JP2010532989A5 - - Google Patents

Info

Publication number

JP2010532989A5

JP2010532989A5 JP2010515648A JP2010515648A JP2010532989A5 JP 2010532989 A5 JP2010532989 A5 JP 2010532989A5 JP 2010515648 A JP2010515648 A JP 2010515648A JP 2010515648 A JP2010515648 A JP 2010515648A JP 2010532989 A5 JP2010532989 A5 JP 2010532989A5

Authority

JP

Japan

Prior art keywords

seq

homologous

amino acid

coordinates

sequence

Prior art date

2008-07-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000002773 nucleotide Substances 0.000 claims 93
• 125000003729 nucleotide group Chemical group 0.000 claims 93
• 150000001413 amino acids Chemical class 0.000 claims 77
• 125000003275 alpha amino acid group Chemical group 0.000 claims 56
• 102000040430 polynucleotide Human genes 0.000 claims 55
• 108091033319 polynucleotide Proteins 0.000 claims 55
• 239000002157 polynucleotide Substances 0.000 claims 55
• 108090000765 processed proteins & peptides Proteins 0.000 claims 47
• 102000004196 processed proteins & peptides Human genes 0.000 claims 33
• 229920001184 polypeptide Polymers 0.000 claims 29
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 18
• 230000004770 neurodegeneration Effects 0.000 claims 16
• 208000015122 neurodegenerative disease Diseases 0.000 claims 16
• 229920002477 rna polymer Polymers 0.000 claims 14
• 208000024827 Alzheimer disease Diseases 0.000 claims 12
• 208000018737 Parkinson disease Diseases 0.000 claims 12
• 208000032319 Primary lateral sclerosis Diseases 0.000 claims 12
• 206010046298 Upper motor neurone lesion Diseases 0.000 claims 12
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 12
• 201000010901 lateral sclerosis Diseases 0.000 claims 12
• 208000005264 motor neuron disease Diseases 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 12
• 108020004707 nucleic acids Proteins 0.000 claims 12
• 150000007523 nucleic acids Chemical class 0.000 claims 12
• 208000002320 spinal muscular atrophy Diseases 0.000 claims 12
• 239000012472 biological sample Substances 0.000 claims 11
• 239000003153 chemical reaction reagent Substances 0.000 claims 11
• 108020004414 DNA Proteins 0.000 claims 8
• 102000053602 DNA Human genes 0.000 claims 8
• 230000000295 complement effect Effects 0.000 claims 8
• 238000000034 method Methods 0.000 claims 8
• 108091034117 Oligonucleotide Proteins 0.000 claims 5
• 210000001124 body fluid Anatomy 0.000 claims 4
• 239000010839 body fluid Substances 0.000 claims 4
• 108020004459 Small interfering RNA Proteins 0.000 claims 3
• 239000004055 small Interfering RNA Substances 0.000 claims 3
• 102100032912 CD44 antigen Human genes 0.000 claims 2
• 238000002965 ELISA Methods 0.000 claims 2
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
• 239000002299 complementary DNA Substances 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical group OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 claims 2
• 238000012544 monitoring process Methods 0.000 claims 2
• 230000037361 pathway Effects 0.000 claims 2
• 238000003752 polymerase chain reaction Methods 0.000 claims 2
• 238000003757 reverse transcription PCR Methods 0.000 claims 2
• 150000003384 small molecules Chemical group 0.000 claims 2
• 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims 1
• 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 claims 1
• 238000000636 Northern blotting Methods 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• -1 amino amino Chemical group 0.000 claims 1
• 239000003184 complementary RNA Substances 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 238000003365 immunocytochemistry Methods 0.000 claims 1
• 238000003364 immunohistochemistry Methods 0.000 claims 1
• 239000003607 modifier Substances 0.000 claims 1
• 238000003753 real-time PCR Methods 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000001262 western blot Methods 0.000 claims 1