JP2010535026A5 - - Google Patents
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- Publication number
- JP2010535026A5 JP2010535026A5 JP2010518815A JP2010518815A JP2010535026A5 JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5 JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- influenza
- peptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 101710154606 Hemagglutinin Proteins 0.000 claims 15
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 15
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 15
- 101710176177 Protein A56 Proteins 0.000 claims 15
- 239000000185 hemagglutinin Substances 0.000 claims 15
- 102000011931 Nucleoproteins Human genes 0.000 claims 11
- 108010061100 Nucleoproteins Proteins 0.000 claims 11
- 206010022000 influenza Diseases 0.000 claims 11
- 241000712461 unidentified influenza virus Species 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349807P | 2007-08-02 | 2007-08-02 | |
| US60/953,498 | 2007-08-02 | ||
| PCT/IL2008/001062 WO2009016639A2 (en) | 2007-08-02 | 2008-08-03 | Multimeric multiepitope influenza vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535026A JP2010535026A (ja) | 2010-11-18 |
| JP2010535026A5 true JP2010535026A5 (OSRAM) | 2011-09-15 |
| JP5654345B2 JP5654345B2 (ja) | 2015-01-14 |
Family
ID=40305020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518815A Expired - Fee Related JP5654345B2 (ja) | 2007-08-02 | 2008-08-03 | 多量体マルチエピトープインフルエンザワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8747861B2 (OSRAM) |
| EP (1) | EP2173376B1 (OSRAM) |
| JP (1) | JP5654345B2 (OSRAM) |
| KR (1) | KR101580660B1 (OSRAM) |
| CN (1) | CN101795709B (OSRAM) |
| AU (1) | AU2008281384C1 (OSRAM) |
| BR (1) | BRPI0815008B8 (OSRAM) |
| CA (1) | CA2695399C (OSRAM) |
| DK (1) | DK2173376T3 (OSRAM) |
| EA (1) | EA017887B1 (OSRAM) |
| ES (1) | ES2539818T3 (OSRAM) |
| HR (1) | HRP20150479T1 (OSRAM) |
| HU (1) | HUE025149T2 (OSRAM) |
| MX (1) | MX2010001284A (OSRAM) |
| PL (1) | PL2173376T3 (OSRAM) |
| PT (1) | PT2173376E (OSRAM) |
| WO (1) | WO2009016639A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008527009A (ja) | 2005-01-19 | 2008-07-24 | バクシネート コーポレーション | 病原体関連分子パターンおよび抗原を含む組成物ならびに免疫応答を刺激するためのそれらの使用 |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP3058954B1 (en) | 2007-08-27 | 2017-03-01 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| SG190562A1 (en) | 2008-04-18 | 2013-06-28 | Vaxinnate Corp | Deletion mutants of flagellin and methods of use |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| CN103118691B (zh) | 2010-08-23 | 2016-08-24 | 康干细胞生物科技有限公司 | 预防和治疗免疫病变和炎性疾病的包括用nod2激动剂处理的干细胞或其培养物的药物组合物 |
| WO2012115715A2 (en) * | 2011-02-21 | 2012-08-30 | Vaxinnate Corporation | Compositions with enhanced immunogenicity and/or reduced reactogenicity and methods of use |
| WO2012114323A1 (en) * | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| JP6113155B2 (ja) * | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すｈ１ｎ１インフルエンザの抗原 |
| WO2013037804A1 (en) * | 2011-09-12 | 2013-03-21 | Laboratorios Del Dr. Esteve, S.A. | Method for monitoring cytotoxic t lymphocyte (ctl) responses by a delayed-type hypersensitivity reaction using defined ctl viral epitopes |
| EP3494989B1 (en) * | 2012-01-26 | 2025-07-16 | Longhorn Vaccines and Diagnostics, LLC | Composite antigenic sequences and vaccines |
| JP2015514097A (ja) * | 2012-04-02 | 2015-05-18 | フォリア バイオテック インコーポレイテッド | 組換えパパイヤモザイクウイルスコートタンパク質およびインフルエンザワクチンにおけるその使用 |
| CN103055311B (zh) * | 2012-12-28 | 2014-05-21 | 中山大学 | 一种传染性喉气管炎粘膜疫苗及其制备方法和应用 |
| AU2014204826A1 (en) * | 2013-01-10 | 2015-07-09 | Seqirus UK Limited | Influenza virus immunogenic compositions and uses thereof |
| WO2015151103A1 (en) * | 2014-04-03 | 2015-10-08 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| US10291197B2 (en) * | 2016-02-03 | 2019-05-14 | Cg Discovery, Inc. | Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites and methods of use thereof |
| JP2019064924A (ja) * | 2016-02-24 | 2019-04-25 | Ａｇｃ株式会社 | インフルエンザワクチン |
| CN111148528A (zh) | 2016-12-28 | 2020-05-12 | 英福瓦克思公司 | 流感疫苗 |
| WO2019061297A1 (zh) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | 一种cd4辅助性t细胞表位融合肽及其疫苗 |
| JP7382634B2 (ja) * | 2017-12-21 | 2023-11-17 | 株式会社グリーンバイオメッド | 交差免疫抗原ワクチン及びその調製方法 |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| CN111315407B (zh) * | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| US20220273790A1 (en) * | 2019-06-18 | 2022-09-01 | Citranvi Biosciences, Llc | Rationally engineered carrier proteins for vaccines |
| US20240277831A1 (en) * | 2020-02-14 | 2024-08-22 | University Of Washington | Polypeptides, compositions, and their use to treat or limit development of an infection |
| US11149286B1 (en) * | 2020-08-17 | 2021-10-19 | Mayo Foundation For Medical Education And Research | Adenovirus vectors and methods for using adenovirus vectors |
