JP2010526868A - 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド - Google Patents

改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド Download PDF

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JP2010526868A
JP2010526868A JP2010508009A JP2010508009A JP2010526868A JP 2010526868 A JP2010526868 A JP 2010526868A JP 2010508009 A JP2010508009 A JP 2010508009A JP 2010508009 A JP2010508009 A JP 2010508009A JP 2010526868 A JP2010526868 A JP 2010526868A
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amino acid
antibody
modified
human
antibodies
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Japanese (ja)
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グレッグ エルソン，
オリビエ ルジェール，
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ノビミューン エスアー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010508009A 2007-05-14 2008-05-14 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド Withdrawn JP2010526868A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93027607P 2007-05-14 2007-05-14
PCT/IB2008/003978 WO2009101479A2 (en) 2007-05-14 2008-05-14 Fc receptor-binding polypeptides with modified effector functions

Related Child Applications (1)

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JP2013213487A Division JP2014005306A (ja) 2007-05-14 2013-10-11 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド

Publications (1)

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JP2010526868A true JP2010526868A (ja) 2010-08-05

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JP2010508009A Withdrawn JP2010526868A (ja) 2007-05-14 2008-05-14 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2013213487A Withdrawn JP2014005306A (ja) 2007-05-14 2013-10-11 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2014218179A Withdrawn JP2015017133A (ja) 2007-05-14 2014-10-27 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2016221204A Active JP6360128B2 (ja) 2007-05-14 2016-11-14 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2018028606A Withdrawn JP2018087234A (ja) 2007-05-14 2018-02-21 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2020074563A Pending JP2020111613A (ja) 2007-05-14 2020-04-20 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド

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JP2013213487A Withdrawn JP2014005306A (ja) 2007-05-14 2013-10-11 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2014218179A Withdrawn JP2015017133A (ja) 2007-05-14 2014-10-27 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2016221204A Active JP6360128B2 (ja) 2007-05-14 2016-11-14 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2018028606A Withdrawn JP2018087234A (ja) 2007-05-14 2018-02-21 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド
JP2020074563A Pending JP2020111613A (ja) 2007-05-14 2020-04-20 改変されたエフェクター機能を有するＦｃ受容体結合ポリペプチド

Country Status (14)

Country Link
US (3) US8546539B2 (he)
EP (1) EP2173381B1 (he)
JP (6) JP2010526868A (he)
CN (1) CN101720232B (he)
AU (1) AU2008350535B2 (he)
CA (1) CA2689680C (he)
DK (1) DK2173381T3 (he)
ES (1) ES2441189T3 (he)
IL (1) IL202107A (he)
MX (1) MX2009012319A (he)
PL (1) PL2173381T3 (he)
PT (1) PT2173381E (he)
SI (1) SI2173381T1 (he)
WO (1) WO2009101479A2 (he)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014505056A (ja) * 2011-01-10 2014-02-27 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用法
JP2015514094A (ja) * 2012-03-29 2015-05-18 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用
JP2018523827A (ja) * 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

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PT2173381E (pt) * 2007-05-14 2013-12-13 Novimmune Sa Polipéptidos que se ligam ao receptor fc, com funções efectivadoras modificadas
IE20090514A1 (en) * 2009-07-06 2011-02-16 Opsona Therapeutics Ltd Humanised antibodies and uses therof
AU2014338991B2 (en) * 2013-10-22 2020-06-11 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers
WO2015082716A1 (en) 2013-12-06 2015-06-11 Novimmune S.A. Anti-tlr4 antibodies and methods of use thereof
AU2018244574A1 (en) * 2017-03-28 2019-10-31 Lyvgen Biopharma Holdings Limited Therapeutic agents and methods for enhancing immune responses in tumor microenvironment
US11623963B2 (en) * 2017-10-03 2023-04-11 Merck Patent Gmbh Cysteine engineered antigen-binding molecules
AR122263A1 (es) * 2019-05-09 2022-08-31 Genentech Inc Métodos para producir anticuerpos
KR20220129026A (ko) * 2020-01-17 2022-09-22 유니버시티 오브 테네시 리서치 파운데이션 아밀로이드 제거를 위한 키메라 항원 수용체
CN115697410A (zh) * 2020-04-20 2023-02-03 艾德沙生物科技研究公司 用于治疗急性呼吸窘迫综合征的组合物和方法
EP4204003A1 (en) * 2020-08-28 2023-07-05 Board of Regents, The University of Texas System Antibodies specific to ccl21 and methods of use
WO2024040115A2 (en) * 2022-08-16 2024-02-22 University Of Vermont And State Agricultural College ANTIBODIES FOR PLATELET FCγRIIA AND RELATED METHODS OF USE
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

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US20060134709A1 (en) * 2004-11-10 2006-06-22 Jeffery Stavenhagen Engineering Fc antibody regions to confer effector function
WO2006077471A2 (en) * 2004-12-10 2006-07-27 Novimmune S.A. Combining therapies targeting multiple toll-like receptors and use thereof
WO2006085967A2 (en) * 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS

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PT2173381E (pt) * 2007-05-14 2013-12-13 Novimmune Sa Polipéptidos que se ligam ao receptor fc, com funções efectivadoras modificadas
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Publication number Priority date Publication date Assignee Title
WO2005065015A2 (en) * 2003-12-10 2005-07-21 Novimmune Sa Neutralizing antibodies and methods of use thereof
WO2006085967A2 (en) * 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
US20060134709A1 (en) * 2004-11-10 2006-06-22 Jeffery Stavenhagen Engineering Fc antibody regions to confer effector function
WO2006077471A2 (en) * 2004-12-10 2006-07-27 Novimmune S.A. Combining therapies targeting multiple toll-like receptors and use thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014505056A (ja) * 2011-01-10 2014-02-27 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用法
JP2017137319A (ja) * 2011-01-10 2017-08-10 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用法
JP2015514094A (ja) * 2012-03-29 2015-05-18 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用
JP2018523827A (ja) * 2015-08-06 2018-08-23 ノビミューン エスアー Ｔｌｒ４依存性障害の診断および処置のための患者集団を特定するための方法および組成物

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Publication number Publication date
JP2018087234A (ja) 2018-06-07
PT2173381E (pt) 2013-12-13
CA2689680A1 (en) 2009-08-20
IL202107A0 (en) 2011-08-01
US8546539B2 (en) 2013-10-01
US20120142098A1 (en) 2012-06-07
DK2173381T3 (da) 2013-12-02
EP2173381A2 (en) 2010-04-14
EP2173381B1 (en) 2013-10-02
JP2014005306A (ja) 2014-01-16
US9688755B2 (en) 2017-06-27
WO2009101479A2 (en) 2009-08-20
US20140038287A1 (en) 2014-02-06
JP2020111613A (ja) 2020-07-27
MX2009012319A (es) 2010-03-01
JP2015017133A (ja) 2015-01-29
AU2008350535A1 (en) 2009-08-20
WO2009101479A3 (en) 2010-02-25
US20170298129A1 (en) 2017-10-19
CN101720232A (zh) 2010-06-02
PL2173381T3 (pl) 2014-03-31
JP6360128B2 (ja) 2018-07-18
IL202107A (he) 2014-05-28
AU2008350535B2 (en) 2013-08-22
CA2689680C (en) 2017-11-07
JP2017036333A (ja) 2017-02-16
CN101720232B (zh) 2013-07-10
SI2173381T1 (sl) 2014-01-31
ES2441189T3 (es) 2014-02-03

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