JP2011073997A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavity, which prevents or improves intraoral diseases such as periodontal disease etc. <P>SOLUTION: The composition for oral cavity includes a hen egg antibody obtained from a hen egg immunized against an enzyme produced by Porphyromonas gingivalis and an anti-inflammatory agent. The amount of the hen egg antibody mixed is preferably 0.001-10 wt.%. The anti-inflammatory agent is preferably at least one kind selected from the group consisting of ε-aminocaproic acid, a glycyrrhizic acid salt, glycyrrhetinic acid, tocopherol acetate and lysozyme chloride. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an oral composition.

  Dental plaque (plaque) adheres as a cause of caries, and it has been pointed out that its removal is important in oral hygiene. The plaque contains Porphyromonas gingivalis, which produces a proteolytic enzyme called gingipain for growth. This enzyme destroys gingival tissue, promotes gingival inflammation, and periodontal disease progresses.

  As a method for removing plaque adhering to the tooth surface, mechanical plaque removal using a toothbrush or the like is generally used. However, the mechanical method using a toothbrush or the like cannot sufficiently remove plaque unless it is performed for a long time with a well-trained and well-polished method.

  Thus, as a method for removing plaque, for example, a method using an oral composition containing a bactericide is known (see, for example, Patent Document 1).

  However, the method described in Patent Document 1 cannot sufficiently remove plaque, and does not sufficiently prevent or improve dental caries and periodontal disease.

JP 2001-181162 A

  An object of the present invention is to provide an oral composition capable of preventing or improving periodontal disease.

Such an object is achieved by the present inventions (1) to (4) below.
(1) a chicken egg antibody obtained from a chicken egg immunized with an enzyme produced by Porphyromonas gingivalis;
An oral composition comprising an anti-inflammatory agent.

  (2) The composition for oral cavity as described in said (1) whose compounding quantity of the said egg egg antibody is 0.001-10 wt%.

  (3) The oral cavity according to (1) or (2), wherein the anti-inflammatory agent is at least one selected from the group consisting of ε-aminocaproic acid, glycyrrhizinates, glycyrrhetinic acid, tocopherol acetate and lysozyme chloride. Composition.

  (4) The above (1) satisfying the relationship of 0.02 ≦ A / B ≦ 1000, where A [wt%] is the amount of the chicken egg antibody and B [wt%] is the amount of the anti-inflammatory agent. ) To the oral composition according to any one of (3).

  ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which can prevent or improve a periodontal disease can be provided.

Hereinafter, preferred embodiments of the oral composition of the present invention will be described in detail.
The oral composition in the present specification includes toothpastes, toothpastes, liquid dentifrices, dentifrices such as liquid dentifrices, troches, tablets, creams, ointments, patches, mouthwashes Agent, chewing gum and the like.

  The composition for oral cavity of the present invention is used for the purpose of preventing and improving periodontal disease, and includes a chicken egg antibody as described later, and also includes an anti-inflammatory agent. Yes.

  By the way, conventionally, various oral compositions have been developed to prevent or ameliorate periodontal disease. However, with conventional oral compositions, it is difficult to sufficiently remove dental plaque. It did not prevent or improve periodontal disease.

  On the other hand, the composition for oral cavity of this invention can exhibit the prevention and improvement effect which was excellent in the periodontal disease by including the chicken egg antibody which is mentioned later, and an anti-inflammatory agent.

Hereinafter, each component will be described in detail.
[Chicken egg antibody]
A chicken egg antibody is an antibody obtained from a chicken egg immunized with an enzyme produced by Porphyromonas gingivalis, and has a function of inactivating the enzyme produced by Porphyromonas gingivalis.

  Porphyromonas gingivalis is present in plaque because it dislikes oxygen. This Porphyromonas gingivalis produces a proteolytic enzyme called gingipain for growth. This enzyme destroys gingival tissue, promotes gingival inflammation, and periodontal disease progresses.

