JP2010540509A5 - - Google Patents
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- Publication number
- JP2010540509A5 JP2010540509A5 JP2010526364A JP2010526364A JP2010540509A5 JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5 JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- compound according
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 6
- 230000002062 proliferating Effects 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000001419 dependent Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719038A GB0719038D0 (en) | 2007-09-28 | 2007-09-28 | Compound |
| GB0719038.2 | 2007-09-28 | ||
| GB0806844.7 | 2008-04-15 | ||
| GB0806844A GB0806844D0 (en) | 2008-04-15 | 2008-04-15 | Compound |
| PCT/GB2008/003305 WO2009040556A1 (en) | 2007-09-28 | 2008-09-29 | Pyrimidine derivatives as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Division JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540509A JP2010540509A (ja) | 2010-12-24 |
| JP2010540509A5 true JP2010540509A5 (pt-PT) | 2011-10-06 |
| JP5410432B2 JP5410432B2 (ja) | 2014-02-05 |
Family
ID=40199600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526364A Active JP5410432B2 (ja) | 2007-09-28 | 2008-09-29 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
| JP2013230231A Active JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Active JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8563542B2 (pt-PT) |
| EP (2) | EP2205603B1 (pt-PT) |
| JP (2) | JP5410432B2 (pt-PT) |
| CN (1) | CN101878216B (pt-PT) |
| CA (1) | CA2700979C (pt-PT) |
| ES (2) | ES2585110T3 (pt-PT) |
| HK (2) | HK1187895A1 (pt-PT) |
| PL (2) | PL2205603T3 (pt-PT) |
| RU (2) | RU2478100C2 (pt-PT) |
| WO (1) | WO2009040556A1 (pt-PT) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5243970B2 (ja) | 2006-02-14 | 2013-07-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なジヒドロジアゼピン |
| WO2009023269A2 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5h-pyrimido [4, 5-b[1, 4] diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases |
| GEP20125704B (en) | 2007-09-25 | 2012-12-10 | Takeda Pharmaceuticals Co | Plk kinase inhibitors |
| ES2585110T3 (es) * | 2007-09-28 | 2016-10-03 | Cyclacel Limited | Derivados de pirimidina como inhibidores de proteína cinasa |
| MX2011000026A (es) | 2008-06-23 | 2011-02-24 | Vertex Pharma | Inhibidores de proteina cinasas. |
| CA2728830A1 (en) * | 2008-06-23 | 2010-01-21 | Jean-Damien Charrier | Protein kinase inhibitors |
| KR101702609B1 (ko) | 2009-06-17 | 2017-02-03 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| EP2480550B1 (en) * | 2009-09-25 | 2016-02-10 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| WO2011038185A2 (en) | 2009-09-25 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| CN103038230B (zh) | 2010-06-04 | 2016-05-25 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的氨基嘧啶衍生物 |
| JP5986094B2 (ja) | 2010-11-10 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｌｒｒｋ２調節薬としてのピラゾールアミノピリミジン誘導体 |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| GB201205752D0 (en) * | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
| EP3388436B1 (en) * | 2013-03-15 | 2020-08-12 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone compounds and methods of treating disorders |
| KR20160034379A (ko) | 2013-07-25 | 2016-03-29 | 다나-파버 캔서 인스티튜트 인크. | 전사 인자의 억제제 및 그의 용도 |
| RU2019104421A (ru) | 2013-11-13 | 2019-04-17 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения ингибиторов репликации вирусов гриппа |
| NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| EP3099693A4 (en) * | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| KR101517414B1 (ko) * | 2014-04-24 | 2015-05-04 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| ES2764178T3 (es) | 2014-12-16 | 2020-06-02 | Kayla Therapeutics | Dinucleótidos cíclicos fluorados para inducción de citocinas |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| WO2017044849A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| PE20181086A1 (es) | 2015-09-11 | 2018-07-05 | Dana Farber Cancer Inst Inc | Acetamida tienotrizolodiazepinas y usos de las mismas |
