JP2010532751A5 - - Google Patents
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- Publication number
- JP2010532751A5 JP2010532751A5 JP2010514127A JP2010514127A JP2010532751A5 JP 2010532751 A5 JP2010532751 A5 JP 2010532751A5 JP 2010514127 A JP2010514127 A JP 2010514127A JP 2010514127 A JP2010514127 A JP 2010514127A JP 2010532751 A5 JP2010532751 A5 JP 2010532751A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- group
- hydrogen
- methyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- -1 carboxy, carboxy ester Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 241001317099 Dystaxia Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 201000005625 Neuroleptic malignant syndrome Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 230000003291 dopaminomimetic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 208000010916 pituitary tumor Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 230000005748 tumor development Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0713189.9 | 2007-07-06 | ||
| GBGB0713189.9A GB0713189D0 (en) | 2007-07-06 | 2007-07-06 | Amino acid derivatives |
| PCT/GB2008/002313 WO2009007696A1 (en) | 2007-07-06 | 2008-07-04 | Amino acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532751A JP2010532751A (ja) | 2010-10-14 |
| JP2010532751A5 true JP2010532751A5 (enExample) | 2011-08-18 |
| JP5422557B2 JP5422557B2 (ja) | 2014-02-19 |
Family
ID=38440555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514127A Expired - Fee Related JP5422557B2 (ja) | 2007-07-06 | 2008-07-04 | アミノ酸誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8258097B2 (enExample) |
| EP (1) | EP2176217B1 (enExample) |
| JP (1) | JP5422557B2 (enExample) |
| CN (1) | CN101730678B (enExample) |
| AU (1) | AU2008273923B2 (enExample) |
| BR (1) | BRPI0814800A2 (enExample) |
| CA (1) | CA2692608A1 (enExample) |
| GB (1) | GB0713189D0 (enExample) |
| MX (1) | MX2010000150A (enExample) |
| NZ (1) | NZ583075A (enExample) |
| WO (1) | WO2009007696A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6567049B2 (ja) | 2014-10-21 | 2019-08-28 | アッヴィ・インコーポレイテッド | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| AU2016258179B2 (en) | 2015-05-06 | 2021-07-01 | Synagile Corporation | Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use |
| AU2016314617A1 (en) * | 2015-09-02 | 2018-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
| EP3749677A1 (en) | 2018-02-08 | 2020-12-16 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd | Dopamine precursors |
| CA3117983A1 (en) | 2018-11-15 | 2020-05-22 | Abbvie Inc. | Pharmaceutical formulations for subcutaneous administration |
| BR112022003974A2 (pt) * | 2019-09-05 | 2022-05-24 | Neuroderm Ltd | Composições líquidas que compreendem um conjugado de aminoácido de levodopa e seus usos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH562199A5 (enExample) * | 1970-10-30 | 1975-05-30 | Hoffmann La Roche | |
| JPS5422337A (en) | 1977-07-18 | 1979-02-20 | Kyowa Hakko Kogyo Co Ltd | Alphamethyldopa derivatives |
| IT1226727B (it) * | 1988-07-29 | 1991-02-05 | Simes | Farmaci precursori della dopamina. |
-
2007
- 2007-07-06 GB GBGB0713189.9A patent/GB0713189D0/en not_active Ceased
-
2008
- 2008-07-04 WO PCT/GB2008/002313 patent/WO2009007696A1/en not_active Ceased
- 2008-07-04 US US12/667,917 patent/US8258097B2/en not_active Expired - Fee Related
- 2008-07-04 NZ NZ583075A patent/NZ583075A/en not_active IP Right Cessation
- 2008-07-04 EP EP08775861A patent/EP2176217B1/en not_active Not-in-force
- 2008-07-04 AU AU2008273923A patent/AU2008273923B2/en not_active Ceased
- 2008-07-04 CN CN200880023320.1A patent/CN101730678B/zh not_active Expired - Fee Related
- 2008-07-04 CA CA 2692608 patent/CA2692608A1/en not_active Abandoned
- 2008-07-04 MX MX2010000150A patent/MX2010000150A/es active IP Right Grant
- 2008-07-04 BR BRPI0814800-7A2A patent/BRPI0814800A2/pt not_active IP Right Cessation
- 2008-07-04 JP JP2010514127A patent/JP5422557B2/ja not_active Expired - Fee Related