JP2010519208A5 - - Google Patents
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- Publication number
- JP2010519208A5 JP2010519208A5 JP2009549670A JP2009549670A JP2010519208A5 JP 2010519208 A5 JP2010519208 A5 JP 2010519208A5 JP 2009549670 A JP2009549670 A JP 2009549670A JP 2009549670 A JP2009549670 A JP 2009549670A JP 2010519208 A5 JP2010519208 A5 JP 2010519208A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- replaced
- carbon atoms
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 230000004406 elevated intraocular pressure Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004188 dichlorophenyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 C*C(C)CCC(CCCC(F)(F)F)=O Chemical compound C*C(C)CCC(CCCC(F)(F)F)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89018107P | 2007-02-15 | 2007-02-15 | |
| US60/890,181 | 2007-02-15 | ||
| PCT/US2008/053386 WO2008100809A1 (en) | 2007-02-15 | 2008-02-08 | Gamma-lactams for the treatment of glaucoma or elevated intraocular pressure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519208A JP2010519208A (ja) | 2010-06-03 |
| JP2010519208A5 true JP2010519208A5 (OSRAM) | 2011-03-31 |
| JP5566696B2 JP5566696B2 (ja) | 2014-08-06 |
Family
ID=39511007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549670A Expired - Fee Related JP5566696B2 (ja) | 2007-02-15 | 2008-02-08 | 緑内障または上昇眼内圧の治療用ガンマ‐ラクタム類 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8362054B2 (OSRAM) |
| EP (1) | EP2118094B1 (OSRAM) |
| JP (1) | JP5566696B2 (OSRAM) |
| KR (1) | KR20090109587A (OSRAM) |
| CN (1) | CN101657445B (OSRAM) |
| AU (1) | AU2008216499B2 (OSRAM) |
| BR (1) | BRPI0807600A2 (OSRAM) |
| CA (1) | CA2678191A1 (OSRAM) |
| ES (1) | ES2404169T3 (OSRAM) |
| MX (1) | MX2009008734A (OSRAM) |
| NZ (1) | NZ598945A (OSRAM) |
| WO (1) | WO2008100809A1 (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ585103A (en) * | 2007-10-23 | 2012-04-27 | Allergan Inc | Substituted lactams derivatives and their uses for glaucoma and ocullar hypertension |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004521954A (ja) * | 2001-07-16 | 2004-07-22 | エフ．ホフマン−ラ ロシュ アーゲー | Ｅｐ４受容体作用薬としてのプロスタグランジン類似体 |
| KR100437972B1 (ko) * | 2001-10-27 | 2004-07-02 | 한국과학기술연구원 | 피롤리디논 유도체, 이의 제조 방법 및 이를 포함하는제약 조성물 |
| CN1653046A (zh) * | 2002-03-05 | 2005-08-10 | 小野药品工业株式会社 | 8－氮杂前列腺素衍生化合物以及包含该化合物作为活性成分的药物 |
| US6573294B1 (en) * | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| US7419999B2 (en) * | 2002-06-10 | 2008-09-02 | Applied Research Systems Ars Holding N.V. | Gamma lactams as prostaglandin agonists and use thereof |
| AU2003275838A1 (en) * | 2002-10-25 | 2004-05-13 | Beunard, Jean-Luc | Pyrrolidin-2-on derivatives as ep4 receptor agonists |
| US7091231B2 (en) | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US20080249028A1 (en) | 2005-03-09 | 2008-10-09 | Roger Williams Hospital | Thyrotropin-Releasing Hormone Analogs and Method of Use |
| CN105520941B (zh) * | 2005-03-10 | 2020-05-01 | 阿勒根公司 | 作为治疗剂的取代的γ内酰胺 |
| CA2645867A1 (en) | 2006-03-20 | 2007-09-27 | Allergan, Inc. | Substituted gamma lactams as prostaglandin ep2 agonists |
-
2008
- 2008-02-08 BR BRPI0807600-6A patent/BRPI0807600A2/pt not_active IP Right Cessation
- 2008-02-08 CA CA002678191A patent/CA2678191A1/en not_active Abandoned
- 2008-02-08 US US12/527,155 patent/US8362054B2/en not_active Expired - Fee Related
- 2008-02-08 MX MX2009008734A patent/MX2009008734A/es active IP Right Grant
- 2008-02-08 KR KR1020097018979A patent/KR20090109587A/ko not_active Ceased
- 2008-02-08 JP JP2009549670A patent/JP5566696B2/ja not_active Expired - Fee Related
- 2008-02-08 NZ NZ598945A patent/NZ598945A/xx not_active IP Right Cessation
- 2008-02-08 EP EP08729358.5A patent/EP2118094B1/en not_active Not-in-force
- 2008-02-08 ES ES08729358T patent/ES2404169T3/es active Active
- 2008-02-08 WO PCT/US2008/053386 patent/WO2008100809A1/en not_active Ceased
- 2008-02-08 CN CN2008800120472A patent/CN101657445B/zh not_active Expired - Fee Related
- 2008-02-08 AU AU2008216499A patent/AU2008216499B2/en not_active Ceased