JP2010523492A5 - - Google Patents
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- Publication number
- JP2010523492A5 JP2010523492A5 JP2010501048A JP2010501048A JP2010523492A5 JP 2010523492 A5 JP2010523492 A5 JP 2010523492A5 JP 2010501048 A JP2010501048 A JP 2010501048A JP 2010501048 A JP2010501048 A JP 2010501048A JP 2010523492 A5 JP2010523492 A5 JP 2010523492A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- ethyl
- methyl
- hydroxypyrrolidin
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 8
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 7
- JHLHNYVMZCADTC-LOSJGSFVSA-N asimadoline Chemical compound C([C@@H](N(C)C(=O)C(C=1C=CC=CC=1)C=1C=CC=CC=1)C=1C=CC=CC=1)N1CC[C@H](O)C1 JHLHNYVMZCADTC-LOSJGSFVSA-N 0.000 claims 5
- GMJSLABTEURMBF-CLSOAGJSSA-N n-[(1s)-2-[(3s)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-n-methyl-2,2-diphenylacetamide;hydrochloride Chemical compound Cl.C([C@@H](N(C)C(=O)C(C=1C=CC=CC=1)C=1C=CC=CC=1)C=1C=CC=CC=1)N1CC[C@H](O)C1 GMJSLABTEURMBF-CLSOAGJSSA-N 0.000 claims 4
- -1 (3S) -3- hydroxypyrrolidine-1-yl Chemical group 0.000 claims 3
- 206010012735 Diarrhoea Diseases 0.000 claims 3
- 208000023505 abnormal feces Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010000060 Abdominal distension Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010033372 Pain and discomfort Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 230000008991 intestinal motility Effects 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92084107P | 2007-03-30 | 2007-03-30 | |
| US60/920,841 | 2007-03-30 | ||
| PCT/US2008/056317 WO2008121496A1 (en) | 2007-03-30 | 2008-03-07 | Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013101705A Division JP2013173790A (ja) | 2007-03-30 | 2013-05-13 | 下痢型および交替型過敏性腸症候群の処置のためのカッパ−オピエートアゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523492A JP2010523492A (ja) | 2010-07-15 |
| JP2010523492A5 true JP2010523492A5 (cg-RX-API-DMAC7.html) | 2011-05-12 |
| JP5416085B2 JP5416085B2 (ja) | 2014-02-12 |
Family
ID=39795494
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501048A Expired - Fee Related JP5416085B2 (ja) | 2007-03-30 | 2008-03-07 | 下痢型および交替型過敏性腸症候群の処置のためのカッパ−オピエートアゴニスト |
| JP2013101705A Pending JP2013173790A (ja) | 2007-03-30 | 2013-05-13 | 下痢型および交替型過敏性腸症候群の処置のためのカッパ−オピエートアゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013101705A Pending JP2013173790A (ja) | 2007-03-30 | 2013-05-13 | 下痢型および交替型過敏性腸症候群の処置のためのカッパ−オピエートアゴニスト |
Country Status (19)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2136801E (pt) * | 2007-03-30 | 2012-12-06 | Tioga Pharmaceuticals Inc | Agonistas kappa-opiáceos para o tratamento do síndrome do intestino irritável com predomínio de diarreia ou alternância |
| WO2012012410A2 (en) * | 2010-07-19 | 2012-01-26 | Dr. Reddy's Laboratories Ltd. | Kappa opioid receptor agonists |
| US8637538B1 (en) | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| CA2893427C (en) | 2012-12-24 | 2023-01-10 | Neurogastrx, Inc. | Methods for treating gi tract disorders |
| WO2015200369A1 (en) | 2014-06-24 | 2015-12-30 | Neurogastrx, Inc. | Prodrugs of metopimazine |
| JP6410641B2 (ja) | 2015-03-04 | 2018-10-24 | ローム株式会社 | ワイヤレス送電装置、異物検出方法、充電器 |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
| ES2906979T3 (es) | 2016-12-21 | 2022-04-21 | Tioga Pharmaceuticals Inc | Formulaciones farmacéuticas sólidas de asimadolina |
| WO2019122361A1 (en) | 2017-12-22 | 2019-06-27 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis |
