JP2010537788A5 - - Google Patents
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- JP2010537788A5 JP2010537788A5 JP2010524185A JP2010524185A JP2010537788A5 JP 2010537788 A5 JP2010537788 A5 JP 2010537788A5 JP 2010524185 A JP2010524185 A JP 2010524185A JP 2010524185 A JP2010524185 A JP 2010524185A JP 2010537788 A5 JP2010537788 A5 JP 2010537788A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery member
- therapeutic agent
- tip
- delivery
- elongated body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003814 drug Substances 0.000 claims 13
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims 6
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims 6
- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- 229960002930 sirolimus Drugs 0.000 claims 6
- 210000003709 Heart Valves Anatomy 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 229960001592 Paclitaxel Drugs 0.000 claims 3
- JSDRRTOADPPCHY-HSQYWUDLSA-N Quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 3
- XUKUURHRXDUEBC-KAYWLYCHSA-N atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 3
- 229960005370 atorvastatin Drugs 0.000 claims 3
- 230000003115 biocidal Effects 0.000 claims 3
- 230000002708 enhancing Effects 0.000 claims 3
- 239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 claims 3
- 229960001455 quinapril Drugs 0.000 claims 3
- 200000000009 stenosis Diseases 0.000 claims 3
- 230000036262 stenosis Effects 0.000 claims 3
- 229930003347 taxol Natural products 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229960003753 Nitric Oxide Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (21)
- 心臓弁に治療薬を送達するためのデバイスであって、
先端および長手方向軸線を有する長尺状の本体と、
長尺状の本体に接続された複数の送達部材であって、各部材は第１端、中間部分および第２端を有し、少なくとも１つの送達部材の第１端および第２端は、長尺状の本体の先端より基端側の位置で長尺状の本体に接続されている送達部材とを含んでなり、
前記少なくとも１つの送達部材の中間部分は、長尺状の本体に接続されていないことと、
前記複数の送達部材が展開された状態にあるとき、長尺状の本体の長手方向軸線に対して直交する断面において、複数の送達部材の群の直径は０．５ｃｍ〜２．５ｃｍであることとを特徴とする、デバイス。 - 本体はルーメンを有するものとしてさらに規定される、請求項１に記載のデバイス。
- 少なくとも１つの送達部材がルーメンを有する、請求項２に記載のデバイス。
- 送達部材はそれぞれルーメンおよび該ルーメンと連通している１以上の開口部を有し、液体が１以上の開口部を通してその送達部材から流出できるようになっている、請求項３に記載のデバイス。
- ２〜５００個の送達部材を含んでなる、請求項１に記載のデバイス。
- 全ての送達部材の第１端および第２端が本体に接続されており、さらに全ての送達部材の中間部分が本体に接続されていない、請求項１に記載のデバイス。
- 少なくとも１つの送達部材の少なくとも一部が治療薬でコーティングされている、請求項１に記載のデバイス。
- 治療薬は、ラパマイシン、パクリタキセル、シロリムス、酸化窒素を増強する薬剤、スタチン、アンジオテンシン変換酵素（ＡＣＥ）阻害剤、ＰＰＡＲアゴニスト、抗炎症剤、狭窄抑制物質、抗生物質、アトルバスタチン、およびキナプリルのいずれかである、請求項７に記載のデバイス。
- 各送達部材は長さが１ｃｍ〜２０ｃｍである、請求項１に記載のデバイス。
- 前記長尺状の本体の先端と、前記少なくとも１つの送達部材が長尺状の本体に接続される最も先端側の位置との間の距離は、１ｃｍ〜１５ｃｍである、請求項９に記載のデバイス。
