JP2010519311A - 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製およびその使用方法 - Google Patents

長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製およびその使用方法 Download PDF

Info

Publication number
JP2010519311A
JP2010519311A JP2009550992A JP2009550992A JP2010519311A JP 2010519311 A JP2010519311 A JP 2010519311A JP 2009550992 A JP2009550992 A JP 2009550992A JP 2009550992 A JP2009550992 A JP 2009550992A JP 2010519311 A JP2010519311 A JP 2010519311A
Authority
JP
Japan
Prior art keywords
acid
dpan
epimer
oil
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009550992A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010519311A5 (enExample
Inventor
リンダ アーターバーン
ウィリアム バークレー
ビンディ ダンギ
ジェームズ フラット
ジャン リー
ダット ヴィンジャモーリ
エルスウィク メリー バン
Original Assignee
マーテック バイオサイエンシーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マーテック バイオサイエンシーズ コーポレーション filed Critical マーテック バイオサイエンシーズ コーポレーション
Publication of JP2010519311A publication Critical patent/JP2010519311A/ja
Publication of JP2010519311A5 publication Critical patent/JP2010519311A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/36Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009550992A 2007-02-20 2008-02-20 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製およびその使用方法 Pending JP2010519311A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89070107P 2007-02-20 2007-02-20
PCT/US2008/054456 WO2008103753A2 (en) 2007-02-20 2008-02-20 Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same

Publications (2)

Publication Number Publication Date
JP2010519311A true JP2010519311A (ja) 2010-06-03
JP2010519311A5 JP2010519311A5 (enExample) 2011-04-07

Family

ID=39710725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009550992A Pending JP2010519311A (ja) 2007-02-20 2008-02-20 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製およびその使用方法

Country Status (5)

Country Link
US (1) US20110190389A1 (enExample)
EP (1) EP2120920A4 (enExample)
JP (1) JP2010519311A (enExample)
CN (1) CN101663031A (enExample)
WO (1) WO2008103753A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015510517A (ja) * 2012-02-15 2015-04-09 アニダ ファーマ インコーポレイテッド 筋萎縮性側索硬化症の治療方法
JP2015140323A (ja) * 2014-01-29 2015-08-03 岩手県 Ppar活性化剤
JP2016520612A (ja) * 2013-05-30 2016-07-14 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 新規n−3イムノリソルベント:構造及び作用
JP2022554152A (ja) * 2019-10-25 2022-12-28 ヌシード ニュートリショナル ユーエス インク. 濃縮多価不飽和脂肪酸組成物
WO2023090313A1 (ja) * 2021-11-16 2023-05-25 京都府公立大学法人 摂食量亢進用及び/又は食欲不振改善用組成物並びに一過性受容器電位アンキリン1を活性化するための組成物
US12337049B2 (en) 2021-05-26 2025-06-24 Amorepacific Corporation Method for whitening skin using composition for skin whitening
US12447117B2 (en) 2018-10-24 2025-10-21 Amorepacific Corporation Composition and method of enhancing skin barrier using the same

