JP2010539191A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010539191A5 JP2010539191A5 JP2010525113A JP2010525113A JP2010539191A5 JP 2010539191 A5 JP2010539191 A5 JP 2010539191A5 JP 2010525113 A JP2010525113 A JP 2010525113A JP 2010525113 A JP2010525113 A JP 2010525113A JP 2010539191 A5 JP2010539191 A5 JP 2010539191A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- hydrogen
- unsubstituted
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 66
- 239000001257 hydrogen Substances 0.000 claims 62
- 150000001875 compounds Chemical class 0.000 claims 40
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 39
- 239000000651 prodrug Substances 0.000 claims 37
- 229940002612 prodrug Drugs 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 33
- 150000002148 esters Chemical class 0.000 claims 28
- 229910052757 nitrogen Inorganic materials 0.000 claims 27
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 150000002431 hydrogen Chemical group 0.000 claims 23
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 23
- 125000000623 heterocyclic group Chemical group 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 229920006395 saturated elastomer Polymers 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 125000005842 heteroatom Chemical group 0.000 claims 13
- 125000001931 aliphatic group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 238000010276 construction Methods 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 7
- -1 OR 3 Inorganic materials 0.000 claims 6
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 5
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 5
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 5
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000003927 aminopyridines Chemical class 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 150000002016 disaccharides Chemical class 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 150000002772 monosaccharides Chemical class 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 150000004043 trisaccharides Chemical class 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 3
- 125000002723 alicyclic group Chemical group 0.000 claims 3
- 230000005494 condensation Effects 0.000 claims 3
- 238000009833 condensation Methods 0.000 claims 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 3
- 150000004867 thiadiazoles Chemical class 0.000 claims 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical compound NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 150000003852 triazoles Chemical class 0.000 claims 2
- VJHTZTZXOKVQRN-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine Chemical compound NC1=NC=NS1 VJHTZTZXOKVQRN-UHFFFAOYSA-N 0.000 claims 1
- YGTAZGSLCXNBQL-UHFFFAOYSA-N 1,2,4-thiadiazole Chemical compound C=1N=CSN=1 YGTAZGSLCXNBQL-UHFFFAOYSA-N 0.000 claims 1
- ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical compound NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 claims 1
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 claims 1
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims 1
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims 1
- ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical group NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 claims 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- 229930182816 L-glutamine Natural products 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- 229930182844 L-isoleucine Natural products 0.000 claims 1
- 239000004395 L-leucine Substances 0.000 claims 1
- 235000019454 L-leucine Nutrition 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 229930195722 L-methionine Natural products 0.000 claims 1
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 1
