JP2010540564A5 - - Google Patents
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- Publication number
- JP2010540564A5 JP2010540564A5 JP2010527251A JP2010527251A JP2010540564A5 JP 2010540564 A5 JP2010540564 A5 JP 2010540564A5 JP 2010527251 A JP2010527251 A JP 2010527251A JP 2010527251 A JP2010527251 A JP 2010527251A JP 2010540564 A5 JP2010540564 A5 JP 2010540564A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- eye
- ocular
- scaav
- interfering rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97655207P | 2007-10-01 | 2007-10-01 | |
| PCT/US2008/078380 WO2009046059A1 (en) | 2007-10-01 | 2008-10-01 | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540564A JP2010540564A (ja) | 2010-12-24 |
| JP2010540564A5 true JP2010540564A5 (https=) | 2012-09-13 |
Family
ID=40042637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527251A Pending JP2010540564A (ja) | 2007-10-01 | 2008-10-01 | 自己相補的なａａｖが媒介する眼の障害を処置または予防するための干渉ｒｎａ分子の送達 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090087413A1 (https=) |
| EP (1) | EP2192926A1 (https=) |
| JP (1) | JP2010540564A (https=) |
| KR (1) | KR20100061792A (https=) |
| CN (1) | CN101815536A (https=) |
| AU (1) | AU2008308784B2 (https=) |
| BR (1) | BRPI0817937A2 (https=) |
| CA (1) | CA2694091A1 (https=) |
| MX (1) | MX2010001608A (https=) |
| RU (1) | RU2010117178A (https=) |
| WO (1) | WO2009046059A1 (https=) |
| ZA (1) | ZA201000423B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| EP2287323A1 (en) | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| HRP20190144T1 (hr) * | 2010-04-23 | 2019-03-22 | University Of Florida Research Foundation, Inc. | Pripravci raav-gvanilat ciklaze i postupci za liječenje leberove urođene amauroze-1 (lca1) |
| CN103505743A (zh) | 2012-06-21 | 2014-01-15 | 北京命码生科科技有限公司 | 含功能性microRNA/siRNA的细胞微粒子及其应用 |
| EP4012035B1 (en) * | 2014-09-16 | 2024-11-06 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| PT4012035T (pt) * | 2014-09-16 | 2025-02-11 | Genzyme Corp | Vetores virais adenoassociados para tratar o glaucoma de miocilina (mioc) |
| BR112017005235B1 (pt) * | 2014-09-16 | 2023-10-31 | Genzyme Corporation | Vetores virais adeno-associados para o tratamento de glaucoma de miocilina (myoc) |
| GB201809588D0 (en) * | 2018-06-12 | 2018-07-25 | Univ Bristol | Materials and methods for modulating intraocular and intracranial pressure |
| AU2020361533A1 (en) | 2019-10-08 | 2022-04-28 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| IL296103A (en) | 2020-03-05 | 2022-11-01 | Neotx Therapeutics Ltd | Methods and compositions for treating cancer with immune cells |
| WO2021245224A1 (en) * | 2020-06-05 | 2021-12-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating ocular diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ522840A (en) * | 2000-06-01 | 2004-12-24 | Univ North Carolina | A parvovirus vector that carries a duplexed genome resulting in co-packaging of strands of plus and minus polarity tethered together |
| US20040209832A1 (en) * | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20050048529A1 (en) * | 2002-02-20 | 2005-03-03 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
| US20040198682A1 (en) * | 2001-11-30 | 2004-10-07 | Mcswiggen James | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
| US20060229266A1 (en) * | 2003-08-13 | 2006-10-12 | Kumar Nalin M | Silencing of tgf-beta receptor type II expression by sirna |
| WO2006042252A2 (en) * | 2004-10-08 | 2006-04-20 | Potentia Pharmeceuticals, Inc. | Viral complement control proteins for eye disorders |
| TWI401316B (zh) * | 2004-12-23 | 2013-07-11 | Alcon Inc | 用於治療青光眼之血清澱粉樣蛋白Ａ的ＲＮＡｉ抑制作用 |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| TW200639252A (en) * | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular hypertension targets |
| KR20080018858A (ko) * | 2005-03-11 | 2008-02-28 | 알콘, 인코퍼레이티드 | 녹내장 치료용 플리즐 관련 단백질―１의 ＲＮＡⅰ－중재저해 |
| GB0521351D0 (en) * | 2005-10-20 | 2005-11-30 | Genomica Sau | Modulation of TRPV expression levels |
| AR057252A1 (es) * | 2005-12-27 | 2007-11-21 | Alcon Mfg Ltd | Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares |
| TW200731980A (en) * | 2005-12-29 | 2007-09-01 | Alcon Mfg Ltd | RNAi-mediated inhibition of HIF1A for treatment of ocular angiogenesis |
| TW200808360A (en) * | 2006-04-13 | 2008-02-16 | Alcon Mfg Ltd | RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions |
| US8298818B2 (en) * | 2006-04-28 | 2012-10-30 | University Of Florida Research Foundation, Inc. | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter |
| ES2413804T3 (es) * | 2006-05-19 | 2013-07-17 | Alcon Research, Ltd. | Inhibición mediada por ARNi de estados relacionados con factor de necrosis tumoral-alfa |
| CN102743767A (zh) * | 2006-08-24 | 2012-10-24 | 爱尔康研究有限公司 | RNAi介导的Gremlin抑制用于治疗眼内压相关的状况 |
| US7872119B2 (en) * | 2007-02-26 | 2011-01-18 | Quark Pharmaceuticals, Inc. | Inhibitors of RTP801 and their use in disease treatment |
| US7973019B1 (en) * | 2007-10-03 | 2011-07-05 | Alcon Research, Ltd. | Transferrin/transferrin receptor-mediated siRNA delivery |
| TW200932274A (en) * | 2007-12-18 | 2009-08-01 | Alcon Res Ltd | Interfering RNA delivery system and uses thereof |
-
2008
- 2008-10-01 RU RU2010117178/15A patent/RU2010117178A/ru not_active Application Discontinuation
- 2008-10-01 MX MX2010001608A patent/MX2010001608A/es not_active Application Discontinuation
- 2008-10-01 CN CN200880110028A patent/CN101815536A/zh active Pending
- 2008-10-01 KR KR1020107003620A patent/KR20100061792A/ko not_active Withdrawn
- 2008-10-01 WO PCT/US2008/078380 patent/WO2009046059A1/en not_active Ceased
- 2008-10-01 BR BRPI0817937 patent/BRPI0817937A2/pt not_active IP Right Cessation
- 2008-10-01 CA CA2694091A patent/CA2694091A1/en not_active Abandoned
- 2008-10-01 EP EP08835867A patent/EP2192926A1/en not_active Withdrawn
- 2008-10-01 US US12/243,100 patent/US20090087413A1/en not_active Abandoned
- 2008-10-01 JP JP2010527251A patent/JP2010540564A/ja active Pending
- 2008-10-01 AU AU2008308784A patent/AU2008308784B2/en not_active Ceased
-
2010
- 2010-01-20 ZA ZA2010/00423A patent/ZA201000423B/en unknown
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