JP2016526021A5 - - Google Patents
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- Publication number
- JP2016526021A5 JP2016526021A5 JP2016513057A JP2016513057A JP2016526021A5 JP 2016526021 A5 JP2016526021 A5 JP 2016526021A5 JP 2016513057 A JP2016513057 A JP 2016513057A JP 2016513057 A JP2016513057 A JP 2016513057A JP 2016526021 A5 JP2016526021 A5 JP 2016526021A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- target polypeptide
- corrole
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- LYNARWYQOUZXDY-UHFFFAOYSA-N corrole Chemical compound N1C(C=C2NC(=CC=3NC4=CC=3)C=C2)=CC=C1C=C1C=CC4=N1 LYNARWYQOUZXDY-UHFFFAOYSA-N 0.000 claims 5
- 238000003384 imaging method Methods 0.000 claims 4
- 239000011572 manganese Substances 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229910052748 manganese Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361821106P | 2013-05-08 | 2013-05-08 | |
| US61/821,106 | 2013-05-08 | ||
| PCT/US2014/037234 WO2014182868A1 (en) | 2013-05-08 | 2014-05-08 | Targeting corroles for tumor toxicity and mri |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526021A JP2016526021A (ja) | 2016-09-01 |
| JP2016526021A5 true JP2016526021A5 (https=) | 2017-06-22 |
| JP6640715B2 JP6640715B2 (ja) | 2020-02-05 |
Family
ID=51864925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513057A Expired - Fee Related JP6640715B2 (ja) | 2013-05-08 | 2014-05-08 | 腫瘍毒性に対する標的コロールおよびｍｒｉ |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9757386B2 (https=) |
| EP (2) | EP3730155A1 (https=) |
| JP (1) | JP6640715B2 (https=) |
| KR (1) | KR20160008523A (https=) |
| CN (2) | CN108451930A (https=) |
| AU (2) | AU2014262653B2 (https=) |
| CA (1) | CA2910030A1 (https=) |
| DK (1) | DK2993983T3 (https=) |
| ES (1) | ES2791043T3 (https=) |
| IL (1) | IL265935B (https=) |
| MX (1) | MX2015015434A (https=) |
| PL (1) | PL2993983T3 (https=) |
| PT (1) | PT2993983T (https=) |
| RU (1) | RU2674146C2 (https=) |
| WO (1) | WO2014182868A1 (https=) |
| ZA (1) | ZA201508092B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009009441A2 (en) | 2007-07-06 | 2009-01-15 | Cedars-Sinai Medical Center | Self-assembling complex for targeting chemical agents to cells |
| WO2010085665A2 (en) | 2009-01-23 | 2010-07-29 | Cedars-Sinai Medical Center | Targeted delivery system |
| US10036009B2 (en) | 2012-08-03 | 2018-07-31 | Cedars-Sinai Medical Center | Isolating traffic-enhancing mutants of drug delivery protein |
| RU2674146C2 (ru) | 2013-05-08 | 2018-12-07 | Седарс-Синай Медикал Центр | Нацеленные корролы, проявляющие опухолевую токсичность и предназначенные для мрт |
| JP6608370B2 (ja) | 2014-01-17 | 2019-11-20 | シーダーズ―シナイ メディカル センター | 受容体標的化構築物およびその使用 |
| US9850293B2 (en) | 2014-04-04 | 2017-12-26 | Cedars-Sinai Medical Center | Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle |
| EP3687998A4 (en) * | 2017-08-31 | 2021-05-19 | Technion Research & Development Foundation Limited | CORROL COMPOSITIONS |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA129822A (en) | 1910-08-24 | 1910-12-13 | The John Bertram And Sons Company, Limited | Motor controlling apparatus |
| CA140995A (en) | 1912-03-05 | 1912-06-11 | Davydd C. Hughes | Type plate mechanism |
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| WO2002094318A1 (en) | 2001-05-18 | 2002-11-28 | University Of Southern California | Vector for targeted delivery to cells |