| AU2019309913B2 (en) | 2018-07-23 | 2025-02-27 | Trevi Therapeutics, Inc. | Treatment of chronic cough, breathlessness and dyspnea |
| AU2021206252A1 (en) | 2020-01-10 | 2022-07-28 | Trevi Therapeutics, Inc. | Methods of administering nalbuphine |
| IL296368A (en) * | 2020-03-18 | 2022-11-01 | Cara Therapeutics Inc | Oligosaccharide formulations of kappa opioid receptor agonists |
| US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
| EP3932390A1 (en) | 2020-07-02 | 2022-01-05 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical gel formulation containing asimadoline |
| JP7464744B2 (ja) * | 2020-10-20 | 2024-04-09 | セトラスホールディングス株式会社 | 診療支援装置、診療支援方法、診療支援プログラム及び診療支援システム |
| WO2022155332A1 (en) * | 2021-01-13 | 2022-07-21 | Blue Therapeutics, Inc. | Methods of treating irritable bowel syndrome |
Family Cites Families (43)
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|---|---|---|---|---|
| US4192883A (en) | 1976-04-09 | 1980-03-11 | Pierre Fabre, S.A. | Amides of pyrrolidinoethylamine which can be used in lung therapy |
| FR2421891A1 (fr) | 1977-10-17 | 1979-11-02 | Fabre Sa Pierre | Obtention industrielle d'amides de la pyrrolidine ethyl amine |
| US4663343A (en) | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
| US4889860A (en) | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4760069A (en) | 1985-09-23 | 1988-07-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| GB8601796D0 (en) | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
| JPH02138254A (ja) | 1988-02-23 | 1990-05-28 | Glaxo Group Ltd | 複素環誘導体 |
| DE4034785A1 (de) | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US5232978A (en) | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| DE3935371A1 (de) | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
| US5389686A (en) | 1989-02-20 | 1995-02-14 | Jouveinal Sa | Analgesic properties of fedotozine |
| DE3916663A1 (de) | 1989-05-23 | 1990-11-29 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US5232266A (en) | 1989-07-24 | 1993-08-03 | Mork William J | Upholstered article of furniture with interchangeable seating module |
| CA2069423A1 (en) | 1989-11-24 | 1991-05-25 | Roberto Colle | Azacyclic derivatives |
| GB8926560D0 (en) | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
| US5300687A (en) | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
| DE4215213A1 (de) | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
| DE4425071C2 (de) | 1994-07-15 | 1996-08-29 | Degussa | Verfahren zur Herstellung optisch aktiver Pyrrolidine mit hoher Enantiomerenreinheit |
| DE19523502A1 (de) | 1995-06-28 | 1997-01-02 | Merck Patent Gmbh | Kappa-Opiatagonisten für entzündliche Darmerkrankungen |
| DE19531464A1 (de) | 1995-08-26 | 1997-02-27 | Merck Patent Gmbh | N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid |
| EP1021204B1 (en) | 1997-09-26 | 2005-12-28 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US20010051181A1 (en) | 1997-12-22 | 2001-12-13 | Van Osdol William W. | Novel formulations for the transdermal administration of asimadoline |
| DE19827633A1 (de) | 1998-04-20 | 1999-10-21 | Merck Patent Gmbh | Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid |
| AR019727A1 (es) | 1998-06-30 | 2002-03-13 | Takeda Chemical Industries Ltd | Composicion farmaceutica |
| JP2000080047A (ja) | 1998-06-30 | 2000-03-21 | Takeda Chem Ind Ltd | 医 薬 |
| DE19849650A1 (de) * | 1998-10-29 | 2000-05-04 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung des Irritable Bowel Syndroms (IBS) |
| EP1033364B1 (en) | 1999-03-01 | 2005-02-23 | Pfizer Products Inc. | Cyano containing oxamic acids and derivatives as thyroid receptor ligands |
