JP2011016757A - Disinfectant detergent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a disinfectant detergent for instruments, which has a disinfecting property, a germicidal property and detergency, is excellent in rust-preventing property so as to prevent rusting of the instrument to be cleaned and hardly leaves any deposit on the instrument.SOLUTION: The disinfectant detergent for instruments is an aqueous solution comprising hypochlorite, orthosilicate and water, provided that 100 mL of the aqueous solution contains 0.10-0.60 g of hypochlorite (calculated in terms of effective chlorine) and 0.7-4.0 g of orthosilicate.

Description

  The present invention relates to a sterilization cleaning agent used for sterilization cleaning and sterilization cleaning of medical instruments, for example.

  In this specification and claims, the term “instrument” is used to include not only instruments but also instruments and instruments.

  As a sterilization cleaning agent for medical devices, a cleaning agent containing sodium hypochlorite and phosphate is known (see Patent Document 1).

  However, the cleaning agent is not sufficient in rust prevention. That is, for example, many medical instruments are made of metal. However, when such metallic medical instruments are washed with the above-described cleaning agent, there is a problem that rust is easily generated in the washed medical instruments. The reason why rust is likely to occur is considered to be because sodium hypochlorite is contained in the cleaning agent.

  Therefore, a cleaning agent containing hypochlorite, sodium metasilicate and water is known as a cleaning agent having sufficiently improved rust prevention. By setting it as such a composition, it has sterilization property or bactericidal property, and is provided with the washing | cleaning property, and the sterilization washing | cleaning agent for instruments excellent in rust prevention property is obtained.

JP 2001-333977 A

  However, when the instrument sterilization detergent having the above composition is actually used, it has excellent anticorrosive properties due to the sodium metasilicate content, but there is a film-like deposit (residue) on the washed medical instrument. It turns out that there is a problem that occurs. Therefore, it has been demanded to develop a sterilization detergent for instruments that has sterilization or bactericidal properties, is excellent in detergency and rust prevention properties, and has few deposits on the instrument after washing.

  This invention was made in view of such a technical background, has sterilization properties or bactericidal properties, has cleaning properties, and is excellent in rust prevention properties so as not to rust the appliance to be cleaned, It is another object of the present invention to provide a sterilization detergent for appliances and a stock solution for the sterilization detergent for appliances, which have little deposits on the instrument.

  In order to achieve the above object, the present invention provides the following means.

[1] An aqueous solution containing hypochlorite, orthosilicate and water,
The content of the hypochlorite is 0.10 to 0.60 g (as effective chlorine) and the content of the orthosilicate is 0.7 to 4.0 g per 100 mL of the aqueous solution. A sanitizing detergent for appliances.

  [2] The disinfecting detergent for appliances according to the above item 1, wherein the hypochlorite is sodium hypochlorite and the orthosilicate is sodium orthosilicate.

  [3] The sterilizing detergent for appliances according to the above item 1 or 2, wherein the aqueous solution has a pH of 11 to 14.

[4] An aqueous stock solution containing hypochlorite, orthosilicate and water,
The aqueous stock solution is diluted with water to a predetermined dilution ratio and used as a sterilization detergent for instruments in a diluted aqueous solution state,
The diluted aqueous solution at the time of use in which the aqueous stock solution is diluted with water to a predetermined dilution ratio has a content of the hypochlorite of 0.10 to 0.60 g (as effective chlorine) per 100 mL of the diluted aqueous solution. A stock solution for a sterilizing detergent for appliances, wherein the orthosilicate content is 0.7 to 4.0 g.

  [5] The stock solution for the sterilizing detergent for appliances according to the item 4, wherein the predetermined dilution ratio is 2 to 10 times.

  [6] The stock solution for sanitizing detergent for appliances according to 4 or 5 above, wherein the hypochlorite is sodium hypochlorite and the orthosilicate is sodium orthosilicate.

  [7] A stock solution for a sterilization detergent for appliances obtained by concentrating the sterilization detergent for appliances according to any one of items 1 to 3.

  [8] A stock solution for sterilization detergent for appliances having the same composition and concentration as those obtained by concentrating the sterilization detergent for appliances according to any one of items 1 to 3.

  [9] The stock solution for a sterilizing detergent for appliances according to the above item 7 or 8, wherein the concentration ratio of the concentration is 2 to 10 times.

