JP2010523676A5 - - Google Patents
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- Publication number
- JP2010523676A5 JP2010523676A5 JP2010503070A JP2010503070A JP2010523676A5 JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5 JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- liposome
- peptide
- hiv
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 9
- 239000002502 liposome Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000000562 conjugate Substances 0.000 claims 4
- 239000000863 peptide conjugate Substances 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 claims 2
- 101710180007 Beta-2-glycoprotein 1 Proteins 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/785,077 US9402893B2 (en) | 2005-04-12 | 2007-04-13 | Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies |
| US11/812,992 US20080057075A1 (en) | 2005-04-12 | 2007-06-22 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US96041307P | 2007-09-28 | 2007-09-28 | |
| PCT/US2008/004709 WO2008127651A1 (en) | 2007-04-13 | 2008-04-11 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523676A JP2010523676A (ja) | 2010-07-15 |
| JP2010523676A5 true JP2010523676A5 (enExample) | 2010-11-18 |
Family
ID=39864256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503070A Pending JP2010523676A (ja) | 2007-04-13 | 2008-04-11 | ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8956627B2 (enExample) |
| EP (1) | EP2139516A4 (enExample) |
| JP (1) | JP2010523676A (enExample) |
| AU (1) | AU2008239628B2 (enExample) |
| CA (1) | CA2683752A1 (enExample) |
| WO (1) | WO2008127651A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1868651A4 (en) | 2005-04-12 | 2010-10-06 | Univ Duke | METHOD FOR INDUCTION OF NEUTRALIZING ANTIBODIES TO THE HIV VIRUS |
| WO2008127651A1 (en) | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| EP2331104A4 (en) * | 2008-09-05 | 2012-10-17 | Univ Duke | METHOD FOR INDUCING AN ANTIVIRAL IMMUNE RESPONSE |
| EP2413951A4 (en) * | 2009-04-03 | 2015-05-20 | Univ Duke | FORMULATION FOR GENERATING A WIDE REACTIVE NEUTRALIZATION OF HIV ANTIBODIES |
| WO2011046623A2 (en) * | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
| JP2013520498A (ja) | 2010-02-25 | 2013-06-06 | デューク ユニバーシティー | 防御的抗ｈｉｖ−１抗体の産生を誘導する方法 |
| WO2013134293A1 (en) * | 2012-03-05 | 2013-09-12 | Duke University | Vaccine formulation |
| US10076567B2 (en) | 2013-09-27 | 2018-09-18 | Duke University | MPER-liposome conjugates and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916588A (en) * | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5831034A (en) | 1987-11-13 | 1998-11-03 | Hermann Katinger | Human monoclonal anti-HIV-I-antibodies |
| US4994440A (en) | 1989-02-13 | 1991-02-19 | Creaven Patrick J | Method for the treatment of renal cell carcinoma |
| DE69311764T2 (de) | 1992-05-14 | 1998-02-05 | Polymun Scient Immunbio Forsch | Peptide, die Antikörper induzieren, die genetisch divergierende HIV-1 Isolationen neutralisieren |
| JPH09500358A (ja) | 1993-03-11 | 1997-01-14 | ザ ユニバーシティ オブ サザンカリフォルニア | 免疫感染性クラスター・ウイルス感染のための治療的戦略 |
| DE69433013T2 (de) | 1993-05-27 | 2004-06-03 | Entremed, Inc. | Zubereitungen und verfahren für die behandlung von krebs und hyperproliferierenden krankheiten |
| DE69418334T2 (de) * | 1993-08-06 | 2000-01-27 | Opperbas Holding B.V., Amsterdam | Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen |
| CZ287808B6 (en) | 1993-09-11 | 2001-02-14 | Polymun Scient Immunbio Forsch | Peptides inducing formation of antibodies, process of their preparation, their use and antibody induced thereby and acting against genetically divergent HIV-1 strains |
| EP0750636A1 (en) | 1994-03-14 | 1997-01-02 | University Of Southern California | Methods to diagnose and treat hiv-1 infection |
| US6156337A (en) * | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ATE219105T1 (de) | 1995-04-19 | 2002-06-15 | Polymun Scient Immunbio Forsch | Monoklonale antikörper gegen hiv-1 und davon hergestellte impfstoffe |
