JP2010535026A5 - - Google Patents
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- Publication number
- JP2010535026A5 JP2010535026A5 JP2010518815A JP2010518815A JP2010535026A5 JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5 JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010518815 A JP2010518815 A JP 2010518815A JP 2010535026 A5 JP2010535026 A5 JP 2010535026A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- influenza
- peptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 101710154606 Hemagglutinin Proteins 0.000 claims 15
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 15
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 15
- 101710176177 Protein A56 Proteins 0.000 claims 15
- 239000000185 hemagglutinin Substances 0.000 claims 15
- 102000011931 Nucleoproteins Human genes 0.000 claims 11
- 108010061100 Nucleoproteins Proteins 0.000 claims 11
- 206010022000 influenza Diseases 0.000 claims 11
- 241000712461 unidentified influenza virus Species 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349807P | 2007-08-02 | 2007-08-02 | |
| US60/953,498 | 2007-08-02 | ||
| PCT/IL2008/001062 WO2009016639A2 (en) | 2007-08-02 | 2008-08-03 | Multimeric multiepitope influenza vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535026A JP2010535026A (ja) | 2010-11-18 |
| JP2010535026A5 true JP2010535026A5 (OSRAM) | 2011-09-15 |
| JP5654345B2 JP5654345B2 (ja) | 2015-01-14 |
Family
ID=40305020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518815A Expired - Fee Related JP5654345B2 (ja) | 2007-08-02 | 2008-08-03 | 多量体マルチエピトープインフルエンザワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8747861B2 (OSRAM) |
| EP (1) | EP2173376B1 (OSRAM) |
| JP (1) | JP5654345B2 (OSRAM) |
| KR (1) | KR101580660B1 (OSRAM) |
| CN (1) | CN101795709B (OSRAM) |
| AU (1) | AU2008281384C1 (OSRAM) |
| BR (1) | BRPI0815008B8 (OSRAM) |
| CA (1) | CA2695399C (OSRAM) |
| DK (1) | DK2173376T3 (OSRAM) |
| EA (1) | EA017887B1 (OSRAM) |
| ES (1) | ES2539818T3 (OSRAM) |
| HR (1) | HRP20150479T1 (OSRAM) |
| HU (1) | HUE025149T2 (OSRAM) |
| MX (1) | MX2010001284A (OSRAM) |
| PL (1) | PL2173376T3 (OSRAM) |
| PT (1) | PT2173376E (OSRAM) |
| WO (1) | WO2009016639A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078657A2 (en) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| CA2697373C (en) | 2007-08-27 | 2019-05-21 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| SG190562A1 (en) | 2008-04-18 | 2013-06-28 | Vaxinnate Corp | Deletion mutants of flagellin and methods of use |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| CN105727250B (zh) | 2010-08-23 | 2023-11-07 | 康干细胞生物科技有限公司 | 预防和治疗免疫病变和炎性疾病的药物组合物 |
| EP2678361A4 (en) * | 2011-02-21 | 2015-06-03 | Vaxinnate Corp | COMPOSITIONS WITH IMPROVED IMMUNOGENICITY AND / OR REDUCED REACTIVITY AND METHOD OF USE THEREOF |
| WO2012114323A1 (en) * | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| CA2839995A1 (en) * | 2011-06-20 | 2012-12-27 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for h1n1 influenza |
| ES2490915B1 (es) * | 2011-09-12 | 2015-09-17 | Laboratorios Del Dr. Esteve, S.A. | Método para monitorizar las respuestas de linfocitos T citotóxicos (LTC) mediante una reacción de hipersensibilidad de tipo retardado usando epítopos de LTC definidos |
| CA3207612A1 (en) * | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| CN104395346A (zh) * | 2012-04-02 | 2015-03-04 | 弗利亚生物技术公司 | 重组木瓜花叶病毒外壳蛋白及其在流感疫苗中的应用 |
| CN103055311B (zh) * | 2012-12-28 | 2014-05-21 | 中山大学 | 一种传染性喉气管炎粘膜疫苗及其制备方法和应用 |
| JP2016506416A (ja) * | 2013-01-10 | 2016-03-03 | ノバルティス アーゲー | インフルエンザウイルス免疫原性組成物およびその使用 |
| EP3125931A4 (en) * | 2014-04-03 | 2017-09-20 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| JP7560938B2 (ja) * | 2016-02-03 | 2024-10-03 | シージー ディスカバリー インコーポレイテッド | 異種エピトープ及び／又は改変された成熟切断部位を有するインフルエンザヘマグルチニンの組成物 |
| JP2019064924A (ja) * | 2016-02-24 | 2019-04-25 | Ａｇｃ株式会社 | インフルエンザワクチン |
| US11111277B2 (en) | 2016-12-28 | 2021-09-07 | Invvax, Inc. | Influenza vaccines |
| WO2019061297A1 (zh) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | 一种cd4辅助性t细胞表位融合肽及其疫苗 |
| US11576962B2 (en) | 2017-12-21 | 2023-02-14 | Green Biomed, Inc. | Cross-immunizing antigen vaccine and method for preparation thereof |
