JP2010534061A - 組換えコレラ菌外毒素 - Google Patents
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- JP2010534061A JP2010534061A JP2010517023A JP2010517023A JP2010534061A JP 2010534061 A JP2010534061 A JP 2010534061A JP 2010517023 A JP2010517023 A JP 2010517023A JP 2010517023 A JP2010517023 A JP 2010517023A JP 2010534061 A JP2010534061 A JP 2010534061A
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- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| CN106478773A (zh) * | 2015-08-25 | 2017-03-08 | 三生国健药业（上海）股份有限公司 | 一种人工合成的新型信号肽 |
| JP2022506990A (ja) * | 2018-11-07 | 2022-01-17 | アプライド モレキュラー トランスポート インコーポレイテッド | トランスサイトーシスのための送達構築物および関連する方法 |
| JP2022512976A (ja) * | 2018-11-07 | 2022-02-07 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
| JP2022545643A (ja) * | 2019-08-13 | 2022-10-28 | キングス・カレッジ・ロンドン | Ｉｌ－１スーパーファミリーのサイトカインの空間時間的に制限された活性が武装化された免疫応答性細胞 |
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| AU2006275865B2 (en) * | 2005-07-29 | 2012-06-28 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH | Mutated Pseudomonas exotoxins with reduced antigenicity |
| US8993295B2 (en) * | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| WO2009149281A1 (en) * | 2008-06-04 | 2009-12-10 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Immunotoxins and uses thereof |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| EP2593469A4 (en) * | 2010-04-20 | 2015-07-15 | Whitehead Biomedical Inst | MODIFIED POLYPEPTIDES AND PROTEINS AND ITS APPLICATION |
| EP2616045B1 (en) | 2010-09-15 | 2017-10-25 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| EP2730289A1 (en) * | 2012-11-07 | 2014-05-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Novel immunoproteases |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
| PL3139965T3 (pl) | 2014-05-07 | 2022-01-31 | Applied Molecular Transport Inc. | Cząsteczki fuzyjne pochodzące z toksyny cholix do doustnego dostarczania ładunku biologicznie czynnego |
| WO2016146833A1 (en) * | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2016207324A1 (en) * | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)−diphthamide adp ribosyltransferase sensitivity and resistance |
| WO2017147542A2 (en) | 2016-02-26 | 2017-08-31 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP4082558B1 (en) | 2018-03-08 | 2023-08-23 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
| EP4380973A2 (en) | 2021-08-02 | 2024-06-12 | Yeda Research and Development Co. Ltd. | Anti-matrix metalloproteinase-14 antibodies for the treatment of cancer |
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| US4892827A (en) | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| US6051405A (en) * | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69131449T2 (de) | 1990-05-11 | 1999-11-25 | The United States Of America, Represented By The Secretary | Verbesserte exotoxine aus pseudomonas mit geringer toxität bei tieren und hoher zelltötender aktivität |
| US6099842A (en) | 1990-12-03 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin |
| GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| WO1993025690A1 (en) | 1992-06-18 | 1993-12-23 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant pseudomonas exotoxin with increased activity |
| US6426075B1 (en) | 1996-11-06 | 2002-07-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Protease-activatable pseudomonas exotoxin A-like proproteins |
| AU6769998A (en) | 1997-03-26 | 1998-10-20 | Board Of Regents, The University Of Texas System | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
| AU4057300A (en) | 1999-03-30 | 2000-10-16 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinacious compounds |
| EP1687016A4 (en) | 2003-11-25 | 2009-07-29 | Anjin Corp | GENETIC VARIANT OF DIPHTHERIC TOXIN |
| US7550426B2 (en) * | 2005-05-18 | 2009-06-23 | Ghc Research Development Corporation | Acetylated therapeutic procytotoxins |
| US8993295B2 (en) | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| WO2009149281A1 (en) * | 2008-06-04 | 2009-12-10 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Immunotoxins and uses thereof |
-
2008
- 2008-07-18 WO PCT/US2008/008786 patent/WO2009014650A2/en not_active Ceased
- 2008-07-18 US US12/669,712 patent/US8524241B2/en active Active
- 2008-07-18 JP JP2010517023A patent/JP2010534061A/ja not_active Withdrawn
- 2008-07-18 EP EP08794573.9A patent/EP2178559B1/en not_active Not-in-force
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106478773A (zh) * | 2015-08-25 | 2017-03-08 | 三生国健药业（上海）股份有限公司 | 一种人工合成的新型信号肽 |
| CN106478773B (zh) * | 2015-08-25 | 2021-09-14 | 三生国健药业（上海）股份有限公司 | 一种人工合成的新型信号肽 |
| JP2022506990A (ja) * | 2018-11-07 | 2022-01-17 | アプライド モレキュラー トランスポート インコーポレイテッド | トランスサイトーシスのための送達構築物および関連する方法 |
| JP2022512976A (ja) * | 2018-11-07 | 2022-02-07 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
| JP7487193B2 (ja) | 2018-11-07 | 2024-05-20 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
| JP7516369B2 (ja) | 2018-11-07 | 2024-07-16 | アプライド モレキュラー トランスポート インコーポレイテッド | トランスサイトーシスのための送達構築物および関連する方法 |
| JP2022545643A (ja) * | 2019-08-13 | 2022-10-28 | キングス・カレッジ・ロンドン | Ｉｌ－１スーパーファミリーのサイトカインの空間時間的に制限された活性が武装化された免疫応答性細胞 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2178559A2 (en) | 2010-04-28 |
| US8524241B2 (en) | 2013-09-03 |
| WO2009014650A2 (en) | 2009-01-29 |
| WO2009014650A3 (en) | 2009-03-12 |
| EP2178559B1 (en) | 2015-06-24 |
| US20100256070A1 (en) | 2010-10-07 |
| EP2178559A4 (en) | 2011-02-02 |
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