JP2010540462A5 - - Google Patents
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- JP2010540462A5 JP2010540462A5 JP2010526066A JP2010526066A JP2010540462A5 JP 2010540462 A5 JP2010540462 A5 JP 2010540462A5 JP 2010526066 A JP2010526066 A JP 2010526066A JP 2010526066 A JP2010526066 A JP 2010526066A JP 2010540462 A5 JP2010540462 A5 JP 2010540462A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydroxy
- carbonyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 95
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 77
- 150000003839 salts Chemical class 0.000 claims 47
- 239000011780 sodium chloride Substances 0.000 claims 47
- 239000012453 solvate Substances 0.000 claims 46
- -1 2-thiazolyl Chemical group 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 28
- 125000001072 heteroaryl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 23
- 125000003710 aryl alkyl group Chemical group 0.000 claims 21
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 21
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 21
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 20
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 11
- 229960003966 nicotinamide Drugs 0.000 claims 10
- 235000005152 nicotinamide Nutrition 0.000 claims 10
- 239000011570 nicotinamide Substances 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- VFQXVTODMYMSMJ-UHFFFAOYSA-N Isonicotinamide Chemical compound NC(=O)C1=CC=NC=C1 VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 claims 7
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 4
- 125000002971 oxazolyl group Chemical group 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- 102100015650 BACE1 Human genes 0.000 claims 3
- 108030001047 EC 3.4.23.46 Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 230000003197 catalytic Effects 0.000 claims 2
- 230000024881 catalytic activity Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- DKNAPXHWYWQOGY-FCIJAXDVSA-N 2-(6-fluoropyridin-3-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-6-[(2R)-2-(4-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carbonyl]pyridine-4-carboxamide Chemical compound CC1=CSC([C@@H]2N(CCC2)C(=O)C=2N=C(C=C(C=2)C(=O)N[C@@H](CC=2C=CC=CC=2)[C@H](O)CNCC=2C=C(C=CC=2)C(F)(F)F)C=2C=NC(F)=CC=2)=N1 DKNAPXHWYWQOGY-FCIJAXDVSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- QMHIMXFNBOYPND-UHFFFAOYSA-N 4-methylthiazole Chemical compound CC1=CSC=N1 QMHIMXFNBOYPND-UHFFFAOYSA-N 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- DEFLNOSTNCSZRB-IDTAVKCVSA-N 9-[(2R,3R,4R,5R)-3,4-dimethoxy-5-(methoxymethyl)oxolan-2-yl]-N-methoxypurin-6-amine Chemical compound CO[C@@H]1[C@H](OC)[C@@H](COC)O[C@H]1N1C2=NC=NC(NOC)=C2N=C1 DEFLNOSTNCSZRB-IDTAVKCVSA-N 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- XWEAWFALJIAQBU-OJDZSJEKSA-N N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-3-methyl-5-[(2R)-2-(4-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carbonyl]benzamide Chemical compound CC1=CSC([C@@H]2N(CCC2)C(=O)C=2C=C(C=C(C)C=2)C(=O)N[C@@H](CC=2C=CC=CC=2)[C@H](O)CNCC=2C=C(C=CC=2)C(F)(F)F)=N1 XWEAWFALJIAQBU-OJDZSJEKSA-N 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97479307P | 2007-09-24 | 2007-09-24 | |
| US60/974,793 | 2007-09-24 | ||
| PCT/US2008/077537 WO2009042694A1 (en) | 2007-09-24 | 2008-09-24 | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540462A JP2010540462A (ja) | 2010-12-24 |
| JP2010540462A5 true JP2010540462A5 (US08084479-20111227-C00115.png) | 2011-11-10 |
| JP5055432B2 JP5055432B2 (ja) | 2012-10-24 |
Family
ID=40343545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526066A Expired - Fee Related JP5055432B2 (ja) | 2007-09-24 | 2008-09-24 | 治療のためのβ−セクレターゼ阻害剤としての（３−ヒドロキシ−４−アミノブタン−２−イル）−３−（２−チアゾール−２−イル−ピロリジン−１−カルボニル）ベンズアミド誘導体及び関連する化合物 |
Country Status (8)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5055432B2 (ja) | 2007-09-24 | 2012-10-24 | コメンティス，インコーポレーテッド | 治療のためのβ−セクレターゼ阻害剤としての（３−ヒドロキシ−４−アミノブタン−２−イル）−３−（２−チアゾール−２−イル−ピロリジン−１−カルボニル）ベンズアミド誘導体及び関連する化合物 |
| CA2772075C (en) * | 2009-09-04 | 2017-02-28 | Rashida A. Karmali | Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| JP2013506713A (ja) * | 2009-10-05 | 2013-02-28 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法 |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US20120053200A1 (en) * | 2010-09-01 | 2012-03-01 | Harald Mauser | Bace 2 inhibitors |
| EP2862861B1 (en) | 2012-06-14 | 2016-01-06 | Daiichi Sankyo Company, Limited | Piperidinylpyrazolopyridine derivative |
| CN105669365B (zh) * | 2016-03-04 | 2022-06-21 | 中国科学院上海有机化学研究所 | 含二氟烷基取代的芳基或杂芳基化合物、制备方法和应用 |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| CN110117237B (zh) * | 2018-02-05 | 2024-02-02 | 中国科学院上海有机化学研究所 | 一种芳香腈或烯基腈类化合物的制备方法 |
| CN110642789B (zh) * | 2019-11-25 | 2020-05-26 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
| CN112321515A (zh) * | 2020-10-21 | 2021-02-05 | 上海馨远医药科技有限公司 | 一种手性1-叔丁基-3-甲基-6-甲基哌嗪-1,3-二甲酸酯的制备方法 |
| WO2023149945A1 (en) * | 2022-02-03 | 2023-08-10 | Purdue Research Foundation | Peptidomimetic inhibitors of protein n-terminal methyltransferase 1, composition, and method of use |
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| JP2013506713A (ja) | 2009-10-05 | 2013-02-28 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法 |
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2008
- 2008-09-24 JP JP2010526066A patent/JP5055432B2/ja not_active Expired - Fee Related
- 2008-09-24 US US12/677,748 patent/US8299267B2/en not_active Expired - Fee Related
- 2008-09-24 CN CN2008801172385A patent/CN101868457B/zh not_active Expired - Fee Related
- 2008-09-24 CA CA2699787A patent/CA2699787A1/en not_active Abandoned
- 2008-09-24 WO PCT/US2008/077537 patent/WO2009042694A1/en active Application Filing
- 2008-09-24 KR KR1020107006815A patent/KR20100059919A/ko not_active Application Discontinuation
- 2008-09-24 EP EP08834393A patent/EP2205596A1/en not_active Withdrawn
- 2008-09-24 MX MX2010002938A patent/MX2010002938A/es active IP Right Grant
