JP2010536854A - 肺ガンの治療 - Google Patents
肺ガンの治療 Download PDFInfo
- Publication number
- JP2010536854A JP2010536854A JP2010521876A JP2010521876A JP2010536854A JP 2010536854 A JP2010536854 A JP 2010536854A JP 2010521876 A JP2010521876 A JP 2010521876A JP 2010521876 A JP2010521876 A JP 2010521876A JP 2010536854 A JP2010536854 A JP 2010536854A
- Authority
- JP
- Japan
- Prior art keywords
- scv
- group
- compound
- administered
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000020816 lung neoplasm Diseases 0.000 title claims abstract description 49
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims abstract description 48
- 201000005202 lung cancer Diseases 0.000 title claims abstract description 48
- 238000011282 treatment Methods 0.000 title claims description 67
- 150000001875 compounds Chemical class 0.000 claims abstract description 42
- CATMPQFFVNKDEY-YPMHNXCESA-N Golotimod Chemical compound C1=CC=C2C(C[C@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)=CNC2=C1 CATMPQFFVNKDEY-YPMHNXCESA-N 0.000 claims description 162
- 108010049353 golotimod Proteins 0.000 claims description 162
- 206010028980 Neoplasm Diseases 0.000 claims description 131
- 230000037396 body weight Effects 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 35
- 230000005855 radiation Effects 0.000 claims description 33
- 210000004072 lung Anatomy 0.000 claims description 25
- 206010027476 Metastases Diseases 0.000 claims description 23
- 201000011510 cancer Diseases 0.000 claims description 23
- 230000009401 metastasis Effects 0.000 claims description 23
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 22
- 229960004316 cisplatin Drugs 0.000 claims description 19
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims description 15
- 230000012010 growth Effects 0.000 claims description 11
- -1 heterocyclic amino acid Chemical group 0.000 claims description 7
- 239000002955 immunomodulating agent Substances 0.000 claims description 7
- 229940121354 immunomodulator Drugs 0.000 claims description 7
- 230000002584 immunomodulator Effects 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-Tryptophan Natural products C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 108010033276 Peptide Fragments Chemical group 0.000 claims description 3
- 102000007079 Peptide Fragments Human genes 0.000 claims description 3
- 150000001412 amines Chemical group 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 229960004799 tryptophan Drugs 0.000 claims description 3
- 229930182827 D-tryptophan Chemical group 0.000 claims description 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims description 2
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims description 2
- 238000011269 treatment regimen Methods 0.000 claims description 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 82
- 241001465754 Metazoa Species 0.000 description 79
- 238000002512 chemotherapy Methods 0.000 description 46
- 230000004614 tumor growth Effects 0.000 description 37
- 230000005764 inhibitory process Effects 0.000 description 34
- 239000003814 drug Substances 0.000 description 28
- 241000699670 Mus sp. Species 0.000 description 26
- 229940079593 drug Drugs 0.000 description 26
- 241000699666 Mus <mouse, genus> Species 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 17
- 239000002953 phosphate buffered saline Substances 0.000 description 17
- 239000013641 positive control Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 231100000433 cytotoxic Toxicity 0.000 description 13
- 230000001472 cytotoxic effect Effects 0.000 description 13
- 239000011550 stock solution Substances 0.000 description 12
- 238000003556 assay Methods 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 11
- 230000001629 suppression Effects 0.000 description 11
- 210000004881 tumor cell Anatomy 0.000 description 11
- 239000007924 injection Substances 0.000 description 10
- 238000002347 injection Methods 0.000 description 10
- 230000000259 anti-tumor effect Effects 0.000 description 9
- 238000001802 infusion Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 7
- 238000011284 combination treatment Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 230000034994 death Effects 0.000 description 6
- 231100000517 death Toxicity 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000012091 fetal bovine serum Substances 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- 238000009097 single-agent therapy Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000004584 weight gain Effects 0.000 description 6
- 235000019786 weight gain Nutrition 0.000 description 6
- 230000004580 weight loss Effects 0.000 description 6
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 5
- 230000006978 adaptation Effects 0.000 description 5
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 238000009395 breeding Methods 0.000 description 5
- 230000001488 breeding effect Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 229960005322 streptomycin Drugs 0.000 description 5
- 238000007920 subcutaneous administration Methods 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 229930182555 Penicillin Natural products 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 230000010261 cell growth Effects 0.000 description 4
