胰臟癌之醫藥配方及其應用 |
| TWI511727B (zh) | 2014-07-02 | 2015-12-11 | Everfront Biotech Inc | 苯酞化合物之應用 |
| NZ728386A (en) * | 2014-07-04 | 2018-02-23 | Everfront Biotech Inc | Use of phthalide compound |
| JP6371898B2 (ja) * | 2014-07-28 | 2018-08-08 | 易珈生技股▲ふん▼有限公司 | ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法 |
| CN112451519A (zh) * | 2014-07-28 | 2021-03-09 | 长弘生物科技股份有限公司 | 丁烯基苯酞的用途及将其制备为医药组合物的方法 |
| ES2850498T3 (es) * | 2016-05-23 | 2021-08-30 | Everfront Biotech Inc | Uso de Z-butilidenftalida en la activación del sistema autoinmune |
| CN113425707B (zh) * | 2021-07-30 | 2022-12-30 | 青岛大学附属医院 | 壬二酸预防蒽环类抗肿瘤药物心肌毒性的应用 |
| IT202300013839A1 (it) * | 2023-07-04 | 2025-01-04 | Akeso S R L | Composizione cosmetica contenente microsfere di chitosano e acido azelaico funzionalizzate con olio ozonizzato |
| IT202300013845A1 (it) * | 2023-07-04 | 2025-01-04 | Akeso S R L | Composizione cosmetica contenente microsfere di chitosano e acido azelaico |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US6297337B1 (en) | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
| WO2003072143A1 (en) | 2002-02-27 | 2003-09-04 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| GB0318682D0 (en) | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
| US20050255060A1 (en) * | 2004-05-10 | 2005-11-17 | Oblong John E | Personal care compositions and methods regulating mammalian hair growth |
| TWI298259B (en) * | 2004-10-08 | 2008-07-01 | Tzu Chi Buddhist General Hospital | Pharmaceutical composition for inhibiting/treating brain cancer |
| CA2615200A1 (en) * | 2008-01-03 | 2009-07-03 | National Research Council Canada | Use of alkylphthalides for inducing phase 2 proteins |
-
2011
- 2011-01-02 DK DK11150003.9T patent/DK2343051T3/da active
- 2011-01-02 ES ES11150003.9T patent/ES2522167T3/es active Active
- 2011-01-02 EP EP11150003.9A patent/EP2343051B1/en active Active
- 2011-01-04 US US12/984,042 patent/US20110165201A1/en not_active Abandoned
- 2011-01-05 JP JP2011000720A patent/JP5727236B2/ja active Active
-
2015
- 2015-04-14 US US14/686,384 patent/US9585864B2/en active Active
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