JP2017508006A5 - - Google Patents
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- Publication number
- JP2017508006A5 JP2017508006A5 JP2016571473A JP2016571473A JP2017508006A5 JP 2017508006 A5 JP2017508006 A5 JP 2017508006A5 JP 2016571473 A JP2016571473 A JP 2016571473A JP 2016571473 A JP2016571473 A JP 2016571473A JP 2017508006 A5 JP2017508006 A5 JP 2017508006A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- vaccine
- amino acid
- peedgtrfhrqask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 3
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 3
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 238000008214 LDL Cholesterol Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000053786 human PCSK9 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14157221 | 2014-02-28 | ||
| EP14157221.4 | 2014-02-28 | ||
| PCT/EP2015/053725 WO2015128287A1 (en) | 2014-02-28 | 2015-02-23 | Pcsk9 vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508006A JP2017508006A (ja) | 2017-03-23 |
| JP2017508006A5 true JP2017508006A5 (enExample) | 2018-02-22 |
| JP6494667B2 JP6494667B2 (ja) | 2019-04-03 |
Family
ID=50179534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571473A Active JP6494667B2 (ja) | 2014-02-28 | 2015-02-23 | Ｐｃｓｋ９ワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10004791B2 (enExample) |
| EP (1) | EP3110439B1 (enExample) |
| JP (1) | JP6494667B2 (enExample) |
| KR (1) | KR102360250B1 (enExample) |
| CN (1) | CN106459209B (enExample) |
| AU (1) | AU2015222283B2 (enExample) |
| BR (1) | BR112016019389A8 (enExample) |
| CA (1) | CA2940315C (enExample) |
| DK (1) | DK3110439T3 (enExample) |
| ES (1) | ES2732741T3 (enExample) |
| IL (1) | IL247159B (enExample) |
| MX (1) | MX374276B (enExample) |
| PL (1) | PL3110439T3 (enExample) |
| RU (1) | RU2698971C2 (enExample) |
| SG (1) | SG11201606685XA (enExample) |
| WO (1) | WO2015128287A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102857456B1 (ko) | 2015-11-03 | 2025-09-08 | 에이씨 이뮨 에스에이 | 인간 환자에서 자가-항원에 대한 예방접종을 위한 방법 |
| US20200270365A1 (en) * | 2016-01-05 | 2020-08-27 | Jiangsu Hengrui Medicine Co., Ltd. | Pcsk9 antibody, antigen-binding fragment thereof, and medical uses thereof |
| ES2571055B1 (es) * | 2016-02-15 | 2016-12-28 | Araclon Biotech, S.L. | Conjugado amiloide y usos y procedimientos del mismo |
| CN106822881A (zh) * | 2016-12-09 | 2017-06-13 | 四川大学 | 一种针对pcsk9的抗高血脂蛋白疫苗 |
| KR102401796B1 (ko) | 2017-04-13 | 2022-05-25 | 카딜라 핼쓰캐어 리미티드 | 신규의 펩타이드 기재 pcsk9 백신 |
| WO2022147373A1 (en) * | 2020-12-31 | 2022-07-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-guided pcsk9-mimicking immunogens lacking 9-residue sequence overlap with human proteins |
| EP4486387A1 (en) | 2022-02-28 | 2025-01-08 | Tridem Bioscience GmbH & Co KG | A conjugate consisting of or comprising at least a ss-glucan or a mannan |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2670576T3 (es) | 2009-09-03 | 2018-05-31 | Pfizer Vaccines Llc | Vacuna de PCSK9 |
| US8802827B2 (en) * | 2009-10-30 | 2014-08-12 | Merck Sharp & Dohme Corp. | AX1 PCSK9 antagonists |
| IN2012DN03824A (enExample) * | 2009-10-30 | 2015-08-28 | Merck Sharp & Dohme | |
| GB201005005D0 (en) * | 2010-03-25 | 2010-05-12 | Angeletti P Ist Richerche Bio | New vaccine |
| RS54639B1 (sr) | 2011-09-13 | 2016-08-31 | Affiris Ag | Pcsk9 vakcina |
| WO2013148284A1 (en) | 2012-03-29 | 2013-10-03 | Genentech, Inc. | Antibodies that bind to a pcsk9 cleavage site and methods of use |
-
2015
- 2015-02-23 DK DK15714770.3T patent/DK3110439T3/da active
- 2015-02-23 CA CA2940315A patent/CA2940315C/en active Active
- 2015-02-23 US US15/122,316 patent/US10004791B2/en active Active
- 2015-02-23 RU RU2016138365A patent/RU2698971C2/ru active
- 2015-02-23 WO PCT/EP2015/053725 patent/WO2015128287A1/en not_active Ceased
- 2015-02-23 CN CN201580015813.0A patent/CN106459209B/zh active Active
- 2015-02-23 EP EP15714770.3A patent/EP3110439B1/en active Active
- 2015-02-23 PL PL15714770T patent/PL3110439T3/pl unknown
- 2015-02-23 MX MX2016010838A patent/MX374276B/es active IP Right Grant
- 2015-02-23 JP JP2016571473A patent/JP6494667B2/ja active Active
- 2015-02-23 BR BR112016019389A patent/BR112016019389A8/pt not_active Application Discontinuation
- 2015-02-23 AU AU2015222283A patent/AU2015222283B2/en not_active Ceased
- 2015-02-23 SG SG11201606685XA patent/SG11201606685XA/en unknown
- 2015-02-23 ES ES15714770T patent/ES2732741T3/es active Active
- 2015-02-23 KR KR1020167026735A patent/KR102360250B1/ko not_active Expired - Fee Related
-
2016
- 2016-08-08 IL IL247159A patent/IL247159B/en active IP Right Grant
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