- 229930182821 L-proline Natural products 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229950003476 aminothiazole Drugs 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 229960005261 aspartic acid Drugs 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 229960002989 glutamic acid Drugs 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 229960003136 leucine Drugs 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- WHLAXDUXKMECTM-UHFFFAOYSA-N oxadiazol-4-amine Chemical compound NC1=CON=N1 WHLAXDUXKMECTM-UHFFFAOYSA-N 0.000 claims 1
- 229960002429 proline Drugs 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical compound NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229960001153 serine Drugs 0.000 claims 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 229960002898 threonine Drugs 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 229960004295 valine Drugs 0.000 claims 1
- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97301707P | 2007-09-17 | 2007-09-17 | |
| US60/973,017 | 2007-09-17 | ||
| US97320107P | 2007-09-18 | 2007-09-18 | |
| US60/973,201 | 2007-09-18 | ||
| US5187508P | 2008-05-09 | 2008-05-09 | |
| US5185708P | 2008-05-09 | 2008-05-09 | |
| US5186208P | 2008-05-09 | 2008-05-09 | |
| US61/051,857 | 2008-05-09 | ||
| US61/051,875 | 2008-05-09 | ||
| US61/051,862 | 2008-05-09 | ||
| US7621308P | 2008-06-27 | 2008-06-27 | |
| US7620808P | 2008-06-27 | 2008-06-27 | |
| US61/076,208 | 2008-06-27 | ||
| US61/076,213 | 2008-06-27 | ||
| US9511108P | 2008-09-08 | 2008-09-08 | |
| US9510008P | 2008-09-08 | 2008-09-08 | |
| US61/095,100 | 2008-09-08 | ||
| US61/095,111 | 2008-09-08 | ||
| PCT/US2008/076731 WO2009075923A2 (en) | 2007-09-17 | 2008-09-17 | 6, 11-bridged biaryl macrolides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014220701A Division JP2015017139A (ja) | 2007-09-17 | 2014-10-29 | ６，１１−架橋ビアリールマクロライド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539191A JP2010539191A (ja) | 2010-12-16 |
| JP2010539191A5 true JP2010539191A5 (enExample) | 2011-07-21 |
| JP5642548B2 JP5642548B2 (ja) | 2014-12-17 |
Family
ID=40455143
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525113A Expired - Fee Related JP5642548B2 (ja) | 2007-09-17 | 2008-09-17 | ６，１１−架橋ビアリールマクロライド |
| JP2014220701A Pending JP2015017139A (ja) | 2007-09-17 | 2014-10-29 | ６，１１−架橋ビアリールマクロライド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014220701A Pending JP2015017139A (ja) | 2007-09-17 | 2014-10-29 | ６，１１−架橋ビアリールマクロライド |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20090118506A1 (enExample) |
| EP (1) | EP2203435B1 (enExample) |
| JP (2) | JP5642548B2 (enExample) |
| KR (2) | KR101223158B1 (enExample) |
| CN (2) | CN101855219B (enExample) |
| AU (1) | AU2008335668C1 (enExample) |
| CA (1) | CA2699733C (enExample) |
| ES (1) | ES2691252T3 (enExample) |
| MX (1) | MX2010002932A (enExample) |
| NZ (2) | NZ600635A (enExample) |
| WO (2) | WO2009039177A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8273720B2 (en) * | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
| EP2203435B1 (en) * | 2007-09-17 | 2018-07-18 | Enanta Pharmaceuticals, Inc. | 6, 11-bridged biaryl macrolides |
| US8354383B2 (en) * | 2007-09-17 | 2013-01-15 | Enanta Pharmaceuticals, Inc. | 6,11-bridged biaryl macrolides |
| WO2009137787A1 (en) | 2008-05-09 | 2009-11-12 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives |
| WO2009137739A1 (en) * | 2008-05-09 | 2009-11-12 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of o-[5-[4-amino-thiazol-2-yl]-pyridin-2-ylmethyl]-hydroxylamine |
| TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
| RU2601550C2 (ru) * | 2010-12-09 | 2016-11-10 | Вокхардт Лимитед | Кетолидные соединения |
| ES2969792T3 (es) * | 2015-11-19 | 2024-05-22 | Biohaven Therapeutics Ltd | Profármacos de amina de compuestos farmacéuticos |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103264A (zh) * | 1984-04-13 | 1987-01-14 | 美国辉瑞有限公司 | 9a-氮杂-9a-高红霉素衍生物 |
| KR960000434B1 (ko) * | 1986-12-17 | 1996-01-06 | 다이쇼 세이야꾸 가부시끼가이샤 | 에리스로마이신 a유도체 및 그의 제조 방법 |
