JPH0931494A - Compounding ingredient for cleaning liquid for medical equipment and cleaning of medical equipment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a compounding ingredient for the cleaning of medical equipments such as artificial dialyzer and its accessories by using sodium hypochlorite as a main component and incorporating a sequestering agent. SOLUTION: This compounding ingredient contains sodium hypochlorite as a main component and further contains an organic and/or inorganic sequestering agent such as polyphosphoric acid salt, alkali metal tripolyphosphate, citric acid salt, polyacrylic acid salt, polyacrylic acid salt- polymaleic acid salt copolymer, aminocarboxylic acid salt or alkali metal nitrilotriacetate and a surfactant such as p-toluenesulfonic acid salt or m- xylenesulfonic acid salt.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a compounding agent for a cleaning solution containing sodium hypochlorite as a main component, which is used for cleaning medical equipment such as artificial dialysis machines and peripheral equipment thereof, and uses the compounding agent. The cleaning method of the medical device that was used.

[0002]

2. Description of the Related Art Artificial dialysis machines are contaminated with body fluids such as blood and its components during use. If left uncontaminated, infection with bacteria and viruses, anaphylaxis due to foreign proteins, etc. will occur. Therefore, it is necessary to remove the attached contaminants by washing and sterilize them after use to eliminate the danger.
In addition, contamination of the dialysate supply device or supply line may cause bacterial growth, which may cause bacterial infection or fever in patients due to endotoxin. In particular, recently, sodium bicarbonate was added for pH adjustment. Since dialysate is widely used, calcium salts such as calcium carbonate precipitate and easily adhere to liquid contact parts such as pipes, which may cause troubles for patient monitoring equipment. Is also required. Furthermore, in the dialysate discharge line,
In addition to the calcium salts, waste products transferred from the blood by dialysis adhere to the soil and become dirty, leading to reverse contamination during subsequent dialysis. Therefore, cleaning and disinfection is also required.

Therefore, conventionally, in order to remove and disinfect adherents and contaminants in the above-mentioned dialysis apparatus and its peripheral equipment, generally, two-step cleaning with an aqueous solution of sodium hypochlorite and an acetic acid solution is performed. It is being appreciated. In addition, an anionic surfactant, sodium hypochlorite and ethylenediaminetetraacetic acid (EDT) are also used for the same purpose.
A) A disinfecting and cleaning agent containing salt has been proposed (Japanese Patent Laid-Open No. Hei 4-
135559). In addition, the present applicant also filed Japanese Patent Application No. 6-18
No. 6117, a sterilizing detergent containing sodium hypochlorite and an anionic surfactant and a sequestering agent selected from polymerized phosphate, polyacrylate-polymaleate copolymer, and polyacrylate. Is proposed.

[0004]

However, in the conventional general cleaning means using sodium hypochlorite and acetic acid, sodium hypochlorite is excellent in sterilizing and disinfecting properties but is poor in cleaning property. The stains of oils and fats and components cannot be removed, and the acetic acid solution can dissolve and remove calcium salts, but has a poor ability to remove other adhering components, so the cleaning and disinfecting effect is not sufficient, and sodium hypochlorite and Since acetic acid invades the metal, the metal parts of the medical equipment and the piping system are liable to corrode, and since the cleaning is performed in two steps, the operation is complicated and a lot of labor and time are spent. there were.

Further, in the disinfecting detergent containing the above-mentioned proposed anionic surfactant, sodium hypochlorite and ethylenediaminetetraacetate, ethylenediaminetetraacetate exerts an excellent removing action on calcium salts as a sequestering agent. However, this ethylenediaminetetraacetic acid salt is decomposed by sodium hypochlorite and loses its efficacy in a short time, and sodium hypochlorite itself is also consumed along with this decomposition, and the sterilizing and deteriorating power decreases with time. Since it is remarkable, it has a problem that it cannot be preserved and needs to be used within an extremely short period of time after production, which is not practical.

On the other hand, a sterilizing detergent using the specific sequestering agent according to the above-mentioned proposal of the present applicant together with sodium hypochlorite and an anionic surfactant has a function of removing calcium salts by the sequestering agent. In addition, the degradability of the metal sequestering agent with sodium hypochlorite is significantly smaller than that of the ethylenediaminetetraacetic acid salt, so that the product has a long life and is highly practical.

However, even if the decomposability of the sequestering agent is small as described above, it takes a considerable period of time to manufacture and ship a sterilizing cleaning agent and actually use it for cleaning in a medical institution delivered after the distribution stage. In addition, the period is not constant and changes in environmental conditions such as temperature are large, so it is possible to reliably prevent deterioration of sterilization power and deterioration of other compounding ingredients due to loss of sodium hypochlorite, and stable sterilization and cleaning. It was difficult to secure power. Further, the proposed cleaning agents have a drawback that the distribution cost is high because the total amount as a liquid agent is large.

In view of the above situation, the present invention provides a medical device cleaning agent using sodium hypochlorite, which can remove calcium salts such as calcium carbonate without impairing the bactericidal activity of sodium hypochlorite. It is a first object of the present invention to provide a means that can be applied and can secure a stable sterilizing and detergency regardless of the length of the period from shipment to distribution and actual use at a medical institution and changes in environmental conditions.

On the other hand, in the artificial dialysis, as described above, the fever of the patient due to endotoxin (due to the transfer of various pyrogenic substances into the blood of the patient through the dialysis membrane due to back filtration and back diffusion) is a problem. In recent years, as a countermeasure, an endotoxin removal filter is installed to perform artificial dialysis and online artificial diafiltration. This endotoxin removal filter removes endotoxin by ultrafiltration through a hollow fiber membrane made of polysulfone, polyamide, polyacrylonitrile, polyester polymer alloy, etc., and is especially directly replenished in blood in online artificial diafiltration. It has an important function of removing endotoxin in the replenisher.

However, in the sterilization cleaning of the dialysis line equipped with such an endotoxin removal filter, since the hollow fiber membrane of the filter has an extremely fine porous structure, the cleaning power may be exerted even inside the structure. It is extremely difficult and there is a risk that residual detergent components will be carried into the blood.Therefore, it is necessary to strictly prevent such detergent components.In particular, detergents containing surfactants reduce the flow rate due to the inclusion of bubbles. However, there is a problem that the detergency deteriorates.

Therefore, a second object of the present invention is to perform a sufficient cleaning effect in the sterilization cleaning of the dialysis line equipped with the above endotoxin removal filter, and to reliably prevent residual cleaning agent components. It is to provide a cleaning agent for bacteria and a cleaning method.

