JP2010528011A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010528011A5 JP2010528011A5 JP2010509380A JP2010509380A JP2010528011A5 JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5 JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound according
- fluoropyridin
- methylphenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- NPFDWHQSDBWQLH-QZTJIDSGSA-N filorexant Chemical compound C([C@@H]1CC[C@H](N(C1)C(=O)C=1C(=CC=C(C)C=1)C=1N=CC=CN=1)C)OC1=CC=C(F)C=N1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93145807P | 2007-05-23 | 2007-05-23 | |
| US60/931,458 | 2007-05-23 | ||
| PCT/US2008/006563 WO2008147518A1 (en) | 2007-05-23 | 2008-05-22 | Pyridyl piperidine orexin receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Division JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528011A JP2010528011A (ja) | 2010-08-19 |
| JP2010528011A5 true JP2010528011A5 (en:Method) | 2011-12-08 |
| JP4881476B2 JP4881476B2 (ja) | 2012-02-22 |
Family
ID=39708485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509380A Expired - Fee Related JP4881476B2 (ja) | 2007-05-23 | 2008-05-22 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Country Status (33)
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008038251A2 (en) * | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| US8133901B2 (en) | 2006-12-01 | 2012-03-13 | Actelion Pharmaceuticals Ltd. | 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors |
| AR064561A1 (es) | 2006-12-28 | 2009-04-08 | Actelion Pharmaceuticals Ltd | Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. |
| CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| CN101679366B (zh) | 2007-05-23 | 2013-08-07 | 默沙东公司 | 吡啶基哌啶食欲素受体拮抗剂 |
| NZ583487A (en) * | 2007-07-27 | 2011-09-30 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[3.3.0]octane derivatives |
| JP2010540429A (ja) * | 2007-09-24 | 2010-12-24 | アクテリオン ファーマシューティカルズ リミテッド | オレキシン受容体拮抗薬としてのピロリジン類及びピペリジン類 |
| WO2009104155A1 (en) * | 2008-02-21 | 2009-08-27 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[2.2.1]heptane derivatives |
| GB0806536D0 (en) * | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| WO2009133522A1 (en) * | 2008-04-30 | 2009-11-05 | Actelion Pharmaceuticals Ltd | Piperidine and pyrrolidine compounds |
| CN102123999B (zh) * | 2008-05-22 | 2014-06-18 | 默沙东公司 | 制备食欲素受体拮抗剂的方法 |
| US8546576B2 (en) * | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| AU2009307913A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| WO2010048014A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| WO2010048013A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| CA2739916A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| EP2348846B1 (en) | 2008-10-21 | 2013-08-28 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| AU2009307920A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| EP2275421A1 (en) | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
| US20120149723A1 (en) * | 2009-08-24 | 2012-06-14 | Romano Di Fabio | 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder |
| US9012636B2 (en) | 2010-10-29 | 2015-04-21 | Merck Sharp & Dohme Corp. | Process for the preparation of an orexin receptor antagonist |
| EP2484674A1 (en) | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro aminic compounds with NK1 antagonist activity |
| WO2012114252A1 (en) * | 2011-02-21 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Novel indole and pyrrolopyridine amides |
| JPWO2013005755A1 (ja) | 2011-07-05 | 2015-02-23 | 大正製薬株式会社 | メチルピペリジン誘導体 |
| KR20190085184A (ko) * | 2011-07-28 | 2019-07-17 | 켐팜 인코포레이티드 | 메틸페니데이트 프로드러그, 이의 제조 방법 및 사용 방법 |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| EP2768305A4 (en) * | 2011-10-21 | 2015-04-29 | Merck Sharp & Dohme | 2,5-DISUBSTITUTED THIOMORPHOLIN OREXINE RECEPTOR ANTAGONISTS |
| ITMI20112329A1 (it) | 2011-12-21 | 2013-06-22 | Rottapharm Spa | Nuovi derivati spiro amminici |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| BR112014019426A8 (pt) | 2012-02-07 | 2017-07-11 | Eolas Therapeutics Inc | Prolinas/ piperidinas substituídas como antagonistas do receptor de orexina |