| US4921836A (en) * | 1989-05-17 | 1990-05-01 | Burroughs Wellcome Co. | Substituted glutamic acids |
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| US5403923A (en) * | 1990-11-28 | 1995-04-04 | Taisho Pharmaceutical Co., Ltd. | 6-0-methylerythromycin A derivatives |
| US5202434A (en) * | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
| US5556839A (en) * | 1991-04-29 | 1996-09-17 | Eli Lilly And Company | Form II Dirithromycin |
| WO1993021199A1 (fr) * | 1992-04-22 | 1993-10-28 | Taisho Pharmaceutical Co., Ltd. | Derive de 5-o-desosaminylerythronolide |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| US5441939A (en) * | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
| FR2738571B1 (fr) * | 1995-09-11 | 1997-10-17 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
| US6274715B1 (en) * | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| BR9711661A (pt) * | 1996-09-04 | 1999-08-24 | Abbott Lab | Composto composi-Æo farmac-utica e processos para controlar uma infec-Æo bacteriana em um mam¡fero e para preparar um composto |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| US5922683A (en) * | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
| US5780605A (en) * | 1997-09-08 | 1998-07-14 | Abbott Laboratories | 6,9-bridged erythromycin derivatives |
| US6046171A (en) * | 1997-10-29 | 2000-04-04 | Abbott Laboratories | 6,11-bridged erythromycin derivatives |
| US6124269A (en) * | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| EP0941998B1 (en) * | 1998-03-03 | 2004-09-01 | Pfizer Products Inc. | 3,6-ketal macrolide antibiotics |
| US6054435A (en) * | 1999-03-19 | 2000-04-25 | Abbott Laboratories | 6-O-substituted macrolides having antibacterial activity |
| JP2002542197A (ja) * | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| HRP990130B1 (en) * | 1999-05-03 | 2004-06-30 | Pliva D D | HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A |
| US6355620B1 (en) * | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
| US7273853B2 (en) * | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| US6841664B2 (en) * | 2002-07-25 | 2005-01-11 | Enanra Pharmaceuticals, Inc. | 6,11-4-carbon bridged ketolides |
| US7064110B2 (en) * | 2002-05-13 | 2006-06-20 | Enanta Pharmaceuticals, Inc. | 6-11 bicycle ketolide derivatives |
| US7022679B2 (en) * | 2002-05-13 | 2006-04-04 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 6-11 bicyclic erythromycin derivatives |
| US7910558B2 (en) * | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
| US6764998B1 (en) * | 2003-06-18 | 2004-07-20 | Enanta Pharmaceuticals, Inc. | 6,11-4C-bicyclic 9a-azalide derivatives |
| US6878691B2 (en) * | 2002-05-13 | 2005-04-12 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| US6753318B1 (en) * | 2002-07-25 | 2004-06-22 | Enanta Pharmaceuticals, Inc. | 6,11-4-carbon bridged erythromycin derivatives |
| US7129221B2 (en) * | 2002-05-13 | 2006-10-31 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclic erythromycin derivatives |
| US7135573B2 (en) * | 2002-05-13 | 2006-11-14 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine |
| EP1506214B1 (en) * | 2002-05-13 | 2010-01-20 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| US6645941B1 (en) * | 2003-03-26 | 2003-11-11 | Enanta Pharmaceuticals, Inc. | 6,11-3C-bicyclic 9a-azalide derivatives |
| AU2003295869A1 (en) * | 2003-11-20 | 2005-07-14 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide drivatives |
| WO2005067564A2 (en) * | 2004-01-07 | 2005-07-28 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic erythromycin derivatives |
| WO2005070113A2 (en) * | 2004-01-09 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | 9n-substituted 6-11 bicyclic erythromycin derivatives |
| US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
| EP1794171A2 (en) * | 2004-07-28 | 2007-06-13 | Ranbaxy Laboratories, Ltd. | Ketolide derivatives as antibacterial agents |