| WO1996040243A1 (en) * | 1995-06-07 | 1996-12-19 | U.S. Department Of The Army | Liposomes containing human immunodeficiency virus glycoprotein and methods for use thereof |
| US5910306A (en) | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| US5901306A (en) * | 1997-06-23 | 1999-05-04 | Sun Microsystems, Inc. | Method and apparatus for reducing a computational result to the range boundaries of a signed 8-bit integer in case of overflow |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6300308B1 (en) | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| WO2003022879A2 (en) | 2001-09-07 | 2003-03-20 | Polymun Scientific Immunbiologische Forschung Gmbh | Peptides mimicking a cryptic epitope of gp41 hiv-1 and antibodies directed against them |
| US7195768B2 (en) | 2001-11-07 | 2007-03-27 | Duke University | Polyvalent immunogen |
| AU2003214044B8 (en) | 2002-01-17 | 2008-11-13 | Polymun Scientific Immunbiologische Forschung Gmbh | Anti-idiotypic antibody inducing HIV-1 neutralizing antibodies |
| US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7384909B2 (en) | 2002-07-15 | 2008-06-10 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents |
| US20040131622A1 (en) | 2002-07-15 | 2004-07-08 | Board Of Regents | Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids |
| US7906115B2 (en) | 2002-07-15 | 2011-03-15 | Thorpe Philip E | Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7611704B2 (en) | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7790159B2 (en) | 2002-07-15 | 2010-09-07 | Board Of Regents, The University Of Texas System | Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids |
| US7678386B2 (en) | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
| MXPA05000652A (es) | 2002-07-15 | 2005-08-19 | Univ Texas | Anticuerpos seleccionados y peptidos de duramicina que se enlazan a fosfolipidos anionicos y aminofosfolipidos y sus usos en el tratamiento de infecciones virales y del cancer. |
| US8246957B2 (en) | 2003-03-27 | 2012-08-21 | Sudhir Paul | Lupus antibodies for passive immunotherapy of HIV/AIDS |
| WO2005111079A2 (en) | 2004-05-14 | 2005-11-24 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Hiv vaccine immunogens and immunization strategies to elicit broadly-neutralizing anti-hiv-1 antibodies against the membrane proximal domain of hiv gp41 |
| US20080057075A1 (en) | 2005-04-12 | 2008-03-06 | Haynes Barton F | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| EP1868651A4 (en) * | 2005-04-12 | 2010-10-06 | Univ Duke | METHOD FOR INDUCTION OF NEUTRALIZING ANTIBODIES TO THE HIV VIRUS |
| WO2008127651A1 (en) | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CN101678091A (zh) | 2007-05-24 | 2010-03-24 | 葛兰素史密丝克莱恩生物有限公司 | 冷冻干燥的抗原组合物 |
| US20120070488A1 (en) | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| WO2009111304A2 (en) | 2008-02-29 | 2009-09-11 | President And Fellows Of Harvard College | A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies |
| SMT202000101T1 (it) | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| EP2413951A4 (en) | 2009-04-03 | 2015-05-20 | Univ Duke | FORMULATION FOR GENERATING A WIDE REACTIVE NEUTRALIZATION OF HIV ANTIBODIES |
| EP2413905A4 (en) | 2009-04-03 | 2012-10-31 | Univ Duke | FORMULATION |
-
2008
- 2008-04-11 WO PCT/US2008/004709 patent/WO2008127651A1/en not_active Ceased
- 2008-04-11 AU AU2008239628A patent/AU2008239628B2/en not_active Ceased
- 2008-04-11 CA CA002683752A patent/CA2683752A1/en not_active Abandoned
- 2008-04-11 EP EP08742782A patent/EP2139516A4/en not_active Withdrawn
- 2008-04-11 JP JP2010503070A patent/JP2010523676A/ja active Pending
- 2008-04-11 US US12/450,779 patent/US8956627B2/en not_active Expired - Fee Related
-
2015
- 2015-02-03 US US14/612,665 patent/US20150147387A1/en not_active Abandoned
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