[0012]

In order to achieve the first object, the invention of claim 1 is a compounding agent for a medical device cleaning liquid containing sodium hypochlorite as a main component,
It is characterized by containing an organic or / and inorganic sequestering agent.

Therefore, in the invention of claim 2, the polymerized phosphate is used as the inorganic sequestering agent in the compounding agent for medical device cleaning liquid of the above-mentioned claim 1, and in the invention of claim 3, the polymerized phosphate is used. An alkali metal tripolyphosphate is used for.

On the other hand, as the organic metal sequestering agent in the compounding agent for a medical device cleaning liquid according to claim 1, citrate is used in the invention of claim 4, polyacrylate is used in the invention of claim 5, In the sixth aspect, a polyacrylate-polymaleate copolymer is used, and in the seventh aspect, an aminocarboxylic acid salt is used. Further, the invention of claim 8 uses an alkali metal nitrilotriacetate as the aminocarboxylic acid salt.

According to a ninth aspect of the present invention, as the compounding agent for a medical device cleaning liquid according to any one of the first to eighth aspects, a composition containing a surfactant together with a sequestering agent is adopted.
In order to achieve the second object in addition to the first object, the invention of claim 10 provides a structure containing paratoluenesulfonate or / and metaxylenesulfonate as the surfactant. The invention of claim 11 is the same as claim 1
The composition in which the sequestering agent in the compounding agent for medical device cleaning liquid of No. 0 is tripolyphosphate is adopted. Furthermore, the invention of claim 12 employs a composition containing a nonionic surfactant as at least a part of the surfactant in the compounding agent for medical device cleaning liquid according to any one of claims 9 to 11.

The invention of claim 13 is the same as claims 1 to 12.
In the compounding agent for medical device cleaning liquid according to any one of
A structure containing alkali hydroxide together with a sequestering agent is adopted. Further, the invention of claim 14 relates to any one of claims 1 to 1.
In the compounding agent for medical device cleaning liquid of any one of 3 above, the composition containing a silicate together with a sequestering agent is adopted.

According to a fifteenth aspect of the present invention, in the first object, the aqueous solution of sodium hypochlorite is used.
The compounding agent for medical device cleaning liquid of any of 3 is mixed to prepare a cleaning liquid containing sodium hypochlorite having an effective chlorine concentration of 0.02 to 0.2% by weight and a sequestering agent, and the cleaning liquid is used for medical device. The present invention relates to a method for cleaning a medical device, characterized in that

According to a sixteenth aspect of the present invention, in order to achieve the second object, in the method for cleaning a medical device according to the fifteenth aspect, paratoluenesulfonic acid salt and / or metaxylenesulfonic acid is used as a surfactant. Claim 1 containing salt
A cleaning liquid is prepared using the compounding agent for medical device cleaning liquid according to 0 or 11, and an artificial dialysis line equipped with an endotoxin removal filter is cleaned with this cleaning liquid. .

The invention according to claim 17 employs a constitution in which the mixing amount of the compounding agent for medical device cleaning liquid according to claim 15 or 16 is set so that the sequestering agent in 1 liter of the cleaning liquid is 50 mg or more. It is a thing.

The invention of claim 18 is the above-mentioned claims 15-1.
7. The method for cleaning a medical device according to any one of 7, wherein the aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight contains a sequestering agent composed of an aminocarboxylic acid salt and an alkali hydroxide. This is a configuration in which a cleaning liquid compounding agent is mixed and the mixed liquid is diluted to prepare the cleaning liquid.

The invention of claim 19 is the same as claims 15 to 1 above.
The method for cleaning a medical device according to any one of 8 above, wherein the aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight contains a sequestering agent, a surfactant, and an alkali hydroxide. The cleaning liquid is prepared by mixing the compounding agent and diluting the mixed liquid.

The invention of claim 20 is the method for cleaning a medical device according to claim 18 or 19, wherein the pH of the mixed solution is 12.5-14.0 due to the alkali hydroxide in the compounding agent for a medical device cleaning liquid. This is a configuration that adjusts to the range of.

[0023]

BEST MODE FOR CARRYING OUT THE INVENTION In most medical institutions equipped with an artificial dialysis machine, hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight is used for disinfecting and cleaning the artificial dialysis machine and its peripheral equipment. I have a tank for disinfecting and washing stock solution that contains an aqueous solution of sodium acid (commercial stock solution).
After diluting about 50 times to an aqueous solution having an effective chlorine concentration of 0.02 to 0.2% by weight, and as described above, after performing the first-stage washing with this diluted sodium hypochlorite aqueous solution,
The second step of washing with acetic acid solution is performed.

However, the sodium hypochlorite stock solution in the stock solution tank is usually consumed within 2 to 3 days, and at most within a week.
It is used for washing within 12 hours at the latest from the minute. Therefore, there is almost no need to consider the deterioration of the sterilizing power over time of the stock solution in the stock solution tank when the storage period exceeds one week, and the stability problem in the diluted aqueous solution used as the cleaning solution is further alleviated. Become.

The compounding agent for a medical device cleaning liquid of the present invention contains an organic or / and inorganic metal sequestering agent, but it is not a compounding agent of sodium hypochlorite in advance, and is used in a medical institution as described above. As described above, it is used by mixing it with the sodium hypochlorite stock solution in the disinfecting and cleaning stock solution tank already installed, or by diluting the stock solution with water during cleaning or by mixing it with the diluted aqueous solution. And
The cleaning liquid prepared by adding this compounding agent has a period (time) from the mixing to the actual cleaning that is much shorter than the above-mentioned cleaning liquid handling practice in the medical period.
Since the progress of the interaction between the metal sequestering agent and sodium hypochlorite contained in the compounding agent is small and the change in environmental conditions such as temperature is small, the strong bactericidal activity of sodium hypochlorite is maintained until the time of washing. In addition, the ability of the sequestering agent to dissolve and remove the calcium salt is not impaired. Therefore, by using this cleaning liquid, medical equipment such as an artificial dialysis machine and its peripheral equipment can be efficiently sterilized and cleaned, and the conventional secondary cleaning with an acetic acid solution becomes unnecessary.

The organic or / and inorganic sequestering agent used in the compounding agent for medical device cleaning liquid of the present invention is not particularly limited, but it is a polymeric phosphate in the inorganic system and a citrate in the organic system, Acrylate salts, polyacrylic acid salt-polymaleic acid salt copolymers, aminocarboxylic acid salts and the like are preferable, and two or more kinds thereof may be used in combination.

