RU2461559C2 - Соединения - Google Patents
Соединения Download PDFInfo
- Publication number
- RU2461559C2 RU2461559C2 RU2009140753/04A RU2009140753A RU2461559C2 RU 2461559 C2 RU2461559 C2 RU 2461559C2 RU 2009140753/04 A RU2009140753/04 A RU 2009140753/04A RU 2009140753 A RU2009140753 A RU 2009140753A RU 2461559 C2 RU2461559 C2 RU 2461559C2
- Authority
- RU
- Russia
- Prior art keywords
- isopropyl
- compound according
- mmol
- compound
- purin
- Prior art date
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92189707P | 2007-04-04 | 2007-04-04 | |
| GB0706632.7 | 2007-04-04 | ||
| US60/921,897 | 2007-04-04 | ||
| GBGB0706632.7A GB0706632D0 (en) | 2007-04-04 | 2007-04-04 | New purine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009140753A RU2009140753A (ru) | 2011-05-10 |
| RU2461559C2 true RU2461559C2 (ru) | 2012-09-20 |
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| RU2009140753/04A RU2461559C2 (ru) | 2007-04-04 | 2008-04-02 | Соединения |
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|---|---|
| US (1) | US8592581B2 (enExample) |
| EP (1) | EP2139893B1 (enExample) |
| JP (1) | JP5466145B2 (enExample) |
| CN (1) | CN101679434B (enExample) |
| AU (1) | AU2008235361B2 (enExample) |
| BR (1) | BRPI0809996B8 (enExample) |
| CA (1) | CA2681529C (enExample) |
| ES (1) | ES2427845T3 (enExample) |
| GB (1) | GB0706632D0 (enExample) |
| MX (1) | MX2009010660A (enExample) |
| PL (1) | PL2139893T3 (enExample) |
| RU (1) | RU2461559C2 (enExample) |
| WO (1) | WO2008122767A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2754441C2 (ru) * | 2019-12-30 | 2021-09-02 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
| US12240869B2 (en) | 2018-11-01 | 2025-03-04 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0219054D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| GB0903346D0 (en) | 2009-02-27 | 2009-04-08 | Cambridge Advanced Tech | Transgenic Plants |
| GB201001075D0 (en) * | 2010-01-22 | 2010-03-10 | Cyclacel Ltd | Crystalline forms |
| DE102011111400A1 (de) * | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
| ES2928714T3 (es) | 2015-01-16 | 2022-11-22 | Massachusetts Gen Hospital | Compuestos para mejorar el empalme del ARNm |
| JP6591036B2 (ja) | 2016-02-26 | 2019-10-16 | 公益財団法人がん研究会 | Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系 |
| ES2939049T3 (es) | 2017-01-26 | 2023-04-18 | Cyclacel Ltd | Proceso para preparar derivados de purina |
| EP3388432A1 (en) | 2017-04-10 | 2018-10-17 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Purine derivatives for use as medicament and for use in treating neurodegenerative or neuro-inflammatory disorders |
| GB202000901D0 (en) | 2020-01-22 | 2020-03-04 | Cyclacel Ltd | Process |
| US12097261B2 (en) | 2021-05-07 | 2024-09-24 | Kymera Therapeutics, Inc. | CDK2 degraders and uses thereof |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
| IL321433A (en) | 2022-12-16 | 2025-08-01 | Astrazeneca Ab | Purines 2,6,9 trimethylated |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020842A1 (fr) * | 1995-12-01 | 1997-06-12 | Centre National De La Recherche Scientifique (C.N.R.S.) | Nouveaux derives de purine possedant notamment des proprietes anti-proliferatives et leurs applications biologiques |
| US20030191086A1 (en) * | 1999-01-26 | 2003-10-09 | Ustav Experimentalni Botaniky Av Cr | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof |
| US20030229105A1 (en) * | 2002-05-21 | 2003-12-11 | Cyclacel Limited | Treatment of autoimmune disorders |
| RU2220968C2 (ru) * | 1996-08-02 | 2004-01-10 | Си Ви Терапьютикс, Инк. | 2,6,9-тризамещенное производное пурина, фармацевтически приемлемая катионная соль, способ ингибирования пролиферации клеток, фармацевтическая композиция |
| GB2392155A (en) * | 2002-08-15 | 2004-02-25 | Cyclacel Ltd | Purine derivatives which may be useful in the treatment of disease, especially proliferative disorders, and methods for their synthesis |
| EP1399446B1 (en) * | 2001-06-27 | 2005-08-03 | Cyclacel Limited | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790958B2 (en) * | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
