JP2010535814A5 - - Google Patents

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Publication number
JP2010535814A5
JP2010535814A5 JP2010520325A JP2010520325A JP2010535814A5 JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5 JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5
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JP
Japan
Prior art keywords
motomeko
opiate
active ingredient
side effects
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010520325A
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English (en)
Japanese (ja)
Other versions
JP5581211B2 (ja
JP2010535814A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/072632 external-priority patent/WO2009023567A1/en
Publication of JP2010535814A publication Critical patent/JP2010535814A/ja
Publication of JP2010535814A5 publication Critical patent/JP2010535814A5/ja
Application granted granted Critical
Publication of JP5581211B2 publication Critical patent/JP5581211B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010520325A 2007-08-09 2008-08-08 第四級オピオイドカルボキサミド Active JP5581211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95496007P 2007-08-09 2007-08-09
US60/954,960 2007-08-09
PCT/US2008/072632 WO2009023567A1 (en) 2007-08-09 2008-08-08 Quaternary opioid carboxamides

Publications (3)

Publication Number Publication Date
JP2010535814A JP2010535814A (ja) 2010-11-25
JP2010535814A5 true JP2010535814A5 (cg-RX-API-DMAC7.html) 2011-09-22
JP5581211B2 JP5581211B2 (ja) 2014-08-27

Family

ID=39941437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010520325A Active JP5581211B2 (ja) 2007-08-09 2008-08-08 第四級オピオイドカルボキサミド

Country Status (14)

Country Link
US (4) US8263807B2 (cg-RX-API-DMAC7.html)
EP (1) EP2190819B1 (cg-RX-API-DMAC7.html)
JP (1) JP5581211B2 (cg-RX-API-DMAC7.html)
KR (1) KR101519682B1 (cg-RX-API-DMAC7.html)
CN (1) CN101827819B (cg-RX-API-DMAC7.html)
AU (1) AU2008286979B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0815020A2 (cg-RX-API-DMAC7.html)
CA (1) CA2694497C (cg-RX-API-DMAC7.html)
EA (1) EA020658B1 (cg-RX-API-DMAC7.html)
ES (1) ES2586245T3 (cg-RX-API-DMAC7.html)
IL (1) IL203459A (cg-RX-API-DMAC7.html)
MX (1) MX2010001371A (cg-RX-API-DMAC7.html)
NO (1) NO341089B1 (cg-RX-API-DMAC7.html)
WO (1) WO2009023567A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

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US8426594B2 (en) * 2007-11-30 2013-04-23 Purdue Pharma L.P. Benzomorphan compounds
AU2009342654B2 (en) * 2009-03-19 2013-09-05 Alkermes Pharma Ireland Limited Morphinan derivatives with high oral bioavailability
WO2011068594A1 (en) * 2009-12-04 2011-06-09 Alkermes, Inc. Morphinan derivatives for the treatment of drug overdose
US8436175B2 (en) 2010-03-22 2013-05-07 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
EP2590649B1 (en) * 2010-07-08 2018-11-28 Alkermes Pharma Ireland Limited Process for the synthesis of substituted morphinans
EP2407469A1 (en) * 2010-07-13 2012-01-18 Chemo Ibérica, S.A. Salt of sitagliptin
RS65091B1 (sr) 2010-08-23 2024-02-29 Alkermes Pharma Ireland Ltd Postupci za lečenje povećanja telesne težine indukovanog antipsihoticima
CA2826154A1 (en) * 2011-02-14 2012-08-23 Alkermes, Inc. Peripherially acting .mu. opioid antagonists
JP2014510071A (ja) * 2011-03-03 2014-04-24 カディラ・ヘルスケア・リミテッド Ｄｐｐ−ｉｖ阻害剤の新規な塩
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2725908B1 (en) * 2011-06-29 2017-05-31 Alkermes, Inc. Peripherally acting opioid compounds
AU2012324012A1 (en) * 2011-12-08 2013-06-27 Purdue Pharma L.P. Quaternized buprenorphine analogs
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
TR201815154T4 (tr) 2011-12-15 2018-11-21 Alkermes Pharma Ireland Ltd Depresi̇f bozukluklarin tedavi̇si̇ne yöneli̇k buprenorfi̇n i̇le kombi̇nasyon hali̇nde sami̇dorfan (alks 33).
US20140066475A1 (en) 2012-09-04 2014-03-06 Euro-Celtique S.A. Method For Treating Pruritus
WO2014190271A2 (en) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limted Methods for treating depressive symptoms
AU2014268361B2 (en) * 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US20160243112A1 (en) * 2015-02-25 2016-08-25 Alkermes, Inc. Treatments for alzheimer's related diseases and disorders
TW202140009A (zh) * 2020-02-13 2021-11-01 大陸商上海翰森生物醫藥科技有限公司 ３－甲醯胺基－４－羥基納曲酮氘代衍生物、其製備方法及其在醫藥上的應用
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
CN115521317B (zh) * 2021-02-02 2025-07-25 山东新时代药业有限公司 一种制备纳呋拉啡中间体的方法
WO2025104754A1 (en) * 2023-11-17 2025-05-22 Msn Laboratories Private Limited, R&D Center A process for the preparation of samidorphan and its intermediates
CN118598813B (zh) * 2024-08-08 2024-10-29 山东齐都药业有限公司 L-苹果酸萨米多芬及其制备方法

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ES252980A1 (es) * 1958-10-30 1960-11-01 Boehringer Sohn Ingelheim Procedimiento para la obtencion de nuevas sales cuaternarias, terapéuticamente valiosas, de la normorfina y de sus derivados
DE2254298A1 (de) * 1972-11-06 1974-05-16 Boehringer Sohn Ingelheim Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
US4032529A (en) * 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates
GB1511319A (en) * 1974-09-20 1978-05-17 Sterling Drug Inc 2,6-methane-3-benzazocine derivatives and their preparation
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
FR2514644A1 (fr) * 1981-10-19 1983-04-22 Sanofi Sa Composition pharmaceutique a action antagoniste peripherique des opiaces
CA1315689C (en) * 1987-09-03 1993-04-06 Leon I. Goldberg Quarternary derivatives of noroxymorphone which relieve nausea and emesis
NZ326331A (en) 1996-01-10 2000-01-28 Smithkline Beecham Spa Heterocycle-condensed morphinoid derivatives and medicaments
ES2121553B1 (es) * 1996-12-23 1999-06-16 Univ Santiago Compostela Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion.
WO2001014382A1 (en) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan
AU6934400A (en) * 1999-08-25 2001-03-19 Barrett R. Cooper Compositions and methods for treating opiate intolerance
JP2003528819A (ja) * 1999-11-29 2003-09-30 アドラー コーポレーション オピオイドおよびそのアンタゴニストに関する新規方法および組成物
DE60109960T2 (de) * 2000-10-31 2006-02-16 Rensselaer Polytechnic Institute 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
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WO2004043964A2 (en) * 2002-11-08 2004-05-27 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
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CA2600350C (en) 2005-03-07 2015-02-10 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
ES2480390T3 (es) 2005-07-21 2014-07-28 Rensselaer Polytechnic Institute 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents

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