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2679224A1 (en) 2007-08-01 2014-01-01 University of Pittsburgh of the Commonwealth System of Higher Education Nitro oleic acid modulation of type II diabetes
WO2009134383A2 (en) 2008-05-01 2009-11-05 Complexa Inc. Vinyl substituted fatty acids
CN102099024B (zh) 2008-06-19 2015-11-25 犹他大学研究基金会 硝化脂质在毒性医疗疗法的副作用的治疗上的用途
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
WO2010033509A2 (en) * 2008-09-16 2010-03-25 The Brigham And Women's Hospital, Inc. 14-hydroxy-docosahexaenoic acid compounds
EP2415748A4 (en) 2009-02-20 2013-08-07 Univ Tokyo NEW INFLAMMATORY COMPOUNDS
FR2942964B1 (fr) * 2009-03-16 2012-08-17 Arkopharma Laboratoires Stimulateur metabolique des ppaps a base d'esters d'acides gras libres insatures, composition huileuse et complement alimentaire les contenant
EP2283839A1 (en) * 2009-06-30 2011-02-16 Institut National des Sciences Appliquées de Lyon Polyunsaturated hydroxylated molecule having an eze geometry and its use in therapy
WO2011014261A1 (en) 2009-07-31 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acids as anti-inflammatory agents
WO2011041639A2 (en) 2009-10-02 2011-04-07 Miller Raymond A Heteroatom containing substituted fatty acids
EP2952183A1 (en) * 2011-07-21 2015-12-09 DSM IP Assets B.V. Fatty acid compositions
EP2744491B1 (en) 2011-08-19 2020-07-29 The University of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
CN103957888B (zh) * 2011-09-29 2017-11-21 PLx 制药公司 用于将药物沿胃肠道靶向释放的pH依赖性载体、其组合物及其制备和应用
HRP20181418T1 (hr) 2012-01-06 2018-11-30 Omthera Pharmaceuticals Inc. Dpa-obogaćeni pripravci omega-3 polinezasićenih masnih kiselina u obliku slobodne kiseline
EP2809317A4 (en) * 2012-02-03 2015-07-22 Univ Pittsburgh FATTY ACIDS AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES
CN104661654A (zh) 2012-05-07 2015-05-27 翁特拉制药公司 他汀类药物和ω-3脂肪酸的组合物
CN110478342A (zh) * 2012-05-10 2019-11-22 索卢泰克斯Na有限责任公司 含有天然专门促消退介质及其前体的具有抗炎活性的油
SI2887923T1 (sl) 2012-08-24 2023-09-29 Sun Pharmaceutical Industries Limited Oftalmična formulacija polioksilnega lipida ali polioksilne maščobne kisline in zdravljenje očesnih stanj
CN106163511A (zh) * 2014-01-24 2016-11-23 国立大学法人京都大学 含有稀有脂肪酸的抗炎剂
US11135228B2 (en) * 2014-10-08 2021-10-05 The Brigham And Women's Hospital, Inc. Cysteinyl-proresolving mediators that promote resolution of infection and organ protection
AU2016289856B2 (en) 2015-07-07 2020-11-26 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
HK1256301A1 (zh) * 2015-07-20 2019-09-20 The Brigham And Women's Hospital, Inc. 提高阿托伐他汀和清除感染的新的 13 系列消退素的说明
KR20170025977A (ko) * 2015-08-31 2017-03-08 재단법인차세대융합기술연구원 옥시리스 마리나로부터 분리된 신규 화합물
WO2017041094A1 (en) 2015-09-03 2017-03-09 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same
WO2017059451A1 (en) 2015-10-02 2017-04-06 Complexa, Inc. Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids
FI3373976T3 (fi) 2015-11-10 2024-03-25 Sun Pharmaceutical Ind Ltd Topikaalisia formulaatioita ja niiden käyttöjä
CA3026040A1 (en) * 2016-06-01 2017-12-07 National Research Council Of Canada Winter aconite fatty acid elongase and uses thereof in the production of fatty acids
JP7490566B2 (ja) 2018-04-16 2024-05-27 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 多価不飽和脂肪酸のマルチヒドロキシ誘導体の生産方法
ES2975792T3 (es) 2018-05-25 2024-07-15 Cardurion Pharmaceuticals Inc Monohidrato y formas cristalinas de 6-[(3s,4s)-4-metil-1- (pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7H-imidazo[1,5-a]pirazin-8-ona
KR20250108770A (ko) 2018-08-31 2025-07-15 카듀리온 파마슈티칼스, 인크. 겸상 세포 질환의 치료를 위한 pde9 억제제
CN109161576B (zh) * 2018-09-26 2020-08-07 武汉中科光谷绿色生物技术有限公司 促进枯草芽孢杆菌发酵生产n-乙酰神经氨酸的方法
KR102673270B1 (ko) * 2018-10-15 2024-06-07 (주)아모레퍼시픽 피부장벽 강화용 조성물
WO2021166998A1 (ja) * 2020-02-18 2021-08-26 国立大学法人北海道大学 レゾルビンe2の安定等価体
CN114354785B (zh) * 2021-12-22 2023-06-27 中国农业科学院油料作物研究所 一种基于保留指数结合化学衍生化质谱特征二级碎片的氧脂素综合定性方法
WO2024108603A1 (zh) * 2022-11-25 2024-05-30 中国科学院深圳先进技术研究院 基于粪便代谢物的神经退行性疾病标志物及其应用
FR3148365A1 (fr) * 2023-05-04 2024-11-08 Pierre Fabre Dermo-Cosmetique Oxylipines dans le traitement de la séborrhée et/ou de l’acné

