JP2010523534A5 - - Google Patents
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- Publication number
- JP2010523534A5 JP2010523534A5 JP2010501585A JP2010501585A JP2010523534A5 JP 2010523534 A5 JP2010523534 A5 JP 2010523534A5 JP 2010501585 A JP2010501585 A JP 2010501585A JP 2010501585 A JP2010501585 A JP 2010501585A JP 2010523534 A5 JP2010523534 A5 JP 2010523534A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- alkyl
- haloalkyl
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92189707P | 2007-04-04 | 2007-04-04 | |
| GB0706632.7 | 2007-04-04 | ||
| US60/921,897 | 2007-04-04 | ||
| GBGB0706632.7A GB0706632D0 (en) | 2007-04-04 | 2007-04-04 | New purine derivatives |
| PCT/GB2008/001173 WO2008122767A2 (en) | 2007-04-04 | 2008-04-02 | 2, 6, 9-substituted purine derivatives having anti proliferative properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523534A JP2010523534A (ja) | 2010-07-15 |
| JP2010523534A5 true JP2010523534A5 (enExample) | 2011-04-21 |
| JP5466145B2 JP5466145B2 (ja) | 2014-04-09 |
Family
ID=38090893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501585A Expired - Fee Related JP5466145B2 (ja) | 2007-04-04 | 2008-04-02 | 抗増殖性を有する２，６，９−置換プリン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8592581B2 (enExample) |
| EP (1) | EP2139893B1 (enExample) |
| JP (1) | JP5466145B2 (enExample) |
| CN (1) | CN101679434B (enExample) |
| AU (1) | AU2008235361B2 (enExample) |
| BR (1) | BRPI0809996B8 (enExample) |
| CA (1) | CA2681529C (enExample) |
| ES (1) | ES2427845T3 (enExample) |
| GB (1) | GB0706632D0 (enExample) |
| MX (1) | MX2009010660A (enExample) |
| PL (1) | PL2139893T3 (enExample) |
| RU (1) | RU2461559C2 (enExample) |
| WO (1) | WO2008122767A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0219054D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| GB0903346D0 (en) | 2009-02-27 | 2009-04-08 | Cambridge Advanced Tech | Transgenic Plants |
| GB201001075D0 (en) * | 2010-01-22 | 2010-03-10 | Cyclacel Ltd | Crystalline forms |
| DE102011111400A1 (de) * | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
| ES2928714T3 (es) | 2015-01-16 | 2022-11-22 | Massachusetts Gen Hospital | Compuestos para mejorar el empalme del ARNm |
| JP6591036B2 (ja) | 2016-02-26 | 2019-10-16 | 公益財団法人がん研究会 | Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系 |
| ES2939049T3 (es) | 2017-01-26 | 2023-04-18 | Cyclacel Ltd | Proceso para preparar derivados de purina |
| EP3388432A1 (en) | 2017-04-10 | 2018-10-17 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Purine derivatives for use as medicament and for use in treating neurodegenerative or neuro-inflammatory disorders |
| BR112021008516A2 (pt) | 2018-11-01 | 2021-09-14 | Syros Pharmaceuticals, Inc. | Inibidores de quinase 7 dependente de ciclina (cdk 7) |
| RU2754441C2 (ru) * | 2019-12-30 | 2021-09-02 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
| GB202000901D0 (en) | 2020-01-22 | 2020-03-04 | Cyclacel Ltd | Process |
| US12097261B2 (en) | 2021-05-07 | 2024-09-24 | Kymera Therapeutics, Inc. | CDK2 degraders and uses thereof |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
| IL321433A (en) | 2022-12-16 | 2025-08-01 | Astrazeneca Ab | Purines 2,6,9 trimethylated |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
| US6790958B2 (en) * | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| MXPA01007851A (es) * | 1999-02-01 | 2003-06-04 | Cv Therapeutics Inc | Inhibidores purina de cinasa 2 e 1kb-alfa dependientes del ciclin. |
| US6627633B2 (en) * | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
| DE60205376T2 (de) * | 2001-06-27 | 2006-04-06 | Cyclacel Ltd. | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
| US6812232B2 (en) * | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
| US6667311B2 (en) * | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
| US20030229105A1 (en) * | 2002-05-21 | 2003-12-11 | Cyclacel Limited | Treatment of autoimmune disorders |
| GB0219052D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| GB0219054D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| US20080125404A1 (en) * | 2004-08-27 | 2008-05-29 | Cyclacel Limited | Purine and Pyrimidine Cdk Inhitbitors and Their use for The Treatment of Autoimmune Diseases |
| GB0706633D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
-
2007
- 2007-04-04 GB GBGB0706632.7A patent/GB0706632D0/en not_active Ceased
-
2008
- 2008-04-02 AU AU2008235361A patent/AU2008235361B2/en not_active Ceased
- 2008-04-02 PL PL08718980T patent/PL2139893T3/pl unknown
- 2008-04-02 BR BRPI0809996A patent/BRPI0809996B8/pt active IP Right Grant
- 2008-04-02 EP EP08718980.9A patent/EP2139893B1/en active Active
- 2008-04-02 JP JP2010501585A patent/JP5466145B2/ja not_active Expired - Fee Related
- 2008-04-02 CN CN2008800189406A patent/CN101679434B/zh active Active
- 2008-04-02 RU RU2009140753/04A patent/RU2461559C2/ru active
- 2008-04-02 WO PCT/GB2008/001173 patent/WO2008122767A2/en not_active Ceased
- 2008-04-02 CA CA2681529A patent/CA2681529C/en active Active
- 2008-04-02 MX MX2009010660A patent/MX2009010660A/es active IP Right Grant
- 2008-04-02 ES ES08718980T patent/ES2427845T3/es active Active
-
2009
- 2009-10-05 US US12/573,337 patent/US8592581B2/en active Active
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