The type of the above-mentioned polymerized phosphate is not particularly limited, but sodium polymetaphosphate and potassium polymetaphosphate, sodium dihydrogen polyphosphate and polypolyphosphate are suitable as those having an appropriate solubility and a high metal-sequestering property. Potassium dihydrogen phosphate, disodium hydrogen polyphosphate and dipotassium hydrogen polyphosphate, sodium polyorthophosphate, potassium polyorthophosphate, etc., in which the P atom in the molecule is 2 to
The number is 10 pieces. Among these, alkali metal salts of tripolyphosphoric acid, tetrapolyphosphoric acid, pentapolyphosphoric acid, pyrophosphoric acid, and hexametaphosphoric acid are preferable, and tripolyphosphoric acid is excellent in solubility of calcium salts such as calcium carbonate. Acid alkali metal salts are most suitable.

As the organic metal sequestering agent, alkali metal salts of the above exemplified components are suitable. Then, the magnitude of the dissolving power of the calcium salt by these is in the order of aminocarboxylic acid salt> polyacrylic acid salt-polymaleic acid salt copolymer> citrate salt> polyacrylic acid salt, except for polyacrylic acid salt. It has greater solubility than the inorganic polysequestering agent tripolyphosphate. Incidentally, both the polyacrylate and the polyacrylate-polymaleate copolymer, if the molecular weight is too large or, conversely, too small, it causes a decrease in the sequestering power and the calcium carbonate dispersive power. It is preferably about 1,000 to 50,000.

By the way, the above-mentioned aminocarboxylic acid salt is
Compared to other sequestering agents, it has a very high dissolution and removability with respect to calcium salts, but on the other hand, it has a strong interaction with sodium hypochlorite. Therefore, in the product form that was previously mixed with sodium hypochlorite like the previously proposed detergent using the ethylenediaminetetraacetic acid salt, the decomposition of both components progresses before it is washed, and sterilization during washing is performed. Since the detergency is remarkably reduced, it cannot be practically used. However, in the present invention, even such an aminocarboxylic acid salt is not a product form preliminarily blended with sodium hypochlorite, and the sodium hypochlorite stock solution or its dilution in a disinfecting and cleaning stock solution tank is used in a medical institution. Since it is added to the liquid, it becomes possible to provide it for washing while maintaining the bactericidal activity of sodium hypochlorite sufficiently, and therefore the extremely high calcium salt removing ability of the aminocarboxylic acid salt can be utilized without any trouble. This is a great advantage of the present invention.

In the case of a compounding agent for a medical device cleaning solution using an aminocarboxylic acid salt as a sequestering agent, in order to further reduce the decomposition of sodium hypochlorite, a stock solution of sodium hypochlorite (effective chlorine concentration 0 .05 to 12% by weight), and a diluent to be used for cleaning (effective chlorine concentration 0.02 to 0.02% by weight).
0.2% by weight) is desirable. However, the stability of sodium hypochlorite is remarkably improved when an alkali metal hydroxide is used together with the aminocarboxylic acid salt, so that it should be mixed with the above stock solution and stored for about one week (normal maximum storage period). Also, sufficient sterilizing and cleaning power can be secured.

As such an aminocarboxylic acid salt,
Nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), hydroxyethylethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DT)
PA), alkali metal salts such as triethylenetetramine hexaacetic acid (TTHA). Of these, nitrilotriacetic acid alkali metal salts are particularly recommended because they have a very high dissolving power for calcium salts and relatively low degradability with respect to sodium hypochlorite.

The compounding amount of the compounding agent for a medical device cleaning solution with respect to the sodium hypochlorite aqueous solution exhibits a function commensurate with the amount at least, and the greater the amount, the higher the metal-sealability. Whether mixed with the above-mentioned stock solution of sodium chlorite or its diluted solution, sequestration in 1 liter of an aqueous solution of sodium hypochlorite having a chlorine concentration of 0.02 to 0.2% by weight, which is a diluent to be washed. It is preferable to set the agent to 50 mg or more. In addition,
The upper limit of the blending amount is naturally determined by the solubility limit in the aqueous solution of sodium hypochlorite depending on the type of the sequestering agent used.

The compounding agent for a medical device cleaning liquid of the present invention may be composed of the above-mentioned sequestering agent alone, but may also be in a form in which various additives are compounded if necessary. Particularly useful among such additives are surfactants, alkali hydroxides, and silicates.

The above-mentioned surfactant is a component that exerts a high detergency by synergistically acting with sodium hypochlorite in the cleaning liquid. That is, sodium hypochlorite shows a good cleaning action for protein-based stains, but is inferior in the cleaning action for oil-and-fat stains, and has no effect of lowering the interfacial tension, and has a wettability with a wash product. Therefore, the cleaning liquid containing only this and the sequestering agent may cause uneven cleaning. Therefore, by adding a compounding agent containing a surfactant together with a sequestering agent to the sodium hypochlorite aqueous solution, the detergency against oily fat-based stains is enhanced, and the wettability and the penetrability to the washed product are improved, Uneven cleaning can be eliminated.

By the way, in the conventional disinfecting detergent containing sodium hypochlorite, it takes a long time from its preparation to the washing. Therefore, when a surfactant is added,
In consideration of mutual stability with sodium hypochlorite, only a very limited type could be used.
Moreover, even if a surfactant that is resistant to sodium hypochlorite is selected, the interaction progresses over a long period of time before it is used for cleaning, thus reducing the amount of available chlorine and avoiding deterioration of the surfactant. It was difficult to do. On the other hand, in the compounding agent of the present invention, it is provided for washing immediately after mixing it with an aqueous solution of sodium hypochlorite or for a short period of time within one week,
Since the interaction between the surfactant contained in the compounding agent and sodium hypochlorite is small, it is possible to use a wide variety of surfactants, for example, a strong detergency which cannot be used conventionally. Nonionic surfactants can also be used.