- 229940127089 cytotoxic agent Drugs 0.000 description 4
- 230000003013 cytotoxicity Effects 0.000 description 4
- 231100000135 cytotoxicity Toxicity 0.000 description 4
- 210000003494 hepatocyte Anatomy 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 4
- 229940049954 penicillin Drugs 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 4
- 230000005760 tumorsuppression Effects 0.000 description 4
- 206010003497 Asphyxia Diseases 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 231100000002 MTT assay Toxicity 0.000 description 3
- 238000000134 MTT assay Methods 0.000 description 3
- 239000012980 RPMI-1640 medium Substances 0.000 description 3
- 241000283984 Rodentia Species 0.000 description 3
- 206010041067 Small cell lung cancer Diseases 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 238000000692 Student's t-test Methods 0.000 description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 230000000816 effect on animals Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000004393 prognosis Methods 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010062580 Concanavalin A Proteins 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 206010015548 Euthanasia Diseases 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 238000003975 animal breeding Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 244000144993 groups of animals Species 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 238000001543 one-way ANOVA Methods 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 description 1
- 206010058354 Bronchioloalveolar carcinoma Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 206010023774 Large cell lung cancer Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 240000005338 Melastoma malabathricum Species 0.000 description 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 101710188315 Protein X Chemical group 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 206010042658 Sweat gland tumour Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 208000002517 adenoid cystic carcinoma Diseases 0.000 description 1
- 208000018234 adnexal spiradenoma/cylindroma of a sweat gland Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
- 125000003164 beta-aspartyl group Chemical group 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 208000002458 carcinoid tumor Diseases 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 125000002642 gamma-glutamyl group Chemical group 0.000 description 1
- 108010054509 gamma-glutamyltryptophan Proteins 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005934 immune activation Effects 0.000 description 1
- 229940124622 immune-modulator drug Drugs 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 208000003849 large cell carcinoma Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 208000016992 lung adenocarcinoma in situ Diseases 0.000 description 1
- 201000009546 lung large cell carcinoma Diseases 0.000 description 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 230000017095 negative regulation of cell growth Effects 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 230000000720 neurosecretory effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 208000012111 paraneoplastic syndrome Diseases 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000004537 potential cytotoxicity Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229910052704 radon Inorganic materials 0.000 description 1
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000000649 small cell carcinoma Diseases 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95753007P | 2007-08-23 | 2007-08-23 | |
| PCT/US2008/009932 WO2009025830A1 (en) | 2007-08-23 | 2008-08-21 | Treatment of lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010536854A true JP2010536854A (ja) | 2010-12-02 |
| JP2010536854A5 JP2010536854A5 (cg-RX-API-DMAC7.html) | 2011-09-29 |
Family
ID=40378469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521876A Pending JP2010536854A (ja) | 2007-08-23 | 2008-08-21 | 肺ガンの治療 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110189305A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2192835A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010536854A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100063078A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101842009A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008289522A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0815772A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2697261A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201070295A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010002046A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ584065A (cg-RX-API-DMAC7.html) |
| UA (1) | UA98508C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009025830A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201001876B (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090119897A (ko) | 2007-02-13 | 2009-11-20 | 사이클론 파아머슈티컬 인코오퍼레이티드 | 점막의 질환으로 인한 조직 악화, 상처 또는 손상을 치료 또는 예방하는 방법 |