| US20230364261A1 (en) * | 2020-09-21 | 2023-11-16 | Sri International | Targeted antigen delivery system and uses thereof |
Family Cites Families (57)
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| US4767842A (en) * | 1973-05-07 | 1988-08-30 | The Ohio State University | Antigenic modification of polypeptides |
| IL61904A (en) * | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
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| US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
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| US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
| US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| GB9201139D0 (en) | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| IL101639A0 (en) | 1992-04-17 | 1992-12-30 | Yeda Res & Dev | Recombinant influenza vaccines |
| EP0761231B1 (en) * | 1992-06-25 | 2000-01-12 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| ES2170075T3 (es) * | 1992-09-16 | 2002-08-01 | Univ Tennessee Res Corp | Vacuna de proteina m recombinante multivalente. |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| ES2162139T5 (es) * | 1993-03-23 | 2008-05-16 | Smithkline Beecham Biologicals S.A. | Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado. |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| RS50101B (sr) | 1996-02-24 | 2009-01-22 | Boehringer Ingelheim International Gmbh., | Farmaceutski preparati za imunomodulaciju |
| US7063967B2 (en) * | 1997-05-08 | 2006-06-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
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| US6355257B1 (en) * | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) * | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| DE69828507T2 (de) * | 1997-05-20 | 2006-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene-saponin analoga mit adjuvans und immunostimulierender wirkung |
| ES2255181T3 (es) | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
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| JP2002523430A (ja) * | 1998-08-21 | 2002-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 熱帯熱マラリア原虫に対する組換え多価マラリアワクチン |
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| JP2003509465A (ja) | 1999-07-19 | 2003-03-11 | エピミューン， インコーポレイテッド | ペプチドおよび核酸組成物を使用する、ｃ型肝炎ウイルスに対する細胞性免疫応答の誘導 |
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| JP2008527009A (ja) | 2005-01-19 | 2008-07-24 | バクシネート コーポレーション | 病原体関連分子パターンおよび抗原を含む組成物ならびに免疫応答を刺激するためのそれらの使用 |
| MX2007015105A (es) * | 2005-06-01 | 2008-03-18 | Variation Biotechnologies Inc | Formulacion de vacuna de influenza a base de peptido. |
| US7260958B2 (en) * | 2005-09-14 | 2007-08-28 | National Taipei University Technology | Electrohydrodynamic condenser device |
| WO2007052057A2 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adminstration routes for priming/boosting with influenza vaccines |
| WO2007066334A1 (en) * | 2005-12-06 | 2007-06-14 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved influenza vaccine |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| EP2069376A4 (en) * | 2006-07-21 | 2013-10-16 | Pharmexa Inc | INDUCTION OF CELLULAR IMMUNE RESPONSES TO INFLUENZA VIRUS BY COMPOSITIONS OF PEPTIDES AND NUCLEIC ACIDS |
| PE20090146A1 (es) * | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| JP2010536878A (ja) | 2007-08-21 | 2010-12-02 | ダイナバックス テクノロジーズ コーポレイション | インフルエンザタンパク質を製造および使用する組成物および方法 |
-
2008
- 2008-08-03 ES ES08789738.5T patent/ES2539818T3/es active Active
- 2008-08-03 EP EP08789738.5A patent/EP2173376B1/en active Active
- 2008-08-03 BR BRPI0815008A patent/BRPI0815008B8/pt not_active IP Right Cessation
- 2008-08-03 KR KR1020107003351A patent/KR101580660B1/ko not_active Expired - Fee Related
- 2008-08-03 CA CA2695399A patent/CA2695399C/en not_active Expired - Fee Related
- 2008-08-03 PT PT87897385T patent/PT2173376E/pt unknown
- 2008-08-03 PL PL08789738T patent/PL2173376T3/pl unknown
- 2008-08-03 HR HRP20150479TT patent/HRP20150479T1/hr unknown
- 2008-08-03 WO PCT/IL2008/001062 patent/WO2009016639A2/en not_active Ceased
- 2008-08-03 DK DK08789738.5T patent/DK2173376T3/en active
- 2008-08-03 US US12/671,617 patent/US8747861B2/en active Active
- 2008-08-03 AU AU2008281384A patent/AU2008281384C1/en not_active Ceased
- 2008-08-03 MX MX2010001284A patent/MX2010001284A/es active IP Right Grant
- 2008-08-03 HU HUE08789738A patent/HUE025149T2/hu unknown
- 2008-08-03 CN CN2008801015810A patent/CN101795709B/zh not_active Expired - Fee Related
- 2008-08-03 EA EA201070219A patent/EA017887B1/ru not_active IP Right Cessation
- 2008-08-03 JP JP2010518815A patent/JP5654345B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-28 US US14/263,359 patent/US9353159B2/en not_active Expired - Fee Related
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