Specific examples of the surfactant used in the present invention include paratoluene sulfonate, metaxylene sulfonate, alkyl diphenyl ether disulfonate (alkyl group having 6 to 16 carbon atoms), polyoxyethylene alkyl sulfate. Salt (alkyl group having 8 to 18 carbon atoms, oxyethylene group having 3 to 15), polyoxyethylene alkylphenyl sulfate (alkyl group having 6 to 16 carbon atoms, oxyethylene group having 2 to 15), alkylbenzene sulfonate (alkyl) Anionic surfactants having 10 to 12 carbon atoms of groups, polyoxyethylene alkyl phenyl ethers (8 to 10 carbon atoms of alkyl groups, 3 to 20 oxyethylene groups), polyoxyethylene alkyl ethers (of alkyl groups) 12 to 14 carbon atoms, 6 to 16 oxyethylene groups, poly Alkoxy polyoxypropylene (average molecular weight 2,000 to 20,000, polyoxyethylene 15 to 85 wt%) non-ionic surface active agents, and the like.

These surfactants may be used alone or in combination of two or more kinds. However, the nonionic surfactant has a strong interaction with sodium hypochlorite and therefore has an anionic surfactant. It is desirable to use it together with an agent. Then
The amount of the surfactant blended is such that the effective chlorine concentration is 0.02 to 0.2.
A range of 50 to 500 mg is suitable for 1 liter of a weight% sodium hypochlorite aqueous solution.

On the other hand, among the above-exemplified surfactants, paratoluene sulfonate and metaxylene sulfonate have low foaming properties, and therefore the object to be cleaned or the equipment handling the cleaning liquid is apt to cause problems due to foaming. In addition to being suitable for the case of the ones, since it has a smaller molecular weight than other surfactants, it can penetrate into the fine structure part and exhibit good detergency, and can be reliably removed from the fine structure part by washing with water. This is advantageous in that it is particularly convenient for washing a dialysis line equipped with an endotoxin removal filter of an artificial dialysis machine.

That is, in a dialysis line equipped with an endotoxin removal filter, as described above, the hollow fiber membrane of the filter has an extremely fine porous structure. In addition, a surfactant with a large molecular weight does not exert sufficient detergency even inside the structure, and the surfactant that has entered the structure remains without being removed by subsequent water washing, and this residue is dialyzed. However, these problems can be solved by using the above-mentioned paratoluenesulfonate and metaxylenesulfonate as surfactants.

When applied to a dialysis line equipped with an endotoxin removal filter, the above-mentioned two kinds of anionic surfactants should be selected as the surfactant, and tripolyphosphate should be selected as the sequestering agent. Is recommended. This is because tripolyphosphate has a greater ability to remove calcium salts than other polymerized phosphates as described above, and also has a function as a cleaning aid and a function to suppress metal corrosion. In addition, since it has a low molecular weight, it penetrates through the inside of the fine pore structure of the filter and spreads throughout the line, and the original action can be sufficiently exerted on the entire line including the inside of the filter. This is because it has better water washability than salts and polymer-based sequestering agents, can be reliably removed from the inside of the filter by washing with water after washing, and there is no risk of residue.

The problems due to bubbles in the equipment to be cleaned and the cleaning liquid are not only the case where the above-mentioned endotoxin removal filter is installed, but also the abnormal operation due to the bubbles in the liquid feed pump, the bubbles in the dilution mixing tank of the dialysate and the cleaning liquid. There are overflows and malfunctions due to bubbles in the liquid level sensors installed in these tanks. These problems can be alleviated by selecting the above-mentioned low-foaming surfactant as the surfactant. Since the sequestering agent has no foaming property, the compounding agent containing no surfactant does not have the above-mentioned problem of foaming.

The above-mentioned alkali hydroxide is a component which functions as a stabilizer for increasing the stability of sodium hypochlorite by increasing the pH and has an effect of suppressing the metal corrosion due to sodium hypochlorite to some extent. Sodium hydroxide and potassium hydroxide can be preferably used. Thus, the stabilizing action of sodium hypochlorite by this alkali hydroxide is remarkably exhibited in a system containing an organic sequestering agent and a system containing a surfactant, and particularly the sequestering agent is an aminocarboxylic acid salt. Is extremely large if.
For example, when a compounding agent using sodium nitrilotriacetate as a sequestering agent is mixed with a sodium hypochlorite stock solution (effective chlorine concentration of 2 to 12% by weight), the residual rate of effective chlorine after storage at 30 ° C. for 7 days is With a compounding agent containing no alkali hydroxide, the content is about 35%, but with a compounding agent containing alkali hydroxide, it is improved to 80% or more. Therefore, even if a compounding agent using an aminocarboxylic acid salt as a sequestering agent is mixed with the above stock solution and subjected to washing one week after the mixing (usually the longest storage period), sufficient sterilizing and detergency is exerted. be able to.

When the compounding agent is mixed with the stock solution of sodium hypochlorite, such an alkali hydroxide is set to an amount such that the pH of the mixed solution is in the range of 12.5-14.0. Is good. When mixed with the diluting liquid used for the above washing, that is, an aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.02 to 0.2% by weight, the pH thereof is 11.0 to.
It is preferable to set the content in the compounding agent and the mixing amount of the compounding agent so as to be in the range of 12.5. If the pH is too low, a sufficient stabilizing effect cannot be obtained, and if it is too high, it may adversely affect the equipment to be cleaned.

The above-mentioned silicate is a component which exerts a remarkable effect as an inhibitor of metal corrosion caused by sodium hypochlorite. That is, as described above, alkali hydroxide also has a function of suppressing the above metal corrosion to some extent, but by using a compounding agent containing this silicate, cleaning of medical equipment such as artificial dialysis equipment and peripheral equipment thereof can be performed. It is possible to reliably prevent metal corrosion associated with the above, and thus avoid deterioration of durability of the device due to the metal corrosion.

The silicate is not particularly limited as long as it is water-soluble, but sodium silicate and potassium silicate are preferable. However, the amount used, from the viewpoint of use effect and economical efficiency, regardless of whether the compounding agent is mixed with any of the stock solution of sodium hypochlorite and its diluted solution,
Diluent for cleaning, that is, effective chlorine concentration 0.03 to 0.
A range of 3 to 100 mg is suitable for 1 liter of a 2% by weight aqueous sodium hypochlorite solution.

The compounding agent for medical device cleaning liquid of the present invention is commercialized in the form of an aqueous solution or a powder (when it does not contain a liquid component), and as described above, it is stored in a disinfecting and cleaning stock solution tank in a medical institution at a high concentration. Sodium hypochlorite aqueous solution (stock solution: effective chlorine concentration 0.5 to 12% by weight) or its diluted aqueous solution, and effective chlorine concentration 0.02 to 0.2
It is used for cleaning medical equipment such as artificial dialysis equipment and its peripheral equipment as a cleaning liquid of weight%. However, since this cleaning liquid is excellent in strong sterilization property with sodium hypochlorite and excellent dissolution and removal property of calcium salt with the sequestering agent, it is possible to perform sufficient sterilization cleaning with only one cleaning operation. The secondary washing with the acetic acid solution can be omitted.

