JP2010523676A5 - - Google Patents

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Publication number
JP2010523676A5
JP2010523676A5 JP2010503070A JP2010503070A JP2010523676A5 JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5 JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5
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JP
Japan
Prior art keywords
composition
liposome
peptide
hiv
immunogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010503070A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010523676A (ja
Filing date
Publication date
Priority claimed from US11/785,077 external-priority patent/US9402893B2/en
Priority claimed from US11/812,992 external-priority patent/US20080057075A1/en
Application filed filed Critical
Priority claimed from PCT/US2008/004709 external-priority patent/WO2008127651A1/en
Publication of JP2010523676A publication Critical patent/JP2010523676A/ja
Publication of JP2010523676A5 publication Critical patent/JP2010523676A5/ja
Pending legal-status Critical Current

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JP2010503070A 2007-04-13 2008-04-11 ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 Pending JP2010523676A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/785,077 US9402893B2 (en) 2005-04-12 2007-04-13 Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
US11/812,992 US20080057075A1 (en) 2005-04-12 2007-06-22 Method of inducing neutralizing antibodies to human immunodeficiency virus
US96041307P 2007-09-28 2007-09-28
PCT/US2008/004709 WO2008127651A1 (en) 2007-04-13 2008-04-11 Method of inducing neutralizing antibodies to human immunodeficiency virus

Publications (2)

Publication Number Publication Date
JP2010523676A JP2010523676A (ja) 2010-07-15
JP2010523676A5 true JP2010523676A5 (enExample) 2010-11-18

Family

ID=39864256

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010503070A Pending JP2010523676A (ja) 2007-04-13 2008-04-11 ヒト免疫不全ウイルスに対する中和抗体を誘導する方法

Country Status (6)

Country Link
US (2) US8956627B2 (enExample)
EP (1) EP2139516A4 (enExample)
JP (1) JP2010523676A (enExample)
AU (1) AU2008239628B2 (enExample)
CA (1) CA2683752A1 (enExample)
WO (1) WO2008127651A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110831A2 (en) 2005-04-12 2006-10-19 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
WO2008127651A1 (en) 2007-04-13 2008-10-23 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
US20120070488A1 (en) * 2007-09-28 2012-03-22 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
CA2736030A1 (en) * 2008-09-05 2010-03-11 Barton F. Haynes Method of inducing an anti-viral immune response
EP2413951A4 (en) * 2009-04-03 2015-05-20 Univ Duke FORMULATION FOR GENERATING A WIDE REACTIVE NEUTRALIZATION OF HIV ANTIBODIES
WO2011046623A2 (en) * 2009-10-16 2011-04-21 Duke University Hiv-1 antibodies
JP2013520498A (ja) * 2010-02-25 2013-06-06 デューク ユニバーシティー 防御的抗hiv−1抗体の産生を誘導する方法
WO2013134293A1 (en) * 2012-03-05 2013-09-12 Duke University Vaccine formulation
WO2015048635A1 (en) 2013-09-27 2015-04-02 Duke University Mper-liposome conjugates and uses thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US5831034A (en) * 1987-11-13 1998-11-03 Hermann Katinger Human monoclonal anti-HIV-I-antibodies
US4994440A (en) * 1989-02-13 1991-02-19 Creaven Patrick J Method for the treatment of renal cell carcinoma
DE570357T1 (de) * 1992-05-14 1994-07-28 Polimun Scientific Immunbiologische Forschungsgesellschaft Mbh, Wien Peptide, die Antikörper induzieren, die genetisch divergierende HIV-1 Isolationen neutralisieren.
NZ263373A (en) * 1993-03-11 1997-05-26 Univ Southern California Monoclonal antibodies and use against immunoinfective cluster viruses
EP0702563B1 (en) * 1993-05-27 2003-08-06 EntreMed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
AU7384994A (en) * 1993-08-06 1995-02-28 Opperbas Holding B.V. A method for high loading of vesicles with biopolymeric substances
BR9407531A (pt) 1993-09-11 1997-08-26 Polymun Scient Immunbio Forsch Peptideos que provocam a formação de anticorpos neutralizadores contra cepas de HIV-1 geneticamente divergentes
CA2185129A1 (en) 1994-03-14 1995-09-21 Angeline Douvas Methods to diagnose and treat hiv-1 infection
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2178672T3 (es) 1995-04-19 2003-01-01 Polymun Scient Immunbio Forsch Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos.
AU5978596A (en) * 1995-06-07 1996-12-30 U.S. Department Of The Army Liposomes containing human immunodeficiency virus glycoprote in and methods for use thereof
US5910306A (en) 1996-11-14 1999-06-08 The United States Of America As Represented By The Secretary Of The Army Transdermal delivery system for antigen
US5901306A (en) * 1997-06-23 1999-05-04 Sun Microsystems, Inc. Method and apparatus for reducing a computational result to the range boundaries of a signed 8-bit integer in case of overflow
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US6300308B1 (en) * 1997-12-31 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions for inducing autoimmunity in the treatment of cancers
WO2003022879A2 (en) 2001-09-07 2003-03-20 Polymun Scientific Immunbiologische Forschung Gmbh Peptides mimicking a cryptic epitope of gp41 hiv-1 and antibodies directed against them
US7195768B2 (en) * 2001-11-07 2007-03-27 Duke University Polyvalent immunogen
ATE444310T1 (de) * 2002-01-17 2009-10-15 Polymun Scient Immunbio Forsch Antiidiotypische antikörper die hiv-1 neutralisierende antikörper induzieren
DE60335383D1 (de) 2002-07-15 2011-01-27 Univ Texas Antikörper mit bindung an anionische phospholipide und aminophospholipide und ihre verwendung bei der behandlung von virusinfektionen
US7611704B2 (en) * 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7678386B2 (en) * 2002-07-15 2010-03-16 Board Of Regents The University Of Texas Liposomes coated with selected antibodies that bind to aminophospholipids
US7455833B2 (en) * 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US20040131622A1 (en) * 2002-07-15 2004-07-08 Board Of Regents Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids
US7384909B2 (en) * 2002-07-15 2008-06-10 Board Of Regents, The University Of Texas System Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents
US7906115B2 (en) * 2002-07-15 2011-03-15 Thorpe Philip E Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7790159B2 (en) * 2002-07-15 2010-09-07 Board Of Regents, The University Of Texas System Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids
CA2520382C (en) 2003-03-27 2014-01-28 Sudhir Paul Lupus antibodies for passive immunotherapy of hiv/aids
US8147840B2 (en) * 2004-05-14 2012-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid
US20080057075A1 (en) * 2005-04-12 2008-03-06 Haynes Barton F Method of inducing neutralizing antibodies to human immunodeficiency virus
WO2006110831A2 (en) * 2005-04-12 2006-10-19 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
WO2008127651A1 (en) 2007-04-13 2008-10-23 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
CN101678091A (zh) * 2007-05-24 2010-03-24 葛兰素史密丝克莱恩生物有限公司 冷冻干燥的抗原组合物
US20120070488A1 (en) * 2007-09-28 2012-03-22 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
WO2009111304A2 (en) 2008-02-29 2009-09-11 President And Fellows Of Harvard College A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies
SMT202000101T1 (it) 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
CA2757306A1 (en) 2009-04-03 2010-10-07 Duke University Formulation
EP2413951A4 (en) * 2009-04-03 2015-05-20 Univ Duke FORMULATION FOR GENERATING A WIDE REACTIVE NEUTRALIZATION OF HIV ANTIBODIES

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