| RU2617696C2 (ru) * | 2012-02-17 | 2017-04-26 | ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД | Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2 |
| ITMI20120322A1 (it) | 2012-03-01 | 2013-09-02 | Rottapharm Spa | Composti di 4,4-difluoro piperidina |
| ITMI20120424A1 (it) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
| IN2014DN10490A (en:Method) * | 2012-06-15 | 2015-08-21 | Taisho Pharmaceutical Co Ltd | |
| WO2014081617A1 (en) * | 2012-11-20 | 2014-05-30 | Merck Sharp & Dohme Corp. | Substituted pyridone derivatives as pde10 inhibitors |
| JP2016028017A (ja) * | 2012-12-13 | 2016-02-25 | 大正製薬株式会社 | フッ素置換ピペリジン化合物 |
| EP2934527A4 (en) | 2012-12-20 | 2016-07-13 | Merck Sharp & Dohme | 2-pyridyloxy-4-ESTER-orexin receptor antagonists |
| WO2014099698A1 (en) * | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists |
| WO2014099697A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | 3-ester-4-substituted orexin receptor antagonists |
| US9550786B2 (en) | 2013-01-16 | 2017-01-24 | Merck Sharp & Dohme Corp. | 4-fluoropiperidine orexin receptor antagonists |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| US9745284B2 (en) | 2013-03-08 | 2017-08-29 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ether orexin receptor antagonists |
| EP2988748A1 (en) * | 2013-04-23 | 2016-03-02 | Merck Sharp & Dohme Corp. | Hydroxy-substituted orexin receptor antagonists |
| WO2014176146A1 (en) * | 2013-04-23 | 2014-10-30 | Merck Sharp & Dohme Corp. | Halo and trifluoromethyl substituted orexin receptor antagonists |
| WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2015018029A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2015095441A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-amino-3-ester-pyridyl orexin receptor antagonists |
| WO2015131773A1 (zh) * | 2014-03-06 | 2015-09-11 | 上海海雁医药科技有限公司 | 作为食欲素受体拮抗剂的哌啶衍生物 |
| KR102553870B1 (ko) | 2014-03-27 | 2023-07-10 | 버드 락 바이오, 인크. | 인간 카나비노이드 1(cb1) 수용체 결합 항체 |
| AR101558A1 (es) | 2014-08-13 | 2016-12-28 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores del receptor de orexina |
| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2016065585A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine isoxazole and isothiazole orexin receptor antagonists |
| WO2016065584A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| WO2016065586A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole and tetrazole orexin receptor antagonists |
| WO2016065587A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole orexin receptor antagonists |
| WO2016085783A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| WO2016085784A1 (en) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| WO2016086358A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Hydroxymethyl piperidine orexin receptor antagonists |
| WO2016100162A2 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
| WO2016095205A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Heteroaryl orexin receptor antagonists |
| US9938276B2 (en) | 2014-12-19 | 2018-04-10 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
| WO2016095204A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor antagonists |
| WO2016100161A1 (en) * | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016101119A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Fused heteroaryl derivatives as orexin receptor antagonists |
| WO2016101118A1 (en) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
| CN106349228B (zh) | 2015-07-17 | 2019-07-09 | 广东东阳光药业有限公司 | 取代的喹唑啉酮类化合物及其制备方法和用途 |
| CN111848603B (zh) * | 2015-08-14 | 2022-08-09 | 上海海雁医药科技有限公司 | 食欲素受体拮抗剂受体化合物的制备方法及其中间体和晶型 |
| EP4606387A3 (en) * | 2015-08-25 | 2025-11-19 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US11421026B2 (en) | 2015-09-30 | 2022-08-23 | Bird Rock Bio, Inc. | Antibodies that bind human cannabinoid 1 (CB1) receptor |
| PL3984994T3 (pl) * | 2016-02-04 | 2024-11-04 | Takeda Pharmaceutical Company Limited | Podstawiony związek piperydyny jako agonista oreksyny typu 2 do leczenia narkolepsji |
