JP2010539192A5 - - Google Patents

Info

Publication number

JP2010539192A5

JP2010539192A5 JP2010525114A JP2010525114A JP2010539192A5 JP 2010539192 A5 JP2010539192 A5 JP 2010539192A5 JP 2010525114 A JP2010525114 A JP 2010525114A JP 2010525114 A JP2010525114 A JP 2010525114A JP 2010539192 A5 JP2010539192 A5 JP 2010539192A5

Authority

JP

Japan

Prior art keywords

vaccine composition

composition according

vlp

norovirus

adjuvant

Prior art date

2008-09-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 32
• 229960005486 vaccine Drugs 0.000 claims 30
• 241001263478 Norovirus Species 0.000 claims 12
• 239000002671 adjuvant Substances 0.000 claims 6
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 229920001661 Chitosan Polymers 0.000 claims 3
• 150000004676 glycans Chemical class 0.000 claims 3
• 229940035032 monophosphoryl lipid a Drugs 0.000 claims 3
• 230000003232 mucoadhesive effect Effects 0.000 claims 3
• 229920001282 polysaccharide Polymers 0.000 claims 3
• 239000005017 polysaccharide Substances 0.000 claims 3
• 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 claims 2
• 239000000227 bioadhesive Substances 0.000 claims 2
• 239000002158 endotoxin Substances 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 2
• 229920006008 lipopolysaccharide Polymers 0.000 claims 2
• 239000011859 microparticle Substances 0.000 claims 2
• BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 208000006339 Caliciviridae Infections Diseases 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 229920002567 Chondroitin Polymers 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 229920000045 Dermatan sulfate Polymers 0.000 claims 1
• 241000056533 Houston virus Species 0.000 claims 1
• 102000004856 Lectins Human genes 0.000 claims 1
• 108090001090 Lectins Proteins 0.000 claims 1
• 241000714209 Norwalk virus Species 0.000 claims 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• 229920002125 Sokalan® Polymers 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
• DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
• -1 co-chelates Polymers 0.000 claims 1
• 229940124447 delivery agent Drugs 0.000 claims 1
• 230000008021 deposition Effects 0.000 claims 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
• 229940051593 dermatan sulfate Drugs 0.000 claims 1
• 239000000839 emulsion Substances 0.000 claims 1
• 235000013312 flour Nutrition 0.000 claims 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 239000002523 lectin Substances 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 239000011344 liquid material Substances 0.000 claims 1
• 210000002850 nasal mucosa Anatomy 0.000 claims 1
• 210000001331 nose Anatomy 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• 229960000502 poloxamer Drugs 0.000 claims 1
• 229920001983 poloxamer Polymers 0.000 claims 1
• 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 230000001681 protective effect Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 229930182490 saponin Natural products 0.000 claims 1
• 150000007949 saponins Chemical class 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1
• 239000000277 virosome Substances 0.000 claims 1