  When the composition for oral cavity contains a chicken egg antibody against an enzyme (gingipaine) produced by Porphyromonas gingivalis and an anti-inflammatory agent, oral diseases such as periodontal disease can be prevented or improved. That is, by inactivating the enzyme produced by Porphyromonas gingivalis by the antibody, the destruction of the gingival tissue by the enzyme is suppressed, and the inflammation site is improved by the anti-inflammatory agent, thereby preventing periodontal disease reliably.・ I can improve. Further, by including the above-described antibody and an anti-inflammatory agent, it is possible to suppress the formation of plaque (biofilm) over a long period of time and to prevent the occurrence of periodontal disease.

  The amount of the chicken egg antibody as described above is preferably 0.001 to 10 wt%, more preferably 0.05 to 5 wt%. Thereby, the action of Porphyromonas gingivalis can be more reliably suppressed. On the other hand, if the content of the antibody is less than the lower limit, it becomes difficult to make the amount of the antibody staying in the oral cavity sufficient, and the action of Porphyromonas gingivalis is sufficiently suppressed. May be difficult. On the other hand, if the content of the antibody exceeds the upper limit, an effect sufficient to meet the content may not be obtained sufficiently.

[Anti-inflammatory agent]
Next, the anti-inflammatory agent will be described.

  The anti-inflammatory agent used in the oral composition of the present invention is not particularly limited, and examples thereof include lysozyme chloride, ε-aminocaproic acid, aluminum hydroxyl allantoin, glycyrrhetinic acid, glycyrrhizinates, guaiazulene sulfonic acid, and tocopherol acetate. Etc.

  Among the anti-inflammatory agents described above, it is preferable to use at least one selected from the group consisting of ε-aminocaproic acid, glycyrrhizinates, glycyrrhetinic acid, tocopherol acetate and lysozyme chloride, and ε-aminocaproic acid, glycyrrhetinic acid and acetic acid. It is more preferable to use three tocopherols in combination. As a result, the formation of plaque can be suppressed over a long period of time, and inflammation of the affected area due to periodontal disease can be more effectively prevented, and the effects of the present invention can be made more remarkable.

  Although the compounding quantity of the anti-inflammatory agent in an oral composition is not specifically limited, It is preferable that it is 0.001-5 wt%, and it is more preferable that it is 0.01-1.0 wt%. When the compounding amount of the anti-inflammatory agent is in such a range, oral diseases such as caries and periodontal disease can be prevented or improved more efficiently.

  Moreover, it is preferable to satisfy the relationship of 0.02 ≦ A / C ≦ 1000, where A [wt%] is the amount of chicken egg antibody and C [wt%] is the amount of anti-inflammatory agent. It is more preferable to satisfy the relationship of 1 ≦ A / C ≦ 100. By satisfying such a relationship, it is possible to more effectively exert the effect of combining the egg egg antibody and the anti-inflammatory agent, to suppress the formation of plaque for a longer period of time, and to Inflammation of the affected area due to disease can be more effectively prevented. As a result, the occurrence of oral disease can be more effectively prevented or suppressed.

[Other ingredients]
Moreover, you may mix | blend various components with the composition for oral cavity of this invention according to the dosage form. For example, when the oral composition of the present invention is applied to a toothpaste, an abrasive, a wetting agent, a binder, a foaming agent, a sweetener, an antiseptic, a fragrance component, a medicinal component other than the above, and the like are blended. Can do.

  As abrasives, silica-based abrasives such as silica gel, precipitated silica, igneous silica, hydrous silicic acid, anhydrous silicic acid, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate, anhydrous dibasic calcium phosphate Calcium hydrogen phosphate, calcium pyrophosphate, tribasic magnesium phosphate, tribasic calcium phosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, zirconium silicate, synthetic resin abrasive Of these, one or two or more of these can be used in combination.