[0047]

[Examples] Metal sequestering agents, surfactants, sodium hydroxide (NaOH), and sodium silicate are shown in Table 1 below.
A large number of compounding agents for medical device cleaning liquids (Nos. 1 to 34) having different compositions in the form of an aqueous solution were prepared. The compounding values of each component in Tables 1 and 2 are g, and water is added to these components to make the total amount 100 ml. The components of the sequestering agent and surfactant represented by the symbols in Tables 1 and 2 are as follows.

[Sequestering Agent] PP1 ・ ・ ・ Sodium tripolyphosphate PP2 ・ ・ ・ Sodium tetrapolyphosphate PP3 ・ ・ ・ Sodium pentapolyphosphate PP4 ・ ・ ・ Sodium hexapolyphosphate CA1 ・ ・ ・ Sodium citrate CA2 ・ ・-Sodium gluconate CA3 ... Sodium tartrate CA4 ... Sodium malate PAM ... Sodium polyacrylate-sodium polymaleate copolymer (average molecular weight 7000) PA ... Sodium polyacrylate (average molecular weight 7000) ) NTA: Sodium nitrilotriacetate EDTA: Sodium ethylenediaminetetraacetate DTPA: Sodium diethylenetriaminepentaacetate

[Anionic Surfactant] AS1 ・ ・ ・ Sodium paratoluene sulfonate AS2 ・ ・ ・ Sodium metaxylene sulfonate AS3 ・ ・ ・ Sodium nonyldiphenyl ether disulfonate AS4 ・ ・ ・ Sodium polyoxyethylene nonylphenyl sulfate Ethylene group number 3 to 9) AS5 ... sodium polyoxyethylene dodecyl sulfate (oxyethylene group number 3 to 9) AS6 ... sodium alkylbenzenesulfonate (alkyl group having carbon number 10 to 12)

[Nonionic Surfactant] NS1 ... Polyoxyethylene decyl phenyl ether (10 oxyethylene groups) NS2 ... Polyoxyethylene alkyl ether (10 to 12 carbon atoms of alkyl group, 12 oxyethylene groups) NS3 ... Polyoxyethylene-polypropylene (polyoxyethylene weight 20%, average molecular weight 300
0)

[0051]

[Table 1]

[0052]

[Table 2]

20 ml of each compounding agent described above was used as an aqueous solution of sodium hypochlorite (stock solution) having an effective chlorine concentration of 7.2% by weight.
A washing stock solution was prepared by mixing it with 00 ml, and the stability of sodium hypochlorite and the calcium salt removing property were examined for these washing stock solutions. Tables 3 and 4 show the results. The above-mentioned stability and removability were measured by the following methods. In addition, No. 8 is the solubility of sodium alkylbenzene sulfonate (AS6) used as a surfactant, N
o. Compounds 26 and 27 have low solubility of sodium polyacrylate-sodium polymaleate copolymer (PAM) used for the sequestering agent and are not completely dissolved in the above stock solution, so that the effective chlorine concentration is 2.4% by weight. % Aqueous solution of sodium hypochlorite (three-fold dilution of the stock solution) was used.

[Stability of Sodium Hypochlorite] After leaving the undiluted solution for washing for 7 days at 30 ° C. in the dark, the chlorine content was measured by the iodometric titration method, and the effective chlorine residual rate (%) was determined from the measured value. I asked.

[Calcium Salt Removability] 0.5 g of sodium carbonate was dissolved in the washing stock solution, and 0.25 mol of calcium acetate was added thereto to generate calcium carbonate, and stirring was performed so that the calcium carbonate was dissolved. The end point was a point where the turbidity of the liquid did not disappear even after continuous stirring, and the dissolved amount (mg) of calcium carbonate (CaCO ₃ ) per 20 ml of the compounding agent was determined from the value indicated by this end point.

[0056]

[Table 3]

[0057]

[Table 4]

From Tables 3 and 4, when the compounding agent (No. 1 to 17) using the polymerized phosphate as the sequestering agent was added to the highly concentrated aqueous solution of sodium hypochlorite, both were hypochlorous acid. Although the stability of sodium acid salt is extremely good, regarding the removal ability of calcium salt, tripolyphosphate (No.
1 to 21) are good, but pentapolyphosphate and hexapolyphosphate (Nos. 16 and 17) are slightly inferior, and tetrapolyphosphate (No. 15) is considerably low. In particular, when a nonionic surfactant is contained together with the polymerized phosphate, the stability of sodium hypochlorite tends to be slightly lowered by this nonionic surfactant (No. 9,
11 and 13) are observed, it is understood that addition of alkali hydroxide (Nos. 10, 12, and 14) can almost prevent the decrease in stability.

On the other hand, when a compounding agent (No. 18 to 34) using an organic metal sequestering agent is added to a high concentration aqueous solution of sodium hypochlorite,
Except for gluconate (No. 22), sodium hypochlorite has extremely good stability, but citrate (No. 18 to 21) is excellent in terms of calcium salt removal ability. It can be seen that the gluconate, tartrate, and malate (Nos. 22 to 24) of 1 are significantly inferior. Regarding polyacrylate (No. 25) and polyacrylate-polymaleate copolymer (Nos. 26 and 27), both sodium hypochlorite has extremely good stability, but calcium salts are removed. It can be seen that the ability of the polyacrylate-polymaleate copolymer is very good, whereas that of the polyacrylate is considerably poor.

Further, aminocarboxylic acid salts (Nos. 28 to 3)
In the case of 4), all exhibit excellent calcium salt removing ability, but there is a drawback that the stability of sodium hypochlorite is significantly impaired. However, this drawback is greatly improved by adding an alkali hydroxide (No. 29, 30, 32, 34), and especially in the case of nitrilotriacetate, the above stability is improved by the combined use of an alkali hydroxide (No. 29, 30). It is clear that a sufficient level will be reached.

Next, a cleaning solution is prepared by mixing each of the above-mentioned compounding agents in a volume ratio of 1/300 to a dilute aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.1% by weight for actual cleaning. Then, these washing solutions were examined for stability of sodium hypochlorite, detergency against stains of proteins and fats and oils, corrosiveness against metals, foamability, and residual components of the endotoxin removal filter. The results are shown in Tables 5-9. The above items were measured by the following methods.

