CN101677997B - 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 - Google Patents

用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 Download PDF

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Publication number
CN101677997B
CN101677997B CN2008800173249A CN200880017324A CN101677997B CN 101677997 B CN101677997 B CN 101677997B CN 2008800173249 A CN2008800173249 A CN 2008800173249A CN 200880017324 A CN200880017324 A CN 200880017324A CN 101677997 B CN101677997 B CN 101677997B
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ethyl
treatment
phenyl
methyl
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CN101677997A (zh
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艾伦·曼格尔
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Tioga Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
CN2008800173249A 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 Expired - Fee Related CN101677997B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92084107P 2007-03-30 2007-03-30
US60/920,841 2007-03-30
PCT/US2008/056317 WO2008121496A1 (en) 2007-03-30 2008-03-07 Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome

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CN2012101134057A Division CN102641265A (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

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CN101677997A CN101677997A (zh) 2010-03-24
CN101677997B true CN101677997B (zh) 2012-05-09

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CN2008800173249A Expired - Fee Related CN101677997B (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
CN2012101134057A Pending CN102641265A (zh) 2007-03-30 2008-03-07 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

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US (2) US7960429B2 (cg-RX-API-DMAC7.html)
EP (3) EP2636407A3 (cg-RX-API-DMAC7.html)
JP (2) JP5416085B2 (cg-RX-API-DMAC7.html)
KR (2) KR101208326B1 (cg-RX-API-DMAC7.html)
CN (2) CN101677997B (cg-RX-API-DMAC7.html)
AU (1) AU2008232954A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0809651A2 (cg-RX-API-DMAC7.html)
CA (1) CA2682608A1 (cg-RX-API-DMAC7.html)
CY (1) CY1113317T1 (cg-RX-API-DMAC7.html)
DK (1) DK2136801T3 (cg-RX-API-DMAC7.html)
ES (1) ES2393815T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20120798T1 (cg-RX-API-DMAC7.html)
IL (1) IL201226A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009010409A (cg-RX-API-DMAC7.html)
PL (1) PL2136801T3 (cg-RX-API-DMAC7.html)
PT (1) PT2136801E (cg-RX-API-DMAC7.html)
RU (1) RU2441655C2 (cg-RX-API-DMAC7.html)
SI (1) SI2136801T1 (cg-RX-API-DMAC7.html)
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Cited By (1)

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CN102641265A (zh) * 2007-03-30 2012-08-22 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

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US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
EP2934540B1 (en) 2012-12-24 2023-08-02 Neurogastrx, Inc. Methods for treating gi tract disorders
US9844554B2 (en) 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
JP6410641B2 (ja) 2015-03-04 2018-10-24 ローム株式会社 ワイヤレス送電装置、異物検出方法、充電器
WO2018035046A1 (en) 2016-08-15 2018-02-22 President And Fellows Of Harvard College Treating infections using idsd from proteus mirabilis
WO2018119108A1 (en) 2016-12-21 2018-06-28 Tioga Pharmaceuticals Inc. Splid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
IL318587A (en) 2018-07-23 2025-03-01 Trevi Therapeutics Inc Treatment of chronic cough, shortness of breath and wheezing
AU2021206252A1 (en) 2020-01-10 2022-07-28 Trevi Therapeutics, Inc. Methods of administering nalbuphine
JP2023518711A (ja) * 2020-03-18 2023-05-08 カラ セラピューティクス インコーポレイテッド κオピオイド受容体作動薬のオリゴ糖製剤
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline
WO2022085736A1 (ja) * 2020-10-20 2022-04-28 協和化学工業株式会社 診療支援装置、診療支援方法及び診療支援プログラム
WO2022155332A1 (en) * 2021-01-13 2022-07-21 Blue Therapeutics, Inc. Methods of treating irritable bowel syndrome

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102641265A (zh) * 2007-03-30 2012-08-22 泰奥加制药公司 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂

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US8877800B2 (en) 2014-11-04
US7960429B2 (en) 2011-06-14
RU2009140042A (ru) 2011-05-10
CN102641265A (zh) 2012-08-22
EP2136801A1 (en) 2009-12-30
AU2008232954A2 (en) 2011-12-01
SI2136801T1 (sl) 2013-01-31
KR101263225B1 (ko) 2013-05-13
KR20120058614A (ko) 2012-06-07
PT2136801E (pt) 2012-12-06
RU2441655C2 (ru) 2012-02-10
EP2136801B1 (en) 2012-08-29
CN101677997A (zh) 2010-03-24
EP2636407A3 (en) 2013-11-06
IL201226A0 (en) 2010-05-31
EP2561870A1 (en) 2013-02-27
CY1113317T1 (el) 2016-04-13
MX2009010409A (es) 2010-03-29
CA2682608A1 (en) 2008-10-09
EP2136801A4 (en) 2010-05-26
AU2008232954A1 (en) 2008-10-09
WO2008121496A1 (en) 2008-10-09
EP2636407A2 (en) 2013-09-11
DK2136801T3 (da) 2012-12-17
ES2393815T3 (es) 2012-12-28
JP2010523492A (ja) 2010-07-15
JP2013173790A (ja) 2013-09-05
US20110046174A1 (en) 2011-02-24
PL2136801T3 (pl) 2013-01-31
KR101208326B1 (ko) 2012-12-05
JP5416085B2 (ja) 2014-02-12
US20080242720A1 (en) 2008-10-02
HRP20120798T1 (hr) 2012-11-30
BRPI0809651A2 (pt) 2014-10-07
KR20100016004A (ko) 2010-02-12
HK1139860A1 (en) 2010-09-30

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