JP2010527621A5 - - Google Patents

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Publication number
JP2010527621A5
JP2010527621A5 JP2010509680A JP2010509680A JP2010527621A5 JP 2010527621 A5 JP2010527621 A5 JP 2010527621A5 JP 2010509680 A JP2010509680 A JP 2010509680A JP 2010509680 A JP2010509680 A JP 2010509680A JP 2010527621 A5 JP2010527621 A5 JP 2010527621A5
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JP
Japan
Prior art keywords
replaced
region
monovalent antibody
ala
leu
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JP2010509680A
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English (en)
Japanese (ja)
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JP5511654B2 (ja
JP2010527621A (ja
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Priority claimed from PCT/DK2008/050124 external-priority patent/WO2008145137A2/en
Publication of JP2010527621A publication Critical patent/JP2010527621A/ja
Publication of JP2010527621A5 publication Critical patent/JP2010527621A5/ja
Application granted granted Critical
Publication of JP5511654B2 publication Critical patent/JP5511654B2/ja
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JP2010509680A 2007-05-31 2008-05-30 分子操作により得られた組換え非グリコシル化一価半抗体 Active JP5511654B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200700790 2007-05-31
DKPA200700790 2007-05-31
PCT/DK2008/050124 WO2008145137A2 (en) 2007-05-31 2008-05-30 Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering

Publications (3)

Publication Number Publication Date
JP2010527621A JP2010527621A (ja) 2010-08-19
JP2010527621A5 true JP2010527621A5 (enExample) 2011-07-14
JP5511654B2 JP5511654B2 (ja) 2014-06-04

Family

ID=40039713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010509680A Active JP5511654B2 (ja) 2007-05-31 2008-05-30 分子操作により得られた組換え非グリコシル化一価半抗体

Country Status (6)

Country Link
US (1) US20100325744A1 (enExample)
EP (1) EP2170951A2 (enExample)
JP (1) JP5511654B2 (enExample)
AU (1) AU2008255387B2 (enExample)
CA (1) CA2689895A1 (enExample)
WO (1) WO2008145137A2 (enExample)

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US20160279239A1 (en) * 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
KR101866623B1 (ko) * 2005-11-28 2018-07-04 젠맵 에이/에스 재조합 1가 항체 및 그의 제조 방법
EP2615175B1 (en) * 2007-05-31 2018-08-08 Genmab A/S Monovalent human antibodies
CA2745439C (en) * 2008-12-03 2019-10-15 Genmab A/S Antibody variants having modifications in the constant region
CN104262483A (zh) * 2009-01-26 2015-01-07 根马布股份公司 用于生成抗体混合物的方法
DE102009047243A1 (de) 2009-11-27 2011-06-01 Orgentec Diagnostika Gmbh Monospezifische Polypeptidreagenzien
EP3904391B1 (en) * 2010-03-10 2024-07-10 Genmab A/S Monoclonal antibodies against c-met
RU2013155695A (ru) 2011-06-30 2015-08-10 Дженентек, Инк. Препараты антител против с-мет
SG11201402485UA (en) 2011-11-21 2014-06-27 Genentech Inc Purification of anti-c-met antibodies
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
CA3265373A1 (en) 2014-02-20 2025-10-30 H. Lundbeck A/S Anti-acth antibodies and use thereof
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP6672175B2 (ja) * 2014-05-07 2020-03-25 ノヴォ ノルディスク アー/エス Glp−1及び抗il−21を使用した1型糖尿病の治療
ES2809455T3 (es) 2014-11-17 2021-03-04 Regeneron Pharma Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20
CN107660214B (zh) * 2015-01-08 2022-02-08 根马布股份公司 针对cd3和cd20的双特异性抗体
DK3277725T3 (da) 2015-03-30 2021-01-11 Regeneron Pharma Konstante tungkædeområder med reduceret binding til FC-gammareceptorer
MY195059A (en) 2015-09-23 2023-01-05 Regeneron Pharma Optimized Anti-CD3 Bispecific Antibodies and Uses Thereof
US20190382439A1 (en) * 2015-11-16 2019-12-19 Ubiprotein, Corp. Method for extending half-life of a protein
CA3044082A1 (en) 2017-04-03 2018-10-11 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
TW202021618A (zh) 2018-08-17 2020-06-16 美商23與我有限公司 抗il1rap抗體及其使用方法
ES3009025T3 (en) 2018-08-31 2025-03-25 Regeneron Pharma Dosing strategy that mitigates cytokine release syndrome for cd3/cd20 bispecific antibodies
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
MX2021007589A (es) 2018-12-21 2021-12-10 23Andme Inc Anticuerpos anti il-36 y procedimientos de uso de estos.
KR20230008775A (ko) 2020-05-08 2023-01-16 젠맵 에이/에스 Cd3 및 cd20에 대한 이중특이적 항체
PE20230460A1 (es) 2020-05-29 2023-03-10 23Andme Inc Anticuerpos anti-cd200r1 y metodos de uso de estos
US20230235040A1 (en) 2020-06-22 2023-07-27 Almirall, S.A. Anti-il-36 antibodies and methods of use thereof
PE20231575A1 (es) 2020-09-14 2023-10-04 Ichnos Sciences SA Anticuerpos que se unen a il1rap y usos de estos
WO2024123558A2 (en) * 2022-12-05 2024-06-13 The Scripps Research Institute Engineered lassa viral immunogens and vaccine compositions
WO2024146458A1 (zh) * 2023-01-06 2024-07-11 广东东阳光药业股份有限公司 抗il-11细胞因子人源化抗体

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JP3101690B2 (ja) * 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
GB9206422D0 (en) * 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
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US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7300916B2 (en) * 2001-02-27 2007-11-27 Yoshiko Yasuda Preventives/remedies for thickened scar, keloid or chronic arthritic diseases
US20020197694A1 (en) * 2001-06-20 2002-12-26 Weiping Shao Conjugates of reduced antibodies and biomolecules
GB2380127A (en) * 2001-09-26 2003-04-02 Isis Innovation Treatment of chronic joint inflammation
US7053202B2 (en) * 2001-10-19 2006-05-30 Millennium Pharmaceuticals, Inc. Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
CA2832136C (en) * 2002-09-27 2015-11-17 Xencor Optimized fc variants and methods for their generation
MXPA05004677A (es) * 2002-10-31 2005-11-17 Genentech Inc Metodos y composiciones para aumentar la produccion de anticuerpos.
PT1718677E (pt) * 2003-12-19 2012-07-18 Genentech Inc Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
KR20070041781A (ko) * 2004-08-11 2007-04-19 트루비온 파마슈티칼스, 인코포레이티드 결합 도메인 융합 단백질
AR056142A1 (es) * 2005-10-21 2007-09-19 Amgen Inc Metodos para generar el anticuerpo igg monovalente
KR101866623B1 (ko) * 2005-11-28 2018-07-04 젠맵 에이/에스 재조합 1가 항체 및 그의 제조 방법

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