JP2010523676A5 - - Google Patents
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- Publication number
- JP2010523676A5 JP2010523676A5 JP2010503070A JP2010503070A JP2010523676A5 JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5 JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- liposome
- peptide
- hiv
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 9
- 239000002502 liposome Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000000562 conjugate Substances 0.000 claims 4
- 239000000863 peptide conjugate Substances 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 claims 2
- 101710180007 Beta-2-glycoprotein 1 Proteins 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/785,077 US9402893B2 (en) | 2005-04-12 | 2007-04-13 | Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies |
| US11/812,992 US20080057075A1 (en) | 2005-04-12 | 2007-06-22 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US96041307P | 2007-09-28 | 2007-09-28 | |
| PCT/US2008/004709 WO2008127651A1 (en) | 2007-04-13 | 2008-04-11 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523676A JP2010523676A (ja) | 2010-07-15 |
| JP2010523676A5 true JP2010523676A5 (enExample) | 2010-11-18 |
Family
ID=39864256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503070A Pending JP2010523676A (ja) | 2007-04-13 | 2008-04-11 | ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8956627B2 (enExample) |
| EP (1) | EP2139516A4 (enExample) |
| JP (1) | JP2010523676A (enExample) |
| AU (1) | AU2008239628B2 (enExample) |
| CA (1) | CA2683752A1 (enExample) |
| WO (1) | WO2008127651A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006235507B2 (en) | 2005-04-12 | 2012-08-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| AU2008239628B2 (en) | 2007-04-13 | 2014-01-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CA2736030A1 (en) * | 2008-09-05 | 2010-03-11 | Barton F. Haynes | Method of inducing an anti-viral immune response |
| US9402917B2 (en) | 2009-04-03 | 2016-08-02 | Duke University | Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions |
| WO2011046623A2 (en) * | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
| CA2791025A1 (en) * | 2010-02-25 | 2011-09-01 | Duke University | Method of inducing the production of protective anti-hiv-1 antibodies |
| EP2822599A4 (en) * | 2012-03-05 | 2015-12-23 | Univ Duke | VACCINE FORMULATION |
| US10076567B2 (en) | 2013-09-27 | 2018-09-18 | Duke University | MPER-liposome conjugates and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916588A (en) * | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5831034A (en) * | 1987-11-13 | 1998-11-03 | Hermann Katinger | Human monoclonal anti-HIV-I-antibodies |
| US4994440A (en) * | 1989-02-13 | 1991-02-19 | Creaven Patrick J | Method for the treatment of renal cell carcinoma |
| EP0570357B1 (en) * | 1992-05-14 | 1997-06-25 | Polymun Scientific Immunbiologische Forschung GmbH | Peptides that induce antibodies which neutralize genetically divergent HIV-1 isolates |
| CN1122576A (zh) * | 1993-03-11 | 1996-05-15 | 南加利福尼亚大学 | 免疫感染簇病毒感染的治疗策略 |
| JPH08510751A (ja) * | 1993-05-27 | 1996-11-12 | エントレメッド インコーポレイテッド | 癌及び過増殖性疾患を治療するための組成物及び方法 |
| CA2168671C (en) * | 1993-08-06 | 2007-04-10 | Yechezkel Barenholz | A method for high loading of vesicles with biopolymeric substances |
| HU219507B (hu) | 1993-09-11 | 2001-04-28 | Polymun Scientific Immunobiologische Forschung Gmbh. | Genetikailag divergens HIV-1-törzsekkel szemben neutralizáló ellenanyagok termelődését kiváltó peptidek |
| CA2185129A1 (en) | 1994-03-14 | 1995-09-21 | Angeline Douvas | Methods to diagnose and treat hiv-1 infection |
| US6156337A (en) * | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP0822941B1 (en) * | 1995-04-19 | 2002-06-12 | Polymun Scientific Immunbiologische Forschung GmbH | Monoclonal antibodies against hiv-1 and vaccines made thereof |
| WO1996040243A1 (en) * | 1995-06-07 | 1996-12-19 | U.S. Department Of The Army | Liposomes containing human immunodeficiency virus glycoprotein and methods for use thereof |
| US5910306A (en) | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| US5901306A (en) * | 1997-06-23 | 1999-05-04 | Sun Microsystems, Inc. | Method and apparatus for reducing a computational result to the range boundaries of a signed 8-bit integer in case of overflow |
| US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6300308B1 (en) * | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| AU2002340880B2 (en) | 2001-09-07 | 2007-08-23 | Polymun Scientific Immunbiologische Forschung Gmbh | Peptides mimicking a cryptic epitope of GP41 HIV-1 and antibodies directed against them |
| US7195768B2 (en) * | 2001-11-07 | 2007-03-27 | Duke University | Polyvalent immunogen |
| JP4495969B2 (ja) * | 2002-01-17 | 2010-07-07 | ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング | Ｈｉｖ−１中和抗体を誘導する抗イディオタイプ抗体 |
| US7611704B2 (en) * | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| KR20110025885A (ko) | 2002-07-15 | 2011-03-11 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도 |
| US7906115B2 (en) * | 2002-07-15 | 2011-03-15 | Thorpe Philip E | Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7455833B2 (en) * | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7790159B2 (en) * | 2002-07-15 | 2010-09-07 | Board Of Regents, The University Of Texas System | Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids |
| US7384909B2 (en) * | 2002-07-15 | 2008-06-10 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents |
| US20040131622A1 (en) * | 2002-07-15 | 2004-07-08 | Board Of Regents | Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids |
| US7678386B2 (en) * | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
| US8246957B2 (en) | 2003-03-27 | 2012-08-21 | Sudhir Paul | Lupus antibodies for passive immunotherapy of HIV/AIDS |
| US8147840B2 (en) * | 2004-05-14 | 2012-04-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid |
| AU2006235507B2 (en) * | 2005-04-12 | 2012-08-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20080057075A1 (en) * | 2005-04-12 | 2008-03-06 | Haynes Barton F | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| AU2008239628B2 (en) | 2007-04-13 | 2014-01-30 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| ES2395333T3 (es) * | 2007-05-24 | 2013-02-12 | Glaxosmithkline Biologicals S.A. | Composición liofilizada que contiene WT-1 y CPG |
| US20120070488A1 (en) | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| WO2009111304A2 (en) | 2008-02-29 | 2009-09-11 | President And Fellows Of Harvard College | A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies |
| SMT202000101T1 (it) | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| WO2010114629A2 (en) | 2009-04-03 | 2010-10-07 | Duke University | Formulation |
| US9402917B2 (en) * | 2009-04-03 | 2016-08-02 | Duke University | Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions |
-
2008
- 2008-04-11 AU AU2008239628A patent/AU2008239628B2/en not_active Ceased
- 2008-04-11 CA CA002683752A patent/CA2683752A1/en not_active Abandoned
- 2008-04-11 WO PCT/US2008/004709 patent/WO2008127651A1/en not_active Ceased
- 2008-04-11 EP EP08742782A patent/EP2139516A4/en not_active Withdrawn
- 2008-04-11 US US12/450,779 patent/US8956627B2/en not_active Expired - Fee Related
- 2008-04-11 JP JP2010503070A patent/JP2010523676A/ja active Pending
-
2015
- 2015-02-03 US US14/612,665 patent/US20150147387A1/en not_active Abandoned
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