JP2010526827A5 - - Google Patents
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- Publication number
- JP2010526827A5 JP2010526827A5 JP2010507667A JP2010507667A JP2010526827A5 JP 2010526827 A5 JP2010526827 A5 JP 2010526827A5 JP 2010507667 A JP2010507667 A JP 2010507667A JP 2010507667 A JP2010507667 A JP 2010507667A JP 2010526827 A5 JP2010526827 A5 JP 2010526827A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- composition
- pharmaceutically acceptable
- acceptable salt
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- DCHPLQUDSBXAGH-UHFFFAOYSA-N (2-butan-2-yl-6-propan-2-ylphenyl) carbamate Chemical compound CCC(C)C1=CC=CC(C(C)C)=C1OC(N)=O DCHPLQUDSBXAGH-UHFFFAOYSA-N 0.000 claims 2
- 206010039897 Sedation Diseases 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000002695 general anesthesia Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000036280 sedation Effects 0.000 claims 2
- HTQRYADIGJQWKE-UHFFFAOYSA-N 2-butan-2-yl-6-propan-2-ylaniline Chemical compound CCC(C)C1=CC=CC(C(C)C)=C1N HTQRYADIGJQWKE-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 238000006193 diazotization reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000002960 lipid emulsion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92841607P | 2007-05-09 | 2007-05-09 | |
| US92834507P | 2007-05-09 | 2007-05-09 | |
| PCT/US2008/063088 WO2008141099A1 (en) | 2007-05-09 | 2008-05-08 | Therapeutic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010526827A JP2010526827A (ja) | 2010-08-05 |
| JP2010526827A5 true JP2010526827A5 (Direct) | 2011-06-23 |
Family
ID=39619201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507667A Pending JP2010526827A (ja) | 2007-05-09 | 2008-05-08 | 治療用化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8173849B2 (Direct) |
| EP (2) | EP2152651B1 (Direct) |
| JP (1) | JP2010526827A (Direct) |
| KR (1) | KR20100017435A (Direct) |
| CN (1) | CN101687746A (Direct) |
| AT (1) | ATE540010T1 (Direct) |
| AU (1) | AU2008251484A1 (Direct) |
| BR (1) | BRPI0811284A2 (Direct) |
| CA (1) | CA2685813A1 (Direct) |
| DK (1) | DK2152651T3 (Direct) |
| ES (1) | ES2380824T3 (Direct) |
| IL (1) | IL201735A0 (Direct) |
| MX (1) | MX2009012125A (Direct) |
| MY (1) | MY147215A (Direct) |
| RU (1) | RU2470907C2 (Direct) |
| WO (1) | WO2008141099A1 (Direct) |
| ZA (1) | ZA201007602B (Direct) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009012124A (es) | 2007-05-09 | 2010-02-18 | Pharmacofore Inc | Compuestos terapeuticos estereoisomeros de propofol. |
| US20120283335A1 (en) * | 2008-05-12 | 2012-11-08 | Jenkins Thomas E | Analogs of Propofol, Preparation Thereof and Use as Anesthetics |
| CN102085185B (zh) * | 2010-12-07 | 2013-04-24 | 西安力邦制药有限公司 | 无痛和低注射刺激的新型丙泊酚脂肪乳制剂配方和制备方法 |
| CN102603488B (zh) * | 2012-03-06 | 2017-01-04 | 云南龙海天然植物药业有限公司 | 一种制备高纯度丙泊酚的新方法 |
| CN102731265B (zh) * | 2012-06-12 | 2014-12-10 | 四川百利药业有限责任公司 | 一种高纯度丙泊酚的制备方法 |
| US9284260B2 (en) * | 2012-11-02 | 2016-03-15 | Sumitomo Chemical Company, Limited | Method for producing racemate of compound |
| CN104649867B (zh) * | 2013-11-21 | 2017-02-15 | 辽宁药联制药有限公司 | 一种丙泊酚的制备方法 |
| CN105384607B (zh) * | 2014-08-22 | 2019-08-16 | 四川海思科制药有限公司 | 一种异丙基苯酚衍生物及其制备方法 |
| CN105384608B (zh) * | 2014-08-22 | 2019-08-16 | 四川海思科制药有限公司 | 一种异丙基苯酚衍生物及其制备方法 |
| CN105384604B (zh) * | 2014-08-22 | 2019-07-05 | 四川海思科制药有限公司 | 一种异丙基苯酚衍生物及其制备方法 |
| PT3189834T (pt) * | 2014-09-04 | 2024-03-15 | Sichuan Haisco Pharmaceutical Co Ltd | Utilização de agente de reforço do recetor gabaa na preparação de medicamento sedativo e anestésico |
| CN105820040B (zh) * | 2015-01-22 | 2018-07-24 | 四川海思科制药有限公司 | 一种异丙基苯酚衍生物及其制备方法 |
| CN106278947B (zh) * | 2015-05-19 | 2020-03-06 | 四川海思科制药有限公司 | 苯酚衍生物的晶型及其制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2747982A (en) | 1955-05-11 | 1956-05-29 | Dow Chemical Co | Method and composition for the control of the growth of vegetation |
| US4798846A (en) | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| SU1525139A1 (ru) * | 1987-11-10 | 1989-11-30 | Куйбышевский политехнический институт им.В.В.Куйбышева | Способ получени о-втор-бутилфенола |