| MXPA01007851A (es) * | 1999-02-01 | 2003-06-04 | Cv Therapeutics Inc | Inhibidores purina de cinasa 2 e 1kb-alfa dependientes del ciclin. |
| US6627633B2 (en) * | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
| US6812232B2 (en) * | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
| US6667311B2 (en) * | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
| GB0219052D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| US20080125404A1 (en) * | 2004-08-27 | 2008-05-29 | Cyclacel Limited | Purine and Pyrimidine Cdk Inhitbitors and Their use for The Treatment of Autoimmune Diseases |
| GB0706633D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
-
2007
- 2007-04-04 GB GBGB0706632.7A patent/GB0706632D0/en not_active Ceased
-
2008
- 2008-04-02 AU AU2008235361A patent/AU2008235361B2/en not_active Ceased
- 2008-04-02 PL PL08718980T patent/PL2139893T3/pl unknown
- 2008-04-02 BR BRPI0809996A patent/BRPI0809996B8/pt active IP Right Grant
- 2008-04-02 EP EP08718980.9A patent/EP2139893B1/en active Active
- 2008-04-02 JP JP2010501585A patent/JP5466145B2/ja not_active Expired - Fee Related
- 2008-04-02 CN CN2008800189406A patent/CN101679434B/zh active Active
- 2008-04-02 RU RU2009140753/04A patent/RU2461559C2/ru active
- 2008-04-02 WO PCT/GB2008/001173 patent/WO2008122767A2/en not_active Ceased
- 2008-04-02 CA CA2681529A patent/CA2681529C/en active Active
- 2008-04-02 MX MX2009010660A patent/MX2009010660A/es active IP Right Grant
- 2008-04-02 ES ES08718980T patent/ES2427845T3/es active Active
-
2009
- 2009-10-05 US US12/573,337 patent/US8592581B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020842A1 (fr) * | 1995-12-01 | 1997-06-12 | Centre National De La Recherche Scientifique (C.N.R.S.) | Nouveaux derives de purine possedant notamment des proprietes anti-proliferatives et leurs applications biologiques |
| RU2220968C2 (ru) * | 1996-08-02 | 2004-01-10 | Си Ви Терапьютикс, Инк. | 2,6,9-тризамещенное производное пурина, фармацевтически приемлемая катионная соль, способ ингибирования пролиферации клеток, фармацевтическая композиция |
| US20030191086A1 (en) * | 1999-01-26 | 2003-10-09 | Ustav Experimentalni Botaniky Av Cr | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof |
| EP1399446B1 (en) * | 2001-06-27 | 2005-08-03 | Cyclacel Limited | 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders |
| US20030229105A1 (en) * | 2002-05-21 | 2003-12-11 | Cyclacel Limited | Treatment of autoimmune disorders |
| GB2392155A (en) * | 2002-08-15 | 2004-02-25 | Cyclacel Ltd | Purine derivatives which may be useful in the treatment of disease, especially proliferative disorders, and methods for their synthesis |
Non-Patent Citations (1)
| Title |
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| HAESSLEIN J.-L. "Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future", Current topics in medicinal chemistry, vol.2(9), pp.1037-1050. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12240869B2 (en) | 2018-11-01 | 2025-03-04 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| RU2754441C2 (ru) * | 2019-12-30 | 2021-09-02 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100093769A1 (en) | 2010-04-15 |
| ES2427845T3 (es) | 2013-11-04 |
| RU2009140753A (ru) | 2011-05-10 |
| CA2681529A1 (en) | 2008-10-16 |
| EP2139893A2 (en) | 2010-01-06 |
| CN101679434B (zh) | 2013-09-25 |
| CN101679434A (zh) | 2010-03-24 |
| GB0706632D0 (en) | 2007-05-16 |
| BRPI0809996B1 (pt) | 2019-09-03 |
| BRPI0809996B8 (pt) | 2021-05-25 |
| JP2010523534A (ja) | 2010-07-15 |
| AU2008235361A1 (en) | 2008-10-16 |
| CA2681529C (en) | 2015-06-30 |
| EP2139893B1 (en) | 2013-06-19 |
| JP5466145B2 (ja) | 2014-04-09 |
| HK1139939A1 (en) | 2010-09-30 |
| AU2008235361B2 (en) | 2013-02-14 |
| WO2008122767A3 (en) | 2008-12-31 |
| MX2009010660A (es) | 2010-02-17 |
| WO2008122767A2 (en) | 2008-10-16 |
| BRPI0809996A2 (pt) | 2014-10-14 |
| PL2139893T3 (pl) | 2013-11-29 |
| US8592581B2 (en) | 2013-11-26 |
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