| RU2519738C2 (ru) * | 2011-12-12 | 2014-06-20 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации | Способ лечения рака легкого |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11504943A (ja) * | 1995-10-03 | 1999-05-11 | サイトラン，リミテッド | 血管静止性ジペプチド薬学的組成物およびその使用方法 |
| EP1020179A2 (en) * | 1997-07-04 | 2000-07-19 | Vladimir Evgenievich Nebolsin | Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition |
| JP2001527065A (ja) * | 1997-12-25 | 2001-12-25 | ティー． ウェイ，エドワード | 免疫調節化合物を含有するγ−グルタミルおよびβ−アスパルチルおよびそれを用いた方法 |
| JP2004537579A (ja) * | 2001-06-08 | 2004-12-16 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 免疫調節化合物を用いる結核の処置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744452A (en) * | 1995-11-28 | 1998-04-28 | Edward T. Wei | γ-L-glutamyl containing immunomodulator compounds and methods therewith |
-
2008
- 2008-08-21 NZ NZ584065A patent/NZ584065A/en not_active IP Right Cessation
- 2008-08-21 WO PCT/US2008/009932 patent/WO2009025830A1/en not_active Ceased
- 2008-08-21 AU AU2008289522A patent/AU2008289522A1/en not_active Abandoned
- 2008-08-21 US US12/674,646 patent/US20110189305A1/en not_active Abandoned
- 2008-08-21 CA CA2697261A patent/CA2697261A1/en not_active Abandoned
- 2008-08-21 EP EP08795475A patent/EP2192835A4/en not_active Withdrawn
- 2008-08-21 EA EA201070295A patent/EA201070295A1/ru unknown
- 2008-08-21 UA UAA201003197A patent/UA98508C2/ru unknown
- 2008-08-21 KR KR1020107006244A patent/KR20100063078A/ko not_active Withdrawn
- 2008-08-21 JP JP2010521876A patent/JP2010536854A/ja active Pending
- 2008-08-21 MX MX2010002046A patent/MX2010002046A/es not_active Application Discontinuation
- 2008-08-21 BR BRPI0815772-3A2A patent/BRPI0815772A2/pt not_active IP Right Cessation
- 2008-08-21 CN CN200880112940A patent/CN101842009A/zh active Pending
-
2010
- 2010-03-16 ZA ZA2010/01876A patent/ZA201001876B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11504943A (ja) * | 1995-10-03 | 1999-05-11 | サイトラン，リミテッド | 血管静止性ジペプチド薬学的組成物およびその使用方法 |
| EP1020179A2 (en) * | 1997-07-04 | 2000-07-19 | Vladimir Evgenievich Nebolsin | Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition |
| JP2001527065A (ja) * | 1997-12-25 | 2001-12-25 | ティー． ウェイ，エドワード | 免疫調節化合物を含有するγ−グルタミルおよびβ−アスパルチルおよびそれを用いた方法 |
| JP2004537579A (ja) * | 2001-06-08 | 2004-12-16 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 免疫調節化合物を用いる結核の処置 |
Non-Patent Citations (4)
| Title |
|---|
| BULL EXP BIOL MED., VOL.141 NO.2, P.250-253 (2006), JPN6013014924, ISSN: 0002493917 * |
| CANCER RES., VOL.49, P.4098-4102 (1989), JPN6013014921, ISSN: 0002493915 * |
| DRUGS FUTURE., VOL.29 NO.10, P.985-991 (2004), JPN6013014919, ISSN: 0002493914 * |
| INT J CANCER., VOL.106 P.528-533 (2003), JPN6013014923, ISSN: 0002493916 * |
Also Published As
| Publication number | Publication date |
|---|---|
| UA98508C2 (ru) | 2012-05-25 |
| EP2192835A1 (en) | 2010-06-09 |
| ZA201001876B (en) | 2010-11-24 |
| NZ584065A (en) | 2012-03-30 |
| WO2009025830A1 (en) | 2009-02-26 |
| US20110189305A1 (en) | 2011-08-04 |
| MX2010002046A (es) | 2010-05-03 |
| CA2697261A1 (en) | 2009-02-26 |
| CN101842009A (zh) | 2010-09-22 |
| AU2008289522A1 (en) | 2009-02-26 |
| BRPI0815772A2 (pt) | 2014-09-30 |
| EA201070295A1 (ru) | 2010-10-29 |
| KR20100063078A (ko) | 2010-06-10 |
| EP2192835A4 (en) | 2010-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6918724B2 (ja) | 急性骨髄性白血病（ａｍｌ）のための新規併用治療 | |
| JP2018513185A (ja) | 共結晶組成物及びその医薬用途 | |
| Grem et al. | Toxicity of levamisole and 5-fluorouracil in human colon carcinoma cells | |
| JP2010536854A (ja) | 肺ガンの治療 | |
| AU2002311601C1 (en) | Non-myeloablative tolerogenic treatment with tyrphostins | |
| Baciu et al. | Hypothalamic mechanisms of immunity | |
| US8163702B2 (en) | Treatment of melanoma | |
| US7906486B2 (en) | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa | |
| JP4927530B2 (ja) | エポシロン誘導体および照射による増殖性疾患の処置 | |
| WO2014191989A1 (en) | Conjugate of a taxane and biotin and uses thereof | |
| NZ580463A (en) | Methods for treating cancer with combination of clofarabine and radiation | |
| US10702534B2 (en) | Compositions and methods relating to the radioprotective effects of apilimod | |
| Parthasarathy et al. | EXTH-15. MULTI-FACETED INHIBITION OF TET PATHWAY WITH CELL-PERMEABLE 2HG AND BOBCAT 339 REDUCES PROLIFERATION AND INDUCES APOPTOSIS IN DIPG | |
| Haddad et al. | EXTH-13. LOCAL DELIVERY OF AN IL-15 SUPERAGONIST USING A REPLICATING RETROVIRUS SIGNIFICANTLY IMPROVES SURVIVAL AND LYMPHOCYTE INFILTRATION IN POORLY IMMUNOGENIC MURINE GLIOBLASTOMA MODELS | |
| US20100267637A1 (en) | Treatment of melanoma with alpha thymosin peptides in combination with a kinase inhibitor | |
| AU2023385809A1 (en) | Combination therapies comprising KRAS inhibitors and SHP2 inhibitors | |
| CN120459104A (zh) | 极光激酶b抑制剂用于制备治疗脑干胶质瘤的药物的用途 | |
| EA042139B1 (ru) | Фармацевтические композиции и способы лечения рака | |
| HK1222808B (zh) | 急性骨髓性白血病(aml)的新型组合治疗 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110812 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110812 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130402 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130910 |