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| GB9405593D0 (en) | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5731356A (en) | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| US6254853B1 (en) | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6140374A (en) | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| ATE267586T1 (de) | 1999-02-18 | 2004-06-15 | Supergen Inc | An phosphocholin gebundene prodrug-derivate |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6362234B1 (en) | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| WO2002028411A1 (en) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Compounds for sustained release of orally delivered drugs |
| CA2441744C (en) * | 2001-03-20 | 2011-07-12 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| JP2005517679A (ja) | 2001-12-28 | 2005-06-16 | ギルフォード ファーマシューティカルズ インコーポレイテッド | プロポフォールの水溶性プロドラッグの水ベースの薬学的製剤 |
| US7035343B2 (en) | 2002-01-31 | 2006-04-25 | Qualcomm Inc. | Closed loop transmit diversity antenna verification using trellis decoding |
| US6927036B2 (en) | 2002-02-19 | 2005-08-09 | Xero Port, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| BG65734B1 (bg) | 2002-02-22 | 2009-09-30 | Био Терапютикс - Еоод | Течен мукоадхезивен фармацевтичен състав |
| BR0308857A (pt) | 2002-04-08 | 2005-01-04 | Guilford Pharm Inc | Composições farmacêuticas contendo promedicamentos de propofol, solúveis em água, e métodos de administrar os mesmos |
| DE20215415U1 (de) | 2002-10-08 | 2004-02-26 | Biotechnologie Gesellschaft Mittelhessen Mbh | Wasserlösliche Medikamentenvorstufen von Propofol |
| DE60323756D1 (de) | 2002-10-08 | 2008-11-06 | Fresenius Kabi De Gmbh | Pharmazeutisch aktive oligosaccharid-conjugate |
| ZA200504940B (en) | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| AU2003901815A0 (en) | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| US7230003B2 (en) | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| WO2005033279A2 (en) * | 2003-09-29 | 2005-04-14 | University Of Virginia Patent Foundation | Discovery of novel soluble crystalline anesthetics |
| US7241807B2 (en) | 2004-07-12 | 2007-07-10 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| EP1791521A4 (en) | 2004-09-17 | 2009-10-21 | Eisai Corp North America | METHODS OF ADMINISTERING PROPOFOL PROMOTERS WITH WATER SOLUBLE |
| JP2008525501A (ja) | 2004-12-23 | 2008-07-17 | ゼノポート，インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
| DE102005033496A1 (de) * | 2005-07-19 | 2007-01-25 | Bayer Healthcare Ag | Desinfektionsmittel |
| AU2006328198B2 (en) * | 2005-12-19 | 2013-07-18 | Medizinische Hochschule Hannover | Substituted phenol derivatives as analgesics |
| US7535698B2 (en) | 2006-03-07 | 2009-05-19 | Panasonic Corporation | Case, portable information equipment using the same and manufacturing method of the case |
| US7731356B1 (en) | 2006-07-24 | 2010-06-08 | Daniel Ayers Gilbert | Hanging eyeglasses |
-
2008
- 2008-05-08 DK DK08769340.4T patent/DK2152651T3/da active
- 2008-05-08 AU AU2008251484A patent/AU2008251484A1/en not_active Abandoned
- 2008-05-08 RU RU2009145541/04A patent/RU2470907C2/ru not_active IP Right Cessation
- 2008-05-08 EP EP08769340A patent/EP2152651B1/en active Active
- 2008-05-08 KR KR1020097024778A patent/KR20100017435A/ko not_active Withdrawn
- 2008-05-08 MX MX2009012125A patent/MX2009012125A/es active IP Right Grant
- 2008-05-08 BR BRPI0811284-3A2A patent/BRPI0811284A2/pt not_active IP Right Cessation
- 2008-05-08 AT AT08769340T patent/ATE540010T1/de active
- 2008-05-08 ES ES08769340T patent/ES2380824T3/es active Active
- 2008-05-08 US US12/596,711 patent/US8173849B2/en not_active Expired - Fee Related
- 2008-05-08 JP JP2010507667A patent/JP2010526827A/ja active Pending
- 2008-05-08 WO PCT/US2008/063088 patent/WO2008141099A1/en not_active Ceased
- 2008-05-08 EP EP11177818A patent/EP2392559A1/en not_active Withdrawn
- 2008-05-08 CN CN200880015398A patent/CN101687746A/zh active Pending
- 2008-05-08 MY MYPI20094593A patent/MY147215A/en unknown
- 2008-05-08 CA CA002685813A patent/CA2685813A1/en not_active Abandoned
-
2009
- 2009-10-25 IL IL201735A patent/IL201735A0/en unknown
-
2010
- 2010-10-25 ZA ZA2010/07602A patent/ZA201007602B/en unknown
-
2012
- 2012-04-02 US US13/437,802 patent/US8350097B2/en not_active Expired - Fee Related
- 2012-12-03 US US13/692,853 patent/US20130217783A1/en not_active Abandoned
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