  The sterilization detergent for appliances according to the invention of [1] contains hypochlorite, and the content of hypochlorite per 100 mL of aqueous solution is 0.10 to 0.60 g (as effective chlorine). Therefore, it has good sterilization or bactericidal properties and good cleanability. Furthermore, since 0.7-4.0 g of orthosilicate is contained per 100 mL of aqueous solution, it is excellent in rust prevention property so as not to rust the device to be cleaned and suppresses the amount of deposits on the device sufficiently small. it can.

  In the case of a composition containing metasilicate (not orthosilicate) as in the prior art, a film-like deposit (residue) is generated on the cleaned device. In this invention, there exists an extraordinary effect that the deposit | attachment to an instrument can be suppressed enough by containing orthosilicate instead of metasilicate.

  In the invention of [2], since sodium hypochlorite is used as the hypochlorite, the bactericidal property and the cleaning property can be further improved, and since the sodium orthosilicate is used as the orthosilicate, The deposits can be further reduced.

  In the invention of [3], since the aqueous solution is set to pH 11 to 14, the hypochlorite can be stably present without being decomposed, and thus a sterilizing detergent for appliances excellent in stability is provided. .

  In the stock solution for sterilization detergent for appliances according to the invention of [4], the diluted aqueous solution at the time of use in which the stock solution is diluted with water to a predetermined dilution ratio contains hypochlorite and per 100 mL of the diluted aqueous solution. On the other hand, since the content of hypochlorite is 0.10 to 0.60 g (as effective chlorine), it has good sterilization or bactericidal properties and good detergency. Furthermore, since 0.7 to 4.0 g of orthosilicate is contained per 100 mL of dilute aqueous solution, it is excellent in rust prevention property so as not to rust the appliance to be cleaned, and there are sufficiently few deposits on the appliance. Can be suppressed.

  In the invention of [5], since the predetermined dilution ratio is set to 2 to 10 times, the time until the stock solution is used up can be extended, and the storage space can also be reduced.

  In the invention of [6], since sodium hypochlorite is used as the hypochlorite, the bactericidal property and the cleaning property can be further improved, and since the sodium orthosilicate is used as the orthosilicate, The deposits can be further reduced.

  The stock solution for sterilization detergent for appliances according to the invention of [7] is obtained by concentrating the sterilization detergent for appliances of any one of [1] to [3]. The diluted aqueous solution at the time of use diluted to a predetermined dilution ratio with water contains hypochlorite, and the content of hypochlorite per 100 mL of diluted aqueous solution is 0.10 to 0.60 g (effective (As chlorine), it has good sterilization or bactericidal properties and good detergency. Furthermore, since 0.7 to 4.0 g of orthosilicate is contained per 100 mL of dilute aqueous solution, it is excellent in rust prevention property so as not to rust the appliance to be cleaned, and there are sufficiently few deposits on the appliance. Can be suppressed.

  Since the stock solution for the sterilization detergent for appliances according to the invention of [8] has the same composition and the same concentration as those obtained by concentrating the sterilization detergent for appliances of any one of [1] to [3], this stock solution The diluted aqueous solution at the time of use diluted with water to a predetermined dilution ratio contains hypochlorite, and the content of hypochlorite per 100 mL of diluted aqueous solution is 0.10 to 0.60 g ( As effective chlorine), it has good sterilization or bactericidal properties and good cleanability. Furthermore, since 0.7 to 4.0 g of orthosilicate is contained per 100 mL of dilute aqueous solution, it is excellent in rust prevention property so as not to rust the appliance to be cleaned, and there are sufficiently few deposits on the appliance. Can be suppressed.

  In the invention of [9], since the concentration ratio of concentration is 2 to 10 times, the time until the stock solution is used up can be extended, and the storage space can also be reduced.

  The instrument disinfectant cleaning agent according to the present invention is an aqueous solution containing hypochlorite, orthosilicate and water, and the content of the hypochlorite per 100 mL of the aqueous solution. 0.10 to 0.60 g (as effective chlorine), and the content of the orthosilicate is 0.7 to 4.0 g.