- 複数の送達部材および長尺状の本体を含む治療薬送達カテーテルであって、各送達部材は長尺状の本体に接続された部分と、長尺状の本体の一部に並列して配置されるが長尺状の本体に接続されていない部分とを有する、カテーテル。
- 少なくとも１つの送達部材が少なくとも部分的に治療薬でコーティングされている、請求項１１に記載のカテーテル。
- 治療薬は、ラパマイシン、パクリタキセル、シロリムス、酸化窒素を増強する薬剤、スタチン、アンジオテンシン変換酵素（ＡＣＥ）阻害剤、ＰＰＡＲアゴニスト、抗炎症剤、狭窄抑制物質、抗生物質、アトルバスタチン、およびキナプリルのいずれかである、請求項１２に記載のカテーテル。
- 少なくとも１つの送達部材は１以上の開口部を備えたルーメンを有し、該開口部はそのルーメンとの連通を提供して、液体が１以上の開口部を通してその送達部材から流出できるようになっている、請求項１１に記載のカテーテル。
- 少なくとも１つの送達部材が少なくとも部分的に治療薬でコーティングされている、請求項１４に記載のカテーテル。
- 治療薬は、ラパマイシン、パクリタキセル、シロリムス、酸化窒素を増強する薬剤、スタチン、アンジオテンシン変換酵素（ＡＣＥ）阻害剤、ＰＰＡＲアゴニスト、抗炎症剤、狭窄抑制物質、抗生物質、アトルバスタチン、およびキナプリルのいずれかである、請求項１５に記載のカテーテル。
- 各送達部材は長さが１ｃｍ〜２０ｃｍである、請求項１１に記載のカテーテル。
- カテーテルの先端と、各送達部材が長尺状の本体に接続される位置との間の距離は、１ｃｍ〜１５ｃｍである、請求項１７に記載のカテーテル。
- 心臓弁に治療薬を送達するためのデバイスであって、
先端を有する本体と、本体の一部に沿って長手方向の向きに配置され、本体の先端から１ｍｍを上回る距離に位置付けられた先端を有する、治療薬でコーティングされているフィンと、を含んでなるデバイス。 - 心臓弁に治療薬を送達するためのデバイスであって、
先端を有する本体と、
本体に接続された、複数のナノフィラメントを有する拡張可能なバルーンであって、本体の先端から１ｍｍを上回る距離に位置付けられているバルーンと
を含んでなるデバイス。 - 心臓弁に治療薬を送達するためのデバイスであって、
先端を有する本体と、
本体に接続された、連通を提供するための複数の開口部を有する拡張可能なバルーンであって、流体が１以上の開口部を通してバルーンから流出できるようになっており、本体の先端から１ｍｍを上回る距離に位置付けられているバルーンと
を含んでなるデバイス。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97046407P | 2007-09-06 | 2007-09-06 | |
| PCT/US2008/075408 WO2009033026A1 (en) | 2007-09-06 | 2008-09-05 | Methods and devices for local therapeutic agent delivery to heart valves |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010537788A JP2010537788A (ja) | 2010-12-09 |
| JP2010537788A5 true JP2010537788A5 (ja) | 2012-05-24 |
Family
ID=39945598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524185A Pending JP2010537788A (ja) | 2007-09-06 | 2008-09-05 | 心臓弁へ治療薬を局所送達するための方法およびデバイス |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8556880B2 (ja) |
| EP (1) | EP2195071A1 (ja) |
| JP (1) | JP2010537788A (ja) |
| CN (1) | CN101883605A (ja) |
| CA (1) | CA2698273A1 (ja) |
| WO (1) | WO2009033026A1 (ja) |
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-
2008
- 2008-09-05 CN CN2008801156274A patent/CN101883605A/zh active Pending
- 2008-09-05 US US12/205,341 patent/US8556880B2/en not_active Expired - Fee Related
- 2008-09-05 WO PCT/US2008/075408 patent/WO2009033026A1/en active Application Filing
- 2008-09-05 CA CA2698273A patent/CA2698273A1/en not_active Abandoned
- 2008-09-05 JP JP2010524185A patent/JP2010537788A/ja active Pending
- 2008-09-05 EP EP08829666A patent/EP2195071A1/en not_active Withdrawn
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