| US7229972B2 (en) * | 2004-12-07 | 2007-06-12 | Enanta Pharmaceuticals, Inc. | 3,6-Bicyclolides |
| US20060252710A1 (en) * | 2005-05-04 | 2006-11-09 | Guoqiang Wang | 6-11 Bridged oxime erythromycin derivatives |
| US7384922B2 (en) * | 2005-05-04 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | 6-11 bridged oxime erythromycin derivatives |
| US7589067B2 (en) * | 2005-10-12 | 2009-09-15 | Enanta Pharmaceuticals, Inc. | 6, 11-bridged tricyclic macrolides |
| EP2203435B1 (en) * | 2007-09-17 | 2018-07-18 | Enanta Pharmaceuticals, Inc. | 6, 11-bridged biaryl macrolides |
-
2008
- 2008-09-17 EP EP08859833.9A patent/EP2203435B1/en not_active Not-in-force
- 2008-09-17 US US12/212,596 patent/US20090118506A1/en not_active Abandoned
- 2008-09-17 CN CN200880115910.7A patent/CN101855219B/zh not_active Expired - Fee Related
- 2008-09-17 ES ES08859833.9T patent/ES2691252T3/es active Active
- 2008-09-17 CN CN201410219293.2A patent/CN104004039A/zh active Pending
- 2008-09-17 JP JP2010525113A patent/JP5642548B2/ja not_active Expired - Fee Related
- 2008-09-17 MX MX2010002932A patent/MX2010002932A/es active IP Right Grant
- 2008-09-17 CA CA2699733A patent/CA2699733C/en not_active Expired - Fee Related
- 2008-09-17 AU AU2008335668A patent/AU2008335668C1/en not_active Ceased
- 2008-09-17 NZ NZ600635A patent/NZ600635A/xx not_active IP Right Cessation
- 2008-09-17 US US12/212,447 patent/US20090075915A1/en not_active Abandoned
- 2008-09-17 KR KR1020107008527A patent/KR101223158B1/ko not_active Expired - Fee Related
- 2008-09-17 KR KR1020127028347A patent/KR20120132577A/ko not_active Ceased
- 2008-09-17 NZ NZ584159A patent/NZ584159A/xx not_active IP Right Cessation
- 2008-09-17 WO PCT/US2008/076681 patent/WO2009039177A1/en not_active Ceased
- 2008-09-17 WO PCT/US2008/076731 patent/WO2009075923A2/en not_active Ceased
-
2014
- 2014-10-29 JP JP2014220701A patent/JP2015017139A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010539191A5 (enExample) | ||
| AU2016373533B2 (en) | Novel compounds | |
| ES2691068T3 (es) | Compuestos de indol e indazol como inhibidores de la necrosis celular | |
| RU2006125761A (ru) | Новые производные оксазолидинона | |
| JP2008530099A5 (enExample) | ||
| TN2014000115A1 (fr) | Derives de pyrrolopyrimidines et de purines | |
| NO329166B1 (no) | Indolylmaleimidderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk sammensetning inneholdende en slik forbindelse. | |
| RU2009115963A (ru) | Производные оксадиазола, обладающие противовоспалительными и иммунодепрессантными свойствами | |
| PE20090216A1 (es) | Compuestos triazolil aminopirimidina | |
| CA2565660A1 (en) | Ortho substituted aryl or heteroaryl amide compounds | |
| PT1718608E (pt) | Inibidores da polimerase viral | |
| CO6251317A2 (es) | Procedimiento para sintetizar sal diclorhidrato de ((1s)-1-(((2s) sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil | |
| JP2007534702A5 (enExample) | ||
| MY148566A (en) | Crystalline solvates and complexes of (is) -1, 5- anhydro-1 -c-(3-( (phenyl) methyl) phenyl) -d-glucitol derivatives with amino acids as sglt2 inhibitors for the treatment of diabetes | |
| KR20120055571A (ko) | 종양성 또는 자가면역 질환 치료용 전구약물로서의 푸라자노벤즈이미다졸 | |
| TWI367882B (en) | Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates | |
| WO2009080432A3 (en) | Composition for treatment of tuberculosis | |
| JP2008506758A5 (enExample) | ||
| RU2013139352A (ru) | Аминозамещенные производные 3-гетероароиламинопропионовой кислоты и их применение в качестве фармацевтических средств | |
| ZA200706393B (en) | Novel betullnic acid derivatives A-ring-condensed to a heterocyclic group | |
| JP2010527364A5 (enExample) | ||
| WO2010082212A3 (en) | N-biphenylacyl thiazolidine-2,4-dione derivatives, their synthesis and uses | |
| WO2009142827A4 (en) | Compounds and methods for the treatment of viral infection | |
| JP2003509502A5 (enExample) | ||
| JP2011506393A5 (enExample) |