[Stability of Sodium Hypochlorite] Twenty-four hours after the cleaning liquid was prepared (room temperature: 25 ° C.), the chlorine content was measured by an iodometric titration method, and the effective chlorine residual rate (%) was determined from the measured value. It was

[Protein Detergency] Human hematocrit capillaries were coated with human serum, heated at 80 ° C. for 4 hours, cooled to room temperature, immersed in a cleaning solution, and 15 and 20 minutes later, respectively, amide black. The presence or absence of deposits on the capillaries was examined by the 10B color test. From the results, evaluation was made such that a large amount of adhered substances remained (+), a slight amount remained (±), and no residual substances were observed (-).

[Washability of oils and fats] On a slide glass, 10 μm of soybean oil colored with Sudan III as triglyceride
l, and leave it indoors for 16 hours, then soak it in the cleaning solution,
The time (minutes) until the oil droplet disappeared from the glass surface was measured.

[Corrosion to Metals] The SUS 304 stainless steel plate (5
(0 × 20 × 1 mm, weight: 7.3 g) was immersed for 5 days, and then the weight change was measured and the state of the plate surface was observed.

[Foaming property] 50 ml of the washing solution was placed in a 100-ml volumetric flask equipped with a stopper, and the volume was stopped. After repeating the operation of turning the volumetric flask upside down 20 times, the volume of the bubble at the time of leaving for 30 seconds I checked.

[Residual Persistence to Endotoxin Removal Filter] In a line in which an endotoxin removal filter (ETCF) is installed immediately before a patient monitoring device of an artificial dialysis equipment, the line is washed with water for 1 hour after dialysis (flow rate 5
(00 ml / min), followed by washing with a washing solution for 30 minutes (flow rate 500 ml / min), followed by washing with water (flow rate 500 ml / min), and 30 minutes after this washing with ETC
Water on the inflow side in F was taken out to examine the degree of residual anionic surfactant, and after 60 minutes of washing with water, water was similarly taken out to examine the degree of residual sodium tripolyphosphate. In addition, the test was performed using No. 1 in Table 1 as the cleaning liquid.
It carried out about the case where eight kinds of each compounding agent use of 1,3-8,12 and five kinds of the following AE as ETCF were used. The amount of anionic surfactant and sodium tripolyphosphate was detected by the following method.

[Types of ETCF (Endotoxin Removal Filter)] A ... TET-1.0 (Toray, Hollow Fiber Membrane ... Polysulfone) B ... U-7000 (Gumbro Medical,
Same ... Polyamide C ... PAN-17DX (Made by Asahi Medical Co., Ltd., same ... Polyacrylonitrile) D ... PS-1.6 (Kawasumi Chemical Co., Ltd., same ... Polysulfone) E ... FLX-12DW (Manufactured by Nikkiso Co., Ltd ... Polyester polymer alloy)

[Detection Method] Amount of Anionic Surfactant AS1, AS2 ... Absorption photometric method (275 nm) ... Detection limit 5 ppm AS3 to AS3 ... Methylene blue absorption photometric method Amount of sodium tripolyphosphate ... Molybdenum Blue absorptiometry: Detection limit 0.1ppm

[0070]

[Table 5]

From the results shown in Table 5, when the compounding agent was added to the dilute aqueous solution of sodium hypochlorite immediately before being subjected to washing,
Gluconic acid as a sequestering agent, the use of aminocarboxylic acid is observed to some extent the efficacy of sodium hypochlorite is reduced, but the other, there is no such efficacy reduction, and even aminocarboxylic acid with alkali hydroxide. The combined use (Nos. 29, 30, 32, 34) shows a small decrease in the efficacy, and it can be seen that the nitrilotriacetate, in particular, can exhibit sufficient efficacy by the combined use of alkali hydroxides (Nos. 29, 30).

[0072]

[Table 6]

From the results shown in Table 6, all of the cleaning liquids containing the compounding agent (No. 1 to 17) using the polymerized phosphate as the sequestering agent have good removability to stains of protein and fats and oils. Compounding agent containing a surfactant (No. 4 to 1)
It can be seen that in 7), the removability of grease stains is further improved, and in particular, the compounding agents (Nos. 9 to 14) using a nonionic surfactant are excellent in the removability.

On the other hand, in the cleaning liquid containing the compounding agent containing the organic metal sequestering agent, the metal sequestering agent is citrate (N
o. 18-20), polyacrylate (No. 25),
Polyacrylate-Polymaleate Copolymer (No.
26, 27) has good removability for both protein and oil stains, but carboxylates other than citrate (gluconate, tartrate, malate ... No. 22 to 2)
It can be seen that 4) is inferior in the ability to remove greasy stains. When the sequestering agent is an aminocarboxylic acid salt, the removability of protein stains is good for nitrilotriacetic acid salts (Nos. 28 to 30) and poor for other ethylenediaminetetraacetic acid salts and diethylenetriaminepentaacetic acid salts. However, it can be seen that the improvement is achieved by the combined use of alkali hydroxide (No. 32, 34). In addition, the ability to remove greasy dirt is slightly inferior to the aminocarboxylic acid salt alone, but it is used in combination with a surfactant (No. 30, 3).
2, 34), it can be seen that it improves.

[0075]

[Table 7]

From the results shown in Table 7, when the compounding agent contains a silicate (No. 3, 10, 17, 20, 27, 29), an excellent metal corrosion preventing effect is obtained, and an alkali hydroxide is contained. It can be seen that a slight effect of suppressing metal corrosion can also be obtained by that (No. 2, 19).

[0077]

[Table 8]

From the results shown in Table 8, the foaming property of the cleaning liquid containing the compounding agent containing the surfactant depends on the kind of the surfactant, and the anionic surfactants such as sodium paratoluenesulfonate and metaxylenesulfone are used. It can be seen that foaming during cleaning is suppressed when sodium acidate is used.

[0079]

[Table 9]

From the results shown in Table 9, sodium paratoluenesulfonate (AS1) and sodium metaxylenesulfonate (AS2) were selected from other anionic surfactants (AS3 to AS3).
It can be seen that, as compared with 6), the water-washing property is better, and the metal-sequestering agent tripolyphosphate (PP1) also has better water-washing property and can prevent the residue from remaining on the endotoxin removal filter (ETCF). Therefore, for cleaning the dialysis line in which the filter is installed, a cleaning liquid compounding agent (N
o. 4, 5) prove to be particularly suitable.

