JP2010525023A5 - - Google Patents

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Publication number
JP2010525023A5
JP2010525023A5 JP2010504682A JP2010504682A JP2010525023A5 JP 2010525023 A5 JP2010525023 A5 JP 2010525023A5 JP 2010504682 A JP2010504682 A JP 2010504682A JP 2010504682 A JP2010504682 A JP 2010504682A JP 2010525023 A5 JP2010525023 A5 JP 2010525023A5
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JP
Japan
Prior art keywords
alkyl
methyl
hydrogen
hydroxy
heterocycloalkyl
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Application number
JP2010504682A
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English (en)
Japanese (ja)
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JP2010525023A (ja
JP5379787B2 (ja
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Priority claimed from PCT/EP2008/054977 external-priority patent/WO2008129071A1/en
Publication of JP2010525023A publication Critical patent/JP2010525023A/ja
Publication of JP2010525023A5 publication Critical patent/JP2010525023A5/ja
Application granted granted Critical
Publication of JP5379787B2 publication Critical patent/JP5379787B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010504682A 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤 Expired - Fee Related JP5379787B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2007/003603 2007-04-24
EP2007003603 2007-04-24
PCT/EP2008/054977 WO2008129071A1 (en) 2007-04-24 2008-04-24 Inhibitors of protein kinases

Publications (3)

Publication Number Publication Date
JP2010525023A JP2010525023A (ja) 2010-07-22
JP2010525023A5 true JP2010525023A5 (index.php) 2011-06-16
JP5379787B2 JP5379787B2 (ja) 2013-12-25

Family

ID=39529321

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504682A Expired - Fee Related JP5379787B2 (ja) 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤

Country Status (3)

Country Link
US (2) US8841315B2 (index.php)
JP (1) JP5379787B2 (index.php)
WO (1) WO2008129071A1 (index.php)

Cited By (1)

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US9093366B2 (en) 2012-04-09 2015-07-28 Transphorm Inc. N-polar III-nitride transistors

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JP5921525B2 (ja) * 2010-03-22 2016-05-24 リード ディスカバリー センター ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬的に活性のある二置換のトリアジン誘導体
TWI555737B (zh) 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺
EP2527332A1 (en) 2011-05-24 2012-11-28 Bayer Intellectual Property GmbH 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors
EP2755948B1 (en) 2011-09-16 2016-05-25 Bayer Intellectual Property GmbH Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
ES2587284T3 (es) 2011-09-16 2016-10-21 Bayer Intellectual Property Gmbh 5-Fluoro-pirimidinas 2,4-disustituidas como inhibidores selectivos de CDK9
US8598937B2 (en) 2011-10-07 2013-12-03 Transphorm Inc. High power semiconductor electronic components with increased reliability
US8803246B2 (en) 2012-07-16 2014-08-12 Transphorm Inc. Semiconductor electronic components with integrated current limiters
CA2888371C (en) 2012-10-18 2021-06-08 Ulrich Lucking 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
US20150259300A1 (en) 2012-10-18 2015-09-17 Bayer Pharma Aktiengesellschaft 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfone group
CN105283453B (zh) * 2012-10-18 2018-06-22 拜耳药业股份公司 含砜基的n-(吡啶-2-基)嘧啶-4-胺衍生物
UA115254C2 (uk) 2012-11-15 2017-10-10 Баєр Фарма Акціенгезельшафт Похідні 5-фтор-n-(піридин-2-іл)піридин-2-аміну, що містять сульфоксімінову групу
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物
US9087718B2 (en) 2013-03-13 2015-07-21 Transphorm Inc. Enhancement-mode III-nitride devices
US9245992B2 (en) 2013-03-15 2016-01-26 Transphorm Inc. Carbon doping semiconductor devices
WO2015001021A1 (en) 2013-07-04 2015-01-08 Bayer Pharma Aktiengesellschaft Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors
WO2015009514A1 (en) 2013-07-19 2015-01-22 Transphorm Inc. Iii-nitride transistor including a p-type depleting layer
CN106232596A (zh) 2014-03-13 2016-12-14 拜耳医药股份有限公司 含有砜基团的5‑氟‑n‑(吡啶‑2‑基)吡啶‑2‑胺衍生物
EP3126338B1 (en) 2014-04-01 2019-09-04 Bayer Pharma Aktiengesellschaft Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group
AP2016009483A0 (en) 2014-04-11 2016-10-31 Bayer Pharma AG Novel macrocyclic compounds
US9543940B2 (en) 2014-07-03 2017-01-10 Transphorm Inc. Switching circuits having ferrite beads
US9318593B2 (en) 2014-07-21 2016-04-19 Transphorm Inc. Forming enhancement mode III-nitride devices
ES2691227T3 (es) 2014-10-16 2018-11-26 Bayer Pharma Aktiengesellschaft Derivados fluorados de benzofuranil-pirimidina que contienen un grupo sulfoximina
CN107207475A (zh) 2014-10-16 2017-09-26 拜耳医药股份有限公司 含有砜基团的氟化苯并呋喃基‑嘧啶衍生物
CN107428707A (zh) 2015-03-24 2017-12-01 拜耳制药股份公司 4‑(4‑氟‑2‑甲氧基苯基)‑n‑{3‑[(s‑甲基亚磺酰亚胺基)甲基]苯基}‑1,3,5‑三嗪‑2‑胺用于治疗多发性骨髓瘤的用途
CN107427520A (zh) 2015-03-24 2017-12-01 拜耳医药股份有限公司 4‑(4‑氟‑2‑甲氧基苯基)‑n‑{3‑[(s‑甲基磺酰亚氨基)甲基]苯基}‑1,3,5‑三嗪‑2‑胺用于治疗淋巴瘤的用途
WO2016150902A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating gastric cancers
LT3539961T (lt) 2015-06-29 2021-12-27 Astrazeneca Ab Policikliniai amido dariniai, kaip cdk9 inhibitoriai
WO2017055196A1 (en) 2015-09-29 2017-04-06 Bayer Pharma Aktiengesellschaft Novel macrocyclic sulfondiimine compounds
ES2819869T3 (es) 2015-10-08 2021-04-19 Bayer Pharma AG Nuevos compuestos macrocíclicos modificados
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
WO2017123999A1 (en) 2016-01-15 2017-07-20 Transphorm Inc. Enhancement mode iii-nitride devices having an al(1-x)sixo gate insulator
WO2017210323A1 (en) 2016-05-31 2017-12-07 Transphorm Inc. Iii-nitride devices including a graded depleting layer
US11242356B2 (en) 2017-03-28 2022-02-08 Bayer Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
WO2018177899A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
CA3090843A1 (en) 2018-02-13 2019-08-22 Bayer Aktiengesellschaft Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma

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Publication number Priority date Publication date Assignee Title
HUP0300382A3 (en) * 2000-03-29 2006-11-28 Cyclacel Ltd 2-substituted 4-heteroaryl-pyrimidines and their use in the treatmetn of proliferative disorders and pharmaceutical compositions containing the compounds
GB0205693D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9093366B2 (en) 2012-04-09 2015-07-28 Transphorm Inc. N-polar III-nitride transistors

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