| US6939963B2 (en) * | 2001-07-02 | 2005-09-06 | Technion Research And Development Foundation Ltd. | Method for the preparation of selectively-substituted corroles and new substituted corroles |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| WO2009009441A2 (en) | 2007-07-06 | 2009-01-15 | Cedars-Sinai Medical Center | Self-assembling complex for targeting chemical agents to cells |
| US8791099B2 (en) * | 2007-08-28 | 2014-07-29 | Technion Research And Development Foundation Ltd. | Transition metal complexes of corroles for preventing cardiovascular diseases or disorders |
| ATE556708T1 (de) * | 2008-01-31 | 2012-05-15 | Technion Res & Dev Foundation | Corrole für neuroprotektion und neuro-rescue |
| WO2009151539A1 (en) | 2008-05-24 | 2009-12-17 | Sirnaomics, Inc. | COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMAS |
| WO2010078517A2 (en) | 2008-12-31 | 2010-07-08 | Sirnaomics, Inc. | Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer |
| WO2010085665A2 (en) | 2009-01-23 | 2010-07-29 | Cedars-Sinai Medical Center | Targeted delivery system |
| CN101704820A (zh) * | 2009-09-24 | 2010-05-12 | 江苏大学 | 三(4-氯苯基)咔咯化合物及其合成方法 |
| US20130065778A1 (en) | 2010-01-26 | 2013-03-14 | Yale University | MicroRNA Signatures Predicting Responsiveness To Anti-HER2 Therapy |
| MX2014001823A (es) * | 2011-08-15 | 2014-08-21 | Technion Res & Dev Foundation | Combinaciones de corroles y estatinas. |
| US10036009B2 (en) | 2012-08-03 | 2018-07-31 | Cedars-Sinai Medical Center | Isolating traffic-enhancing mutants of drug delivery protein |
| RU2674146C2 (ru) | 2013-05-08 | 2018-12-07 | Седарс-Синай Медикал Центр | Нацеленные корролы, проявляющие опухолевую токсичность и предназначенные для мрт |
| JP6608370B2 (ja) | 2014-01-17 | 2019-11-20 | シーダーズ―シナイ メディカル センター | 受容体標的化構築物およびその使用 |
| US9850293B2 (en) | 2014-04-04 | 2017-12-26 | Cedars-Sinai Medical Center | Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle |
| BR112018074304A2 (pt) | 2016-05-27 | 2019-10-01 | Cedars Sinai Medical Center | composições de nanopartículas, kit e método para tratar um indivíduo com câncer resistente a fármacos |
-
2014
- 2014-05-08 RU RU2015152033A patent/RU2674146C2/ru active
- 2014-05-08 CA CA2910030A patent/CA2910030A1/en not_active Abandoned
- 2014-05-08 CN CN201810246983.5A patent/CN108451930A/zh not_active Withdrawn
- 2014-05-08 US US14/272,610 patent/US9757386B2/en active Active
- 2014-05-08 KR KR1020157030349A patent/KR20160008523A/ko not_active Ceased
- 2014-05-08 WO PCT/US2014/037234 patent/WO2014182868A1/en not_active Ceased
- 2014-05-08 EP EP20157304.5A patent/EP3730155A1/en not_active Withdrawn
- 2014-05-08 PT PT147944102T patent/PT2993983T/pt unknown
- 2014-05-08 CN CN201480025009.6A patent/CN105307499B/zh not_active Expired - Fee Related
- 2014-05-08 DK DK14794410.2T patent/DK2993983T3/da active
- 2014-05-08 JP JP2016513057A patent/JP6640715B2/ja not_active Expired - Fee Related
- 2014-05-08 MX MX2015015434A patent/MX2015015434A/es unknown
- 2014-05-08 ES ES14794410T patent/ES2791043T3/es active Active
- 2014-05-08 PL PL14794410T patent/PL2993983T3/pl unknown
- 2014-05-08 AU AU2014262653A patent/AU2014262653B2/en not_active Ceased
- 2014-05-08 EP EP14794410.2A patent/EP2993983B1/en active Active
-
2015
- 2015-11-02 ZA ZA2015/08092A patent/ZA201508092B/en unknown
-
2017
- 2017-06-15 US US15/624,228 patent/US10709801B2/en active Active
-
2018
- 2018-10-17 AU AU2018250401A patent/AU2018250401B2/en not_active Ceased
-
2019
- 2019-04-10 IL IL265935A patent/IL265935B/en not_active IP Right Cessation
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