| AU2017217931B2 (en) | 2016-02-12 | 2020-10-22 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| EP3454857A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| HUE067004T2 (hu) | 2016-12-11 | 2024-10-28 | Zevra Therapeutics Inc | Metilfenidát prodrogokat tartalmazó készítmények, eljárások azok elõállítására és felhasználására |
| EP3816153B1 (en) * | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| EP3924058B1 (en) | 2019-02-13 | 2026-01-07 | Merck Sharp & Dohme LLC | 5-alkyl pyrrolidine orexin receptor agonists |
| WO2020247445A1 (en) | 2019-06-04 | 2020-12-10 | Hager Biosciences, Llc | Imidazolo derivatives, compositions and methods as orexin antagonists |
| KR20250036472A (ko) | 2023-09-07 | 2025-03-14 | 경희대학교 산학협력단 | Cid16020046의 체중감소 효능과 비만치료제로 적용 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
| AR016817A1 (es) | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| CA2331735A1 (en) | 1998-05-08 | 1999-11-18 | Smithkline Beecham P.L.C. | Phenylurea and phenylthio urea derivatives |
| AU2804400A (en) | 1999-02-12 | 2000-08-29 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| WO2000047576A1 (en) | 1999-02-12 | 2000-08-17 | Smithkline Beecham Plc | Cinnamide derivatives as orexin-1 receptors antagonists |
| DE60015927T2 (de) | 1999-02-12 | 2005-04-07 | Smithkline Beecham P.L.C., Brentford | Phenylharnstoff und phenylthioharnstoffderivate |
| ATE327230T1 (de) * | 2000-01-20 | 2006-06-15 | Eisai Co Ltd | Piperidinverbindungen und diese enthaltenden medikamente |
| MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
| CA2408343A1 (en) | 2000-05-11 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
| ATE293101T1 (de) * | 2000-06-16 | 2005-04-15 | Smithkline Beecham Plc | Piperidine zur verwendung als orexin rezeptor antagonisten |
| DE60108420T2 (de) * | 2000-11-28 | 2005-12-22 | Smithkline Beecham P.L.C., Brentford | Morpholinderivate als antagonisten an orexinrezeptoren |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| ATE383359T1 (de) * | 2001-05-05 | 2008-01-15 | Smithkline Beecham Plc | N-aroyl zyklische amine |
| JP2004534026A (ja) | 2001-05-05 | 2004-11-11 | スミスクライン ビーチャム パブリック リミテッド カンパニー | オレキシン受容体アンタゴニストとしてのｎ−アロイルサイクリックアミン誘導体 |
| ES2266549T3 (es) | 2001-06-28 | 2007-03-01 | Smithkline Beecham Plc | Derivados de n-aroil-amina ciclicos como antagonistas del receptor de orexina. |
| GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| GB0124463D0 (en) | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
| GB0126292D0 (en) | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
| GB0127145D0 (en) * | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
| GB0130335D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| GB0130388D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| GB0130341D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| GB0130393D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| TWI283241B (en) | 2002-05-29 | 2007-07-01 | Tanabe Seiyaku Co | Novel piperidine compound |
| RU2294927C2 (ru) * | 2002-05-29 | 2007-03-10 | Танабе Сейяку Ко., Лтд. | Производные пиперидина, способы их получения, фармацевтическая композиция на их основе, их применение и способ лечения |
| ITMI20021273A1 (it) * | 2002-06-11 | 2003-12-11 | Milano Politecnico | Sistema e metodo per la rilevazione automatica della limitazione del flusso espiratorio |
| WO2004004733A1 (en) | 2002-07-09 | 2004-01-15 | Actelion Pharmaceuticals Ltd. | 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives |
| JP2006504695A (ja) | 2002-09-18 | 2006-02-09 | グラクソ グループ リミテッド | オレキシン受容体アンタゴニストとしてのｎ−アロイル環状アミン |
| US20060166966A1 (en) * | 2002-10-08 | 2006-07-27 | Cameron Black | 4-amino-azepan-3-one compounds as cathepsin k inhibitors useful in the treatment of osteoporosis |
| RU2334735C2 (ru) | 2002-10-11 | 2008-09-27 | Актелион Фармасьютиклз Лтд. | Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина |
| GB0225944D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| GB0225884D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| GB0225938D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| WO2004052876A1 (en) | 2002-12-12 | 2004-06-24 | Janssen Pharmaceutica, N.V. | Substituted 4-phenyl-[1,3]-dioxanes |