| WO2017066428A1 (en) | 2015-10-13 | 2017-04-20 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Brd4-kinase inhibitors as cancer therapeutics |
| SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| RU2748696C2 (ru) * | 2016-03-04 | 2021-05-28 | Аньхой Нью Стар Фармасьютикал Дивелопмент Ко., Лтд | Пиридиновые соединения, содержащие семь атомов в кольце, способ их получения, фармацевтическая композиция, содержащая указанные соединения, и их применение |
| CN109311901A (zh) * | 2016-04-07 | 2019-02-05 | 达纳-法伯癌症研究所有限公司 | 嘧啶并-二氮杂卓酮激酶骨架化合物及治疗pi3k介导的病变的方法 |
| BR112020008833A2 (pt) * | 2017-11-02 | 2020-10-20 | Calico Life Sciences Llc | moduladores da via de estresse integrada |
| EP3704115A1 (en) | 2017-11-02 | 2020-09-09 | Calico Life Sciences LLC | Modulators of the integrated stress pathway |
| WO2021032959A1 (en) | 2019-08-16 | 2021-02-25 | Cyclacel Limited | Crystalline forms of pyrimidino diazepine derivative |
| CA3145287A1 (en) * | 2019-08-16 | 2021-02-25 | Benjamin Skead | Process for the preparation of a pyrimidino-diazepine derivative |
| US20220378919A1 (en) * | 2019-09-27 | 2022-12-01 | Dana-Farber Cancer Institute, Inc. | Erk5 degraders as therapeutics in cancer and inflammatory diseases |
| TW202404636A (zh) | 2022-04-08 | 2024-02-01 | 美商英伊布里克斯公司 | Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117635D0 (en) | 1991-08-15 | 1991-10-02 | British Telecomm | Phase shifter |
| GB0302220D0 (en) | 2003-01-30 | 2003-03-05 | Cyclacel Ltd | Use |
| EP1599478B1 (de) * | 2003-02-26 | 2007-05-09 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| WO2005117944A2 (en) | 2004-05-26 | 2005-12-15 | The Texas A & M University System | Hsp20 inhibits amyloidogenesis and neurotoxicity |
| JP5002460B2 (ja) * | 2004-10-04 | 2012-08-15 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
| DK1902026T3 (da) | 2005-06-24 | 2010-04-26 | Lilly Co Eli | Tetrahydrocarbazol-derivater, der kan anvendes som androgen-receptor-modulatorer (SARM) |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| JP5243970B2 (ja) * | 2006-02-14 | 2013-07-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なジヒドロジアゼピン |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
| CN102746175B (zh) * | 2007-03-22 | 2014-01-15 | 武田药品工业株式会社 | 可用作plk1抑制剂的取代的嘧啶并二氮杂* |
| GEP20125704B (en) * | 2007-09-25 | 2012-12-10 | Takeda Pharmaceuticals Co | Plk kinase inhibitors |
| ES2585110T3 (es) * | 2007-09-28 | 2016-10-03 | Cyclacel Limited | Derivados de pirimidina como inhibidores de proteína cinasa |
| WO2009067547A1 (en) * | 2007-11-19 | 2009-05-28 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| US8710068B2 (en) | 2009-01-19 | 2014-04-29 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| GB201205752D0 (en) | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
-
2008
- 2008-09-29 ES ES13156251.4T patent/ES2585110T3/es active Active
- 2008-09-29 JP JP2010526364A patent/JP5410432B2/ja active Active
- 2008-09-29 US US12/680,353 patent/US8563542B2/en active Active
- 2008-09-29 PL PL08806455T patent/PL2205603T3/pl unknown
- 2008-09-29 EP EP20080806455 patent/EP2205603B1/en active Active
- 2008-09-29 ES ES08806455T patent/ES2457394T3/es active Active
- 2008-09-29 CN CN2008801182902A patent/CN101878216B/zh active Active
- 2008-09-29 RU RU2010116759/04A patent/RU2478100C2/ru active
- 2008-09-29 PL PL13156251.4T patent/PL2610256T3/pl unknown
- 2008-09-29 CA CA2700979A patent/CA2700979C/en active Active
- 2008-09-29 WO PCT/GB2008/003305 patent/WO2009040556A1/en active Application Filing
- 2008-09-29 EP EP13156251.4A patent/EP2610256B1/en active Active
-
2010
- 2010-12-30 HK HK14100038.8A patent/HK1187895A1/zh unknown
- 2010-12-30 HK HK10112280A patent/HK1146042A1/xx unknown
-
2013
- 2013-02-26 RU RU2013108456A patent/RU2623221C2/ru active
- 2013-06-05 US US13/910,349 patent/US9133199B2/en active Active
- 2013-11-06 JP JP2013230231A patent/JP5863196B2/ja active Active
-
2015
- 2015-08-07 US US14/820,711 patent/US9493471B2/en active Active
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