JP2010527621A5 - - Google Patents

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Publication number
JP2010527621A5
JP2010527621A5 JP2010509680A JP2010509680A JP2010527621A5 JP 2010527621 A5 JP2010527621 A5 JP 2010527621A5 JP 2010509680 A JP2010509680 A JP 2010509680A JP 2010509680 A JP2010509680 A JP 2010509680A JP 2010527621 A5 JP2010527621 A5 JP 2010527621A5
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JP
Japan
Prior art keywords
replaced
region
monovalent antibody
ala
leu
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JP2010509680A
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English (en)
Japanese (ja)
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JP2010527621A (ja
JP5511654B2 (ja
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Priority claimed from PCT/DK2008/050124 external-priority patent/WO2008145137A2/en
Publication of JP2010527621A publication Critical patent/JP2010527621A/ja
Publication of JP2010527621A5 publication Critical patent/JP2010527621A5/ja
Application granted granted Critical
Publication of JP5511654B2 publication Critical patent/JP5511654B2/ja
Active legal-status Critical Current
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JP2010509680A 2007-05-31 2008-05-30 分子操作により得られた組換え非グリコシル化一価半抗体 Active JP5511654B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200700790 2007-05-31
DKPA200700790 2007-05-31
PCT/DK2008/050124 WO2008145137A2 (en) 2007-05-31 2008-05-30 Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering

Publications (3)

Publication Number Publication Date
JP2010527621A JP2010527621A (ja) 2010-08-19
JP2010527621A5 true JP2010527621A5 (enExample) 2011-07-14
JP5511654B2 JP5511654B2 (ja) 2014-06-04

Family

ID=40039713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010509680A Active JP5511654B2 (ja) 2007-05-31 2008-05-30 分子操作により得られた組換え非グリコシル化一価半抗体

Country Status (6)

Country Link
US (1) US20100325744A1 (enExample)
EP (1) EP2170951A2 (enExample)
JP (1) JP5511654B2 (enExample)
AU (1) AU2008255387B2 (enExample)
CA (1) CA2689895A1 (enExample)
WO (1) WO2008145137A2 (enExample)

Families Citing this family (28)

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US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
US10155816B2 (en) * 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
EP2167669A2 (en) 2007-05-31 2010-03-31 Genmab A/S Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
EP3153524B1 (en) * 2008-12-03 2025-04-23 Genmab A/S Antibody variants having modifications in the constant region
CN102365296A (zh) * 2009-01-26 2012-02-29 根马布股份公司 用于生成抗体混合物的方法
DE102009047243A1 (de) 2009-11-27 2011-06-01 Orgentec Diagnostika Gmbh Monospezifische Polypeptidreagenzien
RS66008B1 (sr) * 2010-03-10 2024-10-31 Genmab As Monoklonska antitela protiv c-met
AU2012275233A1 (en) 2011-06-30 2013-11-28 Genentech, Inc. Anti-c-met antibody formulations
AU2012340826A1 (en) 2011-11-21 2014-05-29 Genentech, Inc. Purification of anti-c-met antibodies
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
WO2015127288A1 (en) 2014-02-20 2015-08-27 Alder Biopharmaceuticals, Inc. Anti-acth antibodies and use thereof
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
PL3139948T3 (pl) * 2014-05-07 2020-08-10 Novo Nordisk A/S Leczenie cukrzycy z zastosowaniem glp-1 i anty-il-21
SI3221359T1 (sl) 2014-11-17 2020-08-31 Regeneron Pharmaceuticals, Inc. Metode zravljenja tumorja z uporabo bispecifičnega protitelesa CD3XCD20
CN114478792A (zh) * 2015-01-08 2022-05-13 根马布股份公司 针对cd3和cd20的双特异性抗体
EP3277725B1 (en) 2015-03-30 2020-11-25 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to fc gamma receptors
CN114835797A (zh) * 2015-11-16 2022-08-02 Ubi蛋白公司 用于延长蛋白质半衰期的方法
WO2018187074A1 (en) 2017-04-03 2018-10-11 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
TW202021618A (zh) 2018-08-17 2020-06-16 美商23與我有限公司 抗il1rap抗體及其使用方法
RS66543B1 (sr) 2018-08-31 2025-03-31 Regeneron Pharma Strategija doziranja koja ublažava sindrom oslobađanja citokina za cd3/cd20 bispecifična antitela
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
BR112021010374A2 (pt) 2018-12-21 2021-08-24 23Andme, Inc. Anticorpos anti-il-36 e métodos de uso dos mesmos
US20230227570A1 (en) 2020-05-08 2023-07-20 Genmab A/S Bispecific antibodies against cd3 and cd20
BR112022024339A2 (pt) 2020-05-29 2022-12-27 23Andme Inc Anticorpos anti cd200r1 e métodos de uso dos mesmos
CN116234824A (zh) 2020-06-22 2023-06-06 阿尔米雷尔有限公司 抗il-36抗体及其使用方法
JP2023541627A (ja) 2020-09-14 2023-10-03 イシュノス サイエンシズ ソシエテ アノニム Il1rapに結合する抗体及びその使用
WO2024123558A2 (en) * 2022-12-05 2024-06-13 The Scripps Research Institute Engineered lassa viral immunogens and vaccine compositions
WO2024146458A1 (zh) * 2023-01-06 2024-07-11 广东东阳光药业股份有限公司 抗il-11细胞因子人源化抗体

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AU600575B2 (en) * 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
GB9206422D0 (en) * 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
US6046310A (en) * 1996-03-13 2000-04-04 Protein Design Labs., Inc. FAS ligand fusion proteins and their uses
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7300916B2 (en) * 2001-02-27 2007-11-27 Yoshiko Yasuda Preventives/remedies for thickened scar, keloid or chronic arthritic diseases
US20020197694A1 (en) * 2001-06-20 2002-12-26 Weiping Shao Conjugates of reduced antibodies and biomolecules
GB2380127A (en) * 2001-09-26 2003-04-02 Isis Innovation Treatment of chronic joint inflammation
US7053202B2 (en) * 2001-10-19 2006-05-30 Millennium Pharmaceuticals, Inc. Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
CA2499816C (en) * 2002-09-27 2013-07-30 Xencor, Inc. Optimized fc variants and methods for their generation
NZ538996A (en) * 2002-10-31 2008-04-30 Genentech Inc Methods and compositions for increasing antibody production
WO2005063816A2 (en) * 2003-12-19 2005-07-14 Genentech, Inc. Monovalent antibody fragments useful as therapeutics
CA2578613A1 (en) * 2004-08-11 2007-01-25 Trubion Pharmaceuticals, Inc. Binding domain fusion proteins
AR056142A1 (es) * 2005-10-21 2007-09-19 Amgen Inc Metodos para generar el anticuerpo igg monovalente
US10155816B2 (en) * 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof

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