  The hypochlorite exhibits a sterilizing action, a bactericidal action and a cleaning action. By including this hypochlorite at a specific ratio of 0.10 to 0.60 g as effective chlorine per 100 mL of the aqueous solution, it is possible to provide good sterilization or bactericidal properties and good detergency. it can. When the blending ratio of hypochlorite is smaller than the above lower limit, it is difficult to obtain good sterilizing properties, bactericidal properties and cleaning properties. Further, even if the blending ratio of hypochlorite is larger than the above upper limit, further improvement in sterilization property, bactericidal property or cleaning property cannot be expected. Especially, it is preferable to set content of hypochlorite in the range of 0.15-0.45g (as effective chlorine) with respect to 100 mL of said aqueous solutions, and 0.20-0.40g is more preferable. The range is (as effective chlorine), and the range of 0.25 to 0.35 g (as effective chlorine) is particularly preferable.

  The effective chlorine is quantified according to the “quantification method of sodium hypochlorite” described in the 7th edition of the Food Additives Manual (Yodogawa Shoten). That is, 40 mL of a test sample (sanitary cleaning agent for instruments) was accurately weighed, 10 mL of water was added, 2 g of potassium iodide and 10 mL of acetic acid were added, immediately sealed and left in a dark place for 15 minutes to remove free iodine. Titrate with 0.1 mol / L aqueous sodium thiosulfate solution (indicator: starch reagent). A titer of 1 mL of a 0.1 mol / L aqueous sodium thiosulfate solution corresponds to 3.5453 mg of Cl.

  As the hypochlorite, sodium hypochlorite is preferably used, and in this case, the sterilization property and the cleaning property can be further improved.

  By containing the orthosilicate, it is possible to obtain a rust preventive effect that prevents the appliance to be cleaned from being rusted. Such an antirust effect can also be obtained by adding metasilicate. However, when metasilicate is contained, a lot of film-like deposits (residues) are generated on the cleaned equipment. On the other hand, when the orthosilicate is contained, the amount of deposits on the instrument after cleaning can be suppressed sufficiently. That is, by including orthosilicate at a specific ratio of 0.7 to 4.0 g per 100 mL of the aqueous solution, an effect of being excellent in rust prevention so as not to rust the appliance to be cleaned can be obtained, There is also an effect that the amount of deposits on the appliance after cleaning can be sufficiently reduced. When the blending ratio of orthosilicate is smaller than the above lower limit, sufficient rust prevention properties cannot be obtained, and a sufficient suppression effect on the occurrence of deposits (which are difficult to remove) cannot be obtained. When the blending ratio of orthosilicate is larger than the above upper limit, there arises a problem that gelation and precipitation are likely to occur. Among them, the orthosilicate content is preferably set in the range of 1.5 to 3.5 g, more preferably in the range of 2.0 to 3.5 g, per 100 mL of the aqueous solution. . When the orthosilicate used for blending is a hydrate, the “orthosilicate content” does not include the mass of hydrated water (the mass of moisture).

  As the orthosilicate, sodium orthosilicate is preferably used, and in this case, the amount of deposits on the instrument can be further reduced.

  The aqueous solution (an aqueous solution containing hypochlorite, orthosilicate, and water) is preferably adjusted to pH 11-14. If the pH is less than 11, hypochlorite is easily decomposed and it is difficult to exist stably. Such a regulator for pH adjustment is not particularly limited, and examples thereof include sodium hydroxide.

  The aqueous solution (an aqueous solution containing hypochlorite, orthosilicate and water) may contain other components as long as the effects of the present invention are not impaired.

  Another invention of the present invention is a stock solution for a sterilizing detergent for appliances corresponding to a product obtained by concentrating the sterilizing detergent for appliances according to the above configuration. That is, the stock solution for the sterilization detergent for instruments of the present invention is a concentrate of the sterilization detergent stock solution for instruments obtained by concentrating the sterilization detergent for instruments or the sterilization detergent for instruments described above. This is a stock solution for a sterilization detergent for appliances having the same composition and the same concentration.

  That is, the stock solution for sanitizing detergent for instruments of the present invention is an aqueous stock solution containing hypochlorite, orthosilicate and water, and the aqueous stock solution is diluted with water to a predetermined dilution ratio. The diluted aqueous solution is used as a sterilizing detergent for appliances, and the diluted aqueous solution at the time of use in which the aqueous stock solution is diluted with water to a predetermined dilution ratio is used for 100 mL of the diluted aqueous solution. The hypochlorite content is 0.10 to 0.60 g (as effective chlorine), and the orthosilicate content is 0.7 to 4.0 g.

