JP2010527365A5 - - Google Patents

Info

Publication number

JP2010527365A5

JP2010527365A5 JP2010508500A JP2010508500A JP2010527365A5 JP 2010527365 A5 JP2010527365 A5 JP 2010527365A5 JP 2010508500 A JP2010508500 A JP 2010508500A JP 2010508500 A JP2010508500 A JP 2010508500A JP 2010527365 A5 JP2010527365 A5 JP 2010527365A5

Authority

JP

Japan

Prior art keywords

amino

alkyl

ethyl

methyl

hydrogen

Prior art date

2008-05-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• -1 methoxy, hydroxy, amino, chloro, amino Chemical group 0.000 claims 36
• 125000000217 alkyl group Chemical group 0.000 claims 17
• 229910052739 hydrogen Inorganic materials 0.000 claims 15
• 239000001257 hydrogen Substances 0.000 claims 15
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
• 150000001875 compounds Chemical class 0.000 claims 10
• 125000001153 fluoro group Chemical group F* 0.000 claims 10
• 150000002431 hydrogen Chemical class 0.000 claims 10
• 150000003839 salts Chemical class 0.000 claims 10
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
• 125000001309 chloro group Chemical group Cl* 0.000 claims 2
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000000168 pyrrolyl group Chemical group 0.000 claims 2
• 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 1
• 241001024304 Mino Species 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
• 125000004267 aziridin-2-yl group Chemical group [H]N1C([H])([H])C1([H])* 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1