JP2010534061A5 - - Google Patents

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Publication number
JP2010534061A5
JP2010534061A5 JP2010517023A JP2010517023A JP2010534061A5 JP 2010534061 A5 JP2010534061 A5 JP 2010534061A5 JP 2010517023 A JP2010517023 A JP 2010517023A JP 2010517023 A JP2010517023 A JP 2010517023A JP 2010534061 A5 JP2010534061 A5 JP 2010534061A5
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JP
Japan
Prior art keywords
pharmaceutical composition
protein
protease
fusion protein
activation domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010517023A
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English (en)
Japanese (ja)
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JP2010534061A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/008786 external-priority patent/WO2009014650A2/en
Publication of JP2010534061A publication Critical patent/JP2010534061A/ja
Publication of JP2010534061A5 publication Critical patent/JP2010534061A5/ja
Withdrawn legal-status Critical Current

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JP2010517023A 2007-07-20 2008-07-18 組換えコレラ菌外毒素 Withdrawn JP2010534061A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96130807P 2007-07-20 2007-07-20
PCT/US2008/008786 WO2009014650A2 (en) 2007-07-20 2008-07-18 Recombinant vibrio cholerae exotoxins

Publications (2)

Publication Number Publication Date
JP2010534061A JP2010534061A (ja) 2010-11-04
JP2010534061A5 true JP2010534061A5 (https=) 2011-09-01

Family

ID=40282021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010517023A Withdrawn JP2010534061A (ja) 2007-07-20 2008-07-18 組換えコレラ菌外毒素

Country Status (4)

Country Link
US (1) US8524241B2 (https=)
EP (1) EP2178559B1 (https=)
JP (1) JP2010534061A (https=)
WO (1) WO2009014650A2 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006275865B2 (en) * 2005-07-29 2012-06-28 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH Mutated Pseudomonas exotoxins with reduced antigenicity
US8993295B2 (en) * 2006-07-20 2015-03-31 The General Hospital Corporation Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2009149281A1 (en) * 2008-06-04 2009-12-10 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Immunotoxins and uses thereof
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
EP2593469A4 (en) * 2010-04-20 2015-07-15 Whitehead Biomedical Inst MODIFIED POLYPEPTIDES AND PROTEINS AND ITS APPLICATION
EP2616045B1 (en) 2010-09-15 2017-10-25 Randall J. Mrsny Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
EP2730289A1 (en) * 2012-11-07 2014-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel immunoproteases
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
PL3139965T3 (pl) 2014-05-07 2022-01-31 Applied Molecular Transport Inc. Cząsteczki fuzyjne pochodzące z toksyny cholix do doustnego dostarczania ładunku biologicznie czynnego
WO2016146833A1 (en) * 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2016207324A1 (en) * 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Biomarkers for nad(+)−diphthamide adp ribosyltransferase sensitivity and resistance
CN106478773B (zh) * 2015-08-25 2021-09-14 三生国健药业（上海）股份有限公司 一种人工合成的新型信号肽
WO2017147542A2 (en) 2016-02-26 2017-08-31 Regeneron Pharmaceuticals, Inc. Optimized transglutaminase site-specific antibody conjugation
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP4082558B1 (en) 2018-03-08 2023-08-23 Applied Molecular Transport Inc. Toxin-derived delivery constructs for oral delivery
KR20210110294A (ko) * 2018-11-07 2021-09-07 어플라이드 몰레큘라 트랜스포트 인크. 통과세포외배출용 전달 구조체 및 관련 방법
SG11202104734YA (en) * 2018-11-07 2021-06-29 Applied Molecular Transport Inc Cholix-derived carriers for oral delivery of heterologous payload
EP4013857A1 (en) * 2019-08-13 2022-06-22 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily
CN114599665A (zh) 2019-08-16 2022-06-07 应用分子转运公司 组合物、制剂及白细胞介素产生和纯化
EP4380973A2 (en) 2021-08-02 2024-06-12 Yeda Research and Development Co. Ltd. Anti-matrix metalloproteinase-14 antibodies for the treatment of cancer

Family Cites Families (14)

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US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US6051405A (en) * 1986-09-24 2000-04-18 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Constructs encoding recombinant antibody-toxin fusion proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE69131449T2 (de) 1990-05-11 1999-11-25 The United States Of America, Represented By The Secretary Verbesserte exotoxine aus pseudomonas mit geringer toxität bei tieren und hoher zelltötender aktivität
US6099842A (en) 1990-12-03 2000-08-08 The United States Of America As Represented By The Department Of Health And Human Services Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
WO1993025690A1 (en) 1992-06-18 1993-12-23 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Recombinant pseudomonas exotoxin with increased activity
US6426075B1 (en) 1996-11-06 2002-07-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Protease-activatable pseudomonas exotoxin A-like proproteins
AU6769998A (en) 1997-03-26 1998-10-20 Board Of Regents, The University Of Texas System Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
AU4057300A (en) 1999-03-30 2000-10-16 Board Of Regents, The University Of Texas System Compositions and methods for modifying toxic effects of proteinacious compounds
EP1687016A4 (en) 2003-11-25 2009-07-29 Anjin Corp GENETIC VARIANT OF DIPHTHERIC TOXIN
US7550426B2 (en) * 2005-05-18 2009-06-23 Ghc Research Development Corporation Acetylated therapeutic procytotoxins
US8993295B2 (en) 2006-07-20 2015-03-31 The General Hospital Corporation Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting
WO2009149281A1 (en) * 2008-06-04 2009-12-10 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Immunotoxins and uses thereof

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