| US20020025948A1 (en) | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB0015562D0 (en) | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| US6846831B2 (en) | 2000-08-15 | 2005-01-25 | Cpd, Llc | Method of treating the syndrome of lipodystrophy |
| US6262062B1 (en) | 2000-08-15 | 2001-07-17 | Cpd, Llc | Method of treating the syndrome of coronary heart disease risk factors in humans |
| US6569449B1 (en) | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
| DE10116978A1 (de) | 2001-04-05 | 2002-10-10 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase |
| WO2003048113A1 (en) | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
| JP2005531557A (ja) * | 2002-05-17 | 2005-10-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 選択的オピエート受容体モジュレーターとして効果的な化合物の使用 |
| MXPA05002983A (es) * | 2002-09-18 | 2005-06-22 | Univ Missouri | Analogos de opiato selectivos del receptor opioide d. |
| DE10259245A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| ES2528669T3 (es) | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
| PL1644021T3 (pl) * | 2003-06-13 | 2013-01-31 | Ironwood Pharmaceuticals Inc | Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych |
| WO2005046687A1 (en) * | 2003-10-30 | 2005-05-26 | Tioga Pharmaceuticals, Inc. | Use of selective opiate receptor modulators in the treatment of neuropathy |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| PT2136801E (pt) * | 2007-03-30 | 2012-12-06 | Tioga Pharmaceuticals Inc | Agonistas kappa-opiáceos para o tratamento do síndrome do intestino irritável com predomínio de diarreia ou alternância |
-
2008
- 2008-03-07 PT PT87317483T patent/PT2136801E/pt unknown
- 2008-03-07 WO PCT/US2008/056317 patent/WO2008121496A1/en not_active Ceased
- 2008-03-07 BR BRPI0809651-1A2A patent/BRPI0809651A2/pt not_active IP Right Cessation
- 2008-03-07 EP EP13161453.9A patent/EP2636407A3/en not_active Withdrawn
- 2008-03-07 RU RU2009140042/15A patent/RU2441655C2/ru not_active IP Right Cessation
- 2008-03-07 KR KR1020097022558A patent/KR101208326B1/ko not_active Expired - Fee Related
- 2008-03-07 KR KR1020127010007A patent/KR101263225B1/ko not_active Expired - Fee Related
- 2008-03-07 CN CN2012101134057A patent/CN102641265A/zh active Pending
- 2008-03-07 US US12/044,906 patent/US7960429B2/en not_active Expired - Fee Related
- 2008-03-07 HR HRP20120798AT patent/HRP20120798T1/hr unknown
- 2008-03-07 SI SI200830830T patent/SI2136801T1/sl unknown
- 2008-03-07 DK DK08731748.3T patent/DK2136801T3/da active
- 2008-03-07 AU AU2008232954A patent/AU2008232954A1/en not_active Abandoned
- 2008-03-07 CN CN2008800173249A patent/CN101677997B/zh not_active Expired - Fee Related
- 2008-03-07 CA CA002682608A patent/CA2682608A1/en not_active Abandoned
- 2008-03-07 ES ES08731748T patent/ES2393815T3/es active Active
- 2008-03-07 PL PL08731748T patent/PL2136801T3/pl unknown
- 2008-03-07 EP EP12182095A patent/EP2561870A1/en not_active Withdrawn
- 2008-03-07 EP EP08731748A patent/EP2136801B1/en not_active Not-in-force
- 2008-03-07 MX MX2009010409A patent/MX2009010409A/es not_active Application Discontinuation
- 2008-03-07 JP JP2010501048A patent/JP5416085B2/ja not_active Expired - Fee Related
-
2009
- 2009-09-29 IL IL201226A patent/IL201226A0/en unknown
-
2010
- 2010-11-05 US US12/940,979 patent/US8877800B2/en not_active Expired - Fee Related
-
2012
- 2012-11-06 CY CY20121101057T patent/CY1113317T1/el unknown
-
2013
- 2013-05-13 JP JP2013101705A patent/JP2013173790A/ja active Pending