  Although the compounding quantity of an abrasive | polishing agent is not specifically limited, It is preferable that it is 3-60 wt%, and it is more preferable that it is 10-45 wt%.

  Examples of the wetting agent include polyhydric alcohols such as glycerin, concentrated glycerin, diglycerin, sorbitol, maltitol, dipropylene glycol, propylene glycol, 1,3-butylene glycol, and xylitol. More than one species can be used in combination.

  Although the compounding quantity of a wetting agent is not specifically limited, It is preferable that it is 1-60 wt%, and it is more preferable that it is 5-50 wt%.

  Examples of the binder include carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol ester alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate and derivatives thereof, xanthan gum, guar gum, Examples thereof include gelatin, agar, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, and the like, and one or more of these can be used in combination.

  Although the compounding quantity of a binder is not specifically limited, 0.1-5.0 wt% is preferable and it is more preferable that it is 0.5-3.0 wt%.

  Examples of foaming agents include sodium lauryl sulfate, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acyl glutamate, and the like, 2-alkyl-N-carboxymethyl -N-hydroxyethyl imidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, etc. Of these, one or more of these can be used in combination.

  Although the compounding quantity of a foaming agent is not specifically limited, It is preferable that it is 0.1-10.0 wt%, and it is more preferable that it is 0.5-5.0 wt%.

  Examples of the sweetening agent include saccharin sodium, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, and the like, and one or more of these may be used in combination. it can.

  Although the compounding quantity of a sweetening agent is not specifically limited, It is preferable that it is 0.005-5.0 wt%, and it is more preferable that it is 0.01-3.0 wt%.

  Examples of the preservative include parabens such as methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, and the like, and one or more of these are used in combination. be able to.

  The blending amount of the preservative varies depending on the type and the like, but is preferably 0.005 to 5.0 wt%, and more preferably 0.01 to 3.0 wt%.

  Examples of the fragrance component include 1-menthol, anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal, etc. Two or more kinds can be used in combination. Although these components may be mix | blended with a single item, you may mix | blend the essential oil etc. which contain these. In addition to the above fragrance components, fragrance components such as aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes, ketones, and lactones, and essential oils may be blended within a range that does not interfere with the effects of the present invention.

  Although the compounding quantity of a fragrance | flavor component is not specifically limited, It is preferable that it is 0.02-2 wt%, and it is more preferable that it is 0.05-1.5 wt%.

  Medicinal ingredients include monofluorophosphate, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, bisabolol, ascorbic acid, tocopherol acetate, ε-aminocaproic acid, tranexamic acid, aluminum hydroxyl Allantoin, aluminum lactate, dihydrocholesterol, copper chlorophyllin salt, guaiazulene sulfonate, dextranase, pyridoxine hydrochloride, sodium chloride and the like can be mentioned, and one or more of these can be blended.

  In addition to the above-mentioned components, for example, pigments such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents such as edetate, cha extract, tea dry distillation liquid, sodium glutamate And so on.

  The obtained composition such as a toothpaste can be used by being filled into an aluminum tube, a laminate tube, a glass vapor deposition tube, a plastic tube, a plastic bottle, an aerosol container or the like.

  As mentioned above, although the composition for oral cavity of this invention was demonstrated, this invention is not limited to this. For example, the composition for oral cavity of this invention can mix | blend the component which has arbitrary functions other than the component mentioned above.

Next, specific examples of the present invention will be described.
Example 1
A toothpaste was produced according to a conventional method using the following components 1 to 10 (unit: wt%).

1. Chicken egg antibody: 1.0
2. Glycyrrhetinic acid: 0.05
3. Polyoxyethylene hydrogenated castor oil: 2.0
4). Calcium hydrogen phosphate: 30.0
5). Silicic anhydride: 10.0
6). Concentrated glycerin: 25.0
7). Sodium carboxymethyl cellulose: 1.0
8). Polyethylene glycol 400: 2.0
9. Fragrance: 1.0
10. Distilled water: remaining

(Examples 2 to 4)
A toothpaste was produced in the same manner as in Example 1 except that the amounts of the chicken egg antibody and the anti-inflammatory agent were changed as shown in Table 1.