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866046A (en) * 1988-05-31 1989-09-12 Top Laboratories, Inc. Low-dosage sublingual aspirin
US5102670A (en) * 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
US6887901B1 (en) * 1993-06-15 2005-05-03 Brigham & Women's Hospital, Inc. Lipoxin compounds and their use in treating cell proliferative disorders
GB9403857D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US5955496A (en) * 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
PT956013E (pt) * 1996-10-11 2003-08-29 Scarista Ltd Preparacao farmaceutica compreendendo acido eicosapentaenoico e/ou acido estearidonico
US6174695B1 (en) * 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
DE19757414A1 (de) * 1997-12-23 1999-07-01 Nutricia Nv Fettmischung
DE60034775T3 (de) * 1999-03-04 2016-11-24 Suntory Holdings Ltd. Verwendung von Docosapentsäure enthaltendem Material
JP4474082B2 (ja) * 1999-07-07 2010-06-02 キリン協和フーズ株式会社 水酸化脂肪酸およびδ−ラクトン類の製造方法
EP1296923B3 (en) * 2000-02-16 2012-04-11 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
DE10046541A1 (de) * 2000-09-19 2002-03-28 Knoll Ag Mechanisch stabile darreichungsformen, enthaltend Ubichinone
AU2001296661A1 (en) * 2000-10-06 2002-04-15 Michigan State University Divinyl ether synthase gene and protein, and uses thereof
EP1392623A4 (en) * 2001-05-14 2005-05-04 Martek Biosciences Corp PREPARATION AND USE OF A POLAR LIPID RICH FRACTION CONTAINING HIGHLY UNSATURATED OMEGA-3 AND / OR OMEGA-6 FATTY ACIDS FROM MICROBES, SEEDS OF GENETICALLY MODIFIED PLANTS AND MARINE ORGANISMS
US7527935B2 (en) * 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
US6949664B2 (en) * 2002-04-01 2005-09-27 University Of Southern California Trihydroxy polyunsaturated eicosanoids
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
FR2843124B1 (fr) * 2002-08-02 2004-10-15 Goemar Lab Sa Procede de preparation d'acides gras polyinsatures libres et de leurs metabolites d'oxydation
DE60330154D1 (de) * 2002-08-12 2009-12-31 Brigham & Womens Hospital Resolvine: biotemplate zur durchführung therapeutischer anwendungen
US20040166130A1 (en) * 2002-12-23 2004-08-26 L'oreal Lanolin-free cosmetic composition comprising a hydroxylated fatty acid aromatic ester
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
JP2008520739A (ja) * 2004-11-19 2008-06-19 マーテック・バイオサイエンシーズ・コーポレーション 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製および使用方法

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015510517A (ja) * 2012-02-15 2015-04-09 アニダ ファーマ インコーポレイテッド 筋萎縮性側索硬化症の治療方法
JP2016520612A (ja) * 2013-05-30 2016-07-14 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 新規n−3イムノリソルベント:構造及び作用
JP2019163265A (ja) * 2013-05-30 2019-09-26 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 新規n−3イムノリソルベント:構造及び作用
US11667598B2 (en) 2013-05-30 2023-06-06 The Brigham & Women's Hospital Inc. N-3 immunoresolvents: structures and actions
JP2015140323A (ja) * 2014-01-29 2015-08-03 岩手県 Ppar活性化剤
US12447117B2 (en) 2018-10-24 2025-10-21 Amorepacific Corporation Composition and method of enhancing skin barrier using the same
JP2022554152A (ja) * 2019-10-25 2022-12-28 ヌシード ニュートリショナル ユーエス インク. 濃縮多価不飽和脂肪酸組成物
US12337049B2 (en) 2021-05-26 2025-06-24 Amorepacific Corporation Method for whitening skin using composition for skin whitening
WO2023090313A1 (ja) * 2021-11-16 2023-05-25 京都府公立大学法人 摂食量亢進用及び/又は食欲不振改善用組成物並びに一過性受容器電位アンキリン1を活性化するための組成物

Also Published As

Publication number Publication date
WO2008103753A2 (en) 2008-08-28
EP2120920A4 (en) 2011-06-15
WO2008103753A3 (en) 2008-11-27
CN101663031A (zh) 2010-03-03
EP2120920A2 (en) 2009-11-25
US20110190389A1 (en) 2011-08-04

Similar Documents

Publication Publication Date Title
JP2010519311A (ja) 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製およびその使用方法
CN101102988B (zh) 来自长链多不饱和脂肪酸的氧脂素及其制备和使用方法
US7893106B2 (en) Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
US20090318394A1 (en) Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
EP1296923B3 (en) Aspirin-triggered lipid mediators
US20090320148A1 (en) Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same
JP2010519311A5 (enExample)
BRPI0311916B1 (pt) processo para a produção de um óleo microbiano compreendendo ácido araquidônico
AU2014358123B2 (en) Dihomo-gamma-linolenic acid-containing microbial oil and dihomo-gamma-linolenic acid-containing microbial biomass
JP7242769B2 (ja) 遊離多価不飽和脂肪酸含有組成物及びその製造方法
AU2011253846A1 (en) Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
NO348700B1 (en) Cetoleic acid composition
US20110027841A1 (en) Method for preparation of oxylipins
HK1105948B (en) Aspirin triggered lipid mediators

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110218

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110218

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20120705