JP2010536787A - Ｔｏｌｌ様受容体モジュレータ - Google Patents

Ｔｏｌｌ様受容体モジュレータ Download PDF

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Publication number
JP2010536787A
JP2010536787A JP2010521194A JP2010521194A JP2010536787A JP 2010536787 A JP2010536787 A JP 2010536787A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010521194 A JP2010521194 A JP 2010521194A JP 2010536787 A JP2010536787 A JP 2010536787A
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Japan
Prior art keywords
disease
nucleotide
tlr9
tlr
disorder
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JP2010521194A
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English (en)
Japanese (ja)
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JP2010536787A5 (OSRAM
Inventor
カンディマラ，エカンバー，アール．
バガット，ラクシュミ
プッタ，マリカージュナ
ワン，ダキン
アグラワル，サディール
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Aceragen Inc
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Idera Pharmaceuticals Inc
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Publication of JP2010536787A publication Critical patent/JP2010536787A/ja
Publication of JP2010536787A5 publication Critical patent/JP2010536787A5/ja
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
JP2010521194A 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ Withdrawn JP2010536787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95589507P 2007-08-15 2007-08-15
PCT/US2008/073280 WO2009023819A2 (en) 2007-08-15 2008-08-15 Toll like receptor modulators

Publications (2)

Publication Number Publication Date
JP2010536787A true JP2010536787A (ja) 2010-12-02
JP2010536787A5 JP2010536787A5 (OSRAM) 2011-09-29

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JP2010521194A Withdrawn JP2010536787A (ja) 2007-08-15 2008-08-15 Ｔｏｌｌ様受容体モジュレータ

Country Status (9)

Country Link
US (1) US8853375B2 (OSRAM)
EP (1) EP2179061B1 (OSRAM)
JP (1) JP2010536787A (OSRAM)
KR (1) KR20100066512A (OSRAM)
CN (1) CN101821412A (OSRAM)
AU (1) AU2008286735A1 (OSRAM)
CA (1) CA2694973A1 (OSRAM)
MX (1) MX2010001785A (OSRAM)
WO (1) WO2009023819A2 (OSRAM)

Cited By (4)

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JP2013507905A (ja) * 2009-08-27 2013-03-07 イデラ ファーマシューティカルズ インコーポレイテッド 遺伝子発現を阻害する組成物およびその使用
JP2014527819A (ja) * 2011-09-14 2014-10-23 ラナ セラピューティクス インコーポレイテッド 多量体オリゴヌクレオチド化合物
JP2016510213A (ja) * 2013-01-08 2016-04-07 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
US9790494B2 (en) 2012-09-14 2017-10-17 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers

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EP2341059A1 (en) 2005-10-12 2011-07-06 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
JP2010522697A (ja) * 2007-03-16 2010-07-08 ユニバーシティ オブ フロリダ リサーチ ファウンデーション キナーゼタンパク質結合阻害剤
JP2012505221A (ja) * 2008-10-06 2012-03-01 イデラ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
MX2011008067A (es) * 2009-01-30 2011-08-17 Idera Pharmaceuticals Inc Novedosos agonistas sinteticos del receptor 9 tipo toll.
EP2411521B1 (en) 2009-03-25 2015-01-14 The Board of Regents of The University of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
IN2012DN00720A (OSRAM) 2009-07-06 2015-06-19 Ontorii Inc
EP2451974A2 (en) * 2009-07-08 2012-05-16 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
TR201809739T4 (tr) * 2009-07-16 2018-07-23 Mallinckrodt Llc Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları.
WO2011041311A2 (en) * 2009-09-29 2011-04-07 Yale University Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods
JP2011084517A (ja) * 2009-10-15 2011-04-28 Koreaki Taniguchi 核酸により活性化される自然免疫応答の抑制剤及びスクリーニング方法
US20130079505A1 (en) * 2010-03-24 2013-03-28 Mirrx Therapeutics A/S Bivalent antisense oligonucleotides
EP2593095B1 (en) 2010-07-16 2019-03-27 Mallinckrodt LLC (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
CA2811501C (en) 2010-09-17 2017-01-10 Tadatsugu Taniguchi Inhibitor of hmgb protein-mediated immune response activation, and screening method
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
EP3213770B1 (en) 2010-11-19 2021-02-24 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
GB201022049D0 (en) * 2010-12-29 2011-02-02 Imp Innovations Ltd Methods
US8877722B2 (en) 2011-03-25 2014-11-04 Idera Pharmaceuticals, Inc. Compositions for inhibiting gene expression and uses thereof
EP2709642A4 (en) * 2011-05-16 2015-08-26 Haus Bioceuticals Inc THERAPEUTIC COMPOSITIONS OF CERTAIN HERBAL FORMULATIONS AND USES THEREOF
MX347361B (es) 2011-07-19 2017-04-12 Wave Life Sciences Ltd Metodos para la sintesis de acidos nucleicos funcionalizados.
EP2872147B1 (en) 2012-07-13 2022-12-21 Wave Life Sciences Ltd. Method for making chiral oligonucleotides
AU2013287630B2 (en) * 2012-07-13 2017-05-25 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
EP2872485B1 (en) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
CN103845730B (zh) * 2012-12-05 2015-12-09 复旦大学 抗st2/il-1 r4抗体在制备镇痛药物中的用途
CN103845731B (zh) * 2012-12-05 2015-12-02 复旦大学 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用
US20140234377A1 (en) * 2013-02-05 2014-08-21 Nitto Denko Corporation Vaccine composition for mucosal administration
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