  A dilute aqueous solution obtained by diluting the stock solution for the sterilization detergent for equipment to a predetermined dilution ratio with water (sanitization detergent for equipment) has a good sterilization property or a bactericidal property and a good cleanability. Furthermore, it is excellent in the rust prevention property which prevents the appliance to be cleaned from being rusted, and the amount of deposits on the appliance can be suppressed sufficiently.

  The predetermined dilution rate is preferably set to 2 to 10 times. By setting it to 2 times or more, it is possible to lengthen the time until the stock solution is used up and to reduce the storage space. In addition, it is not preferable to increase the concentration of the stock solution until the dilution ratio is designed to exceed 10 times (for example, to concentrate), because orthosilicate is likely to precipitate.

  Next, specific examples of the present invention will be described, but the present invention is not particularly limited to these examples.

<Example 1>
In order to adjust pH after charging 0.30 g of sodium hypochlorite as effective chlorine and 1.64 g of sodium orthosilicate (with hydrated water) (of which hydrated water is 0.41 g) A small amount of sodium hydroxide was added, and purified water was added to adjust the total amount of the aqueous solution to 100 mL. Thus, a sterilizing detergent for equipment (cleaning liquid) having a pH of about 13 was obtained.

<Example 2>
In order to adjust pH after charging 0.30 g of sodium hypochlorite as effective chlorine and 3.28 g of sodium orthosilicate (with water of hydration) into the sample preparation container A small amount of sodium hydroxide was added, and purified water was added to adjust the total amount of the aqueous solution to 100 mL. Thus, a sterilizing detergent for equipment (cleaning liquid) having a pH of about 13 was obtained.

<Comparative Example 1>
In order to adjust pH after charging 0.30 g of sodium hypochlorite as effective chlorine and 1.9 g of sodium metasilicate (with hydrated water) (of which 1.1 g of hydrated water is included) A small amount of sodium hydroxide was added, and purified water was added to adjust the total amount of the aqueous solution to 100 mL. Thus, a sterilizing detergent for equipment (cleaning liquid) having a pH of about 13 was obtained.

<Comparative Example 2>
After adding 0.30 g of sodium hypochlorite as effective chlorine to the sample preparation container, a small amount of sodium hydroxide for pH adjustment is added, and further purified water is added to adjust the total amount of the aqueous solution to 100 mL. Thus, a sterilization detergent (cleaning liquid) for instruments having a pH of about 13 was obtained.

<Comparative Example 3>
A small amount of sodium hydroxide for pH adjustment is added to the sample adjustment container, and further purified water is added to adjust the total amount of the aqueous solution to 100 mL to obtain a sanitizing detergent (cleaning liquid) for instruments having a pH of about 13. It was.

  The sterilization detergents for appliances obtained as described above were evaluated according to the following evaluation methods.

<Cleaning performance evaluation method>
Since the sterilization detergent for instruments of the present invention is required to be able to wash organic substances such as blood adhering to the instrument during clinical use, for example, the following washing test was performed. That is, first, 0.5 g of beef pieces were attached to a slide glass for an optical microscope and dried at 120 ° C. for 1 hour, and then immersed in 20 mL of a disinfectant cleaning agent for each instrument. After 10 minutes, the slide glass is taken out, washed with purified water, stained with amide black solution, further washed with purified water and dried, and then the surface condition of the slide glass is visually observed, and the following judgment is made. The cleaning performance was evaluated based on the criteria. In each example and each comparative example, the cleaning performance was evaluated for three slide glasses (first sample, second sample, and third sample). These evaluation results are shown in Table 1.
(Criteria)
“A”: The dyed state indicating the adhesion mark of the meat piece was not observed at all (there was no adhesion mark), and was sufficiently removed by washing.
“O”: Rarely, a staining state showing a sticking mark of a piece of meat may be slightly observed, but basically a staining state showing a sticking mark of a piece of meat is not observed.
“Δ”: A dyed state showing a sticking mark of a piece of meat is partially observed.
“X”: The staining state showing the adhesion mark of the piece of meat is clearly observed, and the cleaning removal is insufficient.

