JP2011155971A5 - - Google Patents
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- Publication number
- JP2011155971A5 JP2011155971A5 JP2011001700A JP2011001700A JP2011155971A5 JP 2011155971 A5 JP2011155971 A5 JP 2011155971A5 JP 2011001700 A JP2011001700 A JP 2011001700A JP 2011001700 A JP2011001700 A JP 2011001700A JP 2011155971 A5 JP2011155971 A5 JP 2011155971A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- polypeptide
- dna molecule
- hil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 64
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 49
- 239000002773 nucleotide Substances 0.000 claims description 48
- 125000003729 nucleotide group Chemical group 0.000 claims description 48
- 229920001184 polypeptide Polymers 0.000 claims description 48
- 108020004414 DNA Proteins 0.000 claims description 35
- 125000000539 amino acid group Chemical group 0.000 claims description 16
- 230000000295 complement effect Effects 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 108700026244 Open Reading Frames Proteins 0.000 claims description 9
- 239000002299 complementary DNA Substances 0.000 claims description 5
- 102000053602 DNA Human genes 0.000 claims 23
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 108091081021 Sense strand Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 17
- 239000003636 conditioned culture medium Substances 0.000 description 16
- 108091060211 Expressed sequence tag Proteins 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 14
- 150000001413 amino acids Chemical group 0.000 description 12
- 108020004705 Codon Proteins 0.000 description 11
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 10
- 102000046824 human IL1RN Human genes 0.000 description 9
- 238000001262 western blot Methods 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000001502 gel electrophoresis Methods 0.000 description 5
- 238000002864 sequence alignment Methods 0.000 description 5
- 210000004102 animal cell Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 description 3
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 description 3
- 102000004654 Cyclic GMP-Dependent Protein Kinases Human genes 0.000 description 3
- 108010003591 Cyclic GMP-Dependent Protein Kinases Proteins 0.000 description 3
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 3
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 3
- 108020005067 RNA Splice Sites Proteins 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 230000026731 phosphorylation Effects 0.000 description 3
- 238000006366 phosphorylation reaction Methods 0.000 description 3
- 230000001323 posttranslational effect Effects 0.000 description 3
- 102000004557 Interleukin-18 Receptors Human genes 0.000 description 2
- 108010017537 Interleukin-18 Receptors Proteins 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 108091027568 Single-stranded nucleotide Proteins 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 210000005059 placental tissue Anatomy 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11343098P | 1998-12-23 | 1998-12-23 | |
| US60/113,430 | 1998-12-23 | ||
| US11684399P | 1999-01-22 | 1999-01-22 | |
| US60/116,843 | 1999-01-22 | ||
| US12912299P | 1999-04-13 | 1999-04-13 | |
| US60/129,122 | 1999-04-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591188A Division JP5456222B2 (ja) | 1998-12-23 | 1999-12-22 | Ｉｌ−１関連ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011155971A JP2011155971A (ja) | 2011-08-18 |
| JP2011155971A5 true JP2011155971A5 (enExample) | 2012-04-05 |
Family
ID=27381318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591188A Expired - Lifetime JP5456222B2 (ja) | 1998-12-23 | 1999-12-22 | Ｉｌ−１関連ポリペプチド |
| JP2011001700A Pending JP2011155971A (ja) | 1998-12-23 | 2011-01-07 | Ｉｌ−１関連ポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591188A Expired - Lifetime JP5456222B2 (ja) | 1998-12-23 | 1999-12-22 | Ｉｌ−１関連ポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20070042466A1 (enExample) |
| EP (3) | EP2319929A1 (enExample) |
| JP (2) | JP5456222B2 (enExample) |
| AU (1) | AU778759B2 (enExample) |
| CA (1) | CA2354027A1 (enExample) |
| IL (1) | IL143593A0 (enExample) |
| WO (1) | WO2000039297A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ505881A (en) | 1998-01-09 | 2003-05-30 | Immunex Corp | IL-1 delta DNA and polypeptides |
| US6541623B1 (en) * | 1998-04-03 | 2003-04-01 | Hyseq, Inc. | Interleukin—1 receptor antagonist and uses thereof |
