CA2689895A1 - Non-glycosylated recombinant monovalent antibodies - Google Patents
Non-glycosylated recombinant monovalent antibodies Download PDFInfo
- Publication number
- CA2689895A1 CA2689895A1 CA2689895A CA2689895A CA2689895A1 CA 2689895 A1 CA2689895 A1 CA 2689895A1 CA 2689895 A CA2689895 A CA 2689895A CA 2689895 A CA2689895 A CA 2689895A CA 2689895 A1 CA2689895 A1 CA 2689895A1
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- monovalent antibody
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- antibody according
- monovalent
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| DKPA200700790 | 2007-05-31 | ||
| DKPA200700790 | 2007-05-31 | ||
| PCT/DK2008/050124 WO2008145137A2 (en) | 2007-05-31 | 2008-05-30 | Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering |
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| CA2689895A1 true CA2689895A1 (en) | 2008-12-04 |
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| CA (1) | CA2689895A1 (enExample) |
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| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| US10155816B2 (en) * | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| EP2167669A2 (en) | 2007-05-31 | 2010-03-31 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
| EP3153524B1 (en) * | 2008-12-03 | 2025-04-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| CN102365296A (zh) * | 2009-01-26 | 2012-02-29 | 根马布股份公司 | 用于生成抗体混合物的方法 |
| DE102009047243A1 (de) | 2009-11-27 | 2011-06-01 | Orgentec Diagnostika Gmbh | Monospezifische Polypeptidreagenzien |
| RS66008B1 (sr) * | 2010-03-10 | 2024-10-31 | Genmab As | Monoklonska antitela protiv c-met |
| AU2012275233A1 (en) | 2011-06-30 | 2013-11-28 | Genentech, Inc. | Anti-c-met antibody formulations |
| AU2012340826A1 (en) | 2011-11-21 | 2014-05-29 | Genentech, Inc. | Purification of anti-c-met antibodies |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| WO2015127288A1 (en) | 2014-02-20 | 2015-08-27 | Alder Biopharmaceuticals, Inc. | Anti-acth antibodies and use thereof |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PL3139948T3 (pl) * | 2014-05-07 | 2020-08-10 | Novo Nordisk A/S | Leczenie cukrzycy z zastosowaniem glp-1 i anty-il-21 |
| SI3221359T1 (sl) | 2014-11-17 | 2020-08-31 | Regeneron Pharmaceuticals, Inc. | Metode zravljenja tumorja z uporabo bispecifičnega protitelesa CD3XCD20 |
| CN114478792A (zh) * | 2015-01-08 | 2022-05-13 | 根马布股份公司 | 针对cd3和cd20的双特异性抗体 |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| CN114835797A (zh) * | 2015-11-16 | 2022-08-02 | Ubi蛋白公司 | 用于延长蛋白质半衰期的方法 |
| WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
| TW202021618A (zh) | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| RS66543B1 (sr) | 2018-08-31 | 2025-03-31 | Regeneron Pharma | Strategija doziranja koja ublažava sindrom oslobađanja citokina za cd3/cd20 bispecifična antitela |
| AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
| BR112021010374A2 (pt) | 2018-12-21 | 2021-08-24 | 23Andme, Inc. | Anticorpos anti-il-36 e métodos de uso dos mesmos |
| US20230227570A1 (en) | 2020-05-08 | 2023-07-20 | Genmab A/S | Bispecific antibodies against cd3 and cd20 |
| BR112022024339A2 (pt) | 2020-05-29 | 2022-12-27 | 23Andme Inc | Anticorpos anti cd200r1 e métodos de uso dos mesmos |
| CN116234824A (zh) | 2020-06-22 | 2023-06-06 | 阿尔米雷尔有限公司 | 抗il-36抗体及其使用方法 |
| JP2023541627A (ja) | 2020-09-14 | 2023-10-03 | イシュノス サイエンシズ ソシエテ アノニム | Ｉｌ１ｒａｐに結合する抗体及びその使用 |
| WO2024123558A2 (en) * | 2022-12-05 | 2024-06-13 | The Scripps Research Institute | Engineered lassa viral immunogens and vaccine compositions |
| WO2024146458A1 (zh) * | 2023-01-06 | 2024-07-11 | 广东东阳光药业股份有限公司 | 抗il-11细胞因子人源化抗体 |
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| AU600575B2 (en) * | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| US6046310A (en) * | 1996-03-13 | 2000-04-04 | Protein Design Labs., Inc. | FAS ligand fusion proteins and their uses |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US7300916B2 (en) * | 2001-02-27 | 2007-11-27 | Yoshiko Yasuda | Preventives/remedies for thickened scar, keloid or chronic arthritic diseases |
| US20020197694A1 (en) * | 2001-06-20 | 2002-12-26 | Weiping Shao | Conjugates of reduced antibodies and biomolecules |
| GB2380127A (en) * | 2001-09-26 | 2003-04-02 | Isis Innovation | Treatment of chronic joint inflammation |
| US7053202B2 (en) * | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2499816C (en) * | 2002-09-27 | 2013-07-30 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| NZ538996A (en) * | 2002-10-31 | 2008-04-30 | Genentech Inc | Methods and compositions for increasing antibody production |
| WO2005063816A2 (en) * | 2003-12-19 | 2005-07-14 | Genentech, Inc. | Monovalent antibody fragments useful as therapeutics |
| CA2578613A1 (en) * | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
| AR056142A1 (es) * | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| US10155816B2 (en) * | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
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| AU2008255387B2 (en) | 2014-06-26 |
| AU2008255387A1 (en) | 2008-12-04 |
| US20100325744A1 (en) | 2010-12-23 |
| WO2008145137A2 (en) | 2008-12-04 |
| WO2008145137A3 (en) | 2009-02-12 |
| EP2170951A2 (en) | 2010-04-07 |
| JP2010527621A (ja) | 2010-08-19 |
| JP5511654B2 (ja) | 2014-06-04 |
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