<Sterilization performance evaluation method>
Bactericidal performance was evaluated according to the minimum bactericidal concentration (MBC) measurement method. That is, 1 platinum ear amount of each test strain shown below was collected and inoculated into 10 mL of a liquid medium prepared in advance, and the bacteria were cultured at 37 ° C. and the fungi at 25 ° C. for 24 hours. 0.1 mL of this cultured bacterium is collected and added to 10 mL of sterilization detergent for instruments adjusted to each concentration (2-fold dilution, 4-fold dilution, 8-fold dilution, 16-fold dilution, 32-fold dilution) for 5 minutes. After the action and after 10 minutes of action, 1 platinum loop was collected and inoculated into 10 mL of a liquid medium prepared in advance, and the bacteria were cultured at 37 ° C. and the fungus at 25 ° C. for 24 hours. The state of growth of bacteria and fungi after 24 hours of culture is visually observed, and those that are turbid (fungal growth) are indicated as “+”, and those that are not turbid (no fungal growth) are indicated as “−”. ". The sterilization performance evaluation results for Example 1 are shown in Table 2, the sterilization performance evaluation results for Example 2 are shown in Table 3, the sterilization performance evaluation results for Comparative Example 1 are shown in Table 4, and the Comparative Example 2 The sterilization performance evaluation results are shown in Table 5.
(Test strain)
Bacteria (aerobic bacteria)
Staphylococcus aureus FDA 209P
Escherichia coli IFO 12734
Bacteria (anaerobic bacteria)
Fusobacterium nucleatum ATCC 25586
Porphyromonas gingivalis # 381
fungus
Aspergillus niger ATCC 6275
Candida albicans IFO 1594
(Culture medium)
Bacteria (aerobic bacteria)
Trypticase Soy Broth (BBL)
Yeast Extract (BBL)
Bacteria (anaerobic bacteria)
Brain Heart Infusion (BBL)
fungus
GPLP liquid medium “DAIGO” (manufactured by Nippon Pharmaceutical).

<Rust prevention evaluation method>
After 50 mL of the sterilization detergent for instruments was put into a polypropylene container having an inner diameter of 7 cm at the upper opening, a lower inner diameter of 9 cm, and an inner volume of 236 mL, a test iron plate (JIS G3141) having a length of 50 mm × width 20 mm × thickness 0.3 mm was further added. An iron plate; a piece of rust that had been stored in a desiccator under silica gel in advance) was placed in a container, and the whole of the test iron plate was immersed in a disinfecting detergent for instruments. After 1 hour of immersion, the test iron plate is taken out, and this test iron plate is transferred into a test tube previously filled with 5 mL of the sterilizing detergent for the instrument, and the length below the liquid level of the test iron plate (immersion part) is long. The lower half of the test iron plate is immersed in the sterilization cleaner for instruments so that the length is 28 mm, and the upper part (non-immersed part) above the liquid level of the test iron plate is exposed to air. Immediately after the start of immersion, observe the rusted state of the test iron plate after 2 hours, 5 hours, 24 hours, 72 hours, and 1 month, respectively, and take a picture of one side of the test iron plate It was. Image processing is performed using Apple's computer and Adobe application software Adobe Photoshop Ver.7, and the photograph is applied to a grid image divided into 1 mm square grids, from the surface of the test iron plate The ratio (%) of the area of the rust generating part to the total area at the upper position and the ratio (%) of the area of the rust generating part to the total area at the lower position (immersion area) from the liquid level of the test iron plate were measured. The evaluation results are shown in Tables 6 and 7.

<Evaluation method of adhesion control effect>
50 μL of the sterilizing detergent for each instrument was dropped on the surface of a stainless steel plate (SUS304U) that had been washed with ethanol and then dried, and dried at 60 ° C. for 2 hours. Next, it was washed by hand washing under running water and then dried, and the surface was visually observed, and the deposit suppression effect was evaluated based on the following criteria. Furthermore, after carrying out brush washing under running water, it was made to dry and the surface was observed visually and the deposit | attachment suppression effect was evaluated based on the following criteria. In each of the examples and comparative examples, the deposit suppression effect was evaluated for three stainless steel plates (first sample, second sample, and third sample). These evaluation results are shown in Table 8.
(Criteria)
“◎”: The deposit was sufficiently removed.
“◯”: The deposit was almost fully removed.
“Δ”: A portion where the deposits were not removed partially occurred.
“×”: The deposits were hardly removed.