| CL2004000553A1 (es) | 2003-03-20 | 2005-02-04 | Actelion Pharmaceuticals Ltd | Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende. |
| ES2327737T3 (es) | 2003-03-26 | 2009-11-03 | Actelion Pharmaceuticals Ltd. | Derivados de tetrahidroisoquinolil acetamida para uso como antagonistas de receptores de orexina. |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| WO2004096780A1 (en) | 2003-04-28 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Quinoxalinone-3- one derivatives as orexin receptor antagonists |
| HUP0304101A3 (en) | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| HUP0400405A3 (en) | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| HRP20150371T1 (hr) * | 2004-03-01 | 2015-05-08 | Actelion Pharmaceuticals Ltd. | Supstituirani derivati 1,2,3,4-tetrahidroizokinolina |
| WO2006067224A2 (en) | 2004-12-23 | 2006-06-29 | Biovitrum Ab (Publ) | Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists |
| DE102004062544A1 (de) * | 2004-12-24 | 2006-07-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Pyrrolidinone, deren Herstellung und deren Verewendung als Arzneimittel |
| AU2006235302A1 (en) | 2005-04-12 | 2006-10-19 | Merck & Co., Inc. | Amidopropoxyphenyl orexin receptor antagonists |
| EP1879863A1 (en) * | 2005-05-03 | 2008-01-23 | Pfizer, Inc. | Amide resorcinol compounds |
| EP1888563A1 (en) | 2005-05-23 | 2008-02-20 | Merck & Co., Inc. | Proline bis-amide orexin receptor antagonists |
| WO2007019234A2 (en) | 2005-08-04 | 2007-02-15 | Merck & Co., Inc. | Aminoethane sulfonamide orexin receptor antagonists |
| AU2006282955A1 (en) | 2005-08-26 | 2007-03-01 | Merck & Co., Inc. | Diazaspirodecane orexin receptor antagonists |
| WO2007061763A2 (en) | 2005-11-22 | 2007-05-31 | Merck & Co., Inc. | Indole orexin receptor antagonists |
| WO2007126934A2 (en) | 2006-03-29 | 2007-11-08 | Merck & Co., Inc. | Amidoethylthioether orexin receptor antagonists |
| JP2009531447A (ja) | 2006-03-29 | 2009-09-03 | メルク エンド カムパニー インコーポレーテッド | ジアゼパンオレキシン受容体アンタゴニスト |
| US8003654B2 (en) | 2006-04-11 | 2011-08-23 | Actelion Pharmaceuticals Ltd. | N-glycinsulfonamide derivatives and uses as orexin receptor antagonists |
| EP2013209B1 (en) | 2006-04-26 | 2011-01-19 | Actelion Pharmaceuticals Ltd. | Pyrazolo-tetrahydropyridine derivatives as orexin receptor antagonists |
| CA2657623A1 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Bridged diazepan orexin receptor antagonists |
| WO2008008518A1 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Substituted diazepan orexin receptor antagonists |
| EP2049526A2 (en) | 2006-07-14 | 2009-04-22 | Merck & Co., Inc. | 2-substituted proline bis-amide orexin receptor antagonists |
| US7994336B2 (en) | 2006-08-15 | 2011-08-09 | Actelion Pharmaceuticals Ltd. | Azetidine compounds as orexin receptor antagonists |
| US20100029617A1 (en) | 2006-08-28 | 2010-02-04 | Actelion Pharmaceuticals Ltd. | 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives as orexin receptor antagonists |
| WO2008038251A2 (en) | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| US8133901B2 (en) * | 2006-12-01 | 2012-03-13 | Actelion Pharmaceuticals Ltd. | 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors |
| CN101679366B (zh) | 2007-05-23 | 2013-08-07 | 默沙东公司 | 吡啶基哌啶食欲素受体拮抗剂 |
| GB0806536D0 (en) | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| CN102123999B (zh) | 2008-05-22 | 2014-06-18 | 默沙东公司 | 制备食欲素受体拮抗剂的方法 |
| EP2348846B1 (en) * | 2008-10-21 | 2013-08-28 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| AU2009307920A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| CA2739916A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| WO2010048013A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| AU2009307913A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| WO2010048014A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| GB0823467D0 (en) * | 2008-12-23 | 2009-01-28 | Glaxo Group Ltd | Novel Compounds |