| US7033783B2 (en) | 1998-12-14 | 2006-04-25 | Immunex Corp. | Polynucleotide encoding IL-1 zeta polypeptide |
| CA2378954A1 (en) * | 1999-07-16 | 2001-01-25 | Interleukin Genetics, Inc. | The il-1l1 gene and polypeptide products |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| WO2004028479A2 (en) * | 2002-09-25 | 2004-04-08 | Genentech, Inc. | Nouvelles compositions et methodes de traitement du psoriasis |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| PT3319985T (pt) | 2015-07-06 | 2021-01-06 | Immatics Biotechnologies Gmbh | Novos péptidos e combinação de péptidos para uso em imunoterapia do cancro do esófago e outros cancros |
| MX2021007589A (es) | 2018-12-21 | 2021-12-10 | 23Andme Inc | Anticuerpos anti il-36 y procedimientos de uso de estos. |
| CN116041480A (zh) * | 2022-09-05 | 2023-05-02 | 复旦大学附属华山医院 | 重组人il-37蛋白在抗血小板聚集中的应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| GB8724885D0 (en) | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| JPH04501201A (ja) | 1987-12-21 | 1992-03-05 | ジ・アップジョン・カンパニー | 発芽植物種子類のアグロバクテリウム媒介形質転換 |
| AU4005289A (en) | 1988-08-25 | 1990-03-01 | Smithkline Beecham Corporation | Recombinant saccharomyces |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0739904A1 (en) | 1989-06-29 | 1996-10-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| AU8016094A (en) | 1993-10-12 | 1995-05-04 | Mary Lake Polan | Method of contraception |
| US5863769A (en) | 1997-01-28 | 1999-01-26 | Smithkline Beecham Corporation | DNA encoding interleukin-1 receptor antagonist (IL-1raβ) |
| US6117654A (en) * | 1997-08-04 | 2000-09-12 | Millennium Biotherapeutics, Inc. | Nucleic acid molecules encoding Tango-77-polypeptides |
| EP0977779A1 (en) * | 1997-04-21 | 2000-02-09 | Schering Corporation | Mammalian cytokines; related reagents and methods |
| NZ505881A (en) * | 1998-01-09 | 2003-05-30 | Immunex Corp | IL-1 delta DNA and polypeptides |
| EP1068321A2 (en) * | 1998-04-03 | 2001-01-17 | Hyseq, Inc. | A interleukin-1 receptor antagonist and uses thereof |
| US6294655B1 (en) | 1998-04-03 | 2001-09-25 | Hyseq, Inc. | Anti-interleukin-1 receptor antagonist antibodies and uses thereof |
| WO2000008045A2 (en) | 1998-08-07 | 2000-02-17 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tango-93-related protein family and uses thereof |
| US6680380B1 (en) * | 1998-09-18 | 2004-01-20 | Schering Corporation | Nucleic acids encoding mammalian interleukin-1ζ, related reagents and methods |
| WO2000017363A2 (en) * | 1998-09-18 | 2000-03-30 | Schering Corporation | Interleukin-1 like molecule: interleukin-1-zeta; nucleic acids, polypeptides, antibodies, their uses |
| WO2000020595A1 (en) * | 1998-10-08 | 2000-04-13 | Zymogenetics, Inc. | Interleukin-1 homolog |
| ES2249040T3 (es) * | 1998-10-27 | 2006-03-16 | Zymogenetics, Inc. | Homologo de interleuquina-1 zil1a4. |
| ES2267311T3 (es) * | 1998-12-14 | 2007-03-01 | Immunex Corporation | Adns y polipeptidos de il-1 zeta, variantes de empalme il-1 zeta y xrec2 descripcion. |
| US7033783B2 (en) * | 1998-12-14 | 2006-04-25 | Immunex Corp. | Polynucleotide encoding IL-1 zeta polypeptide |
| EP1688430B1 (en) * | 1999-03-23 | 2009-11-18 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1233977A1 (en) | 1999-12-01 | 2002-08-28 | SmithKline Beecham Corporation | Interleukin-1 homologue, mat il-1h4 |
| CA2395417A1 (en) | 1999-12-10 | 2001-06-14 | Amgen Inc. | Interleukin-1 receptor antagonist-related molecules and uses thereof |
-
1999
- 1999-12-22 CA CA002354027A patent/CA2354027A1/en not_active Abandoned
- 1999-12-22 WO PCT/US1999/030720 patent/WO2000039297A2/en not_active Ceased
- 1999-12-22 EP EP10183813A patent/EP2319929A1/en not_active Withdrawn
- 1999-12-22 JP JP2000591188A patent/JP5456222B2/ja not_active Expired - Lifetime
- 1999-12-22 EP EP99968539A patent/EP1141299A2/en not_active Withdrawn
- 1999-12-22 EP EP10183614A patent/EP2330198A1/en not_active Withdrawn
- 1999-12-22 AU AU25935/00A patent/AU778759B2/en not_active Ceased
- 1999-12-22 IL IL14359399A patent/IL143593A0/xx unknown
-
2006
- 2006-10-10 US US11/548,249 patent/US20070042466A1/en not_active Abandoned
-
2009
- 2009-06-30 US US12/495,633 patent/US8628777B2/en not_active Expired - Fee Related
- 2009-07-01 US US12/496,363 patent/US20090269811A1/en not_active Abandoned
- 2009-07-01 US US12/496,197 patent/US7951916B2/en not_active Expired - Fee Related
-
2011
- 2011-01-07 JP JP2011001700A patent/JP2011155971A/ja active Pending
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