Next, each of the above-mentioned compounding agents was mixed at a volume ratio of 1/300 with each of the dilute aqueous solutions of sodium hypochlorite having an effective chlorine concentration of 0.015% by weight. After contacting three kinds of bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, for 5 minutes, they were inoculated on SCDLP agar medium "Daigo", and growth of each bacterium after 37 hours at 37 ° C (+) No (-) I checked. The results are shown in Table 10.

[0082]

[Table 10]

From the results shown in Table 10, it is possible to use the polymerized phosphate (No. 1, 3, 5, 8, 10, 11, 15 to 15) as the sequestering agent.
17), citrate (No. 19), tartrate (No.
23), malate (No. 24), polyacrylate (No. 25), polyacrylate-polymaleate copolymer (No. 26), nitrilotriacetate (No. 2).
It is understood that none of the compounding agents using 8) inhibit the bactericidal property of sodium hypochlorite. On the other hand, the compounding agent using gluconate (No. 22), ethylenediaminetetraacetate (No. 31), and diethylenetriaminepentaacetate (No. 33) as the sequestering agent inhibits the bactericidal property. It can be seen that even with the latter two aminocarboxylic acid salts, the compounding agent (No. 32, 34) in which alkali hydroxide is used in combination does not impair the bactericidal property.

[0084]

According to the invention of claim 1, sodium hypochlorite is used as a compounding agent for a sodium hypochlorite cleaning liquid for cleaning and disinfecting various medical devices such as an artificial dialysis device and its peripheral devices. It is possible to add the ability to remove calcium salts such as calcium carbonate by reducing the deterioration of bactericidal power, and it is stable regardless of the length of the period from shipment to distribution and actual use at medical institutions and changes in environmental conditions, and stable The thing which can prepare the said washing | cleaning liquid which has sterilization detergency is provided.

According to the second aspect of the present invention, since the polymerized phosphate is used as the sequestering agent as the compounding agent for the above-mentioned medical device cleaning liquid, the bactericidal activity of sodium hypochlorite is almost inhibited. The present invention provides a cleaning liquid which, in addition to the calcium salt-removing property, can be imparted with good cleaning properties against stains of proteins and fats and oils.

According to the invention of claim 3, since the polymerized phosphate is an alkali metal tripolyphosphate as a compounding agent for a medical device cleaning liquid using the polymerized phosphate as the sequestering agent, Provided is one which hardly impairs the bactericidal activity of sodium chlorite and can impart good calcium salt removing property to a cleaning solution.

According to the invention of claim 4, as a compounding agent for the above-mentioned medical device cleaning liquid, which contains an organic sequestering agent,
Since the sequestering agent is a citrate, it hardly impairs the bactericidal activity of sodium hypochlorite and can impart excellent calcium salt removing property to a cleaning liquid and good cleaning property against stains of proteins and oils and fats. Will be provided.

According to the invention of claim 5, as the above-mentioned compounding agent for medical device cleaning liquid, which contains an organic sequestering agent,
Since the sequestering agent is a polyacrylic acid salt, it is possible to provide a washing liquid that hardly impairs the bactericidal activity of sodium hypochlorite and can impart good detergency to stains of proteins and fats and oils on the washing liquid.

According to the invention of claim 6, as the above-mentioned compounding agent for medical device cleaning liquid, which contains an organic sequestering agent,
Since the sequestering agent is a polyacrylic acid salt-polymaleic acid salt copolymer, it hardly inhibits the bactericidal activity of sodium hypochlorite, and has excellent calcium salt removal properties by a cleaning solution, and stains on proteins and oils and fats. What can provide good detergency is provided.

According to the invention of claim 7, as the above-mentioned compounding agent for a medical device cleaning liquid, which contains an organic sequestering agent,
Since the sequestering agent is an aminocarboxylic acid salt, it is possible to provide a cleaning liquid which is capable of imparting particularly excellent calcium salt removing property and good cleaning property to protein stains.

According to the invention of claim 8, the aminocarboxylic acid salt is a nitrilotriacetic acid alkali metal salt as a compounding agent for a medical device cleaning liquid using an aminocarboxylic acid salt as the sequestering agent. What provides a very excellent calcium salt removing property is provided.

According to the ninth aspect of the present invention, since the compounding agent for a medical device cleaning liquid contains a surfactant together with a sequestering agent, it is possible to provide the cleaning liquid with a high cleaning property against stains of oil and fat. It

According to the tenth aspect of the present invention, since the surfactant is a specific anionic surfactant as a compounding agent for a medical device cleaning liquid containing a surfactant together with the above-mentioned sequestering agent, the cleaning liquid is generated. In addition to the ability to suppress foaming and to impart good detergency to stains of oils and fats, it is possible to prepare a suitable cleaning liquid when the object to be cleaned or the equipment that handles the cleaning liquid is prone to problems due to foam, and especially an endotoxin removal filter When it is used for cleaning an artificial dialysis line equipped with a filter, it is possible to obtain a good cleaning property for the filter, prevent the surfactant from remaining on the filter, and prepare a highly safe cleaning liquid. Provided.

According to the invention of claim 11, as a compounding agent for a medical device cleaning liquid, which contains the above-mentioned specific anionic surfactant,
Since a specific polymerized phosphate is used for the sequestering agent,
Provided is a product capable of preparing a cleaning liquid having excellent cleaning properties and safety when used for cleaning an artificial dialysis line equipped with an endotoxin removal filter.

According to the twelfth aspect of the present invention, as a compounding agent for a medical device cleaning liquid, which contains a surfactant together with the sequestering agent, at least a part of the surfactant is a nonionic surfactant. In addition, the thing which can give higher washability with respect to the dirt of oils and fats is provided.

According to the thirteenth aspect of the present invention, the compounding agent for a medical device cleaning liquid contains an alkali hydroxide together with a sequestering agent, so that sodium hypochlorite is used when the sequestering agent is organic. Has a good effect of improving stability, particularly when the sequestering agent is an aminocarboxylic acid salt, the stability can be remarkably enhanced, and the stability in the presence of a surfactant can be improved. What can reduce the metal corrosiveness is provided.

According to the fourteenth aspect of the present invention, since the compounding agent for a medical device cleaning liquid contains a silicate together with a sequestering agent, a metal corrosive property of the cleaning liquid can be significantly suppressed.