| US11358984B2 (en) | 2018-08-27 | 2022-06-14 | Regeneran Pharmaceuticals, Inc. | Use of Raman spectroscopy in downstream purification |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| US20220273790A1 (en) * | 2019-06-18 | 2022-09-01 | Citranvi Biosciences, Llc | Rationally engineered carrier proteins for vaccines |
| EP4103230A1 (en) * | 2020-02-14 | 2022-12-21 | University of Washington | Polypeptides, compositions, and their use to treat or limit development of an infection |
| US11149286B1 (en) * | 2020-08-17 | 2021-10-19 | Mayo Foundation For Medical Education And Research | Adenovirus vectors and methods for using adenovirus vectors |
| EP4199907A4 (en) * | 2020-09-21 | 2024-10-09 | SRI International | Targeted antigen delivery system and uses thereof |
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| IL61904A (en) * | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
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| US4643992A (en) * | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
| US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
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| US5093318A (en) * | 1983-11-01 | 1992-03-03 | Scripps Clinic And Research Foundation | Immunostimulating guanosine derivatives and their pharmaceutical compositions |
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| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| GB9201139D0 (en) | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| IL101639A0 (en) | 1992-04-17 | 1992-12-30 | Yeda Res & Dev | Recombinant influenza vaccines |
| ES2108278T3 (es) * | 1992-06-25 | 1997-12-16 | Smithkline Beecham Biolog | Composicion de vacuna con coadyuvantes. |
| ES2170075T3 (es) * | 1992-09-16 | 2002-08-01 | Univ Tennessee Res Corp | Vacuna de proteina m recombinante multivalente. |
| US5683695A (en) * | 1993-02-10 | 1997-11-04 | United Biomedical, Inc. | Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains |
| EP0812593B8 (en) * | 1993-03-23 | 2010-11-10 | SmithKline Beecham Biologicals S.A. | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| DE69535036T3 (de) | 1994-07-15 | 2011-07-07 | The University of Iowa Research Foundation, IA | Immunomodulatorische oligonukleotide |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
| US6355257B1 (en) * | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
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| JP5132851B2 (ja) | 1997-08-05 | 2013-01-30 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 新しい免疫防御性インフルエンザ抗原及びそのワクチン接種への使用 |
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| WO2006078657A2 (en) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
| CN101227919B (zh) | 2005-06-01 | 2011-10-05 | 变异生物技术公司 | 基于肽的流感疫苗制剂 |
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| GB0613977D0 (en) * | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| WO2008039267A2 (en) * | 2006-07-21 | 2008-04-03 | Pharmexa Inc. | Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions |
| AR066405A1 (es) * | 2007-04-20 | 2009-08-19 | Glaxosmithkline Biolog Sa | Vacuna |
| CN101835487A (zh) | 2007-08-21 | 2010-09-15 | 戴纳瓦克斯技术公司 | 制备和使用流感蛋白质的组合物和方法 |
-
2008
- 2008-08-03 KR KR1020107003351A patent/KR101580660B1/ko not_active Expired - Fee Related
- 2008-08-03 HU HUE08789738A patent/HUE025149T2/hu unknown
- 2008-08-03 EP EP08789738.5A patent/EP2173376B1/en active Active
- 2008-08-03 DK DK08789738.5T patent/DK2173376T3/en active
- 2008-08-03 HR HRP20150479TT patent/HRP20150479T1/hr unknown
- 2008-08-03 PT PT87897385T patent/PT2173376E/pt unknown
- 2008-08-03 WO PCT/IL2008/001062 patent/WO2009016639A2/en not_active Ceased
- 2008-08-03 PL PL08789738T patent/PL2173376T3/pl unknown
- 2008-08-03 MX MX2010001284A patent/MX2010001284A/es active IP Right Grant
- 2008-08-03 US US12/671,617 patent/US8747861B2/en active Active
- 2008-08-03 EA EA201070219A patent/EA017887B1/ru not_active IP Right Cessation
- 2008-08-03 JP JP2010518815A patent/JP5654345B2/ja not_active Expired - Fee Related
- 2008-08-03 CN CN2008801015810A patent/CN101795709B/zh not_active Expired - Fee Related
- 2008-08-03 BR BRPI0815008A patent/BRPI0815008B8/pt not_active IP Right Cessation
- 2008-08-03 CA CA2695399A patent/CA2695399C/en not_active Expired - Fee Related
- 2008-08-03 AU AU2008281384A patent/AU2008281384C1/en not_active Ceased
- 2008-08-03 ES ES08789738.5T patent/ES2539818T3/es active Active
-
2014
- 2014-04-28 US US14/263,359 patent/US9353159B2/en not_active Expired - Fee Related
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