JP2007513992A5 - - Google Patents
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- Publication number
- JP2007513992A5 JP2007513992A5 JP2006544346A JP2006544346A JP2007513992A5 JP 2007513992 A5 JP2007513992 A5 JP 2007513992A5 JP 2006544346 A JP2006544346 A JP 2006544346A JP 2006544346 A JP2006544346 A JP 2006544346A JP 2007513992 A5 JP2007513992 A5 JP 2007513992A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- adjuvant
- composition according
- immunogen
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 19
- 239000002671 adjuvant Substances 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000007764 o/w emulsion Substances 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 3
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 3
- 108010055044 Tetanus Toxin Proteins 0.000 claims 3
- 239000002502 liposome Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940118376 tetanus toxin Drugs 0.000 claims 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229960001295 tocopherol Drugs 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 235000010384 tocopherol Nutrition 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 239000003981 vehicle Substances 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0329146.5A GB0329146D0 (en) | 2003-12-16 | 2003-12-16 | Vaccine |
| PCT/EP2004/014379 WO2005058349A2 (en) | 2003-12-16 | 2004-12-14 | Vaccine comprising il-12 or il-23 for treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513992A JP2007513992A (ja) | 2007-05-31 |
| JP2007513992A5 true JP2007513992A5 (enExample) | 2007-12-20 |
Family
ID=30471161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544346A Pending JP2007513992A (ja) | 2003-12-16 | 2004-12-14 | 自己免疫疾患の治療用のｉｌ−１２又はｉｌ−２３を含むワクチン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070048261A1 (enExample) |
| EP (1) | EP1694358A2 (enExample) |
| JP (1) | JP2007513992A (enExample) |
| CA (1) | CA2548512A1 (enExample) |
| GB (1) | GB0329146D0 (enExample) |
| WO (1) | WO2005058349A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108425A1 (en) * | 2004-05-10 | 2005-11-17 | Cytos Biotechnology Ag | Il-23 p19 antigen array and uses thereof |
| CN104278037B (zh) | 2005-10-12 | 2020-09-15 | 艾德拉药物股份有限公司 | 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物 |
| US8377898B2 (en) * | 2006-10-12 | 2013-02-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Ｉｌ-２３拮抗劑於治療感染之用途 |
| EP2349271A2 (en) | 2008-10-06 | 2011-08-03 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
| US9301997B2 (en) | 2009-09-21 | 2016-04-05 | Peptinov Sas | Method of vaccination for limiting articular inflammation in rheumatoid arthritis and multiple sclerosis by administering IL-23 peptides |
| EP2640420B1 (en) | 2010-11-19 | 2018-08-15 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| JP2016514672A (ja) | 2013-03-15 | 2016-05-23 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 抗原およびアジュバントとしてのインターロイキン−２３を有するワクチン |
| EP2998322A4 (en) * | 2013-05-14 | 2016-12-14 | Shanghai Hycharm Inc | EPITOPOXULENT FOR LOW IMMUNOGENOUS PROTEIN AND METHOD OF PREPARATION AND USE THEREOF |
| WO2015157561A1 (en) * | 2014-04-09 | 2015-10-15 | La Jolla Institute For Allergy And Immunology | Specific and unique t cell responses and molecular signatures for treatment and diagnosis of mycobacterium tuberculosis |
| EP3302536A1 (en) * | 2015-06-03 | 2018-04-11 | Affiris AG | Il-23-p19 vaccines |
| GB201522329D0 (en) * | 2015-12-17 | 2016-02-03 | Glaxosmithkline Biolog S A And Inst Nat De La Sante Et De La Rech Medicale Inserm And Université Pie | Use of adjuvants for the prevention and/or treatment of autoimmune diseases |
| MX393869B (es) | 2016-05-18 | 2025-03-24 | Modernatx Inc | Polinucleotidos que codifican interleucina-12 (il12) y usos de los mismos. |
| US11421011B2 (en) | 2017-05-18 | 2022-08-23 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
| JP2020534352A (ja) | 2017-09-07 | 2020-11-26 | キュー バイオファーマ，インコーポレーテッド | コンジュゲーション部位を有するｔ細胞調節多量体ポリペプチド及びその使用方法 |
| GB201907413D0 (en) * | 2019-05-24 | 2019-07-10 | Univ Helsinki | Viral vector |
| EP4186916A4 (en) * | 2020-07-22 | 2024-11-06 | 3H Bio. Co., Ltd. | PEPTIDE FOR IMMUNOTHERAPEUTIC AGENT |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| KR100335320B1 (ko) * | 1995-06-07 | 2002-09-13 | 스티칭 인스티튜트 부르 디에르후데리지 엔 디에르게존드헤이드 | 황체호르몬방출호르몬에대한향상된펩티드,면역원성조성물및백신또는의학용제제,동물을면역시키는방법,및황체호르몬방출호르몬직렬반복펩티드의유사체및백신으로서이들의용도 |
| WO1997020062A1 (en) * | 1995-12-01 | 1997-06-05 | University Of Massachusetts | Il-12 p40 subunit fusion polypeptides and uses thereof |
| GB9712347D0 (en) * | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| PT1049717E (pt) * | 1998-01-23 | 2007-05-31 | Hoffmann La Roche | Anticorpos contra a il-12 humana. |
| AU768002B2 (en) * | 1998-06-15 | 2003-11-27 | Oncoquest Inc. | Immunotherapeutic composition and method for the treatment of prostate cancer |
| US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| US20030082179A1 (en) * | 2001-07-03 | 2003-05-01 | Hutchison James Scott | Parathyroid hormone antibodies and related methods |
-
2003
- 2003-12-16 GB GBGB0329146.5A patent/GB0329146D0/en not_active Ceased
-
2004
- 2004-12-14 CA CA002548512A patent/CA2548512A1/en not_active Abandoned
- 2004-12-14 WO PCT/EP2004/014379 patent/WO2005058349A2/en not_active Ceased
- 2004-12-14 JP JP2006544346A patent/JP2007513992A/ja active Pending
- 2004-12-14 US US10/582,810 patent/US20070048261A1/en not_active Abandoned
- 2004-12-14 EP EP04803988A patent/EP1694358A2/en not_active Withdrawn
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