According to a fifteenth aspect of the present invention, in a method for cleaning various medical devices such as an artificial dialysis machine and peripheral devices thereof, the above-mentioned compounding agent for medical device cleaning liquid is mixed with an aqueous solution of sodium hypochlorite. , Effective chlorine concentration 0.02-
Since a cleaning solution containing 0.2% by weight of sodium hypochlorite and a sequestering agent is prepared and medical devices are cleaned with this cleaning solution, the bactericidal power of sodium hypochlorite can be sufficiently exerted, Calcium salts such as calcium can be efficiently removed.

According to the sixteenth aspect of the present invention, in the above method for cleaning a medical device, particularly when an artificial dialysis line equipped with an endotoxin removal filter is washed,
Since the filter is washed with a washing liquid prepared using a specific anionic surfactant or a compounding agent containing the same and a specific sequestering agent, the filter can be sufficiently washed, and the filter can be washed with water after washing. Residual agent components can be prevented, the risk of residual components being introduced into the blood of a patient can be eliminated, and the reliability and safety of cleaning can be ensured.

According to the seventeenth aspect of the present invention, in the cleaning method, 50 mg of the sequestering agent in 1 liter of the cleaning liquid is used.
From the above, the calcium salt attached to the medical device can be reliably removed.

According to the eighteenth aspect of the present invention, in the cleaning method, an aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight is added to a sequestering agent comprising an aminocarboxylic acid salt and an alkali hydroxide. Is mixed with a compounding agent for a medical device cleaning liquid, and the cleaning liquid is prepared by diluting the mixed liquid, so that an aminocarboxylic acid salt that easily causes decomposition of sodium hypochlorite is concentrated in sodium hypochlorite. Despite being added to the liquid, the decomposition can be suppressed, high sterilizing and detergency properties can be exhibited, and excellent calcium salt removability by the aminocarboxylic acid salt can be secured.

According to the nineteenth aspect of the present invention, in the above cleaning method, an aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight contains a sequestering agent, a surfactant and an alkali hydroxide. To prepare a cleaning solution by mixing the compounding agent for a medical device cleaning solution and diluting the mixed solution, a surfactant that leads to a decrease in the stability of sodium hypochlorite is added to a concentrated solution of sodium hypochlorite. Despite the addition, it is possible to suppress a decrease in the bactericidal activity of sodium hypochlorite and ensure good detergency with a surfactant.

According to the twentieth aspect of the present invention, the above-mentioned cleaning method in which an aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.05 to 12% by weight is mixed with a compounding agent for medical device cleaning liquid containing an alkali hydroxide. In the above, the effect of improving the stability of sodium hypochlorite by alkali hydroxide can be reliably exhibited without adversely affecting the equipment to be cleaned.

Continuation of front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display area C11D 7/36 C11D 7/36

Claims (20)

[Claims] 1. A compounding agent for a medical device cleaning liquid containing sodium hypochlorite as a main component, which contains an organic or / and inorganic sequestering agent. . 2. The compounding agent for a medical device cleaning liquid according to claim 1, which contains a polymerized phosphate as an inorganic sequestering agent. 3. The compounding agent for medical device cleaning liquid according to claim 2, wherein the polymerized phosphate is an alkali metal tripolyphosphate. 4. The compounding agent for a medical device cleaning liquid according to claim 1, which contains a citrate as an organic sequestering agent. 5. The compounding agent for a medical device cleaning liquid according to claim 1, which contains a polyacrylic acid salt as an organic sequestering agent. 6. The compounding agent for medical device cleaning liquid according to claim 1, which contains a polyacrylic acid salt-polymaleic acid salt copolymer as an organic sequestering agent. 7. The compounding agent for a medical device cleaning liquid according to claim 1, which contains an aminocarboxylic acid salt as an organic sequestering agent. 8. The compounding agent for medical device cleaning liquid according to claim 7, wherein the aminocarboxylic acid salt is an alkali metal nitrilotriacetic acid salt. 9. The compounding agent for medical device cleaning liquid according to claim 1, which contains a surfactant together with the sequestering agent. 10. The compounding agent for medical device cleaning liquid according to claim 9, which contains paratoluenesulfonate or / and metaxylenesulfonate as a surfactant. 11. The compounding agent for medical device cleaning liquid according to claim 10, wherein the sequestering agent is tripolyphosphate. 12. The compounding agent for medical device cleaning liquid according to claim 9, which contains a nonionic surfactant as at least a part of the surfactant. 13. The compounding agent for a medical device cleaning liquid according to claim 1, which contains an alkali hydroxide together with a sequestering agent. 14. The compounding agent for medical device cleaning liquid according to claim 1, which contains a silicate together with a sequestering agent. 15. A hypochlorous compound having an effective chlorine concentration of 0.02 to 0.2% by weight is obtained by mixing the sodium hypochlorite aqueous solution with the compounding agent for a medical device cleaning liquid according to claim 1. A method for cleaning a medical device, comprising preparing a cleaning liquid containing sodium acid salt and a sequestering agent, and cleaning the medical device with this cleaning liquid. 16. A cleaning liquid is prepared using the compounding agent for a medical device cleaning liquid according to claim 10 or 11, which contains a paratoluene sulfonate or / and a metaxylene sulfonate as a surfactant, and the cleaning liquid is used. The method for cleaning a medical device according to claim 14, wherein an artificial dialysis line provided with an endotoxin removal filter is cleaned. 17. The mixing amount of the compounding agent for medical device cleaning liquid is
The method for cleaning a medical device according to claim 15 or 16, wherein the sequestering agent in 1 liter of the cleaning liquid is set to 50 mg or more. 18. An aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.5 to 12% by weight is mixed with a compounding agent for medical device cleaning liquid containing an aminocarboxylate sequestering agent and an alkali hydroxide. The method for cleaning a medical device according to claim 15, wherein the mixed solution is diluted to prepare the cleaning solution. 19. An aqueous solution of sodium hypochlorite having an effective chlorine concentration of 0.5 to 12% by weight is mixed with a sequestering agent, a surfactant and a compounding agent for a medical device cleaning liquid containing an alkali hydroxide, The method for cleaning a medical device according to claim 15, wherein the cleaning solution is prepared by diluting a mixed solution. 20. The pH of the mixed solution is adjusted to 12.5 to 14.0 depending on the alkali hydroxide contained in the compounding agent for a medical device cleaning solution.
The method for cleaning a medical device according to claim 18 or 19, wherein the method is adjusted within the range.