JP2010522765A5 - - Google Patents

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Publication number
JP2010522765A5
JP2010522765A5 JP2010501214A JP2010501214A JP2010522765A5 JP 2010522765 A5 JP2010522765 A5 JP 2010522765A5 JP 2010501214 A JP2010501214 A JP 2010501214A JP 2010501214 A JP2010501214 A JP 2010501214A JP 2010522765 A5 JP2010522765 A5 JP 2010522765A5
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JP
Japan
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alkyl
compound
formula
independently
hetar
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JP2010501214A
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English (en)
Japanese (ja)
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JP2010522765A (ja
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Priority claimed from PCT/US2008/058385 external-priority patent/WO2008121687A2/en
Publication of JP2010522765A publication Critical patent/JP2010522765A/ja
Publication of JP2010522765A5 publication Critical patent/JP2010522765A5/ja
Pending legal-status Critical Current

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JP2010501214A 2007-03-28 2008-03-27 受容体チロシンキナーゼとしてのイミダゾ[1,2−a]ピリジン化合物 Pending JP2010522765A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90855607P 2007-03-28 2007-03-28
PCT/US2008/058385 WO2008121687A2 (en) 2007-03-28 2008-03-27 Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2010522765A JP2010522765A (ja) 2010-07-08
JP2010522765A5 true JP2010522765A5 (show.php) 2012-03-22

Family

ID=39731287

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010501214A Pending JP2010522765A (ja) 2007-03-28 2008-03-27 受容体チロシンキナーゼとしてのイミダゾ[1,2−a]ピリジン化合物

Country Status (7)

Country Link
US (1) US20100144751A1 (show.php)
EP (1) EP2139888A2 (show.php)
JP (1) JP2010522765A (show.php)
CN (1) CN101679422A (show.php)
CA (1) CA2682231A1 (show.php)
TW (1) TW200843757A (show.php)
WO (1) WO2008121687A2 (show.php)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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WO2008124323A1 (en) * 2007-04-03 2008-10-16 Array Biopharma Inc. Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
WO2009068567A1 (en) 2007-11-30 2009-06-04 Novartis Ag C2-c5-alkyl-imidazole-bisphosphonates
US8557809B2 (en) 2008-08-19 2013-10-15 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
US8895550B2 (en) 2008-08-19 2014-11-25 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
US8987251B2 (en) 2008-08-19 2015-03-24 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
TWI496779B (zh) * 2008-08-19 2015-08-21 Array Biopharma Inc 作為pim激酶抑制劑之三唑吡啶化合物
US8377924B2 (en) 2009-01-21 2013-02-19 Rigel Pharmaceuticals Inc. Protein kinase C inhibitors and uses thereof
GEP20135907B (en) 2009-06-05 2013-08-12 Pfizer L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
ES2651296T3 (es) 2009-10-30 2018-01-25 Janssen Pharmaceutica, N.V. Derivados de imidazo[1,2-b]piridacina y su uso como inhibidores de PDE10
EP2332917B1 (en) * 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Compounds for PIM kinase inhibition and for treating malignancy
FR2952934B1 (fr) * 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
CA2814826C (en) 2010-11-17 2019-02-12 Actelion Pharmaceuticals Ltd Bridged spiro[2.4]heptane ester derivatives
RU2598846C2 (ru) * 2011-02-25 2016-09-27 Эррэй Биофарма Инк. Триазолопиридиновые соединения как ингибиторы киназы pim
EP2524915A1 (en) 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ.ベー. 1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]キノキサリン誘導体
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
EP2766359B9 (en) 2011-10-14 2017-04-05 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
JP6426603B2 (ja) 2012-06-26 2018-11-21 ヤンセン ファーマシューティカ エヌ.ベー. 神経障害または代謝障害の治療に使用するための、1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]−キノキサリン化合物などのPDE2阻害剤とPDE10阻害剤との組合せ
KR102171706B1 (ko) 2012-07-09 2020-10-30 얀센 파마슈티카 엔.브이. 포스포디에스테라아제 10 효소의 억제제
SG11201503299YA (en) * 2012-09-28 2015-06-29 Univ Vanderbilt Fused heterocyclic compounds as selective bmp inhibitors
EP2943485B1 (en) 2013-01-14 2017-09-20 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
CN105658653A (zh) 2013-08-23 2016-06-08 因赛特公司 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
CN104597194B (zh) * 2015-01-15 2016-07-06 武汉轻工大学 3-氯-1,2-丙二醇的高效液相色谱-荧光检测方法
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
PL3684767T3 (pl) 2017-09-22 2024-10-14 Jubilant Epipad LLC Związki heterocykliczne jako inhibitory pad
PL3697785T3 (pl) 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
SI3704120T1 (sl) 2017-11-24 2024-07-31 Jubilant Episcribe Llc Heterociklične spojine kot inhibitorji prmt5
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
EP3765460A1 (en) 2018-03-14 2021-01-20 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof
CN110833556A (zh) * 2018-08-15 2020-02-25 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗肝纤维化的用途
CN116234549B (zh) * 2020-08-05 2025-11-25 总医院公司 盐诱导激酶抑制剂

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UA75055C2 (uk) * 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
CA2483084A1 (en) * 2002-05-02 2003-11-13 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2005016528A2 (en) * 2003-08-15 2005-02-24 Irm Llc 6-substituted anilino purines as rtk inhibitors
US20050256309A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands

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