(Cleaning performance evaluation results)
As is apparent from Table 1, the cleaning performance of the sanitizing detergent for appliances of Examples 1 and 2 to which orthosilicate was added and contained was sanitized and cleaned for instrument of Comparative Example 2 in which silicate was not added. It was found that the cleaning performance of the agent was exactly the same, so that even if orthosilicate was added, the cleaning performance of hypochlorite was not affected at all. That is, the sterilizing detergent for instruments of Examples 1 and 2 is excellent in cleaning performance.

(Evaluation result of sterilization performance)
The sterilization detergents for instruments of Examples 1 and 2 are not usually diluted and used, but any of the tests of Examples 1 and 2 and Comparative Examples 1 and 2 at a dilution factor of 2 to 16 times. In the sample, no bacterial growth was observed (see Tables 2 to 5). Although there is some variation in the results at 32-fold dilution, it is recognized that these test samples have almost the same bactericidal efficacy (see Tables 2 to 5). That is, the bactericidal effect of the sterilization detergent for appliances of Examples 1 and 2 to which orthosilicate was added and contained was completely the same as that of the sterilization detergent for appliances of Comparative Example 2 to which silicate was not added. Thus, it was found that the addition of orthosilicate had no effect on the hypochlorite bactericidal efficacy.

(Rust prevention evaluation results)
As apparent from Tables 6 and 7, the sanitizing detergent for appliances of Examples 1 and 2 to which orthosilicate was added and contained was the sanitizing detergent for appliance of Comparative Example 1 to which metasilicate was added and contained. Compared to the above, it had much better rust prevention.

(Evaluation results of the deposit suppression effect)
As is clear from Table 8, the disinfecting detergent for appliances of Examples 1 and 2 to which orthosilicate was added and contained did not leave deposits that could not be removed by hand washing or brush cleaning. Even if there is, it can be easily removed by hand washing or brush washing). That is, if the sterilization detergent for appliances of Examples 1 and 2 is used, it is possible to suppress the residue remaining on the appliance to be sufficiently small.

  On the other hand, the sterilization detergent for appliances of Comparative Example 1 to which metasilicate was added and contained produced a lot of deposits on the instruments after washing with this, and these deposits were washed by hand and washed. The brush could not be removed from the instrument. That is, when the sterilization detergent for appliances of Comparative Example 1 was used, many deposits that were difficult to remove were generated.

  The disinfectant cleaning agent for instruments of the present invention is suitably used as a cleaning liquid for medical instruments and the like, but is not particularly limited to such applications.

Claims (9)

An aqueous solution comprising hypochlorite, orthosilicate and water,
The content of the hypochlorite is 0.10 to 0.60 g (as effective chlorine) and the content of the orthosilicate is 0.7 to 4.0 g per 100 mL of the aqueous solution. A sanitizing detergent for appliances.   The disinfectant cleaning agent for instruments according to claim 1, wherein the hypochlorite is sodium hypochlorite and the orthosilicate is sodium orthosilicate.   The sterilizing detergent for appliances according to claim 1 or 2, wherein the aqueous solution has a pH of 11 to 14. An aqueous stock solution containing hypochlorite, orthosilicate and water,
The aqueous stock solution is diluted with water to a predetermined dilution ratio and used as a sterilization detergent for instruments in a diluted aqueous solution state,
The diluted aqueous solution at the time of use in which the aqueous stock solution is diluted with water to a predetermined dilution ratio has a content of the hypochlorite of 0.10 to 0.60 g (as effective chlorine) per 100 mL of the diluted aqueous solution. A stock solution for a sterilizing detergent for appliances, wherein the orthosilicate content is 0.7 to 4.0 g.   The said predetermined dilution rate is 2-10 times, The stock solution for the sterilization detergents for instruments of Claim 4.   The stock solution for the sterilizing detergent for appliances according to claim 4 or 5, wherein the hypochlorite is sodium hypochlorite and the orthosilicate is sodium orthosilicate.   The stock solution for sterilization detergents for instruments obtained by concentrating the sterilization detergent for instruments according to any one of claims 1 to 3.   The stock solution for sterilization detergents for instruments which has the same composition and the same concentration as what concentrated the sterilization detergent for instruments of any one of Claims 1-3.   The stock solution for the sterilization detergent for instruments according to claim 7 or 8, wherein the concentration ratio of the concentration is 2 to 10 times.