| US20120149723A1 (en) | 2009-08-24 | 2012-06-14 | Romano Di Fabio | 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder |
-
2008
- 2008-05-22 CN CN2008800169258A patent/CN101679366B/zh not_active Expired - Fee Related
- 2008-05-22 KR KR1020097024362A patent/KR101480279B1/ko not_active Expired - Fee Related
- 2008-05-22 PL PL08754659T patent/PL2152690T3/pl unknown
- 2008-05-22 UA UAA200913366A patent/UA99620C2/ru unknown
- 2008-05-22 BR BRPI0811842-6A2A patent/BRPI0811842A2/pt active Search and Examination
- 2008-05-22 EP EP08754659A patent/EP2152690B1/en active Active
- 2008-05-22 HR HR20120240T patent/HRP20120240T1/hr unknown
- 2008-05-22 CA CA2687321A patent/CA2687321C/en not_active Expired - Fee Related
- 2008-05-22 MX MX2009012579A patent/MX2009012579A/es active IP Right Grant
- 2008-05-22 JP JP2010509380A patent/JP4881476B2/ja not_active Expired - Fee Related
- 2008-05-22 MY MYPI20094689A patent/MY148544A/en unknown
- 2008-05-22 RU RU2009147733/04A patent/RU2470021C2/ru not_active IP Right Cessation
- 2008-05-22 SI SI200830593T patent/SI2152690T1/sl unknown
- 2008-05-22 RS RS20120111A patent/RS52200B/sr unknown
- 2008-05-22 AU AU2008257411A patent/AU2008257411B2/en not_active Ceased
- 2008-05-22 NZ NZ580887A patent/NZ580887A/en not_active IP Right Cessation
- 2008-05-22 AT AT08754659T patent/ATE540944T1/de active
- 2008-05-22 DK DK08754659.4T patent/DK2152690T3/da active
- 2008-05-22 WO PCT/US2008/006563 patent/WO2008147518A1/en not_active Ceased
- 2008-05-22 US US12/600,388 patent/US8242121B2/en active Active
- 2008-05-22 ES ES08754659T patent/ES2379744T3/es active Active
- 2008-05-22 PT PT08754659T patent/PT2152690E/pt unknown
-
2009
- 2009-10-26 ZA ZA200907495A patent/ZA200907495B/xx unknown
- 2009-10-27 IL IL201790A patent/IL201790A0/en unknown
- 2009-10-30 NI NI200900193A patent/NI200900193A/es unknown
- 2009-11-18 GT GT200900300A patent/GT200900300A/es unknown
- 2009-11-18 SV SV2009003417A patent/SV2009003417A/es not_active Application Discontinuation
- 2009-11-20 DO DO2009000263A patent/DOP2009000263A/es unknown
- 2009-11-20 EC EC2009009749A patent/ECSP099749A/es unknown
- 2009-11-23 CO CO09133050A patent/CO6251266A2/es active IP Right Grant
- 2009-12-04 CR CR11146A patent/CR11146A/es unknown
- 2009-12-17 MA MA32427A patent/MA31451B1/fr unknown
-
2011
- 2011-10-19 JP JP2011229710A patent/JP5639564B2/ja not_active Expired - Fee Related
-
2012
- 2012-04-10 CY CY20121100354T patent/CY1112969T1/el unknown
- 2012-08-07 US US13/568,242 patent/US8569311B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010528011A5 (en:Method) | ||
| JP2010529118A5 (en:Method) | ||
| IL259851A (en) | Compounds and methods of inhibiting antidepressant nhe mediator in the treatment of disorders associated with fluid retention or overload of salts and gastrointestinal disorders | |
| HRP20161577T1 (hr) | Inhibitori replikacije virusa gripe | |
| JP2007529532A5 (en:Method) | ||
| EA201071054A1 (ru) | Твердый препарат, растворяющийся во рту | |
| JP2009535352A5 (en:Method) | ||
| JP2007501251A5 (en:Method) | ||
| HRP20150744T4 (hr) | Modulatori farmakokinetičkih svojstava lijekova | |
| JP2011524850A5 (en:Method) | ||
| WO2010026436A3 (en) | 1,3, 4, 6, 7, 11b-hexahydro-benzo[alpha]quinolizines for the treatment of hyperkinetic movement and related disorders | |
| FR2878159B1 (fr) | Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire | |
| EP2639229A3 (en) | Thiazole Derivative and use thereof as VAP-1 Inhibitor | |
| CL2007003690A1 (es) | Compuestos derivados de 1-azonia-biciclo[2.2.2]octano; proceso de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades pulmonares obstructivas cronicas. | |
| JP2009538276A5 (en:Method) | ||
| JP2007523135A5 (en:Method) | ||
| JP2007516193A5 (en:Method) | ||
| MA32841B1 (fr) | Composés de cycloundeca depsipeptides et leur utilisation comme médicament | |
| JP2008513510A5 (en:Method) | ||
| JP2008515980A5 (en:Method) | ||
| RU2014112324A (ru) | Применение органического соединения для лечения синдрома нунан | |
| WO2012126178A3 (zh) | 用于治疗肝脏疾病的药物组合物 | |
| JP2010500284A5 (en:Method) | ||
| JP2009516719A5 (en:Method) | ||
| JP2012523416A5 (en:Method) |