(Examples 5 to 12)
A toothpaste was produced in the same manner as in Example 1 except that the anti-inflammatory agent shown in Table 1 was added in the amount shown in Table 1.

(Comparative Example 1)
A toothpaste was produced in the same manner as in Example 1 except that the egg antibody and the anti-inflammatory agent were not blended.

(Comparative Example 2)
A toothpaste was produced in the same manner as in Example 1 except that no chicken egg antibody was added.

(Comparative Example 3)
A toothpaste was produced in the same manner as in Example 2 except that the egg antibody was not added and the amount of the anti-inflammatory agent was changed as shown in Table 1.

(Comparative Example 4)
A toothpaste was produced in the same manner as in Example 1 except that no anti-inflammatory agent was added.

(Comparative Example 5)
A toothpaste was produced in the same manner as in Example 3 except that no anti-inflammatory agent was added.

  Table 1 shows the amount of each component in each example and each comparative example. In addition, as a chicken egg antibody used in each example and each comparative example described above, those obtained as immunoglobulins prepared from eggs produced by chickens immunized by gingipain produced by Porphyromonas gingivalis were used. . In the table, glycyrrhetinic acid was indicated as RS, ε-aminocaproic acid as EAC, glycyrrhizic acid salts as LS, tocopherol acetate as VE, and lysozyme chloride as YK.

<Evaluation of periodontal disease prevention and improvement>
85 subjects complaining of gum swelling and bleeding symptoms were arbitrarily grouped into 17 groups of 5 each, and each group was divided into 16 types of dentifrices obtained in each Example and each Comparative Example. The brushing was performed 3 times a day for 3 minutes with any one dentifrice for 14 days. In addition, the dentifrice of the same kind (the same Example or comparative example) was not used between each group. In addition, the use of other oral compositions was prohibited for 14 days.

  After the completion of 14 days, for each subject, the improvement effect of swelling of the gums and bleeding symptoms was determined according to the following four criteria, and based on this improvement effect, the following five criteria for each group Thus, the periodontal disease prevention / amelioration effect of the dentifrice of each Example and each Comparative Example was evaluated.

(Criteria for each subject)
Remarkable: Swelling and bleeding of gums were remarkably improved.
Effective: Swelling and bleeding of gums improved.
Slightly effective: One of swelling and bleeding of gums improved.
No effect: Almost no change was observed before and after use.

(Evaluation criteria for each group)
A: All subjects in the group were markedly effective or effective.
A: Four of the subjects in the group were markedly effective or effective.
○: Three of the subjects in the group were markedly effective or effective.
Δ: One or two of the subjects in the group were effective or effective.
X: There was no subject who showed remarkable or effective.

The above evaluation results are shown in Table 1.
As is clear from Table 1, the dentifrices obtained in each Example had excellent periodontal disease prevention / amelioration effects.

  On the other hand, the dentifrices obtained in each comparative example were all low in the effect of improving periodontal disease.

Claims (4)

An egg antibody obtained from an egg immunized with an enzyme produced by Porphyromonas gingivalis,
An oral composition comprising an anti-inflammatory agent.   The composition for oral cavity of Claim 1 whose compounding quantity of the said egg egg antibody is 0.001-10 wt%.   The oral composition according to claim 1 or 2, wherein the anti-inflammatory agent is at least one selected from the group consisting of ε-aminocaproic acid, glycyrrhizinates, glycyrrhetinic acid, tocopherol acetate and lysozyme chloride.   The relationship of 0.02 ≦ A / B ≦ 1000 is satisfied, where A is a wt% of the chicken egg antibody and B is wt% of the